scholarly journals Comprehensive analysis of the laboratory examination results of patients with an established bronchial asthma diagnosis

2021 ◽  
Vol 25 (3) ◽  
pp. 209-218
Author(s):  
Elena R. Abdrakhmanova ◽  
Natalya V. Vlasova ◽  
Lyaylya M. Masyagutova ◽  
Liliya G. Gizatullina ◽  
Linara A. Rafikova ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Hematological Parameters ◽  
Comprehensive Analysis ◽  
The Body ◽  
Laboratory Research ◽  
Laboratory Examination ◽  
Production Sector ◽  
Industrial Sectors ◽  
Staphylococcus Spp

Relevance. Bronchial asthma is a serious medical and social problem. To confirm the diagnosis, it is necessary to assess the allergic status, to determine the biological markers of the disease. Of particular relevance is a comprehensive analysis of the results of laboratory examination of patients, including data from hematological, immunological, microbiological studies. Aim. To study some laboratory parameters (hematological, immunological and microbiological), the changes of which are most typical for patients with an established diagnosis of bronchial asthma. Matherials and Methods . A clinical and diagnostic examination of women in the non-production and industrial sectors with an established diagnosis of bronchial asthma, performed during a periodic medical examination, was carried out. Results and Discussion . Laboratory research has shown that hematological parameters are characterized by a reduced content of hemoglobin, erythrocyte indices MCV, MCH, MCHS - markers of hypochromia. The surveyed women had increased indices: eosinophils, immunoglobulin E, allergy index, leukocyte intoxication index. High rates of allergization are found in the production sector in 41,51%, in the non-production sector - in 44,44%, which indicates a serious sensitization of the body. Bacterial contamination in the examined groups is represented by coccal flora, where the most significant microorganisms are Staphylococcus aureus, Staphylococcus spp, Streptococcus pyogenes and Candida albicans. Conclusion . The results of the analysis indicate the need to conduct and study further research on the development of markers of early, prenosological health disorders in the process of screening examination of large groups of the working population.

The Need to Develop New Antimicrobial Molecules, as Revealed by in vitro Assessment of Drug Resistance in Staphylococcal Skin Infections Treated with Autologous Bacterial Vaccine

2020 ◽  
Vol 71 (8) ◽  
pp. 292-303
Author(s):  
Madalina Preda ◽  
Alina-Alexandra Serbanescu ◽  
Mara Madalina Mihai ◽  
Gabriela-Loredana Popa ◽  
Loredana Cornelia Sabina Manolescu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Resistance ◽  
Soft Tissues ◽  
The Body ◽  
Laboratory Research ◽  
Soft Tissue Infections ◽  
Resistance Profile ◽  
Bacterial Vaccine ◽  
Staphylococcus Spp

Staphylococcus spp. is a facultative pathogen, which can be found in the commensal microbiota of humans, most often in moist skinfolds and mucous membranes. This microorganism has the ability to cause various infections, in almost every organ of the body, with an increased frequency in the skin and soft tissues, being involved in pathologies like acne, folliculitis, furunculosis, hidradenitis suppurativa, cellulitis, abscesses, but also in secondary infections in diseases with an altered cutaneous barrier. The prolonged evolution of these diseases and severe outcome can be influenced by various factors, most importantly being the antimicrobial resistance. We have evaluated the antimicrobial susceptibility profiles, according to the Comite de l` Antibiogramme de la Societe Francaise de Microbiologie recommendations, for strains of Staphylococcus spp. isolated from acne or different types of skin and soft tissue infections in patients recommended to receive autologous bacterial vaccine. Most frequent identified species was Staphylococcus epidermidis, followed by Staphylococcus aureus. The antimicrobial resistance was higher for antibiotics usually used in the treatment of skin and soft tissue infections, with interesting differences of the resistance profile for the strains isolated from patients before receiving autologous bacterial vaccine compared with the ones from individuals already treated. Another important finding was represented by the differences in the resistance profile according to the age group of the patients. The results of this study underline the importance of antimicrobial resistance surveillance in finding new molecules and alternative therapies, the necessity of a personalized approach in medical acts and of a continuous connection between clinic and laboratory research.

Erythrocyte and reticulocyte parameters during biological monitoring of lead exposure to the body

2020 ◽  
Vol 60 (11) ◽  
pp. 873-876
Author(s):  
Anastasiya G. Khotuleva ◽  
Mariya S. Kozyreva
Keyword(s):  
Biological Monitoring ◽  
Hematological Parameters ◽  
Lead Level ◽  
Statistical Processing ◽  
Absorption Spectrometry ◽  
The Body ◽  
Control Group ◽  
Processing Plant ◽  
Hematological Disorders ◽  
Globin Synthesis

Introduction. The most susceptible to lead is the hematopoietic system of hematopoietic organs due to lead inhibition of heme and globin synthesis and cytotoxic effect on the membrane of Mature red blood cells. The aim of study was to evaluate the informative value of the study of erythrocyte and reticulocyte parameters determined on modern hematological analyzers in patients working in contact with lead during medical and biological monitoring. Materials and methods. 45 employees of the lead battery processing plant and 30 persons of control group were examined. The level of lead in the blood was determined by atomic absorption spectrometry, δ-ALA in the urine-by the reaction of pyrol formation with acetylacetone in terms of gram of creatinine, the study of hematological parameters was performed on a Sysmex HT-2000i analyzer. Statistical processing of the results was performed using the program STATISTICA 10.0. Results. Significant changes in erythrocytic (RDW) and reticulocytic (RET, IRF, LFR, MFR, HFR, RET-He) parameters, erythropoietin in workers in contact with lead compared to the control group, changes in MCV, MCH, RDW, RET indicators in the group working in dynamics after 2 years were revealed. Associations of hematological parameters with biomarkers of exposure and effect (lead level in blood and ALA in urine) were revealed. Conclusions. Assessment of erythrocyte (MCV, MCH, RDW) and reticulocyte parameters (RET% and their distribution by maturity) in dynamics during periodic medical examinations of workers in contact with lead allows us to detect the development of hematological disorders at early stages.

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

A Descriptive Study on Serum IgE and Absolute Eosinophil Count in Children with Bronchial Asthma Attending the Paediatric Department of a Medical College in Central Kerala

2021 ◽  
Vol 8 (33) ◽  
pp. 3097-3103
Author(s):  
Sajna Gamaly Leela ◽  
Menon Narayanankutty Sunilkumar ◽  
Ramaraj Subbiah
Keyword(s):  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Immunoglobulin E ◽  
Asthma Severity ◽  
Health Concern ◽  
Age Group ◽  
Total Ige ◽  
Serum Ige ◽  
Absolute Eosinophil Count ◽  
Paediatric Department

BACKGROUND Bronchial asthma is a major public health concern especially in the paediatric population. An elevated immunoglobulin E (IgE) level is considered as an objective marker of allergy. Because IgE is a mediator of allergic response, quantitative measurement of IgE together with other clinical markers, can provide useful information for the differentiation between atopic and non-atopic diseases. In this study, we wanted to determine serum IgE and absolute eosinophil count (AEC) levels and correlate both levels with severity of asthma in children in the age group of 2 - 15 years admitted in the paediatric department. METHODS This is a descriptive cross-sectional study. After taking the informed consent from the parent or guardian, relevant information on asthmatic symptoms and severity, other associated manifestations, precipitating factors, and family history of asthma were recorded in a pre-designed proforma. A total of 65 children (age group 2 – 15 years old) with bronchial asthma were studied. Investigations such as hemogram and serum IgE levels were determined. Asthma severity was assessed according to global initiative for asthma (GINA) guidelines. RESULTS Among 65 children, 69.2 % were boys. Receiver operating characteristic curve (ROC) analysis showed that total IgE cut-off concentration of 168 IU/ml, distinguishes children with intermittent asthma from those with mild persistent disease. IgE cut-off concentration of 989 IU/ml distinguishes mild persistent from those with moderate persistent asthma. Both showed adequate or good diagnostic efficacy. Cut off value of 168 IU/ml may prove useful in practice, indicating that 75 % of children in intermittent group will have serum concentration of total IgE < 168 IU/ml. No association was observed between AEC and increasing severity of asthma. Only atopic dermatitis with asthma showed increasing trend of IgE levels. CONCLUSIONS Asthmatic children with higher asthma severity have a higher serum total IgE concentration (168 IU/ml and 989 IU/ml are the cut off values for differentiating intermittent from mild persistent and mild persistent from moderate persistent). KEYWORDS Serum IgE, Absolute Eosinophil Count, Childhood Asthma, Asthma Severity

DOSE-DEPENDENT CHARACTER OF DISTURBANCE OF HEMATOPOIETIC AND IMMUNE SYSTEMS FUNCTION, PRODUCTION OF SOME HORMONES IN EXPERIMENTAL URANIUM ACETATE DIHYDRATE EXPOSURE

2021 ◽  
Vol 1 (1) ◽  
pp. 14-19
Author(s):  
Е. G. Trapeznikova ◽  
V. В. Popov ◽  
A. S. Radilov ◽  
V. V. Shilov
Keyword(s):  
Hematological Parameters ◽  
Chronic Administration ◽  
Absolute Number ◽  
Uranyl Acetate ◽  
The Body ◽  
Acetate Dihydrate ◽  
Functional Changes ◽  
Cd8 Cells ◽  
Tnf Α ◽  
Dose Dependent

The paper presents the results of an experimental study of the dose-dependent nature of functional changes in the body systems under chronic administration of uranyl acetate dihydrate in doses of 0.5 and 5.0 mg/kg per element for 18 weeks. The study was performed on 45 male outbred rats. It has been shown that uranyl acetate dihydrate in a dose of 0.5 mg/kg had no significant effect on hematological parameters. At the same time, activation of bactericidal activity of neutrophils, a decrease in the immunoregulatory index, and an increase in the blood concentration of tumor necrosis factor (TNF-α) have been revealed. The toxicant administered to rats in a dose of 5 mg/kg led to a decrease in the absolute number of erythrocytes, hemoglobin, hematocrit, platelets, the release of myelocytes into the blood, basophilia, monocytosis, the appearance of leukolysis cells and plasmatization of lymphocytes. On the part of the immune system, an increase in the biocidal capacity of neutrophilic granulocytes, TNF-α production, an increase in the number of CD8+ cells, and a reduction in the CD4+/CD8+ ratio have been found. Uranyl acetate dihydrate had a dose-dependent effect only on the number of cytotoxic T-lymphocytes, T-cells with the CD4+CD8+ phenotype, on the immunoregulatory index, and on the level of TNF-α. Hyperglycemia and glucosuria were also dose-dependent. An increase in glucose in the blood and urine indicated a violation of carbohydrate metabolism and kidney function. There was a decrease in the concentration of thyroxine, testosterone and an increase in the level of insulin. Uranyl acetate dihydrate led to the development of insulin resistance. The level of hormones did not depend on the dose of the toxicant administered to the animals.

IMMUNOGLOBULIN E IN BRONCHIAL ASTHMA

Allergy ◽  
1974 ◽  
Vol 29 (5) ◽  
pp. 327-336 ◽  
Author(s):  
B. Elgefors ◽  
A. Julin ◽  
S. G. O. Johansson
Keyword(s):  
Bronchial Asthma ◽  
Immunoglobulin E

scholarly journals GLUCOSE HOMEOSTATIC AND PANCREAS PROTECTIVE POTENTIAL OF TECOMELLA UNDULATA ROOT EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC RATS .

2017 ◽  
Vol 10 (6) ◽  
pp. 292
Author(s):  
Kanwar Lal ◽  
Ashok Purohit ◽  
Heera Ram
Keyword(s):  
Hematological Parameters ◽  
Ethanolic Extract ◽  
Serum Biochemistry ◽  
Diabetic Rats ◽  
The Body ◽  
Root Extract ◽  
Standard Drug ◽  
Protective Potential ◽  
Normal Ranges ◽  
Tecomella Undulata

Objective: The study was aimed to evaluate glucose homeostatic and pancreas protective potential of Tecomella undulata root extract in streptozotocin induced diabetic rats.Methods: The ethanolic root extract was prepared by following standard soxhlation methods. The experimental design was divided in to control and treated groups for 28 days of comparative experimental schedule. The body and organ weights, serum biochemistry, histo-pathology, hematology and toxicity profiles were assayed by following standard methods and protocols.Results: The treatment of ethanolic extract of root of T. undulata was significantly (p ≤ 0.001) reduced glucose levels at 7day, 14day, 21day and 28 days in comparison to standard drug of metformin. Correspondingly, lipid profile i.e. total cholesterol, HDL, VLDL, LDL and triglyceride were also altered significantly. Whereas, body and organs weight and hematological parameters were not shown significant changes. Subsequently, toxicity profile i.e. hepatic and renal parameters were remained under normal ranges. Corresponding, the treatment of ethanolic root extract caused normalcy of histoarchitecture of pancreas in comparison to standard drugs.Conclusion: The results of study illustrated that Tecomella undulata root extract possessing particular kind of phytocompounds which caused glucose homeostatic and pancreas protective potential in diabetic rats.

scholarly journals Iron status parameters in preeclamptic women in Gaza, Palestine

2020 ◽  
Vol 28 (1) ◽  
Keyword(s):  
Gestational Age ◽  
Serum Iron ◽  
Biochemical Analysis ◽  
Iron Status ◽  
Gaza Strip ◽  
Hematological Parameters ◽  
Case Control ◽  
The Body ◽  
The Other ◽  
Iron Supplements

Preeclampsia (PE) is a turmoil in the pregnancy appeared with the onset of hypertension and considerable amount of proteinuria. Extra serum iron is a causative component of oxidative stress concerned in the pathogenesis of preeclampsia. This study is a case control, conducted in 2018, and aimed to determine the iron status in preeclamptics as compared to normotensive pregnancies in Gaza strip. About 100 pregnant women with gestational age between 26 to 36 weeks. Fifty of them were preeclamptics and an equal number were without preeclampsia, aged between 18 to 35 years. Interview questionnaires were used to take sociodemographic and clinical data. Anthropometric evaluation and biochemical analysis were conducted. The SPSS version22 was used for data analysis. There was no statistically difference in the gestational age, gestational number and hemoglobin levels in the cases and controls (p≥ 0.05). In contrast, the body mass index (BMI), systolic, diastolic blood pressure (BP), and uric acid (UA) levels were significantly higher in preeclamptics (P<0.001). As well, the majority of cases were have +2 proteinuria on dipstick testing. Further, serum iron and ferritin levels were significantly higher in preeclamptics. On the other hand, ferritin levels had significant direct correlations with gestational number, previous preeclampsia, BMI, systolic BP, diastolic BP, UA, and proteinuria (P<0.05). Likewise, Iron had significant direct correlation with proteinuria (P<0.05). Preeclamptics have higher hematological parameters levels (iron & ferritin) as compared to normotensive women. However, Iron status of preeclamptic women should be assessed before giving iron supplements as these may cause more harm than benefit.

scholarly journals The Effects of Different Exercise Types on Hematological Parameters in Sedentary Women

2018 ◽  
Vol 6 (8) ◽  
pp. 96 ◽  
Author(s):  
Güner Çiçek
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Blood Cell ◽  
Aerobic Exercise ◽  
Hematological Parameters ◽  
Exercise Group ◽  
The Body ◽  
Strength Exercise ◽  
Strength Exercises ◽  
Sedentary Women

The purpose of this study is to investigate the effect of aerobic and strength exercises on hematological parameters in sedentary women. To achieve the purpose of this study, a total of 23 volunteers including aerobic exercise group (AE, n: 10), strength exercise group (SE, n:13) were selected as participants. Two different exercises were applied for 4 days a week, throughout 16 weeks, within 60 minutes for each exercise with the intensity of heart rate (HR) 60-70 percent. The HR was measured using a heart rate monitor for each subject.The women's white blood cell (WBC), thrombocyte (PLT), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT) and mean corpuscular volume (MCV) were measured before and after exercise. For statistical analysis, the Wilcoxon signed-rank test was used for intra-group evaluations, and the Mann Whitney U test was used for inter-group evaluations. After the exercise program, there were a meaningful decrease in the body weight and body mass index (BMI) the women in both intervention groups. In addition, in the hematological results of strength exercise group, some meaningful decreases were determined in the values of RBC, HGB, HCT and MCV (p<0.01). As a results, it was observed that regular aerobic and strength exercises can positively influence the body weight and BMI parameters of sedentary women. Along with this, a meaningful decrease has been found in the values of RBC, HGB, HCT and MCV of strength exercise group compared to aerobic exercise.

scholarly journals The Effect of Exercise on the Total Leukocyte, Absolute Neutrophil, Lymphocyte and Platelet Counts among Sudanese Football Players

2021 ◽  
Vol 11 (6-S) ◽  
pp. 26-32
Author(s):  
Nihad Elsadig Babiker ◽  
Raheeg Mubark Anwer
Keyword(s):  
Physiological Stress ◽  
Hematological Parameters ◽  
Venous Blood ◽  
Age Groups ◽  
The Body ◽  
Case Group ◽  
Football Players ◽  
Platelet Counts ◽  
Significant Difference ◽  
Age Variation

Background: Aerobic exercise induces physiological stress on the body and brings changes in hematological parameters. This study aimed to determine the effect of playing football as an exercise on the total white blood cell count, absolute Neutrophil, lymphocyte and Platelet counts among Sudanese football players. Material and method:  This was a descriptive case control study, done on a number of football players in Khartoum state, Sudan and conducted within the period from August 2021 to October 2021. Three ml of venous blood samples had been collected from every participant in the study, parameters had been measured and calculated using blood cells counter (Sysmex KX-21N).                                                           Results: When compared the TWBCs, Absolute Neutrophil, Lymphocytes and platelet counts between cases and control there was a significant differences with (P ≤0.05). Also there was a significant difference in the case group before and after one hour of exercise with (P =0.00), and in significant differences between different age groups with (P ≥0.05). Conclusion: Playing football for 1 hour cause a significant increase in the TWBCs, absolute Neutrophils, absolute Lymphocytes and Platelets counts. Age variation has no effect on the measured parameters Keywords: Football, TWBCs, Neutrophils, Lymphocytes and Platelets.

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