Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric Illness: Case Report

Background: In this report, we describe a case of domperidone withdrawal in a woman with a history of major depressive disorder and obsessive-compulsive disorder (OCD) who experienced a recurrence of these disorders after stopping domperidone. Case presentation: The symptoms improved after the restarting of domperidone and disappeared gradually as the drug was tapered and discontinued. Clinicians should consider domperidone withdrawal a differential diagnosis in women with a history of depression or anxiety who present with an acute onset of these symptoms following the abrupt discontinuation of domperidone. Conclusion: A gradual taper off of the drug may be effective in minimizing withdrawal symptoms and obviate the need for psychotropic drug use.

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Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive–compulsive disorder and a history of major depressive disorder

Journal of Psychopharmacology ◽

10.1177/0269881113486718 ◽

2013 ◽

Vol 27 (7) ◽

pp. 651-654 ◽

Cited By ~ 23

Author(s):

Mark J Niciu ◽

Beth DG Grunschel ◽

Philip R Corlett ◽

Christopher Pittenger ◽

Michael H Bloch

Keyword(s):

Major Depressive Disorder ◽

Suicidal Ideation ◽

Depressive Disorder ◽

Obsessive Compulsive Disorder ◽

Obsessive Compulsive ◽

Major Depressive ◽

Ketamine Infusion ◽

Compulsive Disorder ◽

Delayed Onset ◽

History Of

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Sleep Patterns in Patients with OCD

CNS Spectrums ◽

10.1017/s1092852900002637 ◽

1996 ◽

Vol 1 (2) ◽

pp. 39-43 ◽

Cited By ~ 2

Author(s):

A. Okasha ◽

M. El Sayed ◽

T. Asaad ◽

A. Self El Dawla ◽

T. Okasha

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Slow Wave Sleep ◽

Efficiency Index ◽

Control Group ◽

Obsessive Compulsive ◽

Major Depressive ◽

Compulsive Disorder ◽

History Of ◽

Psychopathological Disorders

AbstractObjectives:(1) To determine whether there are sleep variables specific for obsessive-compulsive disorder (OCD) that are identifiable on polysomnographic findings; (2) to determine the possible relationship of OCD to other psychopathological disorders, with special emphasis on major depressive disorder (MDD).Methods:Eighteen patients suffering from OCD (five of whom had a comorbid depressive disorder) were assessed by means of a standardized sleep questionnaire, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for the assessment of severity of obsessive-compulsive symptoms, and overnight polysomnography. Results were compared with those from a control group of 18 age- and sex-matched controls with no history of psychiatric disorders.Results:We found a significant decrease in sleep efficiency index (SEI), REM percent, REM latency, and slow wave sleep latency among OCD patients, compared with controls. The presence of comorbid major depression had no effect on the severity of OCD and had no significant effect on the sleep measures.Conclusions:Sleep changes recorded polysomnographically in patients with OCD can be primary in origin and are independent of an associated major depressive disorder.

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