Use of intraoperative fluorescence to enhance robot-assisted radical prostatectomy

2021 ◽  
pp. 1083-1095
Author(s):  
Timothy Rajakumar ◽  
Musaab Yassin ◽  
Omar Musbahi ◽  
Eli Harris ◽  
J Francisco Lopez ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Standard Of Care ◽  
Positive Outcomes ◽  
Fluorescent Tracers ◽  
Robot Assisted ◽  
Guided Surgery ◽  
Visual Contrast ◽  
Fluorescence Guided Surgery ◽  
Meta Analyses ◽  
Effective Use

Robot-assisted radical prostatectomy has become the standard of care for the removal of localized prostate cancer. Positive outcomes depend upon the precise removal of the prostate and associated tissue without damage to nearby structures. This process can be aided by fluorescence-guided surgery to enhance the visual contrast between different structures. Here the authors have conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify ten investigations into the use of fluorescence-guided surgery in robot-assisted radical prostatectomy. These studies used fluorescent tracers to identify structures, including the prostate, neurovascular bundle and lymph nodes. These studies demonstrate the safe and effective use of fluorescence-guided surgery in robot-assisted radical prostatectomy and pave the way for further developments in this field.

scholarly journals Qualitative head-to-head comparison of headlamp and microscope for visualizing 5-ALA fluorescence during resection of glioblastoma

2022 ◽  
Vol 6 (1) ◽  
pp. V7
Keyword(s):  
Aminolevulinic Acid ◽  
Standard Of Care ◽  
High Grade ◽  
Operative Field ◽  
Guided Surgery ◽  
Link Type ◽  
Fluorescence Guided Surgery ◽  
Similar Images ◽  
High Grade Gliomas

Fluorescence-guided surgery (FGS) for high-grade gliomas using 5-aminolevulinic acid has become a new standard of care for neurosurgeons in several countries. In this video the authors present the case of a man with glioblastoma who underwent FGS in which similar images of the operative field were acquired alternating between the microscope and a new commercially available headlight, facilitating the comparison of visualization quality between the two devices. The authors also review some of the principles of fluorescence-guidance surgery that may explain the improved brightness and contrast that they observed when using the headlamp versus the microscope. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21181

scholarly journals The Neurosurgeon’s Armamentarium for Gliomas: An Update on Intraoperative Technologies to Improve Extent of Resection

2021 ◽  
Vol 10 (2) ◽  
pp. 236
Author(s):  
Alexander J. Schupper ◽  
Raymund L. Yong ◽  
Constantinos G. Hadjipanayis
Keyword(s):  
Tumor Tissue ◽  
Imaging Techniques ◽  
Intraoperative Imaging ◽  
Standard Of Care ◽  
Extent Of Resection ◽  
Guided Surgery ◽  
Current State ◽  
Fluorescence Guided Surgery ◽  
Neurosurgical Treatment ◽  
Intraoperative Visualization

Maximal safe resection is the standard of care in the neurosurgical treatment of high-grade gliomas. To aid surgeons in the operating room, adjuvant techniques and technologies centered around improving intraoperative visualization of tumor tissue have been developed. In this review, we will discuss the most advanced technologies, specifically fluorescence-guided surgery, intraoperative imaging, neuromonitoring modalities, and microscopic imaging techniques. The goal of these technologies is to improve detection of tumor tissue beyond what conventional microsurgery has permitted. We describe the various advances, the current state of the literature that have tested the utility of the different adjuvants in clinical practice, and future directions for improving intraoperative technologies.

Optical imaging probes and their potential contribution to radiotracer development

2016 ◽  
Vol 55 (02) ◽  
pp. 51-62 ◽  
Author(s):  
S. Hermann ◽  
M. Schäfers ◽  
C. Höltke ◽  
A. Faust
Keyword(s):  
Optical Imaging ◽  
Fluorescent Dyes ◽  
Great Influence ◽  
Potential Contribution ◽  
Preclinical Evaluation ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Imaging Probes ◽  
Unspecific Binding

SummaryOptical imaging has long been considered a method for histological or microscopic investigations. Over the last 15 years, however, this method was applied for preclinical molecular imaging and, just recently, was also able to show its principal potential for clinical applications (e.g. fluorescence-guided surgery). Reviewing the development and preclinical evaluation of new fluorescent dyes and target-specific dye conjugates, these often show characteristic patterns of their routes of excretion and biodistribution, which could also be interesting for the development and optimization of radiopharmaceuticals. Especially ionic charges show a great influence on biodistribution and netcharge and charge-distribution on a conjugate often determines unspecific binding or background signals in liver, kidney or intestine, and other organs.Learning from fluorescent probe behaviour in vivo and translating this knowledge to radio-pharmaceuticals might be useful to further optimize emerging and existing radiopharmaceuticals with respect to their biodistribution and thereby availability for binding to their targets.

Total anatomical reconstruction during robot-assisted radical prostatectomy in patients with previous prostate surgery

2019 ◽  
Vol 71 (6) ◽  
Author(s):  
Davide Campobasso ◽  
Cristian Fiori ◽  
Daniele Amparore ◽  
Enrico Checcucci ◽  
Diletta Garrou ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Anatomical Reconstruction ◽  
Robot Assisted

Management of erectile dysfunction following robot-assisted radical prostatectomy: a systematic review

2020 ◽  
Vol 72 (5) ◽  
Author(s):  
Michele Marchioni ◽  
Piergustavo De Francesco ◽  
Roberto Castellucci ◽  
Rocco Papalia ◽  
Selçuk Sarikaya ◽  
...  
Keyword(s):  
Systematic Review ◽  
Erectile Dysfunction ◽  
Radical Prostatectomy ◽  
Robot Assisted
Sign in / Sign up

Export Citation Format

Share Document