Pharmacological activities and Therapeutic potential of kaempferitrin in medicine for the treatment of human disorders: A review of medicinal importance and health benefits

2021 ◽  
Vol 21 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Broiler Chickens ◽  
Therapeutic Potential ◽  
Scientific Information ◽  
Aloe Vera ◽  
Crocus Sativus ◽  
Related Complication ◽  
Food Material ◽  
Biological Potential ◽  
Anti Oxidant ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals are valuable for human being as a source of vital component of food material and drugs. Flavonoids are naturally occurring phytochemical produced in plants through metabolisms and they are having anti-hyperlipidemia, anti-inflammatory, anti-oxidant and anti-apoptotic activity. Flavonoids have been identified in the fruits, nuts, vegetables, seeds, stem, flowers and tea. Kaempferol is a natural flavonoidal compound present in edible plants such as apples, broccoli, strawberries, beans, grapefruit, propolis and medicinal plants such as Aloe vera, Ginkgo biloba, Rosmarinus officinalis, Crocus sativus L., Hypericum perforatum L. Kaempferol have anti-oxidant, anti-inflammatory, anti-apoptotic, pro-apoptotic, cardio-protective and anti-cancer activities. Methods: Glycosides of kaempferol such as kaempferitrin also called kaempferol 3,7-dirhamnoside are known to be more abundant than their flavonoid monomers in plants. Various literature databases have been searched to collect all the scientific information of kaempferitrin in the present investigation and analyzed in order to know the therapeutic benefit and biological potential of kaempferitrin. Moreover all the information has been presented here in two broad sections i.e. pharmacological and analytical. Results: From the analysis of all the collected and presented information, it was found that kaempferitrin has potent insulin-mimetic potential and could be used for the treatment of diabetes and related complication. However, it has also shown anti-oxidant, anti-inflammatory, anti-convulsant, anti-osteoporotic, anti-depressant, anthelmintic, immunostimulatory and natriuretic properties and inhibits cell proliferation and apoptosis. Kaempferitrin also improves meat quality of broiler chickens. Conclusions: The presented information in this work will be valuable to justify the biological importance and therapeutic potential of kaempferitrin in the scientific field.

A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

2019 ◽  
Vol 16 ◽  
Author(s):  
Rubina Bhutani ◽  
Garima Kapoor ◽  
Dharam Pal Pathak ◽  
Asif Husain ◽  
Ravi Kant ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Therapeutic Potential ◽  
Pharmaceutical Chemistry ◽  
Biological Potential ◽  
Heterocyclic Derivatives ◽  
Anti Inflammatory ◽  
Clinical Drugs

: Among the various fused heterocyclic rings, benzothiazole and its analogues have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, anti-tubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment of as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

A systematic Review of Aloe vera and its Properties

2021 ◽  
pp. 257-259
Author(s):  
Farha Fatma ◽  
Anil Kumar
Keyword(s):  
Systematic Review ◽  
Medicinal Plant ◽  
Review Paper ◽  
Therapeutic Potential ◽  
Aloe Vera ◽  
Paper Properties ◽  
Beneficial Effects ◽  
Aloe Vera Gel ◽  
Anti Inflammatory ◽  
Pharmaceutical Uses

Aloe vera is one of the oldest medicinal plant ever known, commonly known as Ghrit Kumari. It is well known for its therapeutic potential. Some of its beneficial effects include anticancer, hypoglycemic, antifungal, anti-inflammatory, burn healing properties. Phytochemistry of Aloe vera gel has revealed presence of bioactive chemicals. In this review paper, properties of Aloe vera, its composition, its beneficial effects and pharmaceutical uses, its application in foods and cosmetics etc. have been summarized.

scholarly journals Observing the Anti-oxidant and Anti-inflammatory Effect of Nigella Sativa Combined With Silybum Marianum Extracts on the Acute Peritonitis Mouse Model

2021 ◽  
Vol 24 (3) ◽  
pp. 372-385
Author(s):  
Maryam Bahrami ◽  
◽  
Ali Ghazavi ◽  
Ali Ganji ◽  
Ghasem Mosayebi ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Therapeutic Potential ◽  
Inflammatory Diseases ◽  
Nigella Sativa ◽  
Control Group ◽  
Silybum Marianum ◽  
Acute Peritonitis ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Background and Aim: In addition to free radicals such as Nitric Oxide (NO), inflammation is one of the most important pathophysiological causes of peritonitis. Over thousands of years, Nigella Sativa (NS) and Silybum Marianum (SM) are two plants known for their anti-oxidant and anti-inflammatory properties. However, the effect of its compound is unclear. Thus, in this study, we evaluated the anti-inflammatory effect of NS and SM extracts and their combination on inflammatory diseases like thioglycollate peritoneal. Methods & Materials: Alcoholic extracts of SM and NS were obtained by the soxhlet method. Male Balb/C mice were divided into 5 groups and gavage orally for 14 days with SM, NS, the mixture of extracts of these two, DMSO 30% as the control group, and dexamethasone as the positive control group. The safety profile and acute toxicity in mice were assessed. On day 10, acute peritonitis was induced by thioglycollate 3%. Finally, the total anti-oxidant power and NO concentration were measured by FRAP and Griess method, respectively, in the serum of treated mice. Ethical Considerations: All experimental process was performed following the guidelines according to the Animal Ethics Committee of Arak University of Medical Sciences (IR.ARAKMU.REC.1397.359). Results: Acute toxicity test showed no significant changes in weight and physical appearance of the mice. However, the extract and their mixture decreased NO level significantly (P=0.000) in serum. Also, the mixture significantly increased total anti-oxidant power (P=0.015). Conclusion: Results showed that the SM and NS extract mixture demonstrated anti-inflammatory activity, inhibiting inflammatory mediators such as NO and increasing anti-oxidant power, thus supporting its therapeutic potential in slowing down inflammatory processes in inflammation disorders.

scholarly journals ALOE VERA: A MEDICINAL HERB

2015 ◽  
Vol 3 (11) ◽  
pp. 32-34
Author(s):  
ShailBala Sanghi
Keyword(s):  
Immune System ◽  
Aloe Vera ◽  
Medicinal Herb ◽  
Peptic Ulcers ◽  
Aging Effects ◽  
The World ◽  
Anti Oxidant ◽  
Anti Inflammatory

Aloe vera is a herb distributed all over the world. The herb is used internally to counter most   of the problems of digestion, diabetes, immune system, and peptic ulcers. It also contains anti-bacterial, anti-septic, anti-viral, anti-inflammatory, anti-tumor, anti -oxidant, moisturizing, anti-aging effects.  This review highlights the importance of using Aloe vera as a medicinal herb.

The Chemical Constituents, Anti-Inflammatory, Anti-Oxidant, and Ethnomedicinal Properties of Aloe barbadensis

2022 ◽  
pp. 454-471
Author(s):  
Dickson Adom ◽  
Paul Appiah Sekyere ◽  
Mohan Kumar Krishnappa
Keyword(s):  
Chemical Constituents ◽  
Aloe Vera ◽  
Document Analysis ◽  
The Body ◽  
Extensive Review ◽  
Aloe Barbadensis ◽  
Succulent Plant ◽  
History Of ◽  
Anti Oxidant ◽  
Anti Inflammatory

Aloe vera is a perennial, drought-resisting, succulent plant belonging to the Asphodelaceae family that has a long history of having many tremendous medicinal and anti-inflammatory as well as anti-bacterial properties. This chapter highlights the great potentials of the aloe vera species. Desk study and document analysis guided the systematic and extensive review of both published and unpublished resources on the Aloe vera Species. The chapter contends that horticulturists and plant scientists in the field of agriculture and medicine must pay attention to the Aloe vera as a medicinal plant that possesses the most powerful antibacterial and anti-inflammatory properties, which protects the body against constipation through enhancing the body metabolism, skin, and worm infestations.

Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?

2019 ◽  
Vol 25 (19) ◽  
pp. 2171-2177 ◽  
Author(s):  
Shahzad Khan ◽  
Mohammad A. Kamal
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Therapeutic Potential ◽  
Heart Diseases ◽  
Cardiovascular Complications ◽  
Cancer Drug ◽  
Scutellaria Baicalensis Georgi ◽  
Yellow Color ◽  
Anti Oxidant ◽  
Margin Of Safety ◽  
Anti Inflammatory

<P>Diabetes Mellitus (DM) is now a well-known factor which initiates many metabolic derangements in various tissues and organs including liver, muscle, pancreas, adipose tissue, cardiovascular and nervous system. Cardiovascular complications are the most crucial , and their effects are so intensive that their derangement leads to cardiac failure even in the absence of ischemic heart diseases. This entity of cardiac pathology in DM is often regarded as diabetic cardiomyopathy (DCM). Recently, many plant-derived drugs have been tested to control and alleviate DCM. Wogonin is one of the drugs the characteristics of which have been deeply studied. Wogonin is a flavonoid having yellow color pigment in their leaves and is obtained from the roots of plant Scutellaria Baicalensis Georgi. Wogonin has long been used as an active anti-cancer drug in Chinese medicine practice. In recent past wogonin has shown to possess notable anti-inflammatory, and anti-allergic properties. Wogonin has demonstrated to possess anti-oxidant, anti-viral, anti-inflammatory and also anti-thrombotic properties. </P><P> Wogonin has shown to alleviate apoptosis, and ER stress in the cells and this property can also be used in the treatment of cardiovascular diseases. Notably, wogonin has been documented to have an extensive margin of safety as well as displays little or no organ toxicity following extended intravenous administration. In this review, we discuss recently discovered therapeutic potential of wogonin in the treatment of DCM.</P>

scholarly journals Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis

2020 ◽  
Vol 12 (7) ◽  
pp. 364-378
Author(s):  
Naruemon Klaikeaw ◽  
Jutamas Wongphoom ◽  
Duangporn Werawatganon ◽  
Maneerat Chayanupatkul ◽  
Prasong Siriviriyakul
Keyword(s):  
Aloe Vera ◽  
Alcoholic Steatohepatitis ◽  
Anti Oxidant ◽  
Anti Inflammatory

scholarly journals Recent Advances Regarding the Therapeutic Potential of Adapalene

2020 ◽  
Vol 13 (9) ◽  
pp. 217
Author(s):  
Aura Rusu ◽  
Corneliu Tanase ◽  
Georgiana-Andreea Pascu ◽  
Nicoleta Todoran
Keyword(s):  
Therapeutic Potential ◽  
Biological Effects ◽  
Acne Vulgaris ◽  
Therapeutic Drug ◽  
Oral Drugs ◽  
First Line ◽  
Biological Potential ◽  
Acne Treatment ◽  
Anti Inflammatory ◽  
Active Substances

Adapalene (ADP) is a representative of the third retinoids generation and successfully used in first-line acne treatment. ADP binds to retinoic acid nuclear receptors. The comedolytic, anti-inflammatory, antiproliferative, and immunomodulatory are the known ADP effects. Its safety profile is an advantage over other retinoids. ADP recently was found to be effective in the treatment of several dermatological diseases and photoaging besides the utility in the treatment of acne vulgaris. New biological effects of adapalene with therapeutic potential are highlighted in this review paper. Thus, adapalene could be a valuable therapeutic drug into the treatment of several types of cancer. Additionally, some neurodegenerative diseases could be treated with a suitable formulation for intravenous administration. The antibacterial activity against methicillin-resistant Staphylococcus aureus of an analogue of ADP has been proven. In different therapeutic schemes, ADP is more effective in combination with other active substances. New topical combinations with adapalene include ketoconazole (antifungal), mometasone furoate (anti-inflammatory corticosteroid), nadifloxacin (fluoroquinolone), and alfa and beta hydroxy acids. Combination with oral drugs is a new trend that enhances the properties of topical formulations with adapalene. Several studies have investigated the effects of ADP in co-administration with azithromycin, doxycycline, faropenem, isotretinoin, and valganciclovir. Innovative formulations of ADP also aim to achieve a better bioavailability, increased efficacy, and reduced side effects. In this review, we have highlighted the current studies on adapalene regarding biological effects useful in various treatment types. Adapalene has not been exploited yet to its full biological potential.

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