Facile Synthetic Protocols for the preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-Cancer Drug

2021 ◽  
Vol 18 ◽  
Author(s):  
Rama Mohana Reddy Jaggavarapu ◽  
Venkatanarayana Muvvala ◽  
Ghojala Venkatareddy ◽  
Ravi Kumar Cheedarala

: A facile synthetic protocols were employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for the quality control.

Author(s):  
Nagaraj P Shetti

Abstract-The electrochemical oxidation of an anti-cancer drug Pemetrexed disodium has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentrartion, scan rate, and excipients were investigated to optimize the experimental conditions. According to the liner relation between peak potential, peak current, scan rate and Pemetrexed disodium concentration, differential pulse voltammetric method for the quantitative determination in phosphate Buffer solution was developed. The linear response was obtained in the range of 10 µM to 0.75 µM with a detection limit of 0.19 µM. The electrochemical oxidation of mechanism of an anti-cancer drug Pemetrexed disodium was proposed. Keywords- Pemetrexed disodium, Cyclic Voltammetry, Electochemical Studies, Glassy carbon electrode


2021 ◽  
Author(s):  
Thangamani Suppan ◽  
Hema Priya Mahendran ◽  
Rama Ranjan Bhattacharjee ◽  
Sankarganesh Jeyaraj ◽  
Kallol Mohanta

Dihydropyrimidinones, a Biginelli compound, have been found to be a tumor inhibitor in the last decade. The novel carbon quantum dot- dihydropyrimidinone (CQD-DHPM) nanocomposites have been prepared by a simple...


2012 ◽  
Vol 403 (1) ◽  
pp. 309-321 ◽  
Author(s):  
Ján Stariat ◽  
Vít Šesták ◽  
Kateřina Vávrová ◽  
Milan Nobilis ◽  
Zuzana Kollárová ◽  
...  
Keyword(s):  
Phase I ◽  

2021 ◽  
Vol 23 (09) ◽  
pp. 1006-1019
Author(s):  
Manju Kharb ◽  
◽  
Pawan Jalwal ◽  
Shikha Rathi ◽  
Suresh Kumar ◽  
...  

Background: Taxanes constitute an important class of anti-cancer agents, which are widely prescribed for the management of cancers like breast, lung and ovaries. These agents belong to Biopharmaceutical Classification System (BCS) class IV, which are neither soluble in the aqueous systems nor permeable across the biological membranes. Objectve: Due to these concerns only, the oral bioavailabilities of these drugs are too low. Looking into these concerns, it was envisaged to develop co-crystals of docetaxel with syringic acid. Methods: For the preparation of co-crystals no single method is used. The methods range from spray drying, crystallization, ultrasonication and freeze drying to supercritical fluid methodologies. Results: The novel co-crystal not only improved the solubility and dissolution rates of the drug, but also resulted in improved pharmacokinetic profile. Conclusion: The present findings provide an economic and viable approach to improve the solubility and absorption profile of a drug, which is a vital component of the anticancer chemotherapy. Such studies provide a hope for the development of approaches to improve the solubility and permeability of drugs with challenges.


2004 ◽  
Vol 321 (2) ◽  
pp. 403-412 ◽  
Author(s):  
Shaker Abuharbeid ◽  
Jürgen Apel ◽  
Martin Sander ◽  
Babette Fiedler ◽  
Martin Langer ◽  
...  
Keyword(s):  

2021 ◽  
Vol 11 (2) ◽  
pp. 175-183
Author(s):  
Farha Fatma ◽  
Anil Kumar

Cancer is a serious problem affecting the health of human and isone of the leading cause of mortality worldwide. A normal cell undergoes regulated cell division, differentiation and apoptosis (programmed cell death). When normal cell has lost the usual control over their division, differentiation and apoptosis they become tumor cells. Cancer arises mainly from mutations in somatic cells. Maintenance of genomic integrity is a pre-requisite for a safe and long lasting life. For this purpose, cell has quality control points, referred as checkpoints. The different mechanisms and multiple researchers involved in the field necessiatean understanding of the molecular mechanism to classify tumor and to assess the risk and treatment of disease. Certain therapeutic strategies exist and many more need to be explored. Different experimental therapies are currently in clinical trials and are raising hopes that a new class of anti-cancer drug may soon be available.


Author(s):  
Song-Bin Huang ◽  
Min-Hsien Wu ◽  
Zhanfeng Cui ◽  
Zheng Cui ◽  
Gwo-Bin Lee

This study reports a new perfusion-based, micro three-dimensional (3-D) cell culture platform for drug testing using enabling microfluidic technologies. In this work, a perfusion-based, micro 3-D cell culture platform is designed and is fabricated based on SU-8 lithography and polydimethylsiloxane (PDMS) replication processes. One of the key features of the system is that the incorporation of a multiple medium pumping mechanism, consisting of 15 membrane-based pneumatic micropumps with serpentine-shape (S-shape) layout, coupled with a pneumatic tank, into the micro 3-D cell culture platform to provide efficient and economical culture medium delivery. Moreover, a “smart cell/agarose (scaffold) loading mechanism” was proposed, allowing the cell/3-D scaffold loading process in one step and avoiding too much laborious works and manual error. The results show that in all of the 15 S-shape pneumatic micropumps studied, the medium delivery mechanism is able to provide a uniform flow output ranging from 5.5 to 131 μl/hr depending on the applied pulsation frequency of the micropumps. In addition, the cell/agarose (scaffold) loading mechanism was proved to be able to perform sample loading tasks precisely and accurately in all of the 15 microbioreactors integrated. Furthermore, anti-cancer drug testing was successfully demonstrated using the proposed culture platform and fluorescent microscopic observation. As a whole, because of miniaturization, not only does this perfusion 3-D cell culture platform provide a homogenous and steady cell culture environment, but it also reduces the need for human intervention. Moreover, due to the integrated pumping of the medium and the cell/agarose (scaffold) loading mechanisms, time efficient and economical research work can be achieved. These characteristics are found particularly useful for high-precision and high-throughput 3-D cell culture-based drug testing.


2019 ◽  
Vol 15 (1) ◽  
pp. 37-49
Author(s):  
Om Prakash ◽  
Shazia Usmani ◽  
Ruchi Singh ◽  
Debarshi K. Mahapatra ◽  
Amresh Gupta

Background: Cancer is the second leading cause of death globally and accounted for 8.8 million deaths annually in humans. Lung, prostate, colorectal, stomach and liver cancer are the most common types of cancer in men, while breast, colorectal, lung, cervix and stomach cancer are the most common among women. Numerous drugs that the US Food and Drug Administration (FDA) have approved for use in cancer therapy are derived from plants, including taxanes such as paclitaxel and vinca alkaloids such as vincristine and vinblastine. Still, there is an intense need for a search for numerous bioactive sources to develop a novel anti-cancer drug to overcome this chronic disorder. About more than thirty plants derived natural products have been isolated till date and are currently under clinical trials. As per literature survey from various journals and texts has been found to be novel medicinal agents from bioactive sources are clinically active against various types of cancer cells. Conclusion: Current review has been highlighted on the novel medicinal agents from plant sources have potential effects against many types of cancer, which have been supported by clinical trials. The main findings of these active novel medicinal agents were also summarized and discussed here.


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