TRANSDERMAL THERAPEUTIC SYSTEMS–AN INNOVATIVE METHOD TO PREVENT THE FORMATION OF KELOIDS

Author(s):  
ILYA GULYAKIN

Modern medicine has achieved significant results in the development of techniques to avoid surgeries. However, surgical methods are still one of the main tools for treating pathologies in the human body. Plastic surgery and cosmetology are gaining popularity every year, and sports injuries require the use of combined treatment methods, but any such intervention leads to the risk of keloids. The younger the person, the higher the likelihood of developing a keloid, due to the high degree of elasticity of the skin at an earlier age, which is prone to scarring than in older people. Women are at higher risk of developing keloids than men because their skin is more elastic. Thus, children and young women are most at risk of keloid formation, both as a result of physiological processes of skin scarring and preference for plastic surgery, cosmetic procedures and other methods of correction. In world pharmaceutical practice, there are not enough existing ways to prevent the development of keloid. It is necessary to conduct research on the selection of a fundamentally new structural basis for a transdermal therapeutic system containing the most effective and safe compounds of the regenerating and antioxidant mechanisms of action (vitamins and other biologically active compounds) from the point of view of preventing the formation of keloids, which will help in solving the problem of not only preventing the formation of keloids in the dermis, but also its subsequent growth and exit to the surface layers of the skin.

2019 ◽  
Vol 25 ◽  
pp. 131-136
Author(s):  
B. A. Kurchii

Abscisic acid (ABA) is a biologically active substance that takes part in the various biochemical and physiological processes in the plants. There is currently limited knowledge about how these biochemical and physiological processes are triggered and regulated by ABA. Dozens of receptors have been described for ABA signaling but there is no any information why does ABA have so many receptors and how they act at the molecular levels. In this connection I would like to stress that not all cell proteins conjugated with ABA necessarily can be represented as hormone-receptors complexes. In this paper I proposed that physiological processes in plants are performed at molecular level by elementary chemical reactions (redox reactions) that trigger the cascade of subsequent reactions and that can be caused by various chemical and physical factors. Gene keys (fragments of polynucleotides, non-protein receptors) and gene locks (start fragment of genes) are also described. Keywords: abscisic acid, free radicals, receptors, gene keys, gene locks.


2008 ◽  
Vol 51 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Aleš Čoček

The roots of surgery of the larynx reach into the 19th century. After the gaining of initial experiences, a period of radical surgery followed when most tumours were treated with a total laryngectomy. The middle of the 20th century can be characterised as a period of partial laryngectomies. The mutilation of patients caused by a total laryngectomy was and is one of the main impulses that led to the development of the current phase – combined treatment (radiotherapy, systematic cytostatic chemotherapy, biological treatment, surgery as an emergency treatment). The aim is to treat carcinoma of the larynx without the actual removal of the larynx itself and with the same oncological results as would be reached in cases treated with a total laryngectomy. Despite the development of non-surgical methods, surgery of carcinoma of the larynx remains a significant part of the treatment protocol. This work covers the development of surgery of carcinoma of the larynx from a historical point of view; it also describes current types of operations and discusses the position of surgery in today’s treatment algorithm.


2019 ◽  
pp. 102-121
Author(s):  
Дамиан Воронов

Первая часть статьи рассматривает с христианской точки зрения вопрос о том, как определить момент смерти человека, некоторые вопросы работы головного мозга, диагностические критерии полной остановки биологических и физиологических процессов жизнедеятельности организма как финального опыта человека перед вступлением в вечность. Также в статье дается богословско-философское осмысление таким состояниям, как «определенно жив» и «точно мертв», ибо определение момента смерти человека в силу достижений современной медицины стало более трудным, чем прежде. Автор рассматривает историю вопроса и в заключение формулирует христианское отношение к перспективам духовно-нравственного и социального влияния биомедицинских технологий на жизнь человека XXI века, которые переходят границы допустимых манипуляций с жизнью и смертью. Определение критериев смерти является важной вехой в процессе решения трудной философской проблемы сознания. From the Christian point of view, the first part of the article considers the question of how to determine the time of a person’s death and some issues of the brain’s work and diagnostic criteria for completely stopping the biological and physiological processes of the organism’s life as the final experience of a person before entering eternity. The article also provides a theological and philosophical understanding of such states as “definitely alive” and “certainly dead”, because determining the moment of death of a person due to the achievements of modern medicine has become more difficult than before. The A. examines the history of the issue and, in conclusion, formulates a Christian evaluation of the prospects of the spiritual, moral and social influence of biomedical technologies regarding the life of a 21st century person, which transcends the permissible manipulations with life and death. Determining the criteria for death is an important milestone in the process of solving the difficult philosophical problem of consciousness.


1991 ◽  
Vol 56 (9) ◽  
pp. 1963-1970 ◽  
Author(s):  
Jan Hlaváček ◽  
Václav Čeřovský ◽  
Jana Pírková ◽  
Pavel Majer ◽  
Lenka Maletínská ◽  
...  

In a series of analogues of the cholecystokinin octapeptide (CCK-8) the amino acid residues were gradually modified by substituting Gly by Pro in position 4, Trp by His in position 5, Met by Cle in position 6, or the Gly residue was inserted between Tyr and Met in positions 2 and 3 of the peptide chain, and in the case of the cholecystokinin heptapeptide (CCK-7) the Met residues were substituted by Nle or Aib. These peptides were investigated from the point of view of their biological potency in the peripheral and central region. From the results of the biological tests it follows that the modifications carried out in these analogues and in their Nα-Boc derivatives mean a suppression of the investigated biological activities by 2-3 orders of magnitude (at a maximum dose of the tested substance of 2 . 10-2 mg per animal).This means that a disturbance of the assumed biologically active conformation of CCK-8, connected with a considerable decrease of the biological potency of the molecule, takes place not only after introduction of the side chain into its centre (substitution of Gly4), but also after the modification of the side chains of the amino acids or by extension of the backbone in further positions around this central amino acid.


1967 ◽  
Vol 242 (10) ◽  
pp. 2343-2355
Author(s):  
Joseph L. Izzo ◽  
John W. Bartlett ◽  
Angela Roncone ◽  
Mary Jane Izzo ◽  
William F. Bale

2021 ◽  
Author(s):  
Qiang Sun ◽  
Jiayan Guo ◽  
Siyu Liu ◽  
Mengru Zhu ◽  
Jingyi Feng ◽  
...  

Abstract Background: The treatment of nevi includes surgical treatment and non-surgical treatment. Non-surgical treatment has many defects in the clinic, whereas surgical treatment is applicable to any type of nevi. However, there is no unified standard for surgical methods. Methods: Patients with facial nevi ( width ≤4 cm) and high requirements for beauty were included. Preoperatively, incision design and resection range based on the recommended wrinkles or folds of each region and principle of plastic surgery. Intraoperatively, a nevus flap was formed, and then equally divided by splitting technique. After the splitting nevus flap was resected, suture without tension was performed. Results: 21 patients underwent surgical excision. 14 patients underwent complete excision, while 7 patients underwent serial excision. The patients were satisfied with the appearance, local sensations were normal, and there were no secondary deformities of the surrounding facial organs without recurrence.Conclusion: This method is of added value, which achieved by the correct assessment of the size and location of facial nevi and designed according to the reference marks in each region and complete or serial excision.


2003 ◽  
Vol 60 (4) ◽  
pp. 427-433 ◽  
Author(s):  
Ljubomir Panajotovic ◽  
Jefta Kozarski ◽  
Snezana Krtinic ◽  
Bojan Stanojevic

Surgery is still the most effective treatment modality of skin melanoma. The margins of excision are determined by the thickness of primary tumor. From January 1999 to December 2001, 99 patients (57 male and 42 female, of the average age 55), were surgically treated at the Clinic for Plastic Surgery and Burns of the Military Medical Academy. The most usual localization of the primary tumor was the back (23.23%), followed by the forearm, and the lower leg. Regarding the clinical type of the melanoma, nodular melanoma dominated (62.62%). Microscopic staging of the melanoma (classification according to Clark and Breslow), showed that the majority of patients already suffered from the advanced primary disease, which called for radical excision and the choice of reconstructive methods in the closure of post-excision defects. The reconstructive plastic surgical methods enabled the closure of post-excision tissue defects, regardless of their size, structure, and localization. During the closure of post-excision defects, direct wound closure or split skin draft was performed in 76.76% of patients. Flaps were applied in 19.19% of patients with the primary melanoma of the head, face foot, and hand. The sufficiency of the available reconstructive procedures makes plastic surgery irreplaceable in the surgical treatment of the primary melanoma of the skin.


2022 ◽  
Vol 6 (1) ◽  
pp. 01-07
Author(s):  
Mohammad Azizur Rahman ◽  
Tawhidur Rahman ◽  
Moshiur Rahman ◽  
Mirza Arif

The present article reviews the history of mushroom uses in culinary, food and medicinal values; current status and future aspect of mushroom research. Mushrooms contain biologically active polysaccharides, lipid and proteins in fruit bodies, each of them has a distinct role in health as either nutritional value or medicinal elements. Immunostimulating polysaccharides found in mushrooms, are most important for modern medicine. Several of the mushroom biomolecules have undergone phase I, II, and III clinical trials and are used extensively and successfully throughout the world for the treatment of various cancers and other diseases. Medicinal functions played by the mushrooms include antitumor, antibacterial, antioxidant, antiparasitic, antidiabetic, detoxification, cardiovascular, antihypercholesterolemia, antiviral, antifungal, hepatoprotective, immunomodulating and free radical scavenging. The present review draws attention to nutritional and medicinal importance of mushroom as well as the problems and opportunity in the future development of mushroom research.


2018 ◽  
Vol 26 (2) ◽  
pp. 296-304
Author(s):  
Elena A. Laksaeva

An interest in plants of Amelanchier genus is stimulated by the necessity of search for plant sources rich in biologically active substances and possessing the ability to influence different physiological processes in a human organism. The article gives information about places of growth of different species of Amelanchier (Amelanchier Medic) and about the fact that its fruits contain high concentration of free sugars, relatively low level of organic acids, sufficient amounts of various vitamins and provitamins and a complex of mineral substances. Nutritive and biological value of Amelanchier fruits in complex may produce a beneficial effect on different biochemical and physiological processes of normal vital activity of a human organism. The data are given about a positive influence of enteral introduction of polysaccharides isolated from Amelanchier fruits, on different physiological processes that enhance adaptational reserves of an organism of experimental animals. In particular, it was shown that watersoluble polysaccharide complex (WSPC) of Amelanchier fruits activates erythropoiesis increasing the amount of erythrocytes and hemoglobin in blood of experimental animals and raises concentration of iron. WSPC improves physical working capacity and increases the body mass of experimental animals. Addition of watersoluble polysaccharide complex of Amelanchier fruits to blood of a healthy donor increases thermal, osmotic and peroxide resistance of erythrocyte membranes thus protecting cells against damage under action of adverse factors in the experiment. Fruits of plants of Amelanchier genus may be recommended to be used as a food additive or a product in dietary and prophylactic therapy.


2020 ◽  
Vol 20 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Martyna Godzieba ◽  
Slawomir Ciesielski

Cancer and infectious diseases are one of the greatest challenges of modern medicine. An unhealthy lifestyle, the improper use of drugs, or their abuse are conducive to the increase of morbidity and mortality caused by these diseases. The imperfections of drugs currently used in therapy for these diseases and the increasing problem of drug resistance have forced a search for new substances with therapeutic potential. Throughout history, plants, animals, fungi and microorganisms have been rich sources of biologically active compounds. Even today, despite the development of chemistry and the introduction of many synthetic chemotherapeutics, a substantial part of the new compounds being tested for treatment are still of natural origin. Natural compounds exhibit a great diversity of chemical structures, and thus possess diverse mechanisms of action and molecular targets. Nucleic acids seem to be a good molecular target for substances with anticancer potential in particular, but they may also be a target for antimicrobial compounds. There are many types of interactions of small-molecule ligands with DNA. This publication focuses on the intercalation process. Intercalators are compounds that usually have planar aromatic moieties and can insert themselves between adjacent base pairs in the DNA helix. These types of interactions change the structure of DNA, leading to various types of disorders in the functioning of cells and the cell cycle. This article presents the most promising intercalators of natural origin, which have aroused interest in recent years due to their therapeutic potential.


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