scholarly journals THE PHARMACOECONOMIC IMPACT OF GASTRO-PROTECTIVE AGENTS AT A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 92-96
Author(s):  
NIRUPAMA KULKARNI ◽  
MOPIDEVI RASI ◽  
NAZARIYA NIZAR ◽  
NISHOJA DAVID ◽  
PRASAD N BALI ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Cost Benefit Analysis ◽  
Tertiary Care ◽  
Medical Science ◽  
Cost Effective ◽  
Care Hospital ◽  
Statistical Tool ◽  
Protective Agents ◽  
Cost Effective Treatment ◽  
Study Results

Objectives: The study aimed to evaluate the pharmacoeconomic impact of gastro-protective agents (GPA) by carrying out cost-benefit analysis (CBA) and cost-effective analysis (CEA). Methods: This prospective observational study was carried out by simple randomization technique at Karnataka Institute of Medical Science, Hubballi. Data used were socio-economic details based on modified B. G Prasad scale. Current Index of Medical Specialists updated version March 2021 was used for CBA and CEA. Regression analysis was the statistical tool used in the study. Results: A total of 120 participants were included in the study. 57.5% were male and 42.5% were female. 3.33% were pediatrics, 32.5% were young adults, 37.5% were elder adults and 26.67% were geriatrics. Out of 120 samples, 94 participants were prescribed with pantoprazole, other drugs prescribed include domperidone and pantoprazole, rabeprazole, and ranitidine. The CBA revealed ratio of benefits over costs for pantoprazole was 3.86, ranitidine was 9.31, pantoprazole and domperidone was 0.84 and rabeprazole was 0.84. Additional cost of 138.30 Indian Rupee must be spent on pantoprazole over ranitidine to get cost-effective treatment without disease for one whole year. Conclusion: The CBA revealed that maximum patients received benefits for pantoprazole. CEA gives an idea on best effective treatment over two drugs of different class. Our study concludes that pantoprazole is deemed to be superior over other drugs of GPA prescribed among study participants.

scholarly journals HOW COST EFFECTIVE IS THE TREATMENT? ARE PRESCRIBERS CONCERNED ?

2003 ◽  
Vol 42 (146) ◽  
pp. 86-88
Author(s):  
B P Das ◽  
M A Naga Rani ◽  
G P Rauniar ◽  
H Sangraula
Keyword(s):  
Effective Treatment ◽  
Antimicrobial Agents ◽  
Tertiary Care ◽  
Cost Effective ◽  
Undergraduate Curriculum ◽  
Primary Concern ◽  
Care Hospital ◽  
Poor Countries ◽  
Cost Effective Treatment ◽  
Competitive Prices

ABSTRACTCost-effective treatment should be of primary concern to prescribers in poor countries like Nepal. Thepresent study was carried out at a tertiary care hospital in Nepal to find out the perception of prices ofcommonly prescribed drugs among prescribers. The participants selected randomly were directed to writein 10 minutes on a proforma, the generic name(s) and price of the brand preparation of 18 most commonlyused drugs listed under their brand name.The price of the drug was considered correct if the price mentioned was within a range of 20% above orbelow the brand price. Results indicated that the participants were aware of the composition of majority(80%) of the drugs, but were not aware of the prices of 81.80% of the drugs. No single participant mentionedthe correct prices of all the drugs. Among the drug groups studied, the most accurate data was providedabout composition (90.43%) and price (24.47%) of non steroidal anti-inflammatory drugs (NSAIDs). Onlyin 9.22% of brand preparations of antimicrobial agents (AMA), the prices were mentioned correctly. Hence,sensitisation of physicians about cost-effective treatment is of immense importance and to facilitate this,hospital authorities could provide prescribers with regularly updated price lists of commonly prescribeddrugs and competitive prices of various brand preparations. Pharmacoeconomics may be introduced in the undergraduate curriculum which can be reinforced by continuing medical education.Key Words: Cost-effective, Pharmacoeconomics.

ORAL IRON VERSUS PARENTERAL IRON SUCROSE IN A RURAL TERTIARY CARE HOSPITAL OF SOUTHERN INDIA

2021 ◽  
pp. 48-50
Author(s):  
Ravindra S Pukale ◽  
Kavyashree H B
Keyword(s):  
Tertiary Care ◽  
Mode Of Delivery ◽  
Cell Mass ◽  
Medical Science ◽  
Oral Iron ◽  
Iron Sucrose ◽  
P Value ◽  
Care Hospital ◽  
Study Results ◽  
Group B

Introduction: Nutritional iron deciency is one of the most common deciency disorders affecting more than one billion people, with pregnant women at particular risk. In pregnancy iron decit attributable due to increased iron demand of the feto-placental unit and an increase in maternal red cell mass. 30% of anaemic women have haemoglobin levels below 10g/dl above 10% below 8g/dl. Irrespective of mode of delivery blood loss can also be a contributing factor postnatal. Oral iron therapy and intravenous iron sucrose are the main therapy of iron deciency anaemia. The present study is aimed at comparing both their efcacy side effects. METHOD : Aprospective randomised control study was done from June 2019- September 2020, in the department of Obstetrics and gynaecology, Adichunchanagiri Institute of Medical Science, BG nagara. 253 women including antenatal women between 8-38 weeks gestational age were studied and postnatal women studied with no associated obstetrics and medical complication. They were divided into Group A (Oral) and Group B(Intravenous) by randomization. The two groups were monitored clinically, and for an improvement in laboratory parameters after four weeks on day 30 haemoglobin and haematocrit were repeated in both the groups. This study results were expressed as mean +/- standard deviation. And to test the signicance of difference between Oral and IVmode of treatment, student Ttest was done to verify the statistical signicance. RESULTS: Out of 253 patients in the study the mean age of ANC patients was 24.7+/- 4.4years. Mean age of PNC patients was 24.15+/- 3.5years. The peripheral smear showed Dimorphic anaemia in 9.1% and Microcytic Hypochromic picture in 90.9 % of the patients. Initial haemoglobin of ANC patients was 9.8+/- 0.3g/dl. The initial haemoglobin of PNC patients was 9.73+/- 0.91g/dl. 59.3% of the patient had a haemoglobin between 7.1 and 10.0g/dl. Final haemoglobin of an ANC patient was 11.68+/-0.98g/dl, PNC patients 11.69+/-0.99g/dl. There was a substantial increase in Group Ahaemoglobin (oral iron) raising from 10.2+/-7.2g/dl to 12.0+/-0.92g/dl with a T value of 9.25. as well as in Group B (iron sucrose) raising from 9.3+/-8.5g/dl to 11.3+/-0g/dl with T value of 5.65. In both cases this raise in haemoglobin after four weeks had a p value less than 0.01 which was highly statistically signicant. Conclusion:Intravenous iron sucrose is more effective than oral iron for correction of anaemia with lesser side-effect

scholarly journals Cost of Hemodialysis in a Tertiary Care Hospital in North India

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 47-50
Author(s):  
Mushtaq Ahmad ◽  
Ajaz Mustafa ◽  
M Saleem Najar ◽  
Farooq Ahmad Jan ◽  
Anil Manhas ◽  
...  
Keyword(s):  
Average Cost ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Cost Effective ◽  
Chronic Hemodialysis ◽  
North India ◽  
Care Hospital ◽  
Effective Treatment Option ◽  
Cost Effective Treatment ◽  
Cost Efficient

BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem with significant health consequences and involvement of high cost on treatment worldwide. Although renal transplant is a cost effective treatment option for ESRD, use of hemodialysis in patients with ESRD patients remains one of the most resource intensive and expensive therapeutic intervention. OBJECTIVE: To estimate cost of hemodialysis treatment for patients with ESRD that would help in making policy decisions and enable cost efficient utilization of ESRD programme and hemodialysis. METHODS: 58 patients with ESRD on chronic hemodialysis were incorporated in the present study at a tertiary care teaching hospital between January 2010 to December 2010. Patients who survived less than 3 months after commencement of treatment were excluded. RESULTS: Mean age of the study patients was 46.4±8 in yrs. Among the 54 patients studied 51 % were male. 86% of patients received three sessions of hemodialysis weekly, with duration per session varying between 2 - 4 hours. Average cost was Rs. 2001.84 per session. Estimated total annual burden was Rs. 209449.10 per patient. Average cost borne by hospital was Rs. 951.84 per session/patient (47.55 % of cost bone by the patient); cost born by hospital per patient per year was Rs. 123647.70. Principal expenses (% wise) were: staff salary cost 20.84 %, instrument cost (purchased locally from market) 32.50%, salary cost 20.84%, and rental cost 18.20 %. CONCLUSION: The costs estimated in this study comparable with national average cost of hemodialysis in India but lower as compared to that in other SARC countries; approaches to reduce cost further are needed. JMS 2012;15(1):47-50.

ROLE OF CONVENTIONAL HYSTEROSALPINGOGRAPHY IN THE WORK UP OF FEMALE INFERTILITY IN RURAL TERTIARY CARE HOSPITAL, INDIA

2021 ◽  
pp. 4-9
Author(s):  
P Lakshmi ◽  
V Venkatarathnam ◽  
Ramesh Kumar
Keyword(s):  
Tertiary Care Hospital ◽  
Social Stigma ◽  
Tertiary Care ◽  
Invasive Procedure ◽  
Cost Effective ◽  
Female Infertility ◽  
Care Hospital ◽  
Tubal Patency ◽  
Study Results ◽  
Tubal Blockage

Background: Infertility is a major problem throughout the world. In a country like India, it is associated with a social stigma. The cause can be multifactorial and many couples are seeking medical help for infertility nowadays. As part of the female infertility workup, hysterosalpingography plays an important role. Methods And Material: A retrospective study was done in the department of Radiodiagnosis of a rural tertiary care hospital, India. All patients who were referred for hysterosalpingography study as part of infertility workup between January 2018 and December 2020 to the department of Radiodiagnosis were included in the study. Results: A total of 173 patients are included in the study. Out of these 173 patients, 3 women had repeat Hysterosalpingography studies. 43.2% of these studies are abnormal. 56.8% cases showed normal ndings. Tubal abnormalities were the most common accounting for 34.6% of the total studies. Uterine abnormalities were seen in 6.8% of the total studies. Both fallopian tube and uterine abnormalities were seen in 1.7%. Post-operative follow-up imaging was available for 3 patients. All three patients had a bilateral tubal block in the rst study and showed tubal patency in post recanalization HSG study. Conclusion: Hysterosalpingography is a lesser invasive procedure, cost-effective, and does not require anesthesia compared to laparoscopy. This is a huge advantage, especially in a rural setup. It can be considered as a screening investigation along with an ultrasound examination. Tubal blockage is the most common abnormality accounting for nearly one-third of the causes of infertility in our study. Tuberculosis should always be ruled out as a cause of tubal blockage in India where it is more prevalent.

scholarly journals Diagnostic laparoscopy in acute abdominal pain

2019 ◽  
Vol 6 (4) ◽  
pp. 1104
Author(s):  
Ravichandran Subramaniam
Keyword(s):  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Diagnostic Laparoscopy ◽  
Acute Abdominal Pain ◽  
Tertiary Care ◽  
Medical Science ◽  
Ovarian Torsion ◽  
Care Hospital ◽  
Number Of Patients ◽  
Study Results

Background: Acute Abdominal pain is an important surgical problem in all age groups. Early diagnosis is needed to rule out life threatening conditions. Diagnostic laparoscopy is a modern useful tool in giving proper treatment for all needed individuals. The aim of the present endeavor is to study the use of laparoscope in patients with acute pain over the abdomen, to diagnose and confirm conditions like acute appendicitis, appendicular abscess, doudenal perforation, ileal perforation. Ovarian torsion. mass formation, etc. where clinical and imaging studies are inconclusive.Methods: This study was conducted in the tertiary care hospital and the Department of General Surgery, Melmaruvathur Adhiparasakthi Institute of Medical Science and Research, Melmaruvathur. The period of study was from June 2017 to May 2018. All patients coming to the hospital with acute abdominal pain in the age group of ten years to seventy years were included in this study. Results: Majority of the patients had the findings relevant to the correct clinical diagnosis. However significant number of patients had unexpected findings and so the diagnosis was changed, and treatment also changed. Total 100 patients were included in this prospective study. 79 patients were found to have acute appendicitis. Duodenal perforation seen in 7 patients. Jejunal perforation seen in 2 patients. Mesenteric ischemia seen in 1 patient. Acute cholecystitis seen in 3 patients. Gall bladder perforation seen in 1 patient. Ectopic pregnancy was seen in 2 patients. Ovarian torsion seen in 3 patients. Ileocecal tuberculosis seen in 1 patient. No abnormality seen in 1 patient.Conclusions: The best approach in abdominal pain is to do diagnostic laparoscopy and proceed, rather than going for open laparotomy. Diagnostic laparoscopy gives all benefits of minimal invasive surgery. Not much of pain, shorter period of hospitalization, small scars, low infection rates and most importantly, accurate diagnosis and the correct treatment of most of the intra-abdominal conditions are the gifted things.

Coexistence of Metallo Beta Lactamase Resistant Gene Variants Among Clinical Isolates in Tertiary Care Hospital

2021 ◽  
Vol 18 (4) ◽  
pp. 429-436
Author(s):  
Santhiya K. ◽  
Jayanthi S. ◽  
Ananthasubramanian M. ◽  
Appalaraju B.
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Medical Science ◽  
Geographical Location ◽  
Carbapenem Resistance ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Detection Rates ◽  
Carbapenem Resistant ◽  
Global Threat

Background: Carbapenem-resistant Enterobacteriaceae (CRE) has emerged as a global threat with mortality risk ranging from 48%-71% worldwide. The emergence of MBL resistance is threatening as carbapenem is one of the last line antibiotics. A total 24 variants of NDM resistance raises a concern to the clinicians and epidemiologists worldwide. Objective: The study aims at identifying MBL resistance (NDM, IMP, VIM, GIM, SPM, and SIM) and its coexistence in clinical isolates in a single tertiary care center. Methodology: Forty five clinical isolates characterized phenotypically for Carbapenem resistance obtained from PSG Institute of Medical Science and Research (PSG IMSR), Coimbatore, between February to March 2018 were taken for analysis. Result: Out of the 45 Clinical isolates, 38 isolates (84%) were detected as MBL carriers. VIM, NDM, GIM, and SPM were the predominant resistance genes, with detection rates of 48.8%, 28.8%, 24.4%, and 22.2% respectively. Fifteen isolates were observed to harbor more than one MBL gene in coexistence. Two isolates - U42 and R714 (K. pneumoniae) were found to harbor all 5 MBL variants in combination. Conclusion: 33% of clinical isolates harboring multiple MBL variants is a concern in clinical settings. The presence of SPM and GIM gene amongst isolates in this geographical location within India is an indicator demanding continuous monitoring of these resistance determinants.

scholarly journals Relationship between trajectories of post-stroke disability and self-rated health (NeuroAdapt): protocol for a prospective observational study

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e049944
Author(s):  
Sarah K Schäfer ◽  
Robert Fleischmann ◽  
Bettina von Sarnowski ◽  
Dominic Bläsing ◽  
Agnes Flöel ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
Functional Health ◽  
Care Hospital ◽  
Duration Of Symptoms ◽  
Post Stroke ◽  
Self Rated Health ◽  
Modifying Factors ◽  
Study Results

IntroductionStroke is the leading neurological cause of adult long-term disability in Europe. Even though functional consequences directly related to neurological impairment are well studied, post-stroke trajectories of functional health according to the International Classification of Functioning, Disability and Health are poorly understood. Particularly, no study investigated the relationship between post-stroke trajectories of activities of daily living (ADL) and self-rated health (SRH). However, such knowledge is of major importance to identify patients at risk of unfavourable courses. This prospective observational study aims to investigate trajectories of ADL and SRH, and their modifying factors in the course of the first year after stroke.Methods and analysisThe study will consecutively enrol 300 patients admitted to a tertiary care hospital with acute ischaemic stroke or transient ischaemic attack (TIA; Age, Blood Pressure, Clinical Features, Duration of symptoms, Diabetes score ≥3). Patient inclusion is planned from May 2021 to September 2022. All participants will complete an interview assessing ADL, SRH, mental health, views on ageing and resilience-related concepts. Participants will be interviewed face-to-face 1–5 days post-stroke/TIA in the hospital; and will be followed up after 6 weeks, 3 months, 6 months and 12 months via telephone. The 12-month follow-up will also include a neurological assessment. Primary endpoints are ADL operationalised by modified Rankin Scale scores and SRH. Secondary outcomes are further measures of ADL, functional health, physical activity, falls and fatigue. Views on ageing, social support, resilience-related concepts, affect, frailty, illness perceptions and loneliness will be examined as modifying factors. Analyses will investigate the bidirectional relationship between SRH and ADL using bivariate latent change score models.Ethics and disseminationThe study has been approved by the institutional review board of the University Medicine Greifswald (Ref. BB 237/20). The results will be disseminated through scientific publications, conferences and media. Moreover, study results and potential implications will be discussed with patient representatives.Trial registration numberNCT04704635.

Sign in / Sign up

Export Citation Format

Share Document