Single-atom nanocatalysts for biosensing application

Single-atom (SA) catalysts, as a rising star in catalytic field, have many advantages over traditional nanocatalysts. The enhanced catalytic activity, variable and simple structure as well as clear active sites of SA catalysts advance the innovation of biosensing techniques. In this review, we will provide the latest research progress of SA catalysts in biosensing field, and systematically summarize their sensing applications, especially emphasing on the biosensing strategies on the determination of disease-related biological matrices (H2O2, biological enzyme, NO, etc) and environmental pollutants (organophosphorus pesticides, heavy metal ions and volatile organic compounds). Finally, we will provide the challenges that SA catalysts still faced.