scholarly journals A Comparative Study of Diclofenac with Paracetamol versus Diclofenac with Serratiopeptidase in Pain Associated with Soft Tissue Injury

Author(s):  
Dr. S. E. Gowtham

Abstract: The point of the executives is to ease the pain rapidly and improve practical capacity. NSAIDs are the primary line treatment. Serratiopeptidase is the proteolytic enzyme. The challenge lies in deciding whether only NSAIDs or NSAIDs with proteolytic enzyme will give more prominent indicative help, while additionally being savvy. the primary goal is to think about the adequacy of diclofenac with paracetamol and diclofenac with serratiopeptidase in the administration of delicate tisssue injury. This prospective, open label, observational study was conducted at a tertiary care hospital. Patients over 18 years of age and presenting with soft tissue injury pain (elbow pain, knee pain, general pain, back pain ) of less than 6 weeks duration were enrolled in the study. Forty patients with soft tissue injury pain were randomized into two groups: Group A got diclofenac with paracetamol (50mg/325mg) double a day and Group B got diclofenac with serratiopeptidase (50mg/10mg) double a day for 1 week. The Numerical Rating Scale (NRS) determined the clinically significant results. The decrease in pain intensity in Group B was (MEAN= 3.76), while in Group A it was (MEAN= 3.93). The average cost-effectiveness ratio indicated that diclofenac wit paracetamol was the dominant treatment over diclofenac with serratiopeptidase. Therefore, diclofenacc with paracetamol was found to be the cost-effective option for soft tissue injury pain relief in for 1 week. Both diclofenac wit paracetamol and diclofenac with serratiopeptidase. were clinically effective in reducing the pain intensity and in improving functional ability. H owever, diclofenac wit paracetamol was found to be the cost-effective intervention. Keywords: Paracetamol, diclofenac, Serratiopeptidase, soft tissue injury, pain.

Author(s):  
Priyanka Aggarwal ◽  
Barjinder Singh Sohal ◽  
J. P. Goyal

<p><strong>Background:</strong> To compare the results of endoscopic tympanoplasty with that of conventional tympanoplasty and to evaluate and compare the graft uptake in both of these methods. The study was done to evaluate the improvement in hearing after tympanoplasty and the problems faced while doing the endoscope assisted tympanoplasty.</p><p><strong>Methods: </strong>Between July 2010 to June 2013, 50 patients underwent tympanoplasty, 25 were endoscope assisted (group A) and 25 were microscope assisted (group B). Results of surgery were compared at the end of three and six months post operation.</p><p><strong>Results: </strong>The success rate in terms of graft uptake rate was 88% with endoscope assisted tympanoplasty and 84% with other microscope assisted tympanoplasty. Overall success rate was 86.0%. Mean hearing improvement was (16.24±10.21 dB) and (14.28±7.10 dB) in group A and group B respectively.</p><p><strong>Conclusions: </strong>Tympanoplasty with its visualization of hidden corners, justifies tympanoplasty by using endoscope in selected cases with comparable improved results in the literature. Furthermore, the cost of the endoscope is much less (about 10%) in comparision to operating microscope, making it more cost effective in developing countries. However, the endoscope cannot be employed in every case as one hand is blocked. In terms of Patient comfort, the endoscope assisted outnumbers the benefits of other conventional methods.<strong></strong></p>


2011 ◽  
Vol 24 (02) ◽  
pp. 126-131 ◽  
Author(s):  
C. Davidson ◽  
G. I. Arthurs ◽  
R. L. Meeson

Summary Objectives: Casts applied for orthopaedic conditions can result in soft-tissue injuries. The purpose of our study was to describe the nature and prevalence of such complications. Methods: We performed a retrospective review of medical records of dogs and cats that had a cast placed for an orthopaedic condition between October 2003 and May 2009. The data were analysed and categorised. Results: Of the 60 animals that had a cast placed, 63% developed a soft-tissue injury (60% mild, 20% moderate and 20% severe). Injuries could occur any time during coaptation, and an association with duration of casting and severity (p = 0.42) was not shown. Severe injuries took the longest to resolve (p = 0.003). Sighthounds were significantly more likely to develop a soft-tissue injury (p = 0.04), and cross-breeds were less likely (p = 0.01). All common calcaneal tendon reconstructions suffered soft-tissue injuries, but significance was not shown (p = 0.08). Veterinarians identified the majority of injuries (80%) rather than the owners. The financial cost of treating soft-tissue injuries ranged from four to 121% the cost of the original orthopaedic procedure. Clinical significance: Soft-tissue injuries secondary to casting occur frequently, and can occur at any time during the casting period. Within our study, sighthounds were more likely to develop soft tissue injuries, and should therefore perhaps be considered as a susceptible group. The only reliable way to identify an injury is to remove the cast and inspect the limb.


2019 ◽  
Vol 26 (12) ◽  
pp. 2192-2195
Author(s):  
Taleah Tahir ◽  
Muhammad Afzal ◽  
Malik Nadeem Azam Khan ◽  
Khalid Mehmood Raja ◽  
Wahaj ◽  
...  

Objectives: To ascertain the cost-effectiveness of tunneled catheters to non-tunneled catheter in dialysis patients of a tertiary care hospital. Study Design: Retrospective cross-sectional study. Study Design: Department of Nephrology, Pak Emirates Military Hospital Rawalpindi. Period: Jan 2016 to Jan 2019. Material & Methods: The sample population comprised of 500 patients, being divided into two groups and followed over a period of 03 yrs. Group A had tunneled double lumen and group B had non tunneled double lumen. Dialysis was started on the same day in both groups. Both groups were compared in terms of cost effectiveness. Cost effectiveness included price of catheter, procedure cost, treatment of infection (if any), and change of catheter in case of catheter malfunction. The amount spent on each patient was added and then an average was calculated. Results: Out of 600 patients, 300 were in group A and 300 patients were in group B. The two groups were analogous in gender (male: 52.8% vs 57.8%, p=0.35)age (41 years vs 49 yrs, p=0.71) hypertension and diabetes as the main causes of ESRD  (51% vs 39%, p=0.08 and 32% vs 34%, p=0.38, respectively). Total incurred cost of tunneled double lumen was Rs.19000.00, with average infection free patency time being three months during which Arteriovenous fistula formed. In comparison, non-tunneled double lumen in 300 patients, average cost incurred was Rs.30000.00 including cost incurred on treating sepsis and in two –three insertions in few cases . There was no procedure related mortality. Conclusion: The cost-effectiveness of Tunneled double lumen catheters and clinical benefit of reduction in patency failures and also access related infections make them the first choice for dialysis patients in majority of dialysis centers of our country but large randomized control trials needed as the sample size quite less to detect a difference from the newer agents.


Author(s):  
Akula S ◽  
Nagarathna J ◽  
S K Srinath

Objectives: Research is ongoing to find safe and effective oral hygiene aids for oral self‑care in children. Mouthwashes are used to complete the process of mechanical plaque control. Lack of affordability and side effects of most commercially available mouthwashes limit their use in children. Hence, the cost-effective and easily available essential oil, lemongrass oil, when formulated as a mouthwash, may possibly serve as an adjunct to oral hygiene maintenance. The main objective of this study was to compare the efficacy of lemongrass oil and chlorhexidine (CHX) mouthwash in children. Materials and Methods: Sixty healthy children between 9-12 years were selected. During the initial visit, the plaque pH, plaque index (PI), and gingival index (GI) were assessed, and oral prophylaxis was performed. The patients were randomized into three groups (n=20) and received 0.25% lemongrass oil mouthwash (group A), 0.2% CHX mouthwash (group B), and oral prophylaxis alone (group C). The patients were recalled after 14 and 21 days. ANOVA with post-hoc Bonferroni and paired t-test were used to analyze the results by SPSS software. Results: Intragroup comparison of PI and GI showed a significant decrease between 14 and 21 days in groups A and B (P≤0.05). Intragroup comparison of the mean plaque pH in group A showed a significant increase at day 21 compared with baseline (P=0.028). Conclusion: The results showed that the lemongrass oil mouthwash was effective in reducing PI and GI in children. Thus, it may be used as a good herbal alternative to CHX mouthwash.


2009 ◽  
Vol 21 (1) ◽  
pp. 36-42
Author(s):  
M Masudul Haque ◽  
Md Rabiul Alam ◽  
Md Al Mamun ◽  
Md Mozaffer Hossain ◽  
Md Zahurul Islam

A prospective comparative study was carried out to evaluate haemodynamic and recovery status using infusion of propofol-midazolam-nalbuphine and ketamine-diazepam-tramadol in surgical daycases. Fifty patients of either sex aged within 18-60 years ASA grade I or II requiring routine surgery as day-case basis under GA were selected in Dept of Anaesthesia, CMH, Dhaka during February-May 2006. Cases were randomly divided equally into two groups of 25 each. Group-A received propofolmidazolam- nalbuphine infusion and infusion of ketamine-diazepam-tramadol was used in Group- B for anaesthesia. Haemodynamic parameters, recovery status and home readiness time were monitored and recorded at 10 min intervals. The variations in heart rate, systolic and diastolic BP of both groups were found statistically insignificant (p-values: 0.0524, 0.0513 and 0.0575 respectively). Recovery scores were high in Group-A (p-0.0443) and time for home-readiness were found 242±35 (mean±SD) minutes in Group-A and 367±83 minutes in Group-B (p-0.0329). Drugs used in Group-B were found highly cost effective. It is concluded that by using ketamine, diazepam and tramadol combination (group-B), we can reduce the cost of anaesthesia, which is necessity for majority of patients in our country. On the other hand, propofol, midazolam and nalbuphine combination (group-A), a costlier regime appears suitable for the patients from affluent population. Both the regimes can be practiced with safety.   Journal of BSA, Vol. 21, No. 1, January 2008 36-42


2018 ◽  
Vol 7 (1) ◽  
pp. 35-41
Author(s):  
Muhammad Usman Khan ◽  
Ghazala Noor Nizami ◽  
Ali Farhad

OBJECTIVE To compare the effectiveness of mobilization and self-exercises in the management of adhesive capsulitis of shoulder STUDY DESIGN Randomized Control Trial SAMPLE SELECTION 30 patients of adhesive capsulitis of shoulder from physiotherapy department of tertiary care hospitals of Karachi were selected through simple random sampling technique. PROCEDURE Treatment was continued for 5 days per week for the period of 3 weeks followed by assessment. Patients were randomly divided into two equal groups. Group A was treated with midrange mobilization while group B performed self-exercises. Both groups received TENS and hot pack prior to the exercises. Mean ± SD, frequencies and percentages were used for descriptive analysis. ROM via goniometry and pain intensity through VAS was analyzed by paired t-test within the groups and by independent t-test between the groups, using SPSS. P-value of less than 0.05 was considered significant. RESULTS 60% were females (n=18) and 40% were males (n=12) with mean age of 50.17±6.37 years. Significant improvement (p-value <0.05) in pain and shoulder ROM was observed among patients of Group A as compared to Group B. Pain intensity was decreased to 1.67 ± 0.62 in group A, whereas ROMs in these patients were also better than other group.


1987 ◽  
Vol 148 (2) ◽  
pp. 458-458 ◽  
Author(s):  
DR Pennes ◽  
WA Phillips

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