Updates on the use of liposomes for active tumor targeting in cancer therapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 303-318 ◽  
Author(s):  
Wei Yan ◽  
Sharon SY Leung ◽  
Kenneth KW To
Keyword(s):  
Preparation Method ◽  
Cancer Therapeutics ◽  
Active Targeting ◽  
Anticancer Drug Delivery ◽  
Liposomal Formulations ◽  
Simple Preparation ◽  
Low Toxicity ◽  
Future Direction ◽  
New Anticancer Drugs ◽  
Insight Into

In the development of cancer chemotherapy, besides the discovery of new anticancer drugs, a variety of nanocarrier systems for the delivery of previously developed and new chemotherapeutic drugs have currently been explored. Liposome is one of the most studied nanocarrier systems because of its biodegradability, simple preparation method, high efficacy and low toxicity. To make the best use of this vehicle, a number of multifunctionalized liposomal formulations have been investigated. The objective of this review is to summarize the current development of novel active targeting liposomal formulations, and to give insight into the challenges and future direction of the field. The recent studies in active targeting liposomes suggest the great potential of precise targeted anticancer drug delivery in cancer therapeutics.

scholarly journals Active targeting of nanoparticles: An innovative technology for drug delivery in cancer therapeutics

2019 ◽  
Vol 9 (1-s) ◽  
pp. 408-415 ◽  
Author(s):  
Rupalben Kaushalkumar Jani ◽  
Gohil Krupa
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Cancer Therapeutics ◽  
Active Targeting ◽  
Innovative Technology ◽  
Cross Linking ◽  
Uncontrolled Cell Proliferation ◽  
Insight Into

In nanomedicines, currently a wide array of reported nanoparticle systems is being explored by targeting schemes which suggests great potential of targeted delivery to revolutionize cancer therapeutics. This review  gives insight into recent  challenges in modification of nanoparticle systems for enhanced cancer therapy  acknowledged by researchers to date and also outlines different major targeting strategies of nanoparticle systems that have been utilized for the delivery of therapeutics or imaging agents, targeting ligand and cross-linking agent to cancer  which was divided into three sections: 1) Angiogenesis associated targeting, 2) Uncontrolled cell proliferation targeting and 3) Tumor cell targeting. Keywords: nanoparticles, tumor cells, active targeting, targeting strategies, targeting ligands

scholarly journals Traditional Chinese Herbal, “Dandelion” and Its Applications on Skin-Care

2021 ◽  
Author(s):  
Siukan Law ◽  
Chuiman Lo ◽  
Jie Han ◽  
Albert Wingnang Leung ◽  
Chuanshan Xu
Keyword(s):  
Preparation Method ◽  
Taraxacum Officinale ◽  
Root Extract ◽  
Pharmacological Properties ◽  
Chinese Herbal ◽  
Simple Preparation ◽  
Medicinal Value ◽  
Wide Range ◽  
Long Time ◽  
Low Toxicity

Dandelion (Taraxacum officinale) belongs to the Asteraceae or sunflower family. Its leaves, stems, and roots have been used in traditional Chinese herbal for a long time because dandelion has a wide range of pharmacological properties including anti-microbial, anti-viral, anti-inflammatory, and anti-infectious as well as anti-oxidation especially in the dandelion root extract which is the most medicinal value. A clinical study of dandelion extracts on skin acne and a simple preparation method of the dandelion extract would be discussed since the dandelion extract has low toxicity on the skin, even is non-toxic based on the British Herbal Pharmacopoeia recommendation. 

Scanning electron microscopy of human iliac bone by a simple preparation method

1990 ◽  
Vol 48 (3) ◽  
pp. 226-227
Author(s):  
Toshihiko Takita ◽  
Tomonori Naguro ◽  
Toshio Kameie ◽  
Akihiro Iino ◽  
Kichizo Yamamoto
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Preparation Method ◽  
Specimen Preparation ◽  
Real Surface ◽  
Public Attention ◽  
Preparation Methods ◽  
The Real ◽  
Simple Preparation ◽  
Scanning Electron

Recently with the increase in advanced age population, the osteoporosis becomes the object of public attention in the field of orthopedics. The surface topography of the bone by scanning electron microscopy (SEM) is one of the most useful means to study the bone metabolism, that is considered to make clear the mechanism of the osteoporosis. Until today many specimen preparation methods for SEM have been reported. They are roughly classified into two; the anorganic preparation and the simple preparation. The former is suitable for observing mineralization, but has the demerit that the real surface of the bone can not be observed and, moreover, the samples prepared by this method are extremely fragile especially in the case of osteoporosis. On the other hand, the latter has the merit that the real information of the bone surface can be obtained, though it is difficult to recognize the functional situation of the bone.

scholarly journals Development and Stability Studies of Novel Liposomal Vancomycin Formulations

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Krishna Muppidi ◽  
Andrew S. Pumerantz ◽  
Jeffrey Wang ◽  
Guru Betageri
Keyword(s):  
Particle Size ◽  
Encapsulation Efficiency ◽  
Antimicrobial Agents ◽  
Preparation Method ◽  
Physical Stability ◽  
Liposomal Formulations ◽  
Promising Strategy ◽  
Activity Variable ◽  
Distribution Studies

A promising strategy to improve the therapeutic efficiency of antimicrobial agents is targeted therapy. Although vancomycin has been considered a gold standard for the therapy of MRSA pneumonia, clinical failure rates have also been reported owing to its slow, time-dependent bactericidal activity, variable lung tissue penetration and poor intracellular penetration into macrophages. Liposomal encapsulation has been established as an alternative for antimicrobial delivery to infected tissue macrophages and offers enhanced pharmacodynamics, pharmacokinetics and decreased toxicity compared to standard preparations. The aim of the present work is to prepare vancomycin in two different liposomal formulations, conventional and PEGylated liposomes using different methods. The prepared formulations were optimized for their particle size, encapsulation efficiency and physical stability. The dehydration-rehydration was found to be the best preparation method. Both the conventional and PEGylated liposomal formulations were successfully formulated with a narrow particle size and size distribution and % encapsulation efficiency of and , respectively. Both the formulations were stable at C for 3 months. These formulations were successfully used to evaluate for their intracellular killing of MRSA and in vivo pharmacokinetic and bio-distribution studies.

scholarly journals PUBLICATION TREND ON TRAVEL PREFERENCES OF SENIOR TOURISTS FROM 2000 TO 2020

2021 ◽  
Vol 6 (26) ◽  
pp. 172-185
Author(s):  
Nurul Ain Farhana Zainordin ◽  
Syed Muhammad Rafy Syed Jaafar ◽  
Nurul Diyana Md Khairi
Keyword(s):  
Literature Review ◽  
The Other ◽  
Ageing Population ◽  
Market Segment ◽  
Future Directions ◽  
Tourism Research ◽  
Review Analysis ◽  
Future Direction ◽  
Insight Into

The ageing population is the crucial phenomenon that has led to the new market segment in tourism known as 'senior tourists.' A senior tourist is determined as an older traveller or grey tourist. The number of elderly keeps growing throughout time; hence, grey tourists will be relevant preferences, differing from the younger tourists. This paper aims to evaluate the relevant studies regarding travel preferences that involve senior tourists. The objective is to understand the publication trend behind the development of travel preferences for senior tourists. The findings suggest that the overall travel preferences among senior tourists studied include 12 aspects of travel preferences. Researchers tend to focus on the aspect of accommodation among senior tourists compared to the other elements. At the end of the review, this paper is set out to outline the literature review analysis to provide greater insight into the development of travel preferences among grey tourists in tourism research from 2000 to 2020. This paper's output offers future directions to explore the offer trends and future direction in tourism and behaviour literature.

scholarly journals Condition Monitoring Technologies for Synthetic Fiber Ropes - a Review

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Espen Oland ◽  
Rune Schlanbusch ◽  
Shaun Falconer
Keyword(s):  
Condition Monitoring ◽  
State Of The Art ◽  
Degradation Process ◽  
Synthetic Fiber ◽  
Physical Parameters ◽  
The Subject ◽  
Condition Monitoring System ◽  
Future Direction ◽  
Monitoring Technologies ◽  
Insight Into

This paper presents a review of different condition monitoring technologies for fiber ropes. Specifically, it presents an overview of the articles and patents on the subject, ranging from the early 70’s up until today with the state of the art. Experimental results are also included and discussed in a conditionmonitoring context,where failuremechanisms and changes in physical parameters give improved insight into the degradation process of fiber ropes. From this review, it is found that automatic width measurement has received surprisingly little attention, and might be a future direction for the development of a continuous condition monitoring system for synthetic fiber ropes.

Three-dimensionally ordered mesoporous multicomponent (Ni, Mo) metal oxide/N-doped carbon composite with superior Li-ion storage performance

Nanoscale ◽  
2018 ◽  
Vol 10 (39) ◽  
pp. 18734-18741 ◽  
Author(s):  
Se Hwan Oh ◽  
Jin Koo Kim ◽  
Yun Chan Kang ◽  
Jung Sang Cho
Keyword(s):  
Metal Oxides ◽  
Preparation Method ◽  
Carbon Composite ◽  
Pyrolysis Process ◽  
Storage Performance ◽  
Simple Preparation ◽  
Ordered Mesoporous ◽  
Ion Storage ◽  
Li Ion ◽  
Spray Pyrolysis Process

A simple preparation method of mesoporous multicomponent metal oxides containing Ni and Mo components with N-doped carbon by spray pyrolysis process is introduced.

Automated Dispensing Devices

2000 ◽  
Vol 35 (6) ◽  
pp. 666-670 ◽  
Author(s):  
Darryl S. Rich
Keyword(s):  
Home Care ◽  
Accreditation Process ◽  
Joint Commission ◽  
Practice Environment ◽  
Fair Game ◽  
Future Direction ◽  
Insight Into ◽  
The Joint Commission

This column addresses questions from readers about any issue, process, standard, or future direction of the Joint Commission, whether it relates to home care, the hospital, or other practice environment. The objective is to give you a better insight into the Joint Commission accreditation process in your own practice site. Any question is fair game.

A simple preparation method for superhydrophobic surface on silicon rubber and its properties

2020 ◽  
Vol 143 ◽  
pp. 105612 ◽  
Author(s):  
Xinyu Zhou ◽  
Guangfei Wang ◽  
Meimei Wang ◽  
Yu Zhang ◽  
Wanlei Yin ◽  
...  
Keyword(s):  
Superhydrophobic Surface ◽  
Preparation Method ◽  
Silicon Rubber ◽  
Simple Preparation
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