scholarly journals A Novel Drug Delivery System: Review on Microspheres

2021 ◽  
Vol 11 (2-S) ◽  
pp. 156-161
Author(s):  
Hans Raj ◽  
Shagun Sharma ◽  
Ankita Sharma ◽  
Kapil Kumar Verma ◽  
Amit Chaudhary
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Magnetic Microspheres ◽  
Oral Drug ◽  
Optimum Level ◽  
Target Tissue ◽  
Fixed Rate ◽  
Target Drug ◽  
Novel Drug

Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the right timeframe, resulting in little toxicity and minimal side effects. There are different approaches to supplying the medicinal drug to the target site in a continuous managed manner. One such strategy is the use of microspheres as drug carriers. In this article, the value of the microsphere is seen as a novel drug delivery carrier to achieve site-specific drug delivery was discussed. Keywords: microspheres, method of preparations, polymer, bioadhesion, types of microspheres

scholarly journals A Novel Drug Delivery of Microspheres

2021 ◽  
Vol 11 (6) ◽  
pp. 257-264
Author(s):  
Smily Walia ◽  
J.S. Dua ◽  
D.N. Prasad
Keyword(s):  
Drug Delivery ◽  
Medication Administration ◽  
Magnetic Microspheres ◽  
Target Tissue ◽  
Polymeric Microspheres ◽  
Target Drug Delivery ◽  
Drug Delivery Carrier ◽  
Target Drug ◽  
Medication Delivery ◽  
Novel Drug

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to a specific region. Microspheres are free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging from 1 to 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption and desorption by regeneration .The study demonstrates how microsphere parameters are planned and measured. Bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, and radioactive microspheres are only a few examples of complicated microspheres. Cosmetics, oral medication administration, target drug delivery, ocular drug delivery, gene delivery, and other industries covered in the paper could all benefit from microspheres. To ensure best therapeutic effectiveness, the agent must be delivered to target tissue at an optimal amount during the appropriate timeframe, with low toxicity and adverse effects. There are several methods for delivering the therapeutic substance to the target site in a controlled manner. The use of microspheres as medication carriers is one such technique. The value of microspheres as a novel drug delivery carrier to accomplish site-specific drug delivery was discussed in this article. Keywords: Microspheres, method of preparations, polymer bioadhesion, types of microspheres.

Evaluation of mesoporous silica nanoparticles for oral drug delivery – current status and perspective of MSNs drug carriers

Nanoscale ◽  
2017 ◽  
Vol 9 (40) ◽  
pp. 15252-15277 ◽  
Author(s):  
Justyna Florek ◽  
Romain Caillard ◽  
Freddy Kleitz
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Current Status ◽  
Oral Drug ◽  
Future Perspectives ◽  
Oral Drug Delivery Systems

Mesoporous silica nanocarriers are discussed as potential oral drug delivery systems, focusing on their advantages and limitations, and future perspectives.

scholarly journals Formulation and Characterization of Cefixime Phytosomes for Oral Drug Delivery

1970 ◽  
Vol 7 (5) ◽  
pp. 65-73
Author(s):  
Saloni Jain ◽  
Rahul Ancheriya ◽  
S Srivastva ◽  
Shankar Lal Soni ◽  
Mukesh Sharma
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Memory Loss ◽  
Oral Drug ◽  
Target Tissue ◽  
Drug Bioavailability ◽  
Age Related ◽  
Health Promoting

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Over the last century, phyto-chemical science and phyto-pharmacological science established numerous plant compounds with various biological activities and health promoting benefits such as anti-mutagenicity, anti-carcinogenicity and anti-oxidative activity, for age-related diseases namely memory loss, osteoporosis, diabetic wounds, immune and liver disorders, etc. Herbal medicines have been known since eons for their safety, efficacy, folk acceptability and fewer side effects.  

Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of Poorly Water-Soluble Drugs

2021 ◽  
Vol 18 ◽  
Author(s):  
Yrysbaeva Aidana ◽  
Yibin Wang ◽  
Jie Li ◽  
Shuyue Chang ◽  
Ke Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Water Soluble ◽  
Oral Drug ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Fast Dissolution

Background: Electrospinning is developing rapidly from an earlier laboratory method into an industrial process. The clinical applications are approached in various ways through electrospun medicated nanofibers. The fast-dissolving oral drug delivery system (DDS) among them is one of the most promising routes in the near future for commercial applications. Methods: Related papers are investigated, including the latest research results, on electrospun nanofiber-based fast-dissolution DDSs. Results: Several relative topics have been concluded: 1) the development of electrospinning, ranging from 1-fluid blending to multi-fluid process and potential applications in the formation of medicated nanofibers involving poorly water-soluble drugs; 2) Selection of appropriate polymer matrices and drug carriers for filament formation; 3) Types of poorly water-soluble drugs ideal for fast oral delivery; 4) The methods for evaluating fast-dissolving nanofibers; 5) The mechanisms that promote the fast dissolution of poorly water-soluble drugs by electrospun nanofibers; 6) the important issues for further development of electrospun medicated nanofibers as oral fast-dissolving drug delivery systems. Conclusions & Perspectives: The unique properties of electrospun-medicated nanofibers can be used as oral fast dissolving DDSs of poorly water-soluble drugs. However, some significant issues need to be investigated, such as scalable productions and solid dosage form conversions.

Design of a Soft, Self-Uncoiling Stent for Extended Retention of Drug Delivery in the Small Intestine

2020 ◽  
Author(s):  
Sunandita Sarker ◽  
Ryan Jones ◽  
Gabriel Chow ◽  
Benjamin Terry
Keyword(s):  
Drug Delivery ◽  
Small Intestine ◽  
Oral Drug Delivery ◽  
Ileocecal Valve ◽  
Drug Carriers ◽  
Oral Formulation ◽  
In Vivo Studies ◽  
Oral Drug ◽  
Biological Drugs

Abstract Despite being the preferred route of drug administration, the oral formulation of biological drugs is limited due to its intrinsic instability, low permeability, and physical, chemical and immunological barriers. Various innovative swallowable technologies such as drug-loaded, dissolvable microneedles, mucoadhesive patches, and various microdevices present unique drug-carrying capabilities. The current work presents a novel soft stent platform that can facilitate contact between the small intestine tissue and drug carriers to enhance drug absorption and increase residence time. This study aims to prove the concept of this novel platform and determine if the soft stent will retain orally to the ileocecal valve longer than a capsule-shaped bolus. Benchtop studies on an intestinal simulator showed successful retention of the soft stent compared to a control capsule. In vivo studies in pig models also showed that the soft stent was retained longer than the control capsule. Overall, this study shows promise that this novel platform could be used for oral drug delivery of biologics.

scholarly journals Advances in Oral Drug Delivery

2021 ◽  
Vol 12 ◽  
Author(s):  
Mohammed S. Alqahtani ◽  
Mohsin Kazi ◽  
Mohammad A. Alsenaidy ◽  
Muhammad Z. Ahmad
Keyword(s):  
Drug Delivery ◽  
Drug Administration ◽  
Drug Absorption ◽  
Oral Drug Delivery ◽  
Oral Route ◽  
Oral Drug ◽  
Drug Bioavailability ◽  
Oral Drug Absorption ◽  
Mucosal Permeability ◽  
Novel Drug

The oral route is the most common route for drug administration. It is the most preferred route, due to its advantages, such as non-invasiveness, patient compliance and convenience of drug administration. Various factors govern oral drug absorption including drug solubility, mucosal permeability, and stability in the gastrointestinal tract environment. Attempts to overcome these factors have focused on understanding the physicochemical, biochemical, metabolic and biological barriers which limit the overall drug bioavailability. Different pharmaceutical technologies and drug delivery systems including nanocarriers, micelles, cyclodextrins and lipid-based carriers have been explored to enhance oral drug absorption. To this end, this review will discuss the physiological, and pharmaceutical barriers influencing drug bioavailability for the oral route of administration, as well as the conventional and novel drug delivery strategies. The challenges and development aspects of pediatric formulations will also be addressed.

scholarly journals Nanoparticulate Drug Delivery Strategies to Address Intestinal Cytochrome P450 CYP3A4 Metabolism towards Personalized Medicine

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1261
Author(s):  
Rui Xue Zhang ◽  
Ken Dong ◽  
Zhigao Wang ◽  
Ruimin Miao ◽  
Weijia Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Practice ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Hybrid Nanoparticles ◽  
Oxidative Enzymes ◽  
Oral Drug ◽  
Proximal Jejunum ◽  
Cyp3a4 Activity ◽  
Drug Bioavailability

Drug dosing in clinical practice, which determines optimal efficacy, toxicity or ineffectiveness, is critical to patients’ outcomes. However, many orally administered therapeutic drugs are susceptible to biotransformation by a group of important oxidative enzymes, known as cytochrome P450s (CYPs). In particular, CYP3A4 is a low specificity isoenzyme of the CYPs family, which contributes to the metabolism of approximately 50% of all marketed drugs. Induction or inhibition of CYP3A4 activity results in the varied oral bioavailability and unwanted drug-drug, drug-food, and drug-herb interactions. This review explores the need for addressing intestinal CYP3A4 metabolism and investigates the opportunities to incorporate lipid-based oral drug delivery to enable precise dosing. A variety of lipid- and lipid-polymer hybrid-nanoparticles are highlighted to improve drug bioavailability. These drug carriers are designed to target different intestinal regions, including (1) local saturation or inhibition of CYP3A4 activity at duodenum and proximal jejunum; (2) CYP3A4 bypass via lymphatic absorption; (3) pH-responsive drug release or vitamin-B12 targeted cellular uptake in the distal intestine. Exploitation of lipidic nanosystems not only revives drugs removed from clinical practice due to serious drug-drug interactions, but also provide alternative approaches to reduce pharmacokinetic variability.

scholarly journals A Comprehensive Review On Pelletization Technology: A Novel Strategy For Formulation Development

2021 ◽  
Vol 001 (03) ◽  
Author(s):  
Akshay Parihar ◽  
Bhupendra Prajapati ◽  
Himanshu Paliwal
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Oral Drug ◽  
The Novel ◽  
Formulation Development ◽  
Oral Drug Delivery System ◽  
Bioactive Agents ◽  
Novel Strategy ◽  
Novel Drug

Pelletization technology is gaining very much attention in present times as it has provided a competent pathway for the oral drug delivery system manufacturing. Pellets offers many biopharmaceuticals as well as technological recompenses over the conventional dosage forms. Pellets offer required strength for dose which can be blended for the delivery of incompatible bioactive agents and helps in providing different release profiles. In this review we will be discussing the extensively used techniques of pelletization, extrusion and spheronization in detail with their methods and applications in the field of pharmacy as a competent pathway for the novel drug delivery systems.

scholarly journals Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Mayank Sharma ◽  
Rajesh Sharma ◽  
Dinesh Kumar Jain
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Antihypertensive Drugs ◽  
Aqueous Solubility ◽  
Oral Route ◽  
Water Soluble ◽  
Oral Drug ◽  
Convenient Route ◽  
Poorly Water Soluble ◽  
Novel Drug

Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.

Polymer-Lipid Hybrid Systems: Scope of Intravenous-To-Oral Switch in Cancer Chemotherapy

2020 ◽  
Vol 10 (2) ◽  
pp. 164-177 ◽  
Author(s):  
Md. Rizwanullah ◽  
Javed Ahmad ◽  
Saima Amin ◽  
Awanish Mishra ◽  
Mohammad Ruhal Ain ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Systems ◽  
Patient Compliance ◽  
Cancer Chemotherapy ◽  
Oral Delivery ◽  
Oral Absorption ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Oral Drug ◽  
Oral Switch

Cancer chemotherapeutic administration by oral route has the potential to create “hospitalization free chemotherapy”. Such a therapeutic approach will improve patient compliance and significantly reduce the cost of treatment. In current clinical practice, chemotherapy is primarily carried out by intravenous injection or infusion and leads to various unwanted effects. Despite the presence of oral delivery challenges like poor aqueous solubility, low permeability, drug stability and substrate for multidrug efflux transporter, cancer chemotherapy delivery through oral administration has gained much attention recently due to having more patient compliance compared to the intravenous mode of administration. In order to address the multifaceted oral drug delivery challenges, a hybrid delivery system is conceptualized to merge the benefits of both polymeric and lipid-based drug carriers. Polymer-lipid hybrid systems have presented various significant benefits as an efficient carrier to facilitate oral drug delivery by surmounting the different associated obstacles. This carrier system has been found suitable to overcome the numerous oral absorption hindrances and facilitate the intravenous-to-oral switch in cancer chemotherapy. In this review, we aimed to discuss the different biopharmaceutic challenges in oral delivery of cancer chemotherapy and how this hybrid system may provide solutions to such challenges.

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