TITLE
Role of closed loop INTELLIVENT -ASV mode ventilation in Head Injury patients as compared to conventional ventilation modes. (Preprint)
BACKGROUND INTRODUCTION Traumatic brain injury (TBI) is common in all hospitals over Pakistan and it is associated with significant morbidity and mortality. It presents with varying levels of severity. Intensive monitoring and early suspicion of complications make it a mandatory sensitive issue. Moderate to severe head injuries require elective and/or emergency mechanical ventilation at an early stage. Hence, choosing an appropriate mode of ventilation and providing optimum ventilation can help prevent secondary brain injury, which result from ischemic and hypoxic changes in the brain due to injury. Mortality and morbidity of head injury coincides directly with the severity of the injury. Moreover, superimposed secondary brain Injury on a primary injury increases the severity of the injury, decreases the time of the therapeutic window and hence increases the morbidity and mortality of the TBI. An appropriate mechanical ventilation therapy at an early stage of a head injury can help preserve the primary injury, decrease the progression to a secondary Injury, prevent a cascade reaction where an Injury imposes further decompression of the brain and hence by decreasing morbidity can help decrease mortality. OBJECTIVE To determine outcomes of head injury patients ventilated with closed loop IntelliVent-ASV mode as compared to conventional SIMV ventilation mode based on maintenance of PEtCO2. METHODS STYDY DESIGN Randomized controlled trial. SETTING POF Hospital, Wah Cantt STUDY PERIOD Six months after approval of synopsis SAMPLING TECHNIQUE Non probability consecutive sampling SAMPLE SIZE A total of 100 patients with head injury fulfilling the inclusion criteria were selected and randomly allocated into two groups containing 50(n) each. RESULTS Data was analysed using SPSS Version 17. EtCO2 was measured continuously via mainstream EtCO2 . The IntelliVent ASV patients were randomally assigned group A while SIMV patients were assigned group B. Mean GCS score among both groups was 6.18+1.27 and 6.22+1.20 .Average EtCO2 reading among both groups was 34.58+2.01 and 35.58+2.12 respectively. Mean no. of manual adjustments among both groups was 7.50+3.40 and 6.25+0.88 respectively. After performing statistical analysis P value was <0.000 which was statistically significant. CONCLUSIONS Closed loop automated mode in head injury patients secure better outcomes than conventional mode in terms of decreased morbidity. Although the study needs more number of patients and time to determine the efficacy of one mode over another. CLINICALTRIAL ISRCTN10127188 https://doi.org/10.1186/ISRCTN10127188