scholarly journals Total RNA Isolation from Separately Established Monolayer and Hydrogel Cultures of Human Glioblastoma Cell Line

BIO-PROTOCOL ◽  
2019 ◽  
Vol 9 (14) ◽  
Author(s):  
Manasi Jogalekar ◽  
Elba Serrano
Keyword(s):  
Cell Line ◽  
Rna Isolation ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Total Rna ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Total Rna Isolation

scholarly journals Enhanced Anti-Tumor Activity in Mice with Temozolomide-Resistant Human Glioblastoma Cell Line-Derived Xenograft Using SN-38-Incorporated Polymeric Microparticle

2021 ◽  
Vol 22 (11) ◽  
pp. 5557
Author(s):  
Tao-Chieh Yang ◽  
Shih-Jung Liu ◽  
Wei-Lun Lo ◽  
Shu-Mei Chen ◽  
Ya-Ling Tang ◽  
...  
Keyword(s):  
Cell Line ◽  
Therapeutic Index ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Therapeutic Benefits ◽  
Biodegradable Poly ◽  
Anti Tumor Activity

Glioblastoma multiforme (GBM) has remained one of the most lethal and challenging cancers to treat. Previous studies have shown encouraging results when irinotecan was used in combination with temozolomide (TMZ) for treating GBM. However, irinotecan has a narrow therapeutic index: a slight dose increase in irinotecan can induce toxicities that outweigh its therapeutic benefits. SN-38 is the active metabolite of irinotecan that accounts for both its anti-tumor efficacy and toxicity. In our previous paper, we showed that SN-38 embedded into 50:50 biodegradable poly[(d,l)-lactide-co-glycolide] (PLGA) microparticles (SMPs) provides an efficient delivery and sustained release of SN-38 from SMPs in the brain tissues of rats. These properties of SMPs give them potential for therapeutic application due to their high efficacy and low toxicity. In this study, we tested the anti-tumor activity of SMP-based interstitial chemotherapy combined with TMZ using TMZ-resistant human glioblastoma cell line-derived xenograft models. Our data suggest that treatment in which SMPs are combined with TMZ reduces tumor growth and extends survival in mice bearing xenograft tumors derived from both TMZ-resistant and TMZ-sensitive human glioblastoma cell lines. Our findings demonstrate that combining SMPs with TMZ may have potential as a promising strategy for the treatment of GBM.

scholarly journals Genomic and transcriptomic characterization of the human glioblastoma cell line AHOL1

2021 ◽  
Vol 54 (3) ◽  
Author(s):  
W.A.S. Ferreira ◽  
C.K.N. Amorim ◽  
R.R. Burbano ◽  
R.A.R. Villacis ◽  
F.A. Marchi ◽  
...  
Keyword(s):  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell

Molecular cytogenetic analysis of a t(7; 10) in a human glioblastoma cell line

1995 ◽  
Vol 84 (2) ◽  
pp. 142
Author(s):  
Dan Fults ◽  
Carolyn A. Pedone ◽  
Xiao Lin Zhu ◽  
Briana J. Williams ◽  
Emma Jones ◽  
...  
Keyword(s):  
Cell Line ◽  
Cytogenetic Analysis ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell ◽  
Molecular Cytogenetic

scholarly journals Recombinant adeno-associated virus (rAAV) expressing TFPI-2 inhibits invasion, angiogenesis and tumor growth in a human glioblastoma cell line

2005 ◽  
Vol 115 (6) ◽  
pp. 998-1005 ◽  
Author(s):  
Niranjan Yanamandra ◽  
Shakuntala Kondraganti ◽  
Christopher S. Gondi ◽  
Meena Gujrati ◽  
William C. Olivero ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Line ◽  
Glioblastoma Cell Line ◽  
Glioblastoma Cell ◽  
Adeno Associated Virus ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cell Line ◽  
Human Glioblastoma Cell
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