scholarly journals The Crimean-Congo haemorrhagic fever tick vector Hyalomma marginatum in south of France: Modelling its distribution and determination of factors influencing its establishment in a newly invaded area

2021 ◽  
Author(s):  
Madiou Thierno Bah ◽  
Vladimir Grobois ◽  
Frédéric Stachurski ◽  
facundo munoz ◽  
Maxime Duhayon ◽  
...  
Keyword(s):  
External Validation ◽  
Haemorrhagic Fever ◽  
Natural Habitats ◽  
Tick Abundance ◽  
Multiple Parameters ◽  
Dry Conditions ◽  
Crimean Congo Haemorrhagic Fever ◽  
Parasitic Load ◽  
The Mean ◽  
First Time

For the first time we built a correlative model for predicting the distribution of H. marginatum, one of the main vector of Crimean-Congo Haemorrhagic fever virus (CCHFV), at high resolution in a recently colonized area, namely south of France. Field tick collections were conducted on horses from 2016 to 2021 in 14 French southern departments, which resulted in a first map of H. marginatum on the national territory. Such updated presence/absence data, as well as the mean number of H. marginatum per examined animal (mean parasitic load) as a proxy of the tick abundance, were correlated to multiple parameters that described the climate and habitats characterizing each collection site, as well as movements of horses as a possible source of tick diffusion and new establishment. Our model highlighted the importance of warm temperatures all along the year, as well as dry conditions during summer and moderate annual humidity for the establishment of H. marginatum. A predominance of open natural habitats in the environment was also identified as a supporting factor, in opposition to artificial and humid habitats that were determined as unsuitable. Based on this model, we predicted the current suitable areas for the establishment of the tick H. marginatum in South of France, with a relatively good accuracy using internal and external validation methods. Concerning tick abundance, some correlative relationships were similar than in the occurrence model but the type of horse movements were also pointed out as an important factor explaining the mean parasitic load, leading to differential exposure to ticks. The limitations of estimating and modelling H. marginatum abundance in a correlative model are discussed.

scholarly journals Molecular epidemiology of Crimean-Congo haemorrhagic fever virus in India

2016 ◽  
Vol 144 (16) ◽  
pp. 3422-3425 ◽  
Author(s):  
P. SINGH ◽  
M. CHHABRA ◽  
P. SHARMA ◽  
R. JAISWAL ◽  
G. SINGH ◽  
...  
Keyword(s):  
Eastern Europe ◽  
N Gene ◽  
Western India ◽  
Haemorrhagic Fever ◽  
Rt Pcr ◽  
Study Region ◽  
Phylogenetic Relatedness ◽  
Cchf Virus ◽  
Crimean Congo Haemorrhagic Fever ◽  
First Time

SUMMARYCrimean-Congo haemorrhagic fever (CCHF) is an emerging zoonotic disease in India which is prevalent in neighbouring countries. CCHF virus (CCHFV) is a widespread tick-borne virus which is endemic in Africa, Asia, Eastern Europe and the Middle East. In the present study, samples of clinically suspected human cases from different areas of northern-western India were tested for the presence of CCHFV by RT–PCR through amplification of nucleocapsid (N) gene of CCHFV. Positive samples were sequenced to reveal the prevailing CCHFV genotype(s) and phylogenetic relatedness. A phylogenetic tree revealed the emergence of diverse strains in the study region showing maximum identity with the Pakistan, Afghanistan and Iran strains, which was different from earlier reported Indian strains. Our findings reveal for the first time the emergence of the Asia 1 group in India; while earlier reported CCHFV strains belong to the Asia 2 group.

Crimean-Congo haemorrhagic fever - the emerging vector-borne disease

2008 ◽  
Vol 63 (4) ◽  
pp. 1-7
Author(s):  
Krzysztof Kostro ◽  
Dorota Luft-Deptuła ◽  
Zdzisław Gliński
Keyword(s):  
Haemorrhagic Fever ◽  
Vector Borne Disease ◽  
Crimean Congo Haemorrhagic Fever ◽  
Vector Borne

RESULTS OF INTRALESIONAL TRIAMCINOLONE ACETONIDE FOR CHALAZION TREATMENT

2011 ◽  
pp. 100-104
Author(s):  
Thi Thu Nguyen ◽  
Viet Hien Vo ◽  
Thi Em Do
Keyword(s):  
Success Rate ◽  
Key Words ◽  
Triamcinolone Acetonide ◽  
Lower Eyelid ◽  
Upper Eyelid ◽  
Interventional Trial ◽  
The Mean ◽  
First Time

The study use intralesional triamcinolone acetonide injection proceduce for chalazion treatment.1. Objectives: To evaluate results of intralesional triamcinolone acetonide injection for chalazion treatment. 2. Method: This noncomparative prospective interventional trial included 72 chalazions of 61 patients. 3. Results: 61 patients (72 chalazions) with 19 males (31.1%) và 42 females (68.9%), the mean age was 24 ± 9,78 years. 31.1% patients was the first time chalazion and 68.9% patients was more than one times chalazion including 78.6% patients was recurrent at the first position and 21.4% patients occur at new position. 72 chalazions with 16 (22.2%) chalazions was treated before and 56 (77.8%) chalazions wasn’t done that. 72 chalazions with 49 chalazions (68.1%) are local in upper eyelid and 23 chalazions (31.9%) are local in lower eyelid. The mean of chalazion diameter is 6.99 ± 3.03mm. Intralesional triamcinolone acetonide is injected to treat 72 chalazions with 16 (22.2%) chalazions are injected through the route of skin and 56 (77.8%) chalazions are injected through the route of conjunctiva. After 2 weeks follow-up, the success rate was 93.1% and 6.9% failed. 4. Conclusion: intralesional triamcinolone acetonide injection for chalazion treatment is really effective. Key words: chalazion, intralesional triamcinolone acetonide.

Synthesis of a silymarin-gold nanoparticle conjugate and analysis of its liver-protecting activity

2021 ◽  
Vol 22 ◽  
Author(s):  
Sergey Staroverov ◽  
Sergey Kozlov ◽  
Alexander Fomin ◽  
Konstantib Gabalov ◽  
Alexey Volkov ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Liver Disease ◽  
Carbon Tetrachloride ◽  
Glutathione Depletion ◽  
Laboratory Animals ◽  
Experimental Hepatitis ◽  
Acute Liver Disease ◽  
The Mean ◽  
Extent Of Damage ◽  
First Time

Background: The liver disease problem prompts investigators to search for new methods of liver treatment. Introduction: Silymarin (Sil) protects the liver by reducing the concentration of free radicals and the extent of damage to the cell membranes. A particularly interesting method to increase the bioavailability of Sil is to use synthesized gold nanoparticles (AuNPs) as reagents. The study considered whether it was possible to use the silymarin-AuNP conjugate as a potential liver-protecting drug. Method: AuNPs were conjugated to Sil and examine the liver-protecting activity of the conjugate. Experimental hepatitis and hepatocyte cytolysis after carbon tetrachloride actionwere used as a model system, and the experiments were conducted on laboratory animals. Result: For the first time, silymarin was conjugated to colloidal gold nanoparticles (AuNPs). Electron microscopy showed that the resultant preparations were monodisperse and that the mean conjugate diameter was 18–30 nm ± 0.5 nm (mean diameter of the native nanoparticles, 15 ± 0.5 nm). In experimental hepatitis in mice, conjugate administration interfered with glutathione depletion in hepatocytes in response to carbon tetrachloride was conducive to an increase in energy metabolism, and stimulated the monocyte–macrophage function of the liver. The results were confirmed by the high respiratory activity of the hepatocytes in cell culture. Conclusion: We conclude that the silymarin-AuNP conjugate holds promise as a liver-protecting agent in acute liver disease caused by carbon tetrachloride poisoning.

Parasite commonality at Swamp Deer (Mammalia: Artiodactyla: Cervidae: Rucervus duvaucelii duvaucelii) and livestock interface

2020 ◽  
Vol 12 (3) ◽  
pp. 15364-15369
Author(s):  
Animesh Talukdar ◽  
Bivash Pandav ◽  
Parag Nigam
Keyword(s):  
Intestinal Parasites ◽  
Uttar Pradesh ◽  
Anthropogenic Pressure ◽  
Wildlife Sanctuary ◽  
Natural Habitats ◽  
Coprological Examination ◽  
Parasitic Load ◽  
Abundance And Diversity ◽  
Swamp Deer ◽  
Different Levels

Interactions between wildlife and livestock have increased over time with increased anthropogenic pressure on limited available natural habitats.  These interactions have resulted in sharing of pathogens between the species resulting in impacting the wild animals’ fitness and reproduction and further influencing their abundance and diversity.  The spatial overlap between Swamp Deer and livestock was studied at Jhilmil Jheel Conservation Reserve (JJCR), Uttarakhand and Kishanpur Wildlife Sanctuary (KWLS), Uttar Pradesh in India, having different levels of interaction with livestock.  The prevalence, load and commonality of gastro-intestinal parasites in the species was studied through coprological examination. Parasitic ova of Strongyle sp., Trichostrongylus sp., Fasciola sp., and Moniezia sp. Amphistomes were encountered in swamp deer and livestock from both the sites. The parasitic species richness and prevalence however, varied between JJCR and KWLS.  The study recorded significant differences between the parasitic load in Swamp Deer with the eggs per gram of 487.5±46.30 at JJCR and 363.64±49.97 at KWLS at varying levels of livestock interactions.

scholarly journals Knowledge, attitude and perceptions about Crimean Congo Haemorrhagic Fever (CCHF) among occupationally high-risk healthcare professionals of Pakistan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ali Ahmed ◽  
Muhammad Saqlain ◽  
Maria Tanveer ◽  
Azhar Hussain Tahir ◽  
Fakhar Ud-Din ◽  
...  
Keyword(s):  
At Risk ◽  
Health Care Professionals ◽  
Work Experience ◽  
Tertiary Care ◽  
Nosocomial Transmission ◽  
Haemorrhagic Fever ◽  
Sources Of Information ◽  
Validated Questionnaire ◽  
Low Middle Income Countries ◽  
Crimean Congo Haemorrhagic Fever

Abstract Background Crimean Congo Haemorrhagic Fever (CCHF), a tropically neglected infectious disease caused by Nairovirus, is endemic in low middle-income countries like Pakistan. Emergency health care professionals (HCPs) are at risk of contracting nosocomial transmission of CCHF. We, therefore, aim to analyze the knowledge, attitudes, and perceptions (KAP) of at-risk physicians, nurses, and pharmacists in Pakistan and the factors associated with good KAP. Method A validated questionnaire (Cronbach’s alpha 0.71) was used to collect data from HCPs in two CCHF endemic metropolitan cities of Pakistan by employing a cross-sectional study design. For data analysis percentages, chi-square test and Spearman correlation were applied by using SPSS version 22. Results Of the 478 participants, 56% (n = 268) were physicians, 37.4% (n = 179) were nurses, and 6.5% (n = 31) were pharmacists. The proportion of HCPs with good knowledge, attitude, and perception scores was 54.3%, 81, and 69%, respectively. Being a physician, having more work experience, having a higher age, working in tertiary care settings, were key factors for higher knowledge (p < 0.001). The correlation coefficient showed significant positive correlation between attitude- perception (r = 0.560, p < 0.001). Conclusion We have observed average knowledge of HCPs. Therefore, we recommend time to time education campaigns and workshops in highly endemic CCHF regions to be launched by health ministries and HCPs, in particular nurses, encouraged to follow authentic academic sources of information to prevent nosocomial transmission.

scholarly journals Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa

2021 ◽  
Author(s):  
Médiha Khamassi Khbou ◽  
Rihab Romdhane ◽  
Faten Bouaicha Zaafouri ◽  
Mohsen Bouajila ◽  
Limam Sassi ◽  
...  
Keyword(s):  
North Africa ◽  
Fever Virus ◽  
Haemorrhagic Fever ◽  
Crimean Congo Haemorrhagic Fever

scholarly journals Neutrosophic ratio-type estimators for estimating the population mean

2021 ◽  
Author(s):  
Zaigham Tahir ◽  
Hina Khan ◽  
Muhammad Aslam ◽  
Javid Shabbir ◽  
Yasar Mahmood ◽  
...  
Keyword(s):  
Minimum Mean Square Error ◽  
Auxiliary Information ◽  
Population Parameter ◽  
Uncertain Information ◽  
Population Mean ◽  
Classical Statistics ◽  
Neutrosophic Statistics ◽  
The Mean ◽  
Type Data ◽  
First Time

AbstractAll researches, under classical statistics, are based on determinate, crisp data to estimate the mean of the population when auxiliary information is available. Such estimates often are biased. The goal is to find the best estimates for the unknown value of the population mean with minimum mean square error (MSE). The neutrosophic statistics, generalization of classical statistics tackles vague, indeterminate, uncertain information. Thus, for the first time under neutrosophic statistics, to overcome the issues of estimation of the population mean of neutrosophic data, we have developed the neutrosophic ratio-type estimators for estimating the mean of the finite population utilizing auxiliary information. The neutrosophic observation is of the form $${Z}_{N}={Z}_{L}+{Z}_{U}{I}_{N}\, {\rm where}\, {I}_{N}\in \left[{I}_{L}, {I}_{U}\right], {Z}_{N}\in [{Z}_{l}, {Z}_{u}]$$ Z N = Z L + Z U I N where I N ∈ I L , I U , Z N ∈ [ Z l , Z u ] . The proposed estimators are very helpful to compute results when dealing with ambiguous, vague, and neutrosophic-type data. The results of these estimators are not single-valued but provide an interval form in which our population parameter may have more chance to lie. It increases the efficiency of the estimators, since we have an estimated interval that contains the unknown value of the population mean provided a minimum MSE. The efficiency of the proposed neutrosophic ratio-type estimators is also discussed using neutrosophic data of temperature and also by using simulation. A comparison is also conducted to illustrate the usefulness of Neutrosophic Ratio-type estimators over the classical estimators.

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