Starring role of Biomarkers and Anticancer Agents as a Major Driver in Precision Medicine of Cancer Therapy

2021 ◽  
Vol 22 ◽  
Author(s):  
Suman Kumar Ray ◽  
Sukhes Mukherjee
Keyword(s):  
Precision Medicine ◽  
Anticancer Agents ◽  
Individual Characteristics ◽  
Treatment Modalities ◽  
Genetic Profile ◽  
Malignant Growth ◽  
New Era ◽  
Life Context ◽  
Contemporary Medicine

: Precision medicine represents the most modern contemporary medicine trend, based on enormous amounts of data relating to people's health, individual characteristics, and life context using the most appropriate strategies to prevent and cure them. Precision medicine in cancer coordinates most precisely and viable treatment to every individual cancer patient based on the disease's genetic profile. Precision medicine changes the standard one size fits all medication model, which has focused on average responses to care. Significantly, consolidating different modern methodologies for streamlining and checking anticancer drugs can have continuous effects on understanding results. Precision medicine can help explicit anticancer treatments using various drugs and even in discovery, thus becoming the paradigm of future cancer medicine. Cancer biomarkers are a significant focus point in precision medicine, and findings of different biomarkers make this field more promising and challenging. Naturally, genetic instability and the collection of extra changes in malignant growth cells are ways that cancer cells use to adapt and survive in a hostile environment, for example, one made by these treatment modalities. Precision medicine is centered around recognizing which treatments are best for individual patients, dependent on their malignant growth and genetic characterization. This new era of genomics, which is progressively referred to as precision medicine, has ignited a new episode in the relationship between genomics and anticancer drug development.

scholarly journals 129 To Examine the Factors Affecting the Health and Wellbeing of Centenarians Living in Ireland

2019 ◽  
Vol 48 (Supplement_3) ◽  
pp. iii1-iii16
Author(s):  
Alison Fagan ◽  
Lorraine Gaffney ◽  
Mary McDonnell-Naughton
Keyword(s):  
Social Services ◽  
Physical Environment ◽  
Social Connectedness ◽  
Well Being ◽  
Individual Characteristics ◽  
Factors Affecting ◽  
Health And Wellbeing ◽  
Contemporary Medicine ◽  
The Life Course

Abstract Background The notable increases in life expectancies worldwide combined with advances in contemporary medicine, escalating healthcare costs and increased demands on social services has driven the interest in centenarians as a model for healthy ageing. According to the United Nations, the global number of centenarians is set to continue to climb, expecting to reach more than 25 million people in 2100 (Robine & Cubaynes, 2017). Though the role of genetics in the context of successful ageing is irrefutable, it is important to recognise that the determinants of ageing go beyond genetics alone and equal credence needs to be given to one’s social and economic circumstances, to their physical environment and finally, to one’s own individual characteristics and behaviours. Methods The study focused on selecting a subsample of participants who were 100 years or older until the saturation point was reached. This study employed story telling (one to one interviews) in order to give centenarians a voice. Stories help us to answer the “big” questions about the meaning of life in general and of our lives specifically. Results A number of key themes emerged from the study denoting the factors that affect the health and wellbeing of Irish centenarians including, social connectedness, resilience & robust personality, continued participation in life throughout the life course and spirituality. Conclusion This research demonstrates that the successful attainment of longevity goes beyond the maintenance of physical health and concludes that in order to promote optimum well-being among older people, it is necessary to take note of the experiences, views and values, of the older person themselves.

Precision Oncology, Signaling and Anticancer Agents in Cancer Therapeutics

2021 ◽  
Vol 21 ◽  
Author(s):  
Dia Advani ◽  
Sudhanshu Sharma ◽  
Smita Kumari ◽  
Rashmi K. Ambasta ◽  
Pravir Kumar
Keyword(s):  
Cancer Treatment ◽  
Precision Medicine ◽  
Anticancer Agents ◽  
Cancer Therapeutics ◽  
Diagnostic Procedures ◽  
Genetic Profile ◽  
Precision Oncology ◽  
Clinical Practices ◽  
Global Alliance ◽  
Healthcare Facilities

Background: The global alliance for genomics and healthcare facilities provides innovational solutions to expedite research and clinical practices for complex and incurable health conditions. Precision oncology is an emerging field explicitly tailored to facilitate cancer diagnosis, prevention and treatment based on patients’ genetic profile. Advancements in “omics” techniques, next-generation sequencing, artificial intelligence and clinical trial designs provide a platform for assessing the efficacy and safety of combination therapies and diagnostic procedures. Method: Data were collected from Pubmed and Google scholar using keywords: “Precision medicine”, “precision medicine and cancer”, “anticancer agents in precision medicine” and reviewed comprehensively. Results: Personalized therapeutics including immunotherapy, cancer vaccines, serve as a groundbreaking solution for cancer treatment. Herein, we take a measurable view of precision therapies and novel diagnostic approaches targeting cancer treatment. The contemporary applications of precision medicine have also been described along with various hurdles identified in the successful establishment of precision therapeutics. Conclusion: This review highlights the key breakthroughs related to immunotherapies, targeted anticancer agents, and target interventions related to cancer signaling mechanisms. The success story of this field in context to drug resistance, safety, patient survival and in improving quality of life is yet to be elucidated. We conclude that, in the near future, the field of individualized treatments may truly revolutionize the nature of cancer patient care.

Immunotherapy strategies for mesothelioma – the role of tumor specific neoantigens in a new era of precision medicine

2018 ◽  
Vol 13 (2) ◽  
pp. 181-192 ◽  
Author(s):  
Linda Ye ◽  
Shaokang Ma ◽  
Bruce W. Robinson ◽  
Jenette Creaney
Keyword(s):  
Precision Medicine ◽  
New Era

scholarly journals Personalised Precision Medicine- a Novel Approach for Oral Cancer Management

2021 ◽  
Author(s):  
Deepa Jatti Patil ◽  
Rakesh Nagaraju
Keyword(s):  
Oral Cancer ◽  
Precision Medicine ◽  
Cancer Diagnosis ◽  
Poor Prognosis ◽  
Neck Region ◽  
Empirical Therapy ◽  
Treatment Modalities ◽  
Cancer Management ◽  
Novel Approach

Oral Cancer is one of the most common malignancies of the head and neck region. Despite technological advancements and improvements in Oral cancer diagnosis and treatment modalities, the 5-year survival rate remains low and is associated with poor prognosis and high mortality rate especially when detected at a later stage. The empirical therapy followed for the treatment of oral cancer includes surgery, radiotherapy and chemotherapy. The treatments are not equally efficacious for all patients, are associated with side effects and poor prognosis. The need of the hour is early diagnosis and tailored treatment therapies for individual patients. With the advent of immunotherapy, the cancer treatment has moved toward personalised precision medicine which tailors’ treatments to each individual. Personalised precision medicine incorporates, molecular profiling of tumours with OMICS technology, biomarkers and companion diagnostics to build databases of patients and devise tailor made treatment approaches for individual patients. This article discusses the role of precision medicine in OSCC prevention, detection, and management by reviewing our understanding of OC from both genetic and OMICS perspectives.

The Contemporary Role of Resection and Ablation in Colorectal Cancer Liver Metastases

2020 ◽  
Vol 04 (03) ◽  
pp. 291-302
Author(s):  
Mariam F. Eskander ◽  
Christopher T. Aquina ◽  
Aslam Ejaz ◽  
Timothy M. Pawlik
Keyword(s):  
Colorectal Cancer ◽  
Portal Vein ◽  
Surgical Oncology ◽  
Portal Vein Ligation ◽  
Safe Alternative ◽  
Colorectal Cancer Liver Metastases ◽  
Liver Remnant ◽  
New Era ◽  
Ablation Therapy

AbstractAdvances in the field of surgical oncology have turned metastatic colorectal cancer of the liver from a lethal disease to a chronic disease and have ushered in a new era of multimodal therapy for this challenging illness. A better understanding of tumor behavior and more effective systemic therapy have led to the increased use of neoadjuvant therapy. Surgical resection remains the gold standard for treatment but without the size, distribution, and margin restrictions of the past. Lesions are considered resectable if they can safely be removed with tumor-free margins and a sufficient liver remnant. Minimally invasive liver resections are a safe alternative to open surgery and may offer some advantages. Techniques such as portal vein embolization, association of liver partition with portal vein ligation for staged hepatectomy, and radioembolization can be used to grow the liver remnant and allow for resection. If resection is not possible, nonresectional ablation therapy, including radiofrequency and microwave ablation, can be performed alone or in conjunction with resection. This article presents the most up-to-date literature on resection and ablation, with a discussion of current controversies and future directions.

MEDIA SOCIALIZATION OF PERSONALITY IN THE CONTEXT OF INMUTATION IN THE MASS MEDIA

2021 ◽  
pp. 104-109
Author(s):  
Chernysh O.O.
Keyword(s):  
Mass Media ◽  
Negative Impact ◽  
Effective Interaction ◽  
Individual Characteristics ◽  
Media Culture ◽  
Active Growth ◽  
Media Space ◽  
The Media ◽  
The Individual

The urgency of the researched problem is connected with the growing role of mass media in modern conditions leads to change of values and transformation of identity of the person. The active growth of the role of the media, their influence on the formation and development of personality leads to the concept of “media socialization” and immutation in the media. The aim of the study is to outline the possibilities of the process of media socialization in the context of immutation in the media. The methods of our research are: analysis of pedagogical, psychological, literature, synthesis, comparison, generalization. The article analyzes the views of domestic and foreign scientists on the problem of immutation in the media and the transformation of the information space. In the context of the mass nature of the immutation of society, the concept of “media socialization” becomes relevant, which is the basis for reducing the negative impact of the media on the individual.The author identifies the lack of a thorough study of the concept of “media socialization” in modern scientific thought. Thus, media socialization is associated with the transformation of traditional means of socialization, and is to assimilate and reproduce the social experience of mankind with the help of new media.The article analyzes the essence of the concepts “media space”, “mass media” and “immutation”. The influence of mass media on the formation and development of the modern personality is described in detail.The study concluded that it is necessary to form a media culture of the individual, to establish safe and effective interaction of young people with the modern media system, the formation of media awareness, media literacy and media competence in accordance with age and individual characteristics for successful media socialization. The role of state bodies in solving the problem of media socialization of the individual was also determined. It is determined that the process of formation of media culture in youth should take place at the level of traditional institutions of socialization of the individual.The author sees the prospect of further research in a detailed analysis and study of the potential of educational institutions as an institution and a means of counteracting the mass nature of the immutation of society.Key words: immutation, media socialization, mass media, media space, information.

From Trinidad and Tobago to the World: Determining the role of Calypso in a new Era

2020 ◽  
Vol 5 ◽  
pp. 7-11
Author(s):  
Malek Abdel-Shehid
Keyword(s):  
Trinidad And Tobago ◽  
Regional Integration ◽  
West African ◽  
Major Influence ◽  
New Era ◽  
Transatlantic Slave Trade ◽  
Cultural Sovereignty ◽  
Caribbean Culture ◽  
Musical Cultures

Calypso is a popular Caribbean musical genre that originated in the island nation of Trinidad and Tobago. The genre was developed primarily by enslaved West Africans brought to the region via the transatlantic slave trade during the seventeenth and eighteenth centuries. Although West-African Kaiso music was a major influence, the genre has also been shaped by other African genres, and by Indian, British, French, and Spanish musical cultures. Emerging in the early twentieth century, Calypso became a tool of resistance by Afro-Caribbean working-class Trinbagonians. Calypso flourished in Trinidad due to a combination of factors—namely, the migration of Afro-Caribbean people from across the region in search of upward social mobility. These people sought to expose the injustices perpetrated by a foreign European and a domestic elite against labourers in industries such as petroleum extraction. The genre is heavily anti-colonial, anti-imperial, and anti-elitist, and it advocated for regional integration. Although this did not occur immediately, Calypsonians sought to establish unity across the region regardless of race, nationality, and class through their songwriting and performing. Today, Calypso remains a unifying force and an important part of Caribbean culture. Considering Calypso's history and purpose, as well as its ever-changing creators and audiences, this essay will demonstrate that the goal of regional integration is not possible without cultural sovereignty.

INTERPRETATION OF SINO-RUSSIAN CULTURE AND HUMANITIES COOPERATION IN THE NEW ERA

2020 ◽  
Vol 10 (3) ◽  
pp. 186-193
Author(s):  
REN YANYAN ◽  
Keyword(s):  
Current Status ◽  
Human Relations ◽  
New Era ◽  
Russian Culture ◽  
The People ◽  
Starting Point ◽  
Cooperative Partnership ◽  
Belt And Road ◽  
The Belt And Road

The friendship between nations lies in the mutual affinity of the people, and the people’s affinity lies in the communion of hearts. The cultural and humanities cooperation between China and Russia has a long history. In recent years, under the role of the“Belt and Road” initiative, the SCO, and the Sino-Russian Humanities Cooperation Committee, Sino-Russian culture and humanities cooperation has continued to deepen. Entering a new era, taking the opportunity to promote Sino-Russian relations into a “new era China-Russia comprehensive strategic cooperative partnership”, the development of human relations between the two countries has entered a new historical starting point, while also facing a series of problems and challenges. This article is based on the current status of Sino-Russian human relations in the new era, interprets the characteristics of Sino-Russian human relations in the new era, analyzes the problems and challenges of Sino-Russian human relations in the new era, and tries to propose solutions and solutions with a view to further developing Sino-Russian cultural and humanities relations in the new era. It is a useful reference, and provides a reference for future related research, and ultimately helps the Sino-Russian cultural and humanities relations in the new era to be stable and far-reaching.

Expanding the Role of N-of-1 Trials in the Precision Medicine Era: Action Priorities and Practical Considerations

2018 ◽  
Author(s):  
Karina W. Davidson ◽  
Ying Kuen Cheung ◽  
Thomas McGinn ◽  
Y. Claire Wang
Keyword(s):  
Precision Medicine
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