scholarly journals REPRODUCTIVE HORMONE LEVELS AND METABOLIC SYNDROME IN WOMEN WITH POLYCYSTIC OVARY SYNDROME IN SANA'A, YEMEN

2021 ◽  
Author(s):  
Libia Sina ◽  
Alariqi Reem ◽  
Wadee Abdullah Al-Shehari ◽  
Wadhah Hassan Edrees ◽  
Raba’a Mohammed Jumaan ◽  
...  
Keyword(s):  
Peer Review ◽  
Polycystic Ovary ◽  
Transvaginal Ultrasound ◽  
Serum Levels ◽  
Reproductive Hormones ◽  
Endocrine Disorders ◽  
Reproductive Hormone ◽  
Age Group ◽  
Childbearing Age ◽  
Group I

Background and Objectives: Polycystic ovary syndromes (PCOs) are the most complex endocrine disorders of the female reproductive system with metabolic and psychiatric manifestations. It affects 5%-10% of women of childbearing age. There are paucity of information on PCOs. Therefore the present study aimed at the effect of reproductive hormones, metabolic syndromes, smoking and khat chewing on the PCOs among women in Sana'a Subjects and Methods: The study included 45 Yemeni women of the age group 18-45 years with PCOS classified into two groups regarding age: Group I 18-29 years old, Group II 30-45 years old and underwent clinical assessment (waist, BMI and sex hormones, blood pressure, glucose, lipids, and insulin), and transvaginal ultrasound. Clinical data, history of other diseases and data of chewing and smoking also collected.” Also the study included 45 healthy control women matched in age with the cases. Results: The prevalence of MS among PCOs patients was 35% and the most prevalent MS risk factors among PCOs patients were waist circumference (WC) 64.4%, and HDL-C 64.4% respectively, while prevalence of triglycerides (TG), hypertension and fasting blood sugar (FBS) were 28.9%, 20% and 13.3%, respectively. PCOs patients had significant increase in serum levels of luteinizing hormone (LH) (p<0.001), Insulin (p<0.001), HOMA-IR (p<0.001), T testosterone (TT) (p<0.001), DHEA-S (p<0.001) and FBS (p<0.016). Lean PCOs patients had a significant increase in TT than overweight/obese PCOs (p < 0.045) and dehydroepiandrosterone sulfate (DHEA-S) was found to be significantly higher in PCOs women with MS (p<0.011). Insulin resistance was significantly higher in PCOs women with hypertension as compared to PCOs women without hypertension (p<0.023). Conclusion: There is a relationship between PCOS and reproductive hormone disorder. Patients had significant increases in serum levels of LH, LH/Follicle Stimulating Hormone (FSH), Insulin, TT, and DHEA-S. Also, a relationship was found between the syndrome and infertility, hirsutism, irregular menstruation, polycystic ovaries and multiple sclerosis.                    Peer Review History: Received: 10 July 2021; Revised: 12 August; Accepted: 6 September, Available online: 15 September 2021 Academic Editor:  Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected] Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, [email protected] Similar Articles: A RETROSPECTIVE STUDY OF THE TREATMENT RESULTS OF 40 DIVERSE PATIENTS OF ANEMIA

ASSOCIATION OF OVARIAN VITAMIN D AND HORMONE RECEPTORS EXPRESSION IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 10 (4) ◽  
pp. 36-42
Author(s):  
S. T. Aigul ◽  
G. A. Demyashkin ◽  
M. R. Orazov ◽  
S. Yu. Kalinchenko ◽  
G. M. Shaimardanova ◽  
...  
Keyword(s):  
Vitamin D ◽  
Hormone Receptors ◽  
Polycystic Ovary ◽  
Married Couples ◽  
Ovarian Cysts ◽  
Control Group ◽  
Endocrine Disorders ◽  
Social Burden ◽  
Metabolism Disorder ◽  
Group I

Infertility is one of the most common diseases of the reproductive system, which carries a significant medical and social burden, affecting from 10 to 15% of married couples, and one of the causes of which is polycystic ovarian syndrome (PCOS), associated with menstrual and endocrine disorders. Changes in the concentration of key enzymes of the metabolic pathway of vitamin D in PCOS may affect the regulation of local tissue homeostasis. Mechanisms of inhibition of cell proliferation under the action of vitamin D have not been fully explored. The aim of the study is to investigate the expression of VDR and hormone receptors in the ovaries of women with PCOS. Material and methods. Patients were divided into main (I) and control groups (II), that included women (n=60) aged 18 to 44 years (mean age - 29.1±3.3 years), who at diagnostic laparoscopy due to infertility of unknown cause. Immunohistochemical (IHC) study of ovarian cysts was performed according to a standard protocol using antibodies to VDR, AR, ERß, PR. The expression of VRD, 1α-OH, 24-OH in samples of ovarian cysts was determined by polymerase chain reaction in real time (PCR-RT). Results. The following IHC expression of the studied markers was observed in the samples of the 1st group cysts of women with PCOS: VDR - 67.7±2.1%; AR - 51.7±1.3%; ERß - 23.1±1.2%; PR - 89.3±2.1%. According to PCR-RT data, the relative VDR expression in group I was 4,31±0,18 arb. u., vs 2,17±0,11 arb. u. in the control group. Conclusions. The key role in PCOS pathogenesis is played by complex metabolism disorder of vitamin D and androgen-estrogen balance as well as decrease of ERß and increase of PR expression level.

Polycystic ovary syndrome

2020 ◽  
pp. 528-535
Author(s):  
Zhongwei Huang ◽  
Eu Leong Yong
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Endometrial Hyperplasia ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Age Group ◽  
Ovary Syndrome ◽  
Reproductive Ageing ◽  
Reproductive Age Group

Polycystic ovary syndrome (PCOS) is an enigmatic condition and its pathophysiology remains to be determined but it is likely to involve the androgen, insulin, and anti-Mullerian hormone pathways. PCOS is diagnosed in women in the reproductive age group based on the Rotterdam criteria. The spectrum of disease involves various phenotypes based on the current diagnostic criteria and this may have reproductive, metabolic, and endocrine consequences. Reproductive issues include that of irregular menstrual cycles and anovulation. Metabolic disorders such as insulin resistance, obesity, dyslipidaemia, and hypertension must be screened for in all women who are diagnosed with PCOS. Long-term risks of metabolic and endocrine disorders in women with PCOS still need further confirmation with more robust data. Reproductive ageing appears to be increased in women with PCOS and they seem to menopause at a later age. Thus far, PCOS appears to be associated with endometrial hyperplasia and cancer.

scholarly journals MON-041 Diagnostic Performance of Ovarian Morphology for Anovulatory Conditions in Lean and Overweight Women

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Heidi Vanden Brink ◽  
Brittany Y Jarrett ◽  
Nigel Pereira ◽  
Steven D Spandorfer ◽  
Kathleen M Hoeger ◽  
...  
Keyword(s):  
Diagnostic Performance ◽  
Polycystic Ovary ◽  
Transvaginal Ultrasound ◽  
Area Under The Curve ◽  
Reproductive Hormones ◽  
Receiver Operating Characteristic Curves ◽  
Health History ◽  
Diagnostic Potential ◽  
Ovarian Morphology ◽  
Ovarian Size

Abstract Introduction: Sonographic evidence of polycystic ovarian morphology (PCOM) is a cardinal feature of polycystic ovary syndrome (PCOS), a condition which reflects a spectrum of phenotypes. The criteria to define PCOM are based on an upper threshold for follicle number and ovarian size in lean, regularly cycling women. Whether ovarian features can be used to distinguish between distinct anovulatory conditions is unclear, as is any impact of body mass index (BMI) on the diagnostic performance of ovarian morphology for anovulatory conditions. Objectives: To determine whether ovarian morphology can discriminate between women with regular cycles, normoandrogenic anovulation (NA-Anov), and hyperandrogenic (HA-Anov) anovulation. Any impact of BMI-specific thresholds to improve the diagnostic performance of ovarian morphology for anovulatory conditions was determined. Methods: Women with HA-Anov (biochemical and/or clinical hyperandrogenism and irregular cycles; N=53), NA-Anov (irregular cycles in the absence of hyperandrogenism; N=42), and normoandrogenic women with regular cycles (Controls, N=41) underwent a reproductive health history, physical exam, transvaginal ultrasound scan of their ovaries and fasting blood tests for reproductive hormones. Follicle number per ovary (FNPO, 2-9mm) and ovarian volume (OV) were determined. The diagnostic performance of sonographic markers for anovulatory conditions was tested using receiver operating characteristic curves. Results: FNPO and OV discriminated between HA-Anov and Controls when all women were considered (area under the curve [AUC]=0.82, sensitivity [Se] 72%, specificity [Sp] 90% and AUC=0.84, Se 77%, Se 81%, respectively). The diagnostic accuracy (AUC = 0.87) and sensitivity (83%) of FNPO improved in lean women (BMI &lt; 25kg/m2), whereas specificity (93%) improved for women with overweight/obesity (BMI &gt; 25kg/m2). By contrast, the diagnostic performance of OV declined when BMI was considered. FNPO discriminated between HA-Anov and NA-Anov in lean women (AUC=0.77) whereas OV discriminated between anovulatory conditions in women with overweight or obesity (AUC=0.76). FNPO, but not OV, differentiated between NA-Anov and controls – albeit thresholds were lower for women in lean (&gt;22 follicles) versus overweight categories (&gt;38 follicles). Conclusion: Ovarian morphology has diagnostic potential for anovulatory conditions – but its performance is impacted by BMI status. OV differentiated between HA and NA status, whereas follicle counts discriminated anovulatory conditions from controls suggesting differential roles for FNPO and OV in reproductive dysfunction. Consideration of BMI improved diagnostic performance in some cases, however the overlap in morphological features between NA- and HA-Anov is too extensive to propose condition-specific thresholds at this time.

Disposition of Chloramphenicol in Low Birth Weight Infants

PEDIATRICS ◽  
1980 ◽  
Vol 66 (4) ◽  
pp. 573-578
Author(s):  
John P. Glazer ◽  
Michele A. Danish ◽  
Stanley A. Plotkin ◽  
Sumner J. Yaffe
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Drug Disposition ◽  
Serum Levels ◽  
Age Group ◽  
Low Birth Weight Infants ◽  
Dosage Regimens ◽  
Group I ◽  
First Choice ◽  
Group Ii

Although infrequently an antibiotic of first choice for neonates, chloramphenicol (CL) may be indicated in selected instances of infection caused by aminoglycoside-resistant enterobacteriaciae, anaerobes, and ampicillin-resistant Haemophilus influenzae. Use of CL in neonates has been limited since the recognition that vascular collapse may occur as a consequence of dosage regimens tolerated by adults. With an assay that detects only active CL, we studied drug disposition in 13 low birth weight infants, eight between 1 and 8 days of age (group I), and five between 11 days and 8 weeks of age (group II). Peak serum CL concentrations ranged from 11.2 to 36.2 µg/ml in group I and from 10.0 to 36.2 µg/ml in group II, at doses ranging from 15 to 50 mg/kg/day, and 25 to 50 mg/kg/day, in groups I and II, respectively. Serum CL half-lives (T½) ranged from 10 to 36 hours in four of the eight group I patients; three of the remaining patients had T½ greater than 48 hours and the fourth patient accumulated CL in the interval between doses. T½ in group II ranged from 5.5 to 15.7 hours. Observed differences in T½ between groups I and II were statistically significant (P = .05) and could not be accounted for by factors other than postnatal age. These preliminary data suggest that although there appears to be an inverse relationship between CL T½ and postnatal age, there is sufficient variability in serum levels that monitoring must be performed in low birth weight infants treated with this drug.

scholarly journals Clinical Significance of Inflammatory Markers in Polycystic Ovary Syndrome: Their Relationship to Insulin Resistance and Body Mass Index

2009 ◽  
Vol 26 (4) ◽  
pp. 163-170 ◽  
Author(s):  
Nervana Samy ◽  
Maha Hashim ◽  
Magda Sayed ◽  
Mohamed Said
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Homa Index ◽  
Risk Markers ◽  
Ovary Syndrome ◽  
Group I ◽  
Hs Crp

Background: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance (IR) and related disorders. Elevated serum levels of high sensitivity CRP (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factorα(TNF-α) reflect low-grade chronic inflammation and have been associated with several insulin-resistant states; they are useful cardiovascular risk markers. The objective of this study was to investigate whether soluble inflammatory markers are altered in PCOS focusing on its relationship with obesity and indexes of insulin resistance.Patients and methods: One hundred and eight women with PCOS and 75 healthy women were recruited. Patients were divided according to body mass index (BMI) into two groups; group I (BMI < 27 kg/m2) and group II (BMI ≥ 27 Kg/m2). Serum levels of hs-CRP, IL-6, and TNF-α, lipid and hormone profiles were measured.Results: PCOS patients had increased levels of testosterone, luteinizing hormone (LH), androstendione, insulin level and HOMA index compared to healthy BMI matched controls. High-density lipoprotein (HDL) concentrations were significantly reduced in both patient groups compared to their controls, while triglyceride levels were significantly increased in obese group compared to controls. There were no significant difference in serum inflammatory markers hs-CRP, IL-6 and TNF-αbetween group I and their matched controls. On the other hand, there were significant increase in these markers between group II and their matched controls. There were highly significant positive correlation between hs-CRP and IL-6 (r= 0.702,P< 0.001) and between hs-CRP and TNF-α(r= 0.621,P<0.001), also between IL-6 and TNF-α(r= 0.543,P< 0.001). These inflammatory markers correlated significantly with BMI and HOMA index. Multiple regression analysis revealed that BMI and HOMA were predictors of IL-6 levels (b= 11.173,P< 0.001,b= 13.564,P< 0.001 respectively) and BMI was the only predictor of hs-CRP levels (b= 12.578,P< 0.001) and TNF-αlevels (b= 0.134,P< 0.001).Conclusion: PCOS and obesity induce an increase in serum inflammatory cardiovascular risk markers. The precise mechanisms underlying these associations require additional studies to clarify the state of the cardiovascular system in women with PCOS compared with controls in large numbers of patients to determine the relative contribution of different factors including insulin resistance, androgen status and BMI.

Characterization of a prospective human model for study of the reproductive hormone responses to major illness

2008 ◽  
Vol 295 (1) ◽  
pp. E63-E69 ◽  
Author(s):  
Daniel I. Spratt ◽  
Robert S. Kramer ◽  
Jeremy R. Morton ◽  
F. Lee Lucas ◽  
Karen Becker ◽  
...  
Keyword(s):  
Animal Studies ◽  
Time Course ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Reproductive Hormones ◽  
Human Model ◽  
Reproductive Hormone ◽  
Cabg Surgery

With critical illness, serum testosterone levels fall markedly, whereas estrogen levels rise. Although animal studies suggest adaptive advantages, no prospective model has been available for studies in humans. We hypothesized that coronary artery bypass graft (CABG) surgery would provide such a model by eliciting the same reproductive hormone and other endocrine responses as reported with major nonsurgical illnesses. We further hypothesized that those responses would occur consistently in all CABG patients with predictable time courses, providing reliable windows for prospective studies. In 17 men undergoing CABG, serum levels of reproductive hormones, cortisol, thyroid hormones, and IGF-I were measured before and for up to 5 wk after surgery. Changes in serum levels of reproductive and other hormones were similar to those reported in nonsurgical critically ill patients. Time course for onset, duration, and recovery of reproductive hormone changes were consistent among all patients. A window for studying the testosterone and estrogen responses was established as the first 5 days following CABG. Practical use of this model was demonstrated by evaluating, in another seven men, changes in gonadotroph responsiveness to GnRH following CABG. Finally, to determine whether our findings in CABG could be extended to other surgeries, we demonstrated similar endocrine responses in 12 men following abdominal aortic aneurysm resection. We conclude that patients undergoing CABG surgery provide a useful human model for the prospective evaluation of the reproductive axis responses to acute illness. Other major surgeries are likely to also be suitable for these studies.

scholarly journals Effect of Cinnamaldehyde on Female Reproductive Hormones in 7, 12 Dimethyl Benzanthracene Induced Ovarian Cancer Rats

2021 ◽  
Vol 9 (11) ◽  
pp. 346-350
Author(s):  
Madhuri Boggiti
Keyword(s):  
Ovarian Cancer ◽  
Biological Activities ◽  
Serum Levels ◽  
Treated Group ◽  
Current Treatment ◽  
Reproductive Hormones ◽  
Group Vi ◽  
Group V ◽  
Group Iii ◽  
Group I

Abstract: Ovarian cancer is the deadliest type of cancer in women. It is often presented at an advanced stage and has a poor prognosis. The current treatment methods for this tumor are not safe and have serious side effects. It has been suggested that the use of steroids for hormonal purposes is linked to the development of ovarian cancer. The current study aims to investigate the effects of cinnamaldehyde on these hormones. The objective of this study was to investigate the effects of cinnamaldehyde on the reproductive hormones of rats after being induced to develop ovarian cancer. Cinnamaldehyde is an active compound that has been used in Asia for over 4000 years. Cinnamaldehyde has different biological activities including antimicrobial, antiinflammatory, antiviral, antioxidant, antitumor were reported by many investigators. In the present study, animals were randomly allocated into VI groups: Group -I served as a control with normal water and group-II was drug control (50 mg/kg b. w) rats received only cinnamaldehyde orally for 36 weeks. The rats in group III were given a single dose of 7,12 Dimethyl benzanthracene (100 µg/rat) dissolved in 10 µL of sesame oil to surgically exposed left ovary and maintained up to 36 weeks to initiate ovarian carcinogenesis. Group IV rats received DMBA + cinnamaldehyde 50 mg/kg b. w (before starting the experiment and continued up to 24 weeks). Group V rats received DMBA + cinnamaldehyde 50 mg/kg b. w (25-36 weeks). Group VI rats received DMBA + cinnamaldehyde 50 mg/kg b. w (1-36 weeks). Serum levels of Estrogen, progesterone, LH, FSH were estimated using ELISA. The results showed that significant increase in serum level of Estrogen, LH, FSH, and decreased progesterone in only DMBA treated group when compared with control groups. Also, there was a significant decrease in serum levels of Estrogen, LH, FSH, and increased progesterone in cinnamaldehyde treated groups (dose-dependent) when compared to only DMBA treated group. The results of the present study suggested that cinnamaldehyde has anticancer activity and further investigations are needed for evaluating the anticancer potential and mechanism of its action. Keywords: Cinnamaldehyde, DMBA, Ovarian cancer, Reproductive hormones.

scholarly journals Assessment of Leptin and Prolactin in Women with Polycystic Ovarian Syndrome

2019 ◽  
pp. 1-7
Author(s):  
Roshni G. Sadaria ◽  
B. V. Ravi
Keyword(s):  
Polycystic Ovary ◽  
Serum Levels ◽  
Prolactin Secretion ◽  
Reproductive Age ◽  
Endocrine Disorders ◽  
Medical Sciences ◽  
Direct Role ◽  
Serum Leptin ◽  
Healthy Women ◽  
Positive Correlations

Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women at reproductive age and is characterized by infertility, hirsutism, obesity, insulin resistance, and menstrual irregularities. Leptin, an adipocyte derived hormone, serves as a link relaying metabolic signals to the neuronal networks in the brain to modulate hypothalamo-pituitary- ovarian axis. Circulating leptin correlates strongly with obesity, which is frequently associated with PCOS. PCOS is associated with hyperandrogenemia and relatively high estrogen levels, which could stimulate prolactin secretion. Aims: 1. To assess serum leptin and prolactin in women with PCOS and to compare them with healthy women as controls. 2. To correlate the leptin, prolactin and body mass index (BMI) among a group of PCOS women and healthy women as controls. Methodology: The study was conducted at Kempegowda Institute of Medical Sciences & Hospital, Bangalore. A comparative study was conducted which includes 30 women who has diagnosed with PCOS and 30 healthy women with as controls. The age group for the study was 18 to 35 years. Fasting blood samples were drawn to measure serum leptin and prolactin. BMI was also calculated. Interpretation of data was done using SPSS version 13. Results: Significant positive correlations between leptin levels and BMI in cases and controls (ρ= 0.683, p < 0.001; ρ= 0.485, p = 0.007 respectively) were observed. Mean BMI, leptin and prolactin were found elevated in the PCOS women compared to controls but they were not statistically significant. No significant correlation was found between leptin and prolactin. Conclusion: Leptin levels were correlated with BMI both in PCOS women and in the healthy controls. Leptin may not have a direct role in the pathogenesis of PCOS, as the serum levels were not significantly higher in PCOS women and did not correlate with prolactin.

scholarly journals Smoking as a risk factor for the development of polycystic ovary syndrome

2019 ◽  
Vol 87 (3) ◽  
pp. 56-61
Author(s):  
S.V. Gunkov ◽  
S.I. Reheda
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inductively Coupled Plasma ◽  
Polycystic Ovary ◽  
Statistical Significance ◽  
Statistical Processing ◽  
Serum Levels ◽  
Control Group ◽  
Ovary Syndrome ◽  
Inductively Coupled ◽  
Group I

ABSTRACT. Objective. To study the prevalence of smoking among women with polycystic ovary syndrome (PCOS), as well as to establish the relationship between intensity, duration of smoking and serum levels of manganese and nickel. Materials and methods. A questionnaire survey was performed in two groups of women: the control group (I) included 38 healthy women, and the second group included 52 women with PCOS. In both groups, serum levels of manganese and were determined using inductively coupled plasma mass spectrometry. Statistical processing of the results of the survey was conducted using Statistika 8 software program. The U-Mann-Whitney test was used to assess the statistical significance of the obtained results. Comparison of the prevalence of smoking in both groups was performed using the parameter of statistical significance of differences for two relative values. Spearman coefficient was used for correlation analysis. Results. In women with PCOS, significantly higher manganese (p = 0.0012) and nickel (p = 0.0000) serum levels were found. In group I, 3 women reported smoking, in group II — 13 women. Among women with PCOS, the prevalence of smoking was significantly higher (p = 0.0000). Both groups differ neither in duration (p = 0.9463) nor in intensity of smoking (p = 0.7366). Duration and intensity of smoking were not associated with serum manganese. The intensity of smoking also did not affect serum levels of nickel. A positive correlation was found between serum nickel and the duration of smoking. Authors believe that during smoking manganese directly penetrates cerebral structures via olfactory rout. Only its small portion penetrates the bloodstream. This explains the high toxicity of manganese. Conclusion. Among women with PCOS smoking is much more common, however, the intensity and duration of smoking do not differ from the control group. Serum manganese levels are associated neither with duration nor with the intensity of smoking. Serum nickel levels are affected by the duration of smoking, rather than by the intensity of smoking. Keywords: polycystic ovary syndrome, intensity of smoking, duration of smoking, manganese, nickel.

scholarly journals Infants of Hypothyroid Mothers at Risk of Developing Hypothyroidism: A Cross-sectional Study in Qassim Region of Saudi Arabia

2021 ◽  
Vol 9 (B) ◽  
pp. 1398-1404
Author(s):  
Mariam S. Alharbi
Keyword(s):  
Saudi Arabia ◽  
Cross Sectional Study ◽  
Endocrine Disorders ◽  
Age Group ◽  
Women Of Childbearing Age ◽  
Sectional Study ◽  
Childbearing Age ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Comprehensive Survey

Introduction Hypothyroidism is one of the most prevalent endocrine disorders in women of childbearing age. If it goes untreated, can seriously affect maternal and fetal outcomes.Aim This study aimed to assess the prevalence of hypothyroidism in infants born to hypothyroid mothers and to analyze associated fetal complications.Subjects and methods This is a quantitative cross-sectional study conducted among pregnant mothers at Al Qassim region, Saudi Arabia. Data of pregnant women with clinical hypothyroidism during the last five years 2015-2019 were obtained from visiting records of Endocrine Clinic in Qassim University. These participants were contacted and written informed consents were obtained from the participants after a brief introduction of the study. A comprehensive survey questionnaire was used to collect information about demographic and study variables. Results 153 mothers were enrolled. The most common age group was 31 – 45 years with mostly Saudis (93.5%). Complications during pregnancy were detected among 47.1% of mothers. The most common complication during pregnancy was C-section (26.8%). The prevalence of infants with hypothyroidism was 2.6% while the prevalence of newborn babies with temporary/permanent hypothyroidism was 4.6%. Decreased activity (7.8%) and an increased in weight (5.2%) were the most common symptoms of a child at the time of diagnosis.Conclusion Infants with hypothyroidism were not widely prevalent in this study. Cesarean delivery, gestational diabetes and anemia were some of the most common maternal complications during pregnancy.Keywords  

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