QSAR Study on a Series of Aryl Carboxylic Acid Amide Derivatives as Potential Inhibitors of Dihydroorotate Dehydrogenase (DHODH)

Vivek K. Vyas; Manjunath Ghate

doi:10.2174/1573406411309020007

QSAR Study on a Series of Aryl Carboxylic Acid Amide Derivatives as Potential Inhibitors of Dihydroorotate Dehydrogenase (DHODH)

Medicinal Chemistry ◽

10.2174/1573406411309020007 ◽

2013 ◽

Vol 9 (2) ◽

pp. 222-239 ◽

Cited By ~ 3

Author(s):

Vivek K. Vyas ◽

Manjunath Ghate

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Dihydroorotate Dehydrogenase ◽

Carboxylic Acid Amide ◽

Qsar Study ◽

Amide Derivatives ◽

Potential Inhibitors

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CoMFA and CoMSIA Studies on Aryl Carboxylic Acid Amide Derivatives as Dihydroorotate Dehydrogenase (DHODH) Inhibitors

Current Computer - Aided Drug Design ◽

10.2174/157340912803519598 ◽

2012 ◽

Vol 8 (4) ◽

pp. 271-282 ◽

Cited By ~ 8

Author(s):

Vivek K. Vyas ◽

Manjunath Ghate

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Dihydroorotate Dehydrogenase ◽

Carboxylic Acid Amide ◽

Amide Derivatives

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Parallel Iterative Solution-Phase Synthesis of 5-Amino-1-aryl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic Acid Amide Derivatives.

ChemInform ◽

10.1002/chin.200320170 ◽

2003 ◽

Vol 34 (20) ◽

Author(s):

Bernd Brodbeck ◽

Bernd Puellmann ◽

Sebastien Schmitt ◽

Matthias Nettekoven

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Iterative Solution ◽

Solution Phase ◽

Carboxylic Acid Amide ◽

Phase Synthesis ◽

Amide Derivatives ◽

Solution Phase Synthesis ◽

Parallel Iterative

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Parallel iterative solution-phase synthesis of 5-amino-1-aryl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylic acid amide derivatives

Tetrahedron Letters ◽

10.1016/s0040-4039(03)00062-5 ◽

2003 ◽

Vol 44 (8) ◽

pp. 1675-1678 ◽

Cited By ~ 10

Author(s):

Bernd Brodbeck ◽

Bernd Püllmann ◽

Sébastien Schmitt ◽

Matthias Nettekoven

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Iterative Solution ◽

Solution Phase ◽

Carboxylic Acid Amide ◽

Phase Synthesis ◽

Amide Derivatives ◽

Solution Phase Synthesis ◽

Parallel Iterative

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Synthesis of 1-[4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-ylmethyl]-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid amide derivatives and evaluation of their platelet aggregation inhibition activity.

International Journal of ChemTech Research ◽

10.20902/ijctr.2018.110218 ◽

2018 ◽

Keyword(s):

Platelet Aggregation ◽

Carboxylic Acid ◽

Acid Amide ◽

Inhibition Activity ◽

Carboxylic Acid Amide ◽

Platelet Aggregation Inhibition ◽

Amide Derivatives ◽

Aggregation Inhibition

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Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.05.031 ◽

2013 ◽

Vol 23 (14) ◽

pp. 4177-4184 ◽

Cited By ~ 7

Author(s):

Wei Tian ◽

Guangqian Han ◽

Ju Zhu ◽

Jingjing Qi ◽

Qianqian Chen ◽

...

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Carboxylic Acid Amide ◽

Amide Derivatives ◽

Inhibitory Activities

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Solid-Phase Synthesis of 4,6-Diaryl-3,4-dihydropyrimidine-2(1H)-one- 5-carboxylic Acid Amide Derivatives: A Biginelli Three-Component Condensation Protocol Based on Immobilized β-Ketoamides

Journal of Combinatorial Chemistry ◽

10.1021/cc050074c ◽

2006 ◽

Vol 8 (2) ◽

pp. 153-155 ◽

Cited By ~ 27

Author(s):

G. Alexander Gross ◽

Hanns Wurziger ◽

Andreas Schober

Keyword(s):

Carboxylic Acid ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Acid Amide ◽

Carboxylic Acid Amide ◽

Phase Synthesis ◽

Amide Derivatives

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Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Journal of Medicinal Chemistry ◽

10.1021/jm8012932 ◽

2009 ◽

Vol 52 (2) ◽

pp. 234-237 ◽

Cited By ~ 51

Author(s):

David A. Griffith ◽

John R. Hadcock ◽

Shawn C. Black ◽

Philip A. Iredale ◽

Philip A. Carpino ◽

...

Keyword(s):

Carboxylic Acid ◽

Receptor Antagonist ◽

Acid Amide ◽

Carboxylic Acid Amide ◽

Cannabinoid Type 1 Receptor

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Carboxylic Acid Amide Fungicides for the Control of Downy Mildew Diseases

Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals ◽

10.1002/9783527693931.ch30 ◽

2016 ◽

pp. 395-403 ◽

Cited By ~ 1

Author(s):

Clemens Lamberth

Keyword(s):

Carboxylic Acid ◽

Downy Mildew ◽

Acid Amide ◽

Carboxylic Acid Amide

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Reaction of Indole Carboxylic Acid/Amide with Propargyl Alcohols: [4 + 3]-Annulation, Unexpected 3- to 2- Carboxylate/Amide Migration, and Decarboxylative Cyclization

Organic Letters ◽

10.1021/acs.orglett.9b01686 ◽

2019 ◽

Vol 21 (14) ◽

pp. 5447-5451 ◽

Cited By ~ 10

Author(s):

Karuppu Selvaraj ◽

Shubham Debnath ◽

K. C. Kumara Swamy

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Carboxylic Acid Amide ◽

Indole Carboxylic Acid ◽

Decarboxylative Cyclization ◽

Propargyl Alcohols

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Rhodium catalyzed one-step hydroamidation of cyclopentadiene and dicyclopentadiene

Catalysis Science & Technology ◽

10.1039/c5cy00168d ◽

2015 ◽

Vol 5 (5) ◽

pp. 2783-2787 ◽

Cited By ~ 8

Author(s):

Arno Behr ◽

Denys Levikov ◽

Edward Nürenberg

Keyword(s):

Carboxylic Acid ◽

Acid Amide ◽

Amide Group ◽

Carboxylic Acid Amide ◽

Direct Route ◽

One Step ◽

Pharmaceutical Industries

The carboxylic acid amide group is of great importance in the contemporary chemical and pharmaceutical industries. A one-step rhodium catalyzed direct route from alkene to amide is presented via the hydroamidation reaction of cyclopentadiene and dicyclopentadiene.

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