scholarly journals Comparison of clinical, laboratory and radiological features in confirmed and unconfirmed COVID-19 patients

2021 ◽  
Author(s):  
Serkan Surme ◽  
Gulsah Tuncer ◽  
Betul Copur ◽  
Esra Zerdali ◽  
Inci Yilmaz Nakir ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Early Stage ◽  
Close Contact ◽  
Univariate Analysis ◽  
Rt Pcr ◽  
Radiological Findings ◽  
Respiratory Illnesses ◽  
Probable Case ◽  
Study Results

Background: We aimed to compare the clinical, laboratory and radiological findings of confirmed COVID-19 and unconfirmed patients. Methods: This was a single-center, retrospective study. Results: Overall, 620 patients (338 confirmed COVID-19 and 282 unconfirmed) were included. Confirmed COVID‐19 patients had higher percentages of close contact with a confirmed or probable case. In univariate analysis, the presence of myalgia and dyspnea, decreased leukocyte, neutrophil and platelet counts were best predictors for SARS-CoV-2 RT-PCR positivity. Multivariate analyses revealed that only platelet count was an independent predictor for SARS-CoV-2 RT-PCR positivity. Conclusion: Routine complete blood count may be helpful for distinguishing COVID-19 from other respiratory illnesses at an early stage, while PCR testing is unique for the diagnosis of COVID-19.

scholarly journals Quantitative Analysis of the Expression of Human N-myristoyltransferase 1 (hNMT-1) in Cancers

2009 ◽  
Vol 2 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Lifeng Chen ◽  
Binbing Ling ◽  
Jane Alcorn ◽  
Jian Yang
Keyword(s):  
Early Stage ◽  
Covalent Attachment ◽  
Rt Pcr ◽  
Lung Cancers ◽  
Protein Substrates ◽  
Ovarian Cancers ◽  
Potential Biomarker ◽  
Study Results ◽  
Disease Stages ◽  
Kidney Liver

Human N-myristoyltransferase 1 (hNMT-1) catalyzes the covalent attachment of myristic acid to N-terminal glycine residues (myristoylation) of numerous protein substrates. Overexpression of hNMT-1 in colorectal and gallbladder cancers makes it a potential biomarker and drug design target for such cancers. In this study, we investigated hNMT-1 expression during the progression of eight different human cancers using quantitative RT-PCR. The study results showed that hNMT-1 was up-regulated in breast, colon, lung and ovarian cancers but not kidney, liver, prostate and thyroid cancers. This suggests a role for hNMT-1 as a biomarker for detection of breast, colon, lung and ovarian cancers. This study also suggests the available hNMT-1 inhibitors may be potential therapeutic agents against breast and lung cancers through all disease stages, although their use would likely be limited to early stage colon and ovarian cancers.

scholarly journals Evaluation Of Clinical, Laboratory And Radiological Findings In Pediatric Covid-19 Cases And Their Relation With RT-PCR Result

2021 ◽  
Author(s):  
Muhammet Asena ◽  
ilyas yolbaş ◽  
murat Kanğın
Keyword(s):  
Computed Tomography ◽  
Respiratory Distress ◽  
Clinical Laboratory ◽  
Age Groups ◽  
Age Group ◽  
Test Results ◽  
Rt Pcr ◽  
Radiological Findings ◽  
Laboratory Findings ◽  
Pcr Test

Background: The pandemic of the new coronavirus disease (COVID-19) continues to be a major health problem globally. In this study, clinical findings, radiological findings, laboratory findings and polymerase chain reaction (PCR) test results were evaluated according to age groups in pediatric patients with COVID-19. Methods: In this study, PCR (+) and PCR (-) 278 cases diagnosed with COVID-19 between March 15, 2020 and September 30, 2020 were assessed considering clinical symptoms, radiological and laboratory findings and RT-PCR test results. Results: 43.9% of the cases consisted of RT-PCR (+) and 56.1% of RT-PCR (-) cases. Fever was observed at the rate of 64.7%, cough 53.2%, respiratory distress 12.2%, myalgia 24.5%, diarrhea 12.9%, chest X-ray findings 48.2% and computed tomography findings 43.6%. Diarrhea and cough, alanine aminotransferase, aspartate aminotransferase, leukocyte and lymphocyte elevation were determined as significantly higher in younger age group cases, while high myalgia and neutrophilia was observed in older age group children (p <0.05). Fever, high CRP, leukocytosis frequency, high neutrophil, were significantly higher in PCR(-) cases and the frequency of respiratory distress, high lymphocyte and chest computed tomography findings in PCR(+) cases (p <0.05). Conclusion: COVID-19 infection may indicate different nonspecific clinical, laboratory and radiological findings in children according to both adults and pediatric age groups. In addition, the results of the PCR test may give erroneous results in cases due to conditions such as fever, respiratory distress, high CRP, leukocytosis, high neutrophil and CT finding. Keywords: pediatric, COVID-19, RT-PCR

scholarly journals Characteristics, Comorbidities, and Vaccination of COVID-19

2021 ◽  
Vol 9 (12) ◽  
pp. 365-374
Author(s):  
P. Sharmila Nirojini
Keyword(s):  
Early Stage ◽  
Rna Virus ◽  
Close Contact ◽  
Antiviral Agent ◽  
The Body ◽  
Chronic Obstructive ◽  
Rt Pcr ◽  
Loss Of Appetite ◽  
Threatening Situation ◽  
Pcr Test

Abstract: COVID- 19 (Coronavirus disease 2019) is a quite contagious disease this is derived from Orthocoronavirinae family. SARS-CoV-2 viruses are single-stranded, plus-stranded RNA virus that infect numerous animal species, inclusive of humans, and cause respiration, neurological, and liver illnesses. SARS-CoV-2 is generally transferred through respiration droplets during close contact including speaking, coughing, sneezing, and shouting. Typical common symptoms of COVID-19 include respiratory symptoms like Fever and cough, diarrhea, nausea, vomiting, loss of appetite, and neurological manifestations. COVID-19 has currently been recognized using a viral nucleic acid RT-PCR test primarily based totally on affected person nasopharyngeal and throat swabs. The CT score could play a important function in the prognosis of COVID-19 infected patients if the RT-PCR test for swabs became negative at an early stage. COVID-19 patients with comorbidites like Diabetes Mellitus, Hypertension, Asthma, Deep Vein Thrombosis, Chronic Obstructive Pulmonary Disease (COPD), Cardio Vascular Disease, Obesity, Renal Disease, Liver Disease and other comorbidities can develope life-threatening situation. Remdesvir is the primary preference of medication, an antiviral agent that works via way of means of inhibiting viral replication in the body. There is a higher death rate in men while in comparison to women, hypothetically because of sex-based immunological or gendered differences. Vaccines are regarded as the maximum efficient way to halt the pandemic. Keywords: COVID-19, SARS-CoV-2, RT-PCR, comorbity, treatment, vaccine.

Treatment and outcome of patients with uterine carcinosarcoma: Data from developing world.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18102-e18102
Author(s):  
Seema Gulia ◽  
Anne Srikanth ◽  
Dr Ketaki Adsul ◽  
Umesh Mahantshetty ◽  
Jaya Ghosh ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Laboratory ◽  
Early Stage ◽  
Univariate Analysis ◽  
Local Relapse ◽  
Electrolyte Imbalance ◽  
Rank Test ◽  
Advanced Stage ◽  
Uterine Carcinosarcoma ◽  
Early Stage Disease

e18102 Background: To evaluate the clinicopathological factors, outcome and prognostics factors of uterine carcinosarcoma. Methods: All patients of uterine carcinosarcoma treated between January 2013 and December 2018 were identified and their clinical, laboratory and imaging details were retrieved from electronic medical record. Details of the treatment received, toxicity profile and outcome were recorded and analyzed. Patients (including stage I) were considered for four cycles of chemotherapy (Paclitaxel +Carboplatin) followed by radiation (EBRT to pelvis with vaginal brachytherapy). Survival analysis was done using the Kaplan–Meier method and compared between treatment groups using the Log-rank test. Results: Of 81 cases, 48 % presented with early stage disease (FIGOI-II) and 52 % with late stage (FIGO III-IV) disease. Median age was 58 years (30-80 years). Most women (83%) were postmenopausal and 80% of them presented with postmenopausal bleeding. Six patients developed carcinosarcoma on adjuvant tamoxifen (given for breast cancer) after a median drug intake of 8 years. In early stage, 10% patients received only surgical treatment; 46% received both chemotherapy (CT) and radiation therapy (RT) while 33 % received RT alone. In advanced stage, 31% received only CT, 14 % received only RT and 33% received both CT and RT after surgery. About 8% of patients had myelosuppression(grade I/II), 10 % had peripheral neuropathy (grade I/II) and 11% had electrolyte imbalance. At a median follow up of 2 years (1- 80 months), median DFS and OS in early stage group was 28.5 months and 31.0 months while in advanced stage group it was 13.0 months and 15.0 months respectively. Distant metastasis (omentum, peritoneum and lung being the common site) were seen in 30% of patients while local relapse was seen in 5 % cases. On univariate analysis stage of disease and receipt of adjuvant therapy were the factors found to be significantly associated with improved OS (p < 0.001) and adjuvant RT alone was associated with improved DFS (p < 0.023). Conclusions: Adjuvant treatment (chemotherapy and or radiation therapy) is associated with improved overall survival in uterine carcinosarcoma, irrespective of stage at presentation.

Predictors of Faster Decline of Residual Renal Function in Taiwanese Peritoneal Dialysis Patients

2008 ◽  
Vol 28 (3_suppl) ◽  
pp. 191-195 ◽  
Author(s):  
Chia-Te Liao ◽  
Chih-Chung Shiao ◽  
Jenq-Wen Huang ◽  
Kuan-Yu Hung ◽  
Hsueh-Fang Chuang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Function ◽  
Peritoneal Dialysis ◽  
Clinical Laboratory ◽  
Statistical Significance ◽  
Univariate Analysis ◽  
Residual Renal Function ◽  
Measure Data ◽  
Chi Square ◽  
Artery Disease

⋄ Objective Loss of residual renal function (RRF) in peritoneal dialysis (PD) patients is a powerful predictor of mortality. The present study was conducted to determine the predictors of faster decline of RRF in PD patients in Taiwan. ⋄ Methods The study enrolled 270 patients starting PD between January 1996 and December 2005 in a single hospital in Taiwan. We calculated RRF as the mean of the sum of 24-hour urea and creatinine clearance. The slope of the decline of residual glomerular filtration rate (GFR) was the main outcome measure. Data on demographic, clinical, laboratory, and treatment parameters; episodes of peritonitis; and hypotensive events were analyzed by Student t-test, Mann–Whitney U-test, and chi-square, as appropriate. All variables with statistical significance were included in a multivariate linear regression model to select the best predictors ( p < 0.05) for faster decline of residual GFR. ⋄ Results All patients commencing PD during the study period were followed for 39.4 ± 24.0 months (median: 35.5 months). The average annual rate of decline of residual GFR was 1.377 ± 1.47 mL/min/m2. On multivariate analysis, presence of diabetes mellitus ( p < 0.001), higher baseline residual GFR ( p < 0.001), hypotensive events ( p = 0.001), use of diuretics ( p = 0.002), and episodes of peritonitis ( p = 0.043) independently predicted faster decline of residual GFR. Male sex, old age, larger body mass index, and presence of coronary artery disease or congestive heart failure were also risk factors on univariate analysis. ⋄ Conclusions Our results suggested that diabetes mellitus, higher baseline residual GFR, hypotensive events, and use of diuretics are independently associated with faster decline of residual GFR in PD patients in Taiwan.

scholarly journals Exploring the Traveler’s Intentions to Use Public Transport during the COVID-19 Pandemic While Complying with Precautionary Measures

2021 ◽  
Vol 11 (8) ◽  
pp. 3630
Author(s):  
Muhammad Abdullah ◽  
Nazam Ali ◽  
Charitha Dias ◽  
Tiziana Campisi ◽  
Muhammad Ashraf Javid
Keyword(s):  
Public Transport ◽  
Close Contact ◽  
Policy Implications ◽  
Developing Regions ◽  
Infected People ◽  
The Public ◽  
Policy Interventions ◽  
Study Results ◽  
Precautionary Measures ◽  
Safety Guidelines

Public transport use has drastically declined during the COVID-19 pandemic because the virus spreads through close contact with infected people and contaminated surfaces, especially in closed-environments. Evidence suggests that following the necessary safety guidelines can limit the spread of the virus, however, non-compliance to precautionary measures has been reported widely. Ignoring the precautionary measures may lead to quick transmission of the virus since public transport vehicles generally resemble closed-environments. This study explores people’s intentions to use public transport during the COVID-19 pandemic while adhering to precautionary measures. For this purpose, a total of 1516 useable responses were collected through a questionnaire survey conducted in Lahore, Pakistan. Regression models were developed to model the intentions to use public transport during the pandemic, to adhere to the precautionary measures while using public transport during the pandemic, and to use public transport while suffering from COVID-19 disease. The results of this study will help in understanding the intentions of the public transport users during the COVID-19 pandemic. It will also provide insights for policymakers and public transport operators about further necessary actions to promote safe public transport use during the current and any possible future pandemics. As public transport use declined during the pandemic, policy implications for alternative mobility options such as demand-responsive-transport (DRT) are also presented. Considering the study results, a policy interventions framework is proposed to promote the safe use of various public transport modes, particularly in developing regions.

Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction

2011 ◽  
Vol 29 (6) ◽  
pp. 610-618 ◽  
Author(s):  
Bernhard Mlecnik ◽  
Marie Tosolini ◽  
Amos Kirilovsky ◽  
Anne Berger ◽  
Gabriela Bindea ◽  
...  
Keyword(s):  
Predictive Accuracy ◽  
Early Stage ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Tnm Staging ◽  
Time Dependent ◽  
Colorectal Cancers ◽  
Tumor Extension ◽  
T Stage ◽  
Immune Score

Purpose The prognosis of patients with colorectal cancer has sometimes proved uncertain; thus, the prognostic significance of immune criteria was compared with that of the tumor extension criteria using the American Joint Committee on Cancer/International Union Against Cancer–TNM (AJCC/UICC-TNM) staging system. Patients and Methods We studied the intratumoral immune infiltrates in the center of the tumor and in the invasive margin of 599 specimens of stage I to IV colorectal cancers from two independent cohorts. We analyzed these findings in relation to the degree of tumor extension and to the frequency of recurrence. Results Growth of the primary tumor and metastatic spread were associated with decreased intratumoral immune T-cell densities. Sixty percent of patients with high densities of CD8+ cytotoxic T-lymphocyte infiltrate presented with stage Tis/T1 tumor, whereas no patients with low densities presented with such early-stage tumor. In patients who did not relapse, the density of CD8 infiltrates was inversely correlated with T stage. In contrast, in patients whose tumor recurred, the number of CD8 cells was low regardless of the T stage of the tumor. Univariate analysis showed that the immune score was significantly associated with differences in disease-free, disease-specific, and overall survival (hazard ratio [HR], 0.64, 0.60, and 0.70, respectively; P < .005). Time-dependent receiver operating characteristic curve analysis illustrated the predictive accuracy of the immune parameters (c-index = 65.3%, time-dependent c-index [Cτ] = 66.5%). A final stepwise model for Cox multivariate analysis supports the advantage of the immune score (HR, 0.64; P < .001; Cτ = 67.9%) compared with histopathologic features in predicting recurrence as well as survival. Conclusion Assessment of CD8+ cytotoxic T lymphocytes in combined tumor regions provides an indicator of tumor recurrence beyond that predicted by AJCC/UICC-TNM staging.

Comparison of the Prognoses of FIGO Stage I to Stage II Adenosquamous Carcinoma and Adenocarcinoma of the Uterine Cervix Treated With Radical Hysterectomy

2012 ◽  
Vol 22 (8) ◽  
pp. 1389-1397 ◽  
Author(s):  
Seiji Mabuchi ◽  
Mika Okazawa ◽  
Yasuto Kinose ◽  
Koji Matsuo ◽  
Masateru Fujiwara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
High Risk ◽  
Uterine Cervix ◽  
Radical Hysterectomy ◽  
Adenosquamous Carcinoma ◽  
Early Stage ◽  
Univariate Analysis ◽  
Low Risk ◽  
Histological Subtype

ObjectivesTo evaluate the significance of adenosquamous carcinoma (ASC) compared with adenocarcinoma (AC) in the survival of surgically treated early-stage cervical cancer.MethodsWe retrospectively reviewed the medical records of 163 patients with International Federation of Gynecology and Obstetrics stage IA2 to stage IIB cervical cancer who had been treated with radical hysterectomy with or without adjuvant radiotherapy between January 1998 and December 2008. The patients were classified according to the following: (1) histological subtype (ASC group or AC group) and (2) pathological risk factors (low-risk or intermediate/high-risk group). Survival was evaluated using the Kaplan-Meier method and compared using the log-rank test. Multivariate analysis of progression-free survival (PFS) was performed using the Cox proportional hazards regression model to investigate the prognostic significance of histological subtype.ResultsClinicopathological characteristics were similar between the ASC and AC histology groups. Patients with the ASC histology displayed a PFS rate similar to that of the patients with the AC histology in both the low-risk and intermediate/high-risk groups. Neither the recurrence rate nor the pattern of recurrence differed between the ASC group and the AC group. Univariate analysis revealed that patients with pelvic lymph node metastasis and parametrial invasion achieved significantly shorter PFS than those without these risk factors.ConclusionsCharacteristics of the patients and the tumors as well as survival outcomes of ASC were comparable to adenocarcinoma of early-stage uterine cervix treated with radical hysterectomy. Our results in part support that the management of ASC could be the same as the one of AC of the uterine cervix.

Biochemical parameters and relation to disease severity in COVID-19 patients

2021 ◽  
pp. 93-96
Keyword(s):  
Biochemical Parameters ◽  
Troponin I ◽  
Total Bilirubin ◽  
Early Stage ◽  
Length Of Hospital Stay ◽  
Rt Pcr ◽  
Sodium Potassium ◽  
Appropriate Treatment ◽  
Significant Difference ◽  
Severity Of The Disease

Aim: In this study, we aimed to evaluated whether there is an association between the biochemistry parameters obtained from the first blood test after hospitalization of COVID 19 patients and the prognosis and severity of the disease. Thus, we planned to identify patients with a severe course at an early stage and to help physicians determine the appropriate treatment. Material and Method: The study included 106 COVID 19 patients confirmed by RT-PCR. Patients were categorized into two groups: those admitted to the hospital ward and discharged with recovery (mild cases) and those admitted directly or eventually to the intensive care unit (severe cases). Biochemical parameters of the groups were compared with the Mann Whitney-U Test, as none of the compared parameters fit the normal distribution. Results: There was no statistically significant difference between the male-female numbers and ages of the two groups. Statistically significant differences were observed in the length of hospital stay, procalcitonin, hs-troponin I, ferritin, glucose, urea, creatinine, calcium, direct bilirubin, AST, LDH and CRP values (p<0,05). However, no significant difference was found in sodium, potassium, chloride, total bilirubin and ALT tests. Conclusion: The results show that some biochemistry parameters may be used to predict the prognosis of the disease. In particular, procalcitonin, hs troponin I, LDH and CRP values seem to be moderate biomarkers of the prognosis of the disease.

Periaortic air in native and post-operative aorta on computed tomography

2021 ◽  
Author(s):  
Mansi Verma ◽  
Amit Ajit Deshpande ◽  
Niraj Nirmal Pandey ◽  
Sanjeev Kumar
Keyword(s):  
Computed Tomography ◽  
Clinical Laboratory ◽  
Radical Surgery ◽  
Imaging Finding ◽  
Radiological Findings ◽  
Catastrophic Event ◽  
Cross Sectional ◽  
Pictorial Review ◽  
Cross Sectional Imaging ◽  
Indispensable Tool

Periaortic air can be seen in various conditions which can be a benign imaging finding or harbinger of a catastrophic event. The causes vary in native aorta and post-operative aorta. A radiologist has an important part in the management process of these patients, as the treatment varies from conservative to radical surgery based on the aetiology. The presence of periaortic air seen in the light of various clinical, laboratory and radiological findings can guide the radiologist towards a particular aetiology. Cross-sectional imaging, mainly computed tomography, is an indispensable tool in recognising ectopic periaortic air and to identify the associated findings and eventually make an accurate diagnosis. We present a pictorial review of various causes of the periaortic air in native and postoperative aorta, the salient features and management of the described conditions.

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