scholarly journals Clinical observation of low-dose combination chemotherapy in refractory/recurrent paroxysmal nocturnal hemoglobinuria patients: a single-centre retrospective analysis

2021 ◽  
Author(s):  
Liyan Li ◽  
Hui Liu ◽  
Honglei Wang ◽  
Zhaoyun Liu ◽  
Yingying Chen ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Retrospective Analysis ◽  
Low Dose ◽  
Clinical Observation ◽  
Clinical Manifestations ◽  
Chemotherapy Treatment ◽  
Transfusion Independence ◽  
Dose Combination ◽  
Laboratory Examinations ◽  
And Control

Objective We performed a retrospective analysis to investigate the clinical characteristics and therapeutic strategies of 20 refractory/recurrent PNH patients, including the clinical efficacy of chemotherapy treatment and survival. Main Measures The clinical data of 20 classic PNH patients that were refractory/recurrent or had glucocorticoid dependence in our hospital were analyzed, including clinical manifestations, laboratory examinations, treatment efficacy and survival. Key Results Seventeen patients had a marked improvement in anemia after chemotherapy, 14 patients acquired blood transfusion independence, and the Hb of 3 patients increased to normal levels. Although 6 patients still needed blood transfusion, the transfusion interval was significantly prolonged. The percentages of LDH, TBIL and RET, which are indicators of hemolysis, were significantly lower than those before chemotherapy. The dosage of adrenal glucocorticoids was reduced by more than half compared with that before chemotherapy. Conclusions Chemotherapy can reduce PNH clones, promote normal hematopoiesis, and control hemolytic attack. It is a promising and widely used therapeutic method.

scholarly journals Preliminary Efficacy of Tocilizumab Treatment in The Patients With COVID-19.

2021 ◽  
Author(s):  
Yu Chen ◽  
Xijing Zhang
Keyword(s):  
White Cell Count ◽  
Clinical Manifestations ◽  
Treated Group ◽  
Control Group ◽  
Duration Of Symptoms ◽  
Reactive Protein ◽  
Respiratory Parameters ◽  
Clinical Trail ◽  
Laboratory Examinations ◽  
And Control

Abstract Background: Interleukin-6 (IL-6) was considered to be with the severity and mortality in COVID-19 patients, which implies a potential therapeutic target for treatment. We aimed to evaluate the safety and initial efficacy of Tocilizumab treatment for COVID-19 patients.Methods: In the retrospective study, sixty-one patients with COVID-19 with the mean age of 69 were enrolled from Feb 27 to Mar 14, 2020 in Wuhan Huoshenshan Hospital. Twenty-nine of them received one dose (400 mg) of add-on Tocilizumab treatment as the treated group and remaining 32 cases served as control group. The clinical manifestations and laboratory examinations were compared between the two groups.Results: The average duration of symptoms to admission was 28.2 days. Compared with the cases in control group, the treated cases exhibited a significant increase of serum IL-6 on the seventh day since Tocilizumab injection, however, there were no differences in whole blood white cell count, circulating lymphocyte count, serum C-reactive protein, and respiratory parameters or other clinical manifestations between the treated and control groups. There were no adverse events associated with Tocilizumab treatment in the treated COVID-19 patients.Conclusions: In the elder moderate and severe patients with COVID-19, one dose of Tocilizumab treatment was safe but no clinical benefit was observed on the seventh day in this study.Trial registration: Chinese Clinical Trail Registry, ChiCTR2000033705. Registered June 10, 2020 - Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=54989.

Arsenene Nanodots with Selective Killing Effects and their Low‐Dose Combination with ß‐Elemene for Cancer Therapy

2021 ◽  
pp. 2102054
Author(s):  
Chuang Liu ◽  
Shan Sun ◽  
Qiang Feng ◽  
Gongwei Wu ◽  
Yiting Wu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Low Dose ◽  
Dose Combination

scholarly journals Gender differences in blood transfusion strategy for patients with hip fractures - a retrospective analysis

2020 ◽  
Vol 17 (5) ◽  
pp. 620-625
Author(s):  
Rene Burchard ◽  
Alina Daginnus ◽  
Christian Soost ◽  
Jan Schmitt ◽  
Jan Adriaan Graw
Keyword(s):  
Gender Differences ◽  
Blood Transfusion ◽  
Retrospective Analysis ◽  
Hip Fractures ◽  
Transfusion Strategy

Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model

2010 ◽  
Vol 288 (2) ◽  
pp. 251-260 ◽  
Author(s):  
Chung Kwon Kim ◽  
Young Ae Joe ◽  
Suk-Keun Lee ◽  
Eun-Kyoung Kim ◽  
Eunju O ◽  
...  
Keyword(s):  
Low Dose ◽  
Kringle Domain ◽  
Dose Combination ◽  
Glioma Model ◽  
Anti Tumor Activity

Pilot evaluation of a partner-supported online reading intervention for Grade 3–6 children

2021 ◽  
pp. 026565902198940
Author(s):  
Jessica Dean ◽  
Michelle Pascoe ◽  
Jane le Roux
Keyword(s):  
Prospective Study ◽  
Retrospective Analysis ◽  
Reading Intervention ◽  
Reading Difficulties ◽  
Reading Rate ◽  
Control Groups ◽  
Reading Accuracy ◽  
Significant Difference ◽  
Reading Partners ◽  
And Control

Information and communication technology (ICT)-based reading interventions have potential to help children with reading difficulties, especially those in resource-constrained environments who otherwise might not have access to support. This pilot study aimed to describe the impact of an online, partner-supported reading intervention designed for South African children with reading difficulties. Objectives were to qualitatively describe participants’ experience of the intervention, and quantitatively evaluate changes in reading accuracy, rate, comprehension and receptive vocabulary after intervention. Two studies were conducted: (1) A retrospective analysis using data from intervention in mainstream Cape Town schools with peers as reading partners; (2) A prospective study in a Cape Town school with special needs educational provision where speech-language therapists served as reading partners. Both studies used matched participant, pre/post intervention designs. A total of 40 children in grades 3 to 6 participated. In each study the intervention group ( n = 20) received intervention 3 times per week (30 minutes per session) for 10 weeks, while the control group ( n = 20) continued with regular school activities. Participants enjoyed the ICT-based intervention, valued the role of the reading partners, believed they had made literacy gains, and reported positive attitudinal and behavioural changes related to reading. Retrospective analysis revealed no statistically significant differences between intervention and control groups. The prospective study found a statistically significant difference between the intervention and control groups’ gains on one measure of reading rate, but no significant difference in reading accuracy, vocabulary or reading comprehension gains. The study provides a preliminary description of one ICT-based reading intervention. Although an intervention effect could not be demonstrated, the changes noted in reading rate together with qualitative findings suggest a need for further research.

Sign in / Sign up

Export Citation Format

Share Document