Clinical and Laboratory Findings of Viral Influenza among Children Hospitalized in Qazvin Pediatric Hospital in Iran, 2015-2020

2022 ◽  
Vol 18 ◽  
Author(s):  
Khatereh Khamenehpour ◽  
Abolfazl Mahyar ◽  
Fatemeh Bagherabadi ◽  
Samaneh Rouhi ◽  
Zahra Sadat Mohammadi
Keyword(s):  
Febrile Seizure ◽  
Influenza Infection ◽  
Cross Sectional Study ◽  
Clinical Feature ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Appropriate Treatment ◽  
Children Health ◽  
Viral Influenza ◽  
Underlying Diseases

Background: Children are one of the most important groups at risk of catching the influenza infection. The consequences of influenza in some children, especially children with chronic and underlying diseases, can be very severe and lead to hospitalization. Objective: Purpose of this research was to determine children with influenza and their clinical and laboratory findings in Qazvin children hospital between 2015 to 2020 years. Methods: In this descriptive cross-sectional study, epidemiological and clinical finding of children hospitalized due to confirmed influenza were considered. A total of 1468 children with a suspected diagnosis to influenza were included in this study. Then, based on the Real-time Polymerase Chain Reaction (PCR) a total of 229 were confirmed positive to influenza. Statistical analysis was done using software SPSS 23.0, Analysis Of Variance (ANOVA) and t-test (p≤0.05). Results: Most of patients (53.7%) were infected with influenza H1N1 type. Most comorbidity was observed with Central Nervous System (CNS) disease and febrile seizure (each one 3.10%). Highest clinical feature was fever (83.4%). Significant relationship was observed between the season (p=0.001), sore in throat (p=0.001), febrile seizure (p=0.051), muscle and joint pain (p=0.059), rhinorrhea (p=0.006) and shiver (p=0.051) and occurrence of influenza. Also 4 children had died from influenza during hospitalization. Conclusion: Children with influenza disease were found in this study. Influenza has some side effects on children health. Due to the irreversible and dangerous effects of the influenza, early diagnosis and appropriate treatment in children is important.

THE SITUATION OF RECOGNITION OF SOME NON-COMMUNICABLE DISEASES AND TREATMENT AND PREVENTIVE BEHAVIORS OF PEOPLE IN THUA THIEN HUE PROVINCE

2019 ◽  
pp. 80-86
Author(s):  
Phuoc Thuoc Doan ◽  
Thi Huong Nguyen ◽  
Thi Thanh Nhan Tran ◽  
Thi Phuong Thao Nguyen ◽  
Thi Thuy Hang Nguyen ◽  
...  
Keyword(s):  
Dietary Habits ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Sectional Study ◽  
Preventive Behaviors ◽  
Cross Sectional ◽  
Non Communicable Diseases ◽  
Treatment And Prevention ◽  
Knowing That ◽  
Appropriate Treatment

Background: Non-communicable diseases seriously affect public health and socio-economic development of the country due to the high number of people suffering from diseases, being disabled and mortal. However, the proportion of people who recognized themselves a suffering from non-communicable diseases such as hypertension, diabetes and dyslipidemia is not high. For cases that their disease situations have been identified, there are not appropriate treatment and preventive behaviors. Objectives: 1) To determine the proportion of 25 - 84 years old peoplewho identified themselves as suffering from hypertension, diabetes and dyslipidemia. 2) To learn treatment and preventive behaviors in the group of people who identified themselves as suffering from diseases. Methods: A cross-sectional study was conducted with a randomly selected sample of 1600 residents in Thua Thien Hue province. Results: The proportion of people knowing that they are suffering from hypertension, diabetes and dyslipidemia was 29.4%; 3.2% and 7.8% respectively. Among them, the proportion of people who did not treat and treated irregularly accounted for 42.7%; 13.7% and 75.2% respectively; the proportion of people who did not change their lifestyles and dietary habits accounted for 50.1%; 5.9% and 56.8% respectively. Conclusions: The proportion of people who identified themselves as suffering from some non-communicable diseases without appropriate treatment and preventive behaviors is alarming. Interventions are needed to help people realize the importance of treatment and prevention effectively. Key words: Non-communicable diseases, hypertension, diabetes, dyslipidemia

Predictors of Psychiatric Morbidity in Cancer Patients

1994 ◽  
Vol 165 (5) ◽  
pp. 593-598 ◽  
Author(s):  
Judy Harrison ◽  
Peter Maguire
Keyword(s):  
Risk Factors ◽  
Cancer Patients ◽  
Psychiatric Morbidity ◽  
Significant Proportion ◽  
Cross Sectional Study ◽  
Future Research ◽  
Cross Sectional ◽  
Appropriate Treatment ◽  
Study Designs ◽  
Patients Experience

BackgroundA significant proportion of cancer patients experience psychiatric morbidity in association with diagnosis and treatment. If this morbidity is to be reduced, a better understanding is needed of the factors which influence adjustment to cancer.MethodA review of the literature was carried out to explore those factors associated with poor psychological adjustment to cancer. These are described under four headings: characteristics of the patient; disease and treatment variables; the interaction between patient and illness; and environmental factors.ResultsA number of risk factors for psychiatric morbidity can be identified from each of the four areas. Methodological limitations are highlighted, in particular the preponderance of cross-sectional study designs.ConclusionsIncreased awareness of the risk factors for psychiatric morbidity should lead to earlier detection and more appropriate treatment. Future research should focus on those risk factors which are potentially modifiable.

A Cross-Sectional Study to Compare Differences on Clinical and Laboratory Findings in Children with Seropositive and Seronegative Lupus

2021 ◽  
Author(s):  
Shima Salehi ◽  
Rozita Hosseini Shamsabadi ◽  
Hassan Otukesh ◽  
Reza Shiari ◽  
Monir Sharafi
Keyword(s):  
Autoimmune Disease ◽  
Disease Diagnosis ◽  
Cross Sectional Study ◽  
Rapid Identification ◽  
The Body ◽  
Musculoskeletal Symptoms ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Significant Difference ◽  
History Of

Abstract Background: Lupus is an inflammatory and autoimmune disease that involves various tissues and organs of the body. Identification of diagnostic elements to rapid identification of seronegative lupus cases is very important in order to prevent morbidity and progression of disease. This study aimed to compare clinical and laboratory findings of seropositive cases with seronegative lupus patients. Methods: This cross-sectional analytic study was performed on 43 children (17 seronegative and 26 seropositive) with lupus who were admitted to Ali Asghar Hospital during 2007-2017. Seropositive patients had anti-nuclear antibody (ANA) titration >1/80, while seronegative patients had ANA titration <1/80 (at the time of disease diagnosis). Clinical and laboratory findings were compared between two groups.Results: Serositis in patients with ANA- was significantly higher than ANA+ (41.17% vs. 23.07%; p = 0.042). ANA- group had higher autoimmune disease history than ANA+ group (42.85% vs. 15.0%; p = 0.041). The family history of the disease in the ANA- group was greater than ANA+ group (50% vs. 23.52%). The percentage of hypertensive patients in ANA- group was higher than ANA+ group (52.94% vs. 26.92%; p = 0.037). Neurologic symptoms in ANA+ and ANA- groups were 38.46% and 17.64%, respectively (p = 0.043). The frequency of patients with thrombocytopenia in ANA+ group was significantly greater than ANA- group (32% vs. 12.5%; p=0.041). There was no significant difference in other clinical and laboratory findings between two groups. Conclusion: Seronegative lupus patients had higher percentage of musculoskeletal symptoms, autoimmune disease history, familial history of disease, and hypertension, while neurological and thrombocytopenia symptoms were higher in seropositive patients compared to seronegative cases. Therefore, evaluation of these factors can be helpful to diagnosis of seronegative patients.

scholarly journals Clinical Assessment and Management of Spondyloarthritides in the Middle East: A Multinational Investigation

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed Hammoudeh ◽  
Hanan Al Rayes ◽  
Adel Alawadhi ◽  
Kamel Gado ◽  
Khalid Shirazy ◽  
...  
Keyword(s):  
Middle East ◽  
Disease Burden ◽  
Clinical Laboratory ◽  
Management Strategies ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
East Region ◽  
Appropriate Treatment ◽  
Treatment Data ◽  
Middle East Region

Data on spondyloarthritis (SpA) from the Middle East are sparse and the management of these diseases in this area of the world faces a number of challenges, including the relevant resources to enable early diagnosis and referral and sufficient funds to aid the most appropriate treatment strategy. The objective was to report on the characteristics, disease burden, and treatment of SpA in the Middle East region and to highlight where management strategies could be improved, with the overall aim of achieving better patient outcomes. This multicenter, observational, cross-sectional study collected demographic, clinical, laboratory, and treatment data on 169 consecutive SpA patients at four centers (Egypt, Kuwait, Qatar, and Saudi Arabia). The data collected presents the average time from symptom onset to diagnosis along with the presence of comorbidities in the region and comparisons between treatment with NSAIDs and biologics. In the absence of regional registries of SpA patients, the data presented here provide a rare snapshot of the characteristics, disease burden, and treatment of these patients, highlighting the management challenges in the region.

scholarly journals Liver Biomarkers Assay in COVID-19 Cases: A Comparison Study between Alive and Dead Patients

2022 ◽  
Author(s):  
Amir Emami ◽  
Fatemeh Javanmardi ◽  
Ali Akbari ◽  
Babak Shirazi Yeganeh ◽  
Tahereh Rezaei ◽  
...  
Keyword(s):  
Serum Albumin Level ◽  
Critical Role ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Albumin Level ◽  
Hospital Death ◽  
Comparison Study ◽  
Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional

Background: Identifying effective biomarkers plays a critical role on screening; rapid diagnosis; proper managements and therapeutic options, which is helpful in preventing serious complications. The present study aimed to compare the liver laboratory tests between alive and dead hospitalized cases for prediction and proper management of the patients. Methods: This retrospective, cross sectional study consists of all deceased patients admitted in one center in Shiraz, Iran during 19 Feb 2020 to 22 Aug 2021. For further comparison, we selected a 1:2 ratios alive group randomly. Results: Overall, 875 hospitalized cases died due to COVID-19. We selected 1750 alive group randomly. The median age was significantly higher in died group (65.96 vs 51.20). Regarding the laboratory findings during the hospitalization ALT, AST, Bili.D were significantly higher in non-survivors than survivors but Albumin was less in deceased patients. It was revealed elevated levels of Albumin, AST, Bili.T and Bili.D were associated with increasing the risk of in hospital death. Moreover, the predictive effect of ALP and Bili.D had significantly more than others with high sensitivity and specify. Conclusion: We found patients with COVID-19 have reduced serum albumin level, and increase ALT and AST. The current results revealed abnormal liver chemistries is associated with poor outcome, which highlighted the importance of monitoring these patients more carefully and should be given more caution.

scholarly journals Identification of Novel Classes for Patients With Lupus Nephritis Using Two-step Cluster Model

2021 ◽  
Author(s):  
Ting Huang ◽  
Shasha Xie ◽  
Liqing Ding ◽  
Hui Luo
Keyword(s):  
Cluster Analysis ◽  
Evaluation System ◽  
Demographic Data ◽  
White Blood Cells ◽  
Damage Index ◽  
Cross Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Mild Disease ◽  
Cluster 2

Abstract Objectives: To identify and reclassify the patients in the LN cohort, and to further analyze the prominent clinical features and clinical significance of each cluster of patients.Methods: This is a cross-sectional study of a cohort of 635 LN patients from the Rheumatology Department of Xiangya Hospital of Central South University. Demographic data, laboratory findings and clinical evaluation system include physician’s global assessment and the SLICC/ACR Damage Index were collected. Using two-step cluster analysis, patients with similar clinical property were identified and compared.Results: Among the 635 LN patients, 599 patients (94.3%) were female. The mean age of the patients were 33.8 ± 10.4 years. Three subgroups were identified by two-step cluster analysis. Cluster 1 included 130 (20.5%) patients, Cluster 2 included 132(20.8%) patients and Cluster 3 included 373 (58.7%) patients. Cluster 3 was the largest group of mild disease activity, patients in this cluster had lower white blood cells, neutrophils, lymphocytes and mean SDI scores compared to those in the other two clusters. Cluster 1 was the smallest group of severe damage, patients in this cluster had multiple positive auto-antibodies, higher SDI scores and lower complement level. Patients of cluster 2 had the highest levels of granulocytes, but the results of other laboratory tests were roughly between the cluster 1 and cluster 3.Conclusions: This study reclassified three groups of LN patients in a large cohort. Our research shows that the multiple positive ANA antibody may be related to the high SDI score of LN patients. Clinicians can identify patients at different stages through cluster analysis to better implement prognosis.

scholarly journals Use of Lumbar Puncture for First Episode of Febrile Seizure among Children 6 Months to 18 Months of Age: A Cross Sectional Study

2018 ◽  
Vol 3 (2) ◽  
pp. 399-402
Author(s):  
Nirajana Kayastha ◽  
Ganesh Kumar Rai ◽  
Subhana Karki
Keyword(s):  
Lumbar Puncture ◽  
Febrile Seizure ◽  
Clinical Characteristics ◽  
Cross Sectional Study ◽  
First Episode ◽  
Cross Sectional ◽  
Serious Infection ◽  
Meningitis In Children ◽  
Complex Features ◽  
Seizure Episode

Introduction: Febrile seizure accounts for the majority cases of the pediatric seizure. Fever with seizure can be either due to febrile seizure or underlying serious infection as meningitis. As seizure may be the only manifestation of meningitis it is important to rule out meningitis in children presenting with fever and seizure.Objective: The objective of this study was to determine the incidence of meningitis among children aged 6 to 18 months presenting with first episode of febrile seizure.Methodology: A prospective observational study was conducted among 94 children with first episode of febrile seizure presenting to the emergency and observation wards of Kanti Childrens' Hospital and subjected to lumbar puncture (LP) as per the American Academy of Pediatrics (AAP) recommendations. The proportion of children with meningitis and no meningitis among the study population was determined, clinical characteristics were compared among these groups and the incidence of meningitis in simple febrile seizure and complex febrile seizure was calculated. The collected data was analysed using SPSS.Results: Twenty (21.3%) cases were diagnosed with meningitis among 94 children enrolled in our study. Meningitis was detected in 38.1% of the cases of complex febrile seizure and 7.7% of cases of simple febrile seizure. In the age group 6 to 12 months, 11 (17.4%) had meningitis while in 12 to 18 months of age, 9 (29%) were detected with meningitis. Meningitis was 7.38 times more likely in cases presenting with complex febrile seizure than simple febrile seizure (OR=7.58; 95% CI 2.24-24.4; p<0.001). Regarding the clinical characteristics, vomiting, fever of more than 48 hours duration prior to onset of seizure, impaired consciousness and complex features of seizure were found to be significantly associated with meningitis in our study.Conclusion: The probability of meningitis among children aged 6 to 18 months presenting with first episode of febrile seizure episode is high. In febrile convulsing children less than 18 months of age, meningitis should be considered even in the absence of signs of meningeal irritation.  BJHS 2018;3(2)6:399-402.

Bacteria Associated With Commercially Prepared Mealie Meal From Selected Food Stores in Lusaka District of Zambia

2021 ◽  
Author(s):  
Adeyemo Dayo Omodele ◽  
Hangombe Bernard Mudenda ◽  
John Bwalya Muma ◽  
Musso Munyeme ◽  
Martin Simuunza ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Cross Sectional Study ◽  
Bacillus Species ◽  
Clostridium Tetani ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Food Stores ◽  
South Central ◽  
Spoilage Bacteria ◽  
Food Borne Infections

Abstract Introduction:Mealie meal is a staple diet in the Lusaka district of Zambia. Bacteria associated with commercially prepared mealie meal could be spoilage or pathogenic bacteria. Thus bacterial contamination could result from packaged maize flours purchased from food stores.Material and Methods:A cross-sectional study was carried out from December 2019 - March 2020 for spoilage and pathogenic bacteria associated with mealie meals bought from a selected retail outlet in the Lusaka district. We performed cell culture for the Mealie Meal Samples collected at five study zones in Lusaka district viz: South, Central, East, West, and North. Food stores in each zone were further stratified into sampling units of interest: mall, shop, and street food vendor. Results: Preliminary laboratory findings revealed the following: Spoilage Bacteria - Candida Species, Clostridium Species, and Bacillus Species; Pathogenic Bacteria Species-Clostridium perfringens, Staphylococcus aureus, Clostridium tetani, Bacillus, Escherichia coli, Pseudomonas aeruginosa, and Yersinia pestis.Conclusion:In conclusion, it can be established from the aforementioned laboratory results that food-borne infections could evolve from bacteria associated with commercially prepared mealie meals bought from food stores in the Lusaka district of Zambia.

scholarly journals Fibrinogen status in relapse and remission of childhood nephrotic syndrome

2016 ◽  
Vol 46 (4) ◽  
pp. 149
Author(s):  
Veronica Lily Limantara ◽  
Ida Bagus Mudita ◽  
I Ketut Suarta
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Cross Sectional Study ◽  
Fibrinogen Concentration ◽  
Strongly Correlated ◽  
Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Remission Status ◽  
The Mean

Objective To evaluate fibrinogen concentration of relapsing neph-rotic syndrome (NS) in children, and to investigate relationshipbetween fibrinogen with albumin and cholesterol.Methods A cross-sectional study among NS patients admitted topediatric outpatient clinic and pediatric ward at Sanglah Hospital,Denpasar, from November 1, 2003 to January 31, 2004. All pa-tients were evaluated for clinical and laboratory findings of relapseand remission, including edema, proteinuria, serum albumin, totalcholesterol, as well as total platelet count and fibrinogen concen-tration to evaluate coagulation parameters in nephrotic patients.Results There were 36 patients with the mean age of 7.4 (SD 2.3)years included in this study. Mean fibrinogen concentration in re-lapse state was 671.8 (SD 102.7) mg/dl, while in remission statewas 255.2 (SD 50.5 mg/dl); the mean difference was 416.6 mg/dl(95% CI 362.9;470.4; P<0.001). Fibrinogen was inversely andstrongly correlated with serum albumin concentrations (r=-0.91;P<0.001). Fibrinogen was positively and strongly correlated to to-tal cholesterol (r=0.80; P<0.001). Using multiple regression analy-sis, it was shown that only relapse/remission status was signifi-cantly associated with fibrinogen concentration (P<0.001).Conclusion Fibrinogen status is significantly correlated with re-lapse and remission status of NS in childhood patients.

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