scholarly journals Is the Mandibular Condyle Involved in Medication-Related Osteonecrosis of the Jaw? Audit of a Single Tertiary Referral Center and Literature Review

2021 ◽  
Vol 15 (1) ◽  
pp. 769-777
Author(s):  
Giorgio Lo Giudice ◽  
Antonio Troiano ◽  
Carmelo Lo Faro ◽  
Mario Santagata ◽  
Marco Montella ◽  
...  
Keyword(s):  
Literature Review ◽  
Mandibular Condyle ◽  
Osteonecrosis Of The Jaw ◽  
Tertiary Referral Center ◽  
Site Distribution ◽  
Underlying Malignancy ◽  
Pubmed Database ◽  
Mandibular Body ◽  
Maxilla And Mandible ◽  
Surgery Department

Background: Medication-related osteonecrosis of the jaw (MRONJ) may manifest as exposed mandible bone. Recent reviews of the incidence of MRONJ report primarily as exposed cortical bone of the mandibular body, ramus, and symphysis with no reports of condylar involvement. Objective: The aim of this study is to analyze the topographical incidence of MRONJ, comorbidities, demographics data, and clinical characteristics of patients diagnosed with MRONJ between 2014 and 2019 in the Maxillo-Facial Surgery Department University of Campania “Luigi Vanvitelli”, and compare these results with published reports. Methods: Data on 179 patients were collected for the study, including gender, age, underlying malignancy, medical history, and specific lesion location-identifying premaxilla and posterior sectors area involvement for the maxilla and symphysis, body, ramus, and condyle area for the mandible. A literature review was performed in order to compare our results with similar or higher sample sizes and find if any condylar involvement was ever reported. The research was carried out on PubMed database identifying articles from January 2003 to November 2020, where MRONJ site distribution was discussed, and data were examined to scan for condylar localization reports. Results: 30 patients had maxillary MRONJ, 136 patients had mandibular MRONJ, and 13 patients had lesions located in both maxilla and mandible. None of the patients reported condylar involvement, neither as a single site nor as an additional localization. Literature review results were coherent to our findings showing no mention of condylar MRONJ. Conclusion: Results do not show reports of condylar involvement in MRONJ. Although the pathophysiology of the disease has not been fully elucidated, two possible explanations were developed: the first one based on the condyle embryogenetic origin; the second one based on the bisphosphonate and anti-resorptive medications effects on the different vascular patterns of the mandible areas.

scholarly journals Clinical considerations for medication-related osteonecrosis of the jaw: a comprehensive literature review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mampei Kawahara ◽  
Shinichiro Kuroshima ◽  
Takashi Sawase
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Dental Treatment ◽  
Treatment Strategies ◽  
Osteonecrosis Of The Jaw ◽  
High Dose ◽  
Exclusion Criteria ◽  
Clinical Recommendations ◽  
Pubmed Database ◽  
Clinical Considerations

Abstract Background Medication-related osteonecrosis of the jaw (MRONJ), which was first reported as bisphosphonate-related osteonecrosis of the jaw (BRONJ) in bisphosphonate users, is a rare but severe soft and hard tissue disease induced by several types of medications. There has been a deluge of information about MRONJ, such as epidemiology, risk factors, clinical recommendations for dental treatment to prevent it, and treatment strategies in medication-prescribed users. The aim of this study was to comprehensively review recent articles and provide the current scientific information about MRONJ, especially clinical considerations or recommendations for dental treatment to prevent its occurrence. Materials and methods The current literature review was mainly based on 14 systematic reviews with or without meta-analysis, 4 position papers, 1 consensus statement, 1 clinical guideline, and 2 clinical reviews regarding MRONJ after a PubMed database and manual searches according to inclusion and exclusion criteria. Moreover, 53 articles were selected by manual search in regard to all references from selected articles and other articles identified on the PubMed search, irrespective of publication date, and inclusion and exclusion criteria. Results The incidence and prevalence of MRONJ are relatively low, although they are clearly higher in cancer patients receiving high-dose antiresorptive agents or angiogenesis inhibitors rather than osteoporosis patients receiving oral bisphosphonates or denosumab. There are many types of local, systemic, and other risk factors for the development of MRONJ. Clinical recommendations are provided for each clinical situation of patients to prevent MRONJ. There are also treatment strategies for MRONJ in each stage. Conclusions General dentists should perform appropriate dental treatment to prevent MRONJ in the patients prior to or when receiving medications that could induce MRONJ. Moreover, there are treatment strategies for MRONJ in each stage that oral surgeons could follow. Adequate and updated clinical information regarding MRONJ based on scientific data is required whenever possible.

scholarly journals Stigma Experienced by Parkinson’s Disease Patients: A Descriptive Review of Qualitative Studies

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Marina Maffoni ◽  
Anna Giardini ◽  
Antonia Pierobon ◽  
Davide Ferrazzoli ◽  
Giuseppe Frazzitta
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Literature Review ◽  
Subjective Experience ◽  
Negative Impact ◽  
Social Stigma ◽  
Subjective Symptom ◽  
Point Of View ◽  
Pubmed Database ◽  
Related Quality

Parkinson’s disease (PD) is a neurodegenerative disease characterized by motor and nonmotor symptoms. Both of them imply a negative impact on Health-Related Quality of Life. A significant one is the stigma experienced by the parkinsonian patients and their caregivers. Moreover, stigma may affect everyday life and patient’s subjective and relational perception and it may lead to frustration and isolation. Aim of the present work is to qualitatively describe the stigma of PD patients stemming from literature review, in order to catch the subjective experience and the meaning of the stigma construct. Literature review was performed on PubMed database and Google Scholar (keywords: Parkinson Disease, qualitative, stigma, social problem, isolation, discrimination) and was restricted to qualitative data: 14 articles were identified to be suitable to the aim of the present overview. Results are divided into four core constructs: stigma arising from symptoms, stigma linked to relational and communication problems, social stigma arising from sharing perceptions, and caregiver’s stigma. The principal relations to these constructs are deeply analyzed and described subjectively through patients’ and caregiver’s point of view. The qualitative research may allow a better understanding of a subjective symptom such as stigma in parkinsonian patients from an intercultural and a social point of view.

On the Dangers of Tropical Spiders as a Pet: A Review of Ocular Symptoms Caused by Tarantula Hairs

2021 ◽  
Author(s):  
Maarten B. Jalink ◽  
Robert P. L. Wisse
Keyword(s):  
Literature Review ◽  
Inflammatory Reaction ◽  
Anterior Uveitis ◽  
Posterior Segment ◽  
Ocular Symptoms ◽  
Pubmed Database ◽  
Descemet's Membrane ◽  
Descemet’S Membrane ◽  
Urticating Hairs

Tarantulas are large spiders that can defend themselves by shedding urticating hairs (setae). In this paper, we aim to discuss the ocular conditions caused by these setae through a literature review. In total, 25 cases were identified in the PubMed database. Tarantula setae have a barbed structure that enables migration through the globe. They give rise to a spectrum of complaints, causing a granulomatous inflammatory reaction in the compartment they settle. Superficial corneal hairs cause a mild keratitis, while hairs that penetrate Descemet’s membrane can induce an anterior uveitis. Both can be treated with local steroids; when possible, hairs should be debrided. Setae that migrate into the posterior segment can cause a focal vitritis that can be more difficult to treat, sometimes requiring vitrectomy.

Mandibular Dysmorphology in Unicoronal Synostosis and Plagiocephaly without Synostosis

1996 ◽  
Vol 33 (5) ◽  
pp. 418-423 ◽  
Author(s):  
Alex A. Kane ◽  
Lun-Jou, Lo ◽  
Michael W. Vannier ◽  
Jeffrey L. Marsh
Keyword(s):  
Body Length ◽  
Statistical Significance ◽  
Coronoid Process ◽  
Therapeutic Interventions ◽  
Lateral Side ◽  
Tertiary Referral Center ◽  
Gonial Angle ◽  
Affected Side ◽  
Mandibular Body ◽  
Ct Data

Patients with unicoronal synostosis (UCS) or plagiocephaly without synostosis (PWS) have distinctive skull dysmorphologies. Associated mandibular dymorphologies have been suspected but not quantified. This study was performed to test the hypothesis that discrete mandibular dysmorphology exists in both UCS and PWS. All patients at a tertiary referral center at a medical school-affiliated children's hospital with confirmed diagnosis of UCS or PWS with adequate pretreatment CT data were included in the study population, which population was comprised of 20 UCS, 23 PWS, and 8 normal infants. Each patient had a head CT scan using 2-mm slices. 3-D images were created using AnalyzeTM, a biomedical imaging program. The mandibles were isolated, and the coordinates of 8 landmarks were sampled from each mandible by a single investigator: a single volume value was measured, and 9 linear distances and 4 angles were calculated. Corresponding measurements from each hemimandible were expressed as ratios of ipsilateral/contra lateral side. In UCS, the affected side was defined as the side ipsilateral to the synostosis; in PWS, the affected side was defined as the side ipsilateral to the occipital flattening. The results from both groups were t tested for statistical significance. For UCS, statistically significant (p < .001) findings included: ipsilateral hemimandibular volume 5% smaller than contralateral; affected hemimandibular body length 1.9% shorter; affected gonial angle 2.6% more acute; affected coronoid process tilted anteriorly 2.5%; and distances from condylion and tip of the coronoid process to the chin landmarks 4% shorter on the affected side. For PWS, significant findings included: affected hemimandibular volume 3.8% larger; ramal height 3.5% shorter; mandibular body length 3% longer; and coronoid process tilted anteriorly by 2.3% on the affected side. In the UCS/PWS comparison, findings included: affected hemimandibular volume in UCS 8.7% less; affected gonial angle in UCS 3% more acute; affected mandibular corpus length in UCS 5% shorter; distances from the condylion and the tip of the coronoid process to the chin landmarks 4% shorter on the affected side in UCS. The hypothesized presence of diagnosis specific mandibular dysmorphology in UCS and PWS is confirmed. This analysis forms the baseline for study of the effects of unperturbed growth or therapeutic interventions upon the dentoskeletal dysmorphology of these anomalies.

scholarly journals Effects of the condylar process fracture on facial symmetry in rats submitted to protein undernutrition

2011 ◽  
Vol 26 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Lucimar Rodrigues ◽  
Luciana Corrêa ◽  
João Gualberto de Cerqueira Luz
Keyword(s):  
Serum Proteins ◽  
Mandibular Condyle ◽  
Median Line ◽  
Condylar Fracture ◽  
Fracture Group ◽  
Facial Symmetry ◽  
Maxilla And Mandible ◽  
The Right ◽  
Condyle Fracture ◽  
Cephalometric Measurements

PURPOSE: To investigate the facial symmetry of rats submitted to experimental mandibular condyle fracture and with protein undernutrition (8% of protein) by means of cephalometric measurements. METHODS: Forty-five adult Wistar rats were distributed in three groups: fracture group, submitted to condylar fracture with no changes in diet; undernourished fracture group, submitted to hypoproteic diet and condylar fracture; undernourished group, kept until the end of experiment, without condylar fracture. Displaced fractures of the right condyle were induced under general anesthesia. The specimens were submitted to axial radiographic incidence, and cephalometric mensurations were made using a computer system. The values obtained were subjected to statistical analyses among the groups and between the sides in each group. RESULTS: There was significative decrease of the values of serum proteins and albumin in the undernourished fracture group. There was deviation of the median line of the mandible relative to the median line of the maxilla, significative to undernutrition fracture group, as well as asymmetry of the maxilla and mandible, in special in the final period of experiment. CONCLUSION: The mandibular condyle fracture in rats with proteic undernutrition induced an asymmetry of the mandible, also leading to consequences in the maxilla.

scholarly journals Gambaran Kualitas Hidup Lansia Yang Tinggal Di Panti Sosial : Literature Review

2021 ◽  
Vol 1 ◽  
pp. 1605-1614
Author(s):  
K Krisdiyanti ◽  
Dyah Putri Aryati
Keyword(s):  
Quality Of Life ◽  
Nursing Home ◽  
Literature Review ◽  
Elderly People ◽  
Life Quality ◽  
The Elderly ◽  
Care Homes ◽  
Pubmed Database ◽  
Elderly Living

AbstractThe increasing number of the elderly population is a phenomenom that occurs today. The high level of dependence of the elderly causes the elderly to have the potential to be placed in care homes. The elderly are individuals who hane a high risk of isease and stressors. This, of course, requires efforts to ensure the life of the elderly, not only seen from fulfillment of the needs of the elderly but also the life quality of the eldely. The study aims to describe the quality of life of the elderly who live in care homes. The study used a literature review method by searching for articles in the Pubmed database, and google sholar. The search was conducted by combining keywords: “Elderly, “Elderly people”, “Quality of life”, “WHOQOL-BREF”, and “Nursing home” with the year 2011-2021. Participants in this study were 395 respondents of elderly living in care homes. The results of the literature review of 6 articles showed that there are 73 respondents (18,5%) with low category of life quality, 195 respondents (49,9%) with medium category of life quality, and 127 repondents (32,1%) high category of the life quality. From this study, it can be concluded that the quality of life of the elderly living in care homes is mostly (49,9%) in moderate category. The role of nurses is needed to improve the quality of life of the elderly who live in care homes.Keywords: care homes; elderly; quality of life; WHOQOL-BREF AbstrakTerjadinya peningkatan jumlah populasi lanjut usia merupakan fenomena yang terjadi saat ini. Tingkat ketergantungan lansia yang tinggi mengakibatkan lansia berpontesi untuk ditempatkan di panti sosial. Lansia merupakan individu yang memiliki resiko tinggi dan rentan terhadap penyakit serta stresor. Hal ini tentunya dibutuhkan upaya untuk menjamin hidup lansia, tidak hanya dilihat dari pemenuhan kebutuhan lansia namun juga dilihat dari kualitas hidup lansia. Penelitian ini bertujuan untuk mengetahui gambaran kualitas hidup lansia yang tinggal di panti sosial. Penelitian ini menggunakan metode literature review, untuk pencarian artikel dengan mengakses database Pubmed, dan googlescholar. Pencarian dilakukan dengan mengkombinasi kata kunci: “elderly”, “elderly people”, “Quality of life”, “WHOQOL-BREF”, “Nursing home” dengan batasan tahun 2011-2021. Partisipan pada studi ini adalah lansia yang tinggal di panti sosial dengan total 395 lansia. Hasil penelitian literature review dari 6 artikel menunjukan kualitas hidup lansia dengan kategori rendah 73 responden (18,5%), sedang 195 responden (49,9%) dan tinggi 127 responden (32,1%). Dari penelitian ini diketahui bahwa kualitas hidup lansia yang tinggal di panti sosial sebagian besar (49,9%) dalam kategori sedang. Perlu adanya peran perawat untuk meningkatkan kualitas hidup lansia yang tinggal di panti sosial.Kata kunci : kualitas hidup; lansia; panti sosial; WHOQOL-BREF

scholarly journals Description of Cognitive Function in Diabetes Mellitus: A Literature Review

2021 ◽  
pp. 209-219
Author(s):  
Susy Puspasari ◽  
Endar Andrianto
Keyword(s):  
Diabetes Mellitus ◽  
Executive Function ◽  
Cognitive Function ◽  
Literature Review ◽  
Search Term ◽  
Pubmed Database ◽  
Psychomotor Functions ◽  
Patients With Diabetes ◽  
Quantitative Design ◽  
Sugar Levels

Cognitive decline in diabetes mellitus is not fully understood, though is generally ascribed to blood sugar levels exceeding normal (hyperglycemia), hypoglycemia conditions and insulin resistance. Cognitive function consists of aspects of memory, attention, executive function, perception, language, and psychomotor functions which affect the decline in cognitive function, especially in people with Diabetes Mellitus. This study aims to summarize the results of research on cognitive function in people with Diabetes Mellitus. The research method used was a literature review with an assessment using JBI critical appraisal tools. Articles were sourced via the PubMed database and Google Scholar using the search term ‘Cognitive Function AND Diabetes Mellitus’. The inclusion criteria were studies with quantitative design, full text, a population comprised of patients with Diabetes Mellitus, written in Indonesian or English. Six articles were reviewed, all the results state that patients with Diabetes Mellitus experienced a decrease in cognitive function, especially in the Executive Function, Visuospatial, and the Memory Domains.   Keywords: Cognitive function, Diabetes mellitus, Literature review

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