scholarly journals COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

2021 ◽  
Author(s):  
Mohammad Ashraful Amin ◽  
Md. Taufiqul Islam ◽  
Ishtiakul Islam Khan ◽  
Zahid Hasan Khan ◽  
Firdausi Qadri ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Sore Throat ◽  
Dengue Infection ◽  
High Grade ◽  
Rt Pcr ◽  
High Grade Fever

Bangladesh recently faced large outbreaks of both COVID-19 and Dengue fever. A 28-year-old woman suffered from symptoms including hemoptysis as first presentation followed by high-grade fever, sore throat, and fatigue. SARS-CoV-2 was confirmed by RT-PCR and also diagnosed dengue later on.COVID-19 and dengue fever could be a harmful combination.

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

scholarly journals DENGUE FEVER;

2012 ◽  
Vol 19 (05) ◽  
pp. 688-694
Author(s):  
SHAHBAZ BAIG ◽  
ABDUL SATTAR ◽  
SHAHBAZ AHMAD
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Cross Sectional Study ◽  
High Grade Fever ◽  
Cross Sectional ◽  
The People ◽  
Number Of Patients ◽  
The Family ◽  
Health Significance ◽  
Vector Borne

Dengue infection is one of the most common mosquito borne viral diseases of public health significance. It has been identifiedas a clinical entity since 1780. Dengue is caused by viruses that are small enveloped viruses and are members of the family Flaviviridae genusFlavivirus. It is a vector borne disease and is a global health threat. In Pakistan first epidemic was reported in 1994 and since then cases arereported every years. This year dengue infection raised the number of patients and increased the deaths. Objectives: To assess theknowledge, attitude and practices of the people regarding Dengue fever. Study Design: Cross Sectional Study. Setting: Aziz Bhatti Town,Lahore. Duration of Study: One Month. Material and methods: Convenient sampling. The investigator himself collected the information fromthe sample under study. First of all, an informed consent was obtained from the respondent under study and secrecy of the information wasensured. Data was entered and cleaned using Epi Data version 3. Data was analyzed using Epi info version 3.5.1. Results: Out of 41respondent families only 2.4% did not hear about dengue fever while 97.6% respondents were well aware of the dengue fever. 80.5% wereaware of high grade fever in dengue fever, 73.2% were aware of associated body aches. 92.7% were aware that dengue fever is preventable.95.1% were using mats, coils & repellents while 2.4% were using smoke of wet wood.36.6% were covering the water containers. 75.6% werekeeping environment dry and clean.68.3% were having opinion that they will consult GP in case of illness.85.4% told that TV/Radio were thesource of above mentioned knowledge while 9.8% doctor and 4.9% got information through newspapers. only 4.9% respondents were havingopinion that government had sprayed for dengue fever.7.3% families experienced the patient of dengue fever in their family. Conclusions: Inthis study the results are the almost same with little variations as found in other studies. The knowledge, attitude and practice are the almostsame in every studies with little variation. Majority of the families were well aware of dengue fever.

scholarly journals “DENGUE ENCEPHALITIS – A RARE MANIFESTATION OF DENGUE FEVER.”

2020 ◽  
pp. 1-2
Author(s):  
Showkat Nazir Wani ◽  
Anish Garg Atul Kaushik ◽  
Atul Kaushik ◽  
Naveen Tariq
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Dengue Fever ◽  
High Grade ◽  
High Grade Fever ◽  
Altered Sensorium ◽  
Mri Brain ◽  
Northern India ◽  
Rare Manifestation ◽  
History Of

We report a case of dengue fever with features of encephalitis from Northern India. A 22 years female presented with history of high-grade fever with chills for 2 days followed by altered sensorium and MRI brain, revealed characteristic changes consistent with Encephalitis with hemorrhage mainly involving the bilateral thalami. The diagnosis of dengue was confirmed by the presence of dengue antigen in the serum and the presence of dengue antibodies in the serum as well as cerebrospinal fluid. Dengue is not primarily a neurotropic virus and encephalopathy is an uncommon finding in dengue. This case explains the importance of considering dengue encephalitis as the differential diagnosis of fever with altered sensorium, especially in countries like India where dengue is rampant.

scholarly journals Chikungunya Outbreak from 1952-2019: A Prospective to Cope-Up with this Re-emerging Disease

2020 ◽  
Vol 11 (4) ◽  
pp. 11724-11736
Keyword(s):  
Dengue Fever ◽  
Human Population ◽  
Review Article ◽  
Emerging Disease ◽  
High Grade ◽  
High Grade Fever ◽  
Study Results ◽  
The Family ◽  
Heavy Burden ◽  
The Common

Chikungunya is a mosquito-borne disease caused by the alphavirus that belongs to the family Togaviridae. It was first identified in 1952 when the first outbreak of chikungunya occurred in the Tanganyika. From them, several outbreaks had been taken place around the globe, making a severe threat to the human population. High-grade fever, nausea, and body pain mislead the disease with Dengue fever. Disease effects are long-lasting; the disease is characterized by severe joint pains, which leads to arthralgia. To date, no direct treatment is available for the infection, which puts a heavy burden on society. In this review article, the authors focus on the outbreaks of chikungunya since1952 to 2019 worldwide. The mutations occurred in the proteome of chikungunya. The evolution occurred because of those mutations and their effects on human societies. The study results that the two mutations in the proteome made the species more vulnerable to society. The outbreak study suggests that numerous chikungunya cases had been identified worldwide with the common symptoms that turn severe with these mutations. This study result reveals that scientists and researchers must focus on the disease's intensity and work progressively to find the solution for this emerging disease.

Study of Cardiac Manifestation in Patients with Seropositive Dengue Fever and to Find Correlation with Subclinical Cardiac Involvement

2021 ◽  
Vol 8 (12) ◽  
pp. 28-33
Author(s):  
Rishad Ahmed
Keyword(s):  
Dengue Fever ◽  
Cardiac Involvement ◽  
Randomized Study ◽  
Dengue Infection ◽  
Clinical Manifestations ◽  
Denv Infection ◽  
Left Ventricular ◽  
High Grade Fever ◽  
Plasma Leakage ◽  
Cardiac Manifestation

Objective: The main objective of the present study was to observe the electrocardiogram (ECG) changes in dengue fever and to find correlation with subclinical cardiac involvement. Methods: This was an observational, prospective, non-randomized study. High grade fever for one to five days diagnosed as dengue infection later confirmed by dengue tests (NS1, IgG and IgM ELISA) were included in this study. Prior to the commencement of the study informed consent was taken from all the participants. With 12 lead ECG taken during the febrile phase of dengue fever randomly selected serologically confirmed cases of dengue fever were evaluated at an interval of 24 hrs. for a total of five days. On the day of admission when the patient was afebrile, echocardiography was done. Plasma leakage was diagnosed by presence of any one of four: subcutaneous oedema (pedal oedema, facial puffiness) or pleural effusion or pericardial effusion or ascites. Result: A total 80 patients who were admitted to hospital during study periods due to symptoms of dengue fever and IgM dengue positive status were included in this study. Among this total population of 80 patients (N=80) 48 were male and 32 were female. Out of these, majority were diagnosed as DF 52 (65%), 23 (29%) were diagnosed as DHF and rest only 5 (6%) were diagnosed as DSS. Total 54 patients were found to have normal ECG among which 35 were having dengue fever, 16 were having DHF and 3 were having DSS. Total 2 patients were diagnosed to have left ventricular hypertrophy among which one had dengue fever and rest two had DHF. ST depression was observed in total 7 patients in which 5 were had dengue fever and 2 were had DHF. Relative bradycardia was found in 14, tall t waves in 2 and ventricular ectopics in 1 patient (table 2). Abnormal ECG findings were compared using Chi-square test and were found to be statistically significant (P < 0.05) in dengue fever and DHF. There was statistically significant correlation between ECG abnormalities and abdominal pain and mucosal bleed. The presence of plasma leakage were observed among 77 (96.3%) patients. Proportion of echocardiography abnormalities were higher among patients with plasma leak 6 (30%) as compared to without plasma leak 9 (15%), this difference was not found to be statistically significant Conclusion: In all type of Dengue infections incidence of cardiac involvement was quite high. Due to the overlapping clinical manifestations such as capillary leak associated with DENV infection, tachycardia, pulmonary edema, and hypotension as well as due to the low index of clinical suspicion cardiac involvement in dengue fever is often underdiagnosed. Keywords: Cardiac manifestation, dengue infection, echocardiography, electrocardiography.

High Incidence of Dengue Fever in Karachi and the Benefits of Ultrasound for Diagnosis of Complications

2020 ◽  
Author(s):  
Samia Perwaiz Khan
Keyword(s):  
Pericardial Effusion ◽  
Liver Injury ◽  
Dengue Fever ◽  
Joint Pain ◽  
High Grade ◽  
Ultrasound Scan ◽  
High Grade Fever ◽  
High Incidence ◽  
Laboratory Investigations ◽  
The Common

Background: Dengue fever presentations are from asymptomatic fever to most serious complications. Acute high-grade fever, muscle and joint pain, myalgia, skin rashes, hemorrhage and circulatory shock are the common symptoms. There has been reported increase in number of dengue fever and last few years. Urgent diagnosis is critical to avoid complications like liver injury, cardiomyopathy, pneumonia, orchitis, oophoritis, seizures and encephalopathies. This study aimed to determine the complication caused by dengue fever after the diagnosis by clinical and laboratory investigation by performing ultrasound abdomen and thorax. Methods: In this study one hundred and twenty one (121) patients diagnosed with dengue fever and laboratory investigations done from Jinnah Medical Hospital (JMH) and Pathological & Molecular Laboratories from August to November 2019. Ultrasound of abdomen and thorax was performed for diagnosing complications such as ascites, pleural and pericardial effusion through Xario-100 sonography machine. Results: Out of one hundred and twenty one (121) patients diagnosed with dengue fever forty-three (43) were found to have developed the complications such as ascites, pleural and pericardial effusion by performing ultrasound abdomen and chest. Conclusion: We found 35 % patients with dengue fever complications by ultrasound, which is most convenient diagnostic tool. Therefore, by performing early ultrasound scan of abdomen and thorax in these patients can reduce the risk of morbidity and mortality.

scholarly journals Sane and safe: Forced social distancing to prevent human-to-human transmission of COVID-19

2021 ◽  
Vol 16 (1) ◽  
pp. 15-17
Author(s):  
Firdous Jahan
Keyword(s):  
Respiratory Tract ◽  
Sore Throat ◽  
Respiratory Tract Infections ◽  
High Grade ◽  
Wild Animals ◽  
High Grade Fever ◽  
Current Outbreak ◽  
Global Concern ◽  
Tract Infections ◽  
The City

The current outbreak of COVID-19, originating from the city of Wuhan in China and ultimately involving over 200 countries, is now a global concern. Evidence indicates that COVID-19 spread to humans from wild animals, causing severe respiratory tract infections in humans; the typical symptoms of COVID include cough, high-grade fever, sore throat, and difficulty in breathing. The infection spreads from human to human via droplets. Therefore, social or physical distancing can reduce spread within communities. Asymptomatic spread can also occur during family gatherings or in the workplace; thus, we must enforce physical distancing as much as possible to reduce the spread of cases.

scholarly journals 1405. Clinical and laboratory features of fatal dengue fever in children: a case-control study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S710-S711
Author(s):  
Dolores E Freire ◽  
Jeniffer D Olaya ◽  
Michael Hawkes
Keyword(s):  
Dengue Fever ◽  
Case Control Study ◽  
Dengue Infection ◽  
Healthcare Providers ◽  
Case Control ◽  
Warning Signs ◽  
Total Leukocyte Count ◽  
Retrospective Case ◽  
Time To Death ◽  
Control Study

Abstract Background Dengue fever (DF) is a mosquito-borne illness that causes significant morbidity and mortality in tropical climates. This study compared the clinical features of fatal DF cases to severe non-fatal, and non-severe controls in Ecuador. Methods Retrospective case-control study of children (1 month to 15 years) hospitalized with serologically-confirmed DF in Guayaquil, Ecuador from 2013 to 2017. Cases of severe, fatal (SF) DF were compared to two control groups: (1) severe DF survivors (SS); and (2) patients with dengue with warning signs (DWS), matched 3:1 to cases for age, sex, and admission date. Observational trial profile Results 1051 patients were admitted with suspected DF and 552 were IgM-positive. Patients were classified as SF (n=11), SS (n=30), or DWS (n=511) (Figure1). Among SF cases, median age was 9.6 years (IQR 5.5-11), 7 (64%) were male, and median time to death was 1.5 days (IQR 0.8-4.0). (Table 1) SF cases had a median of 3 (Range 0-5) encounters with healthcare providers prior to presentation, compared to 2 (Range 0-5, p=0.02) for SS and 2 (Range 0-3, p=0.02) for DWS. Physical findings more common in SF cases than controls included: higher weight, tachycardia, tachypnea, delayed capillary refill, and hepatomegaly (p&lt; 0.05 for all comparisons). Neurological manifestations were more prevalent in the SF group: 9/11 (82%) patients compared to 15/30 (50%, p=0.09) in SS and 7/33 (21%, p&lt; 0.01) in DWS. Total leukocyte count (7.8x103/µL versus 4.5x103/µL, p=0.03) and absolute neutrophil count (5.1x103/µL versus 2.1x103/µL, p=0.03) were higher in SF cases than DWS controls. Fewer SF patients received intravenous dextrose than SS controls (27% versus 70%, p=0.03) (Table 2). Admission characteristics of children with dengue fever Management and outcome Conclusion Delayed recognition by healthcare workers, higher weight, vital sign abnormalities, hepatomegaly, neurological symptoms, leukocytosis, neutrophilia, and lack of dextrose in intravenous solutions were associated with mortality in children with DF. These findings have implications for optimizing the diagnosis and management of severe pediatric dengue infection. Disclosures All Authors: No reported disclosures

scholarly journals Multi-Tissue Transcriptomic-Informed In Silico Investigation of Drugs for the Treatment of Dengue Fever Disease

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1540
Author(s):  
Beatriz Sierra ◽  
Ana Cristina Magalhães ◽  
Daniel Soares ◽  
Bruno Cavadas ◽  
Ana B. Perez ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Dengue Fever ◽  
In Silico ◽  
Serotonin Receptor ◽  
Neglected Tropical Diseases ◽  
Dengue Infection ◽  
Severe Dengue ◽  
Functional Evaluation ◽  
Atpase Inhibitor ◽  
Serotonin Receptor Antagonist

Transcriptomics, proteomics and pathogen-host interactomics data are being explored for the in silico–informed selection of drugs, prior to their functional evaluation. The effectiveness of this kind of strategy has been put to the test in the current COVID-19 pandemic, and it has been paying off, leading to a few drugs being rapidly repurposed as treatment against SARS-CoV-2 infection. Several neglected tropical diseases, for which treatment remains unavailable, would benefit from informed in silico investigations of drugs, as performed in this work for Dengue fever disease. We analyzed transcriptomic data in the key tissues of liver, spleen and blood profiles and verified that despite transcriptomic differences due to tissue specialization, the common mechanisms of action, “Adrenergic receptor antagonist”, “ATPase inhibitor”, “NF-kB pathway inhibitor” and “Serotonin receptor antagonist”, were identified as druggable (e.g., oxprenolol, digoxin, auranofin and palonosetron, respectively) to oppose the effects of severe Dengue infection in these tissues. These are good candidates for future functional evaluation and clinical trials.

scholarly journals Infectious Disease Relational Data Analysis Using String Grammar Non-Euclidean Relational Fuzzy C-Means

2021 ◽  
Vol 18 (15) ◽  
pp. 8153
Author(s):  
Apiwat Budwong ◽  
Sansanee Auephanwiriyakul ◽  
Nipon Theera-Umpon
Keyword(s):  
High Risk ◽  
Dengue Fever ◽  
Policy Development ◽  
Dengue Infection ◽  
Prevention Policy ◽  
Fuzzy C Means ◽  
North East ◽  
B Virus ◽  
North And South ◽  
Better Than

Statistical analysis in infectious diseases is becoming more important, especially in prevention policy development. To achieve that, the epidemiology, a study of the relationship between the occurrence and who/when/where, is needed. In this paper, we develop the string grammar non-Euclidean relational fuzzy C-means (sgNERF-CM) algorithm to determine a relationship inside the data from the age, career, and month viewpoint for all provinces in Thailand for the dengue fever, influenza, and Hepatitis B virus (HBV) infection. The Dunn’s index is used to select the best models because of its ability to identify the compact and well-separated clusters. We compare the results of the sgNERF-CM algorithm with the string grammar relational hard C-means (sgRHCM) algorithm. In addition, their numerical counterparts, i.e., relational hard C-means (RHCM) and non-Euclidean relational fuzzy C-means (NERF-CM) algorithms are also applied in the comparison. We found that the sgNERF-CM algorithm is far better than the numerical counterparts and better than the sgRHCM algorithm in most cases. From the results, we found that the month-based dataset does not help in relationship-finding since the diseases tend to happen all year round. People from different age ranges in different regions in Thailand have different numbers of dengue fever infections. The occupations that have a higher chance to have dengue fever are student and teacher groups from the central, north-east, north, and south regions. Additionally, students in all regions, except the central region, have a high risk of dengue infection. For the influenza dataset, we found that a group of people with the age of more than 1 year to 64 years old has higher number of influenza infections in every province. Most occupations in all regions have a higher risk of infecting the influenza. For the HBV dataset, people in all regions with an age between 10 to 65 years old have a high risk in infecting the disease. In addition, only farmer and general contractor groups in all regions have high chance of infecting HBV as well.

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