Lean body mass and total body weight versus body surface area as determinant of docetaxel pharmacokinetics and toxicity

Aim: In our study we examined whether anthropometric and body composition parameters, i.e. body surface area (BSA), lean body mass (LBM) and total body weight (TBW), are correlated with docetaxel clearance and exposure. In addition, LBM, TBW and a fixed dose were compared to BSA as dosing parameters for dose individualisation of docetaxel. Methods: Thirty-six patients affected by breast or castration-resistant prostate carcinoma receiving docetaxel chemotherapy entered the study. LBM was measured by a Dual Energy Xray Absorptiometry (DEXA) scanner before treatment. Blood samples were collected up to 180 minutes after dosing to analyse docetaxel concentrations and to determine individual pharmacokinetic (PK) parameters. Results: No significant correlations were found between the docetaxel pharmacokinetic parameters clearance and volume of distribution and the anthropometric and body composition variables BSA, LBM and TBW. AUC was significantly but poorly correlated with BSA (r=0.452 [p=0.016]) and with TBW (r=0.476 (p=0.011]). The Mean Absolute Percentage Error and Mean Error of simulated dosing based on LBM and fixed dosing ME were not significant different compared to BSA. For TBW, only the MAPE of dosing was significant higher compared to BSA (24.1 vs. 17.1, P=0.001). Conclusion: There is no correlations between docetaxel pharmacokinetics and the anthropometric and body composition variables BSA, LBM and TBW. Dose individualisation of docetaxel based on LBM or TBW or fixed dosing cannot be recommended over BSA based dosing.

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Increases in adipose and total body weight, but not in lean body mass, associated with subcutaneous administration of Sonic hedgehog-Ig fusion protein to mice

Drug Development Research ◽

10.1002/ddr.10115 ◽

2002 ◽

Vol 57 (3) ◽

pp. 107-114 ◽

Cited By ~ 5

Author(s):

Pauline L. Martin ◽

Joan Lane ◽

Louise Pouliot ◽

Malcolm Gains ◽

Rudolph Stejskal ◽

...

Keyword(s):

Body Weight ◽

Fusion Protein ◽

Lean Body Mass ◽

Body Mass ◽

Sonic Hedgehog ◽

Subcutaneous Administration ◽

Total Body Weight ◽

Total Body

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Loss of lean body mass within one week as a major determinant for total weight loss at one month after gastrectomy for gastric cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2015.33.3_suppl.219 ◽

2015 ◽

Vol 33 (3_suppl) ◽

pp. 219-219

Author(s):

Toru Aoyama ◽

Takaki Yoshikawa ◽

Taiichi Kawabe ◽

Hirohito Fujikawa ◽

Tsutomu Hayashi ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Lean Body Mass ◽

Body Mass ◽

Early Period ◽

Body Weight Loss ◽

Total Body Weight ◽

Late Period ◽

Total Body ◽

Total Body Weight Loss

219 Background: Postoperative changes in body weight and composition during first 1 month after gastrectomy remained unclear. Methods: The patients who underwent gastrectomy for gastric cancer between May 2010 and October 2013 were examined. Body weight and composition were evaluated by bioelectrical impedance analyzer within 1 week before surgery (first measurement), at 1 week after surgery (second measurement), and at 1 month after surgery (third measurement). The changes of the early period were defined as the differences until the second measurement, while those of the late period as the differences from the second to the third measurement. Results: Two-hundred forty four patients were selected for this study. Total body weight loss (BWL) within 1 month was -3.4 kg and the rate of body weight at 1 month to the preoperative body weight was 94.1%. BWL was significantly greater in the early period rather than that of the late period (-2.1 kg vs -1.2 kg, p<0.001). In the early period, loss of lean body mass was significantly greater than loss of fat mass (-1.5 kg vs -0.6 kg, p<0.001). The same trend was observed regardless of type of gastrectomy and surgical approach. Conclusions: Loss of lean body mass within 1 week was a major determinant for total body weight loss at 1 month. To maintain lean body mass within 1 week and total body weight at 1 month, future trial should be focused on not the surgical approach but nutritional intervention within 1 week.

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Lean Body Mass Is Better Than Body Surface Area in Correcting GFR

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e318263905b ◽

2013 ◽

Vol 38 (5) ◽

pp. e210-e215 ◽

Cited By ~ 5

Author(s):

Hongwei Si ◽

Zhili Lei ◽

Sijin Li ◽

Jianzhong Liu ◽

Jianhua Geng ◽

...

Keyword(s):

Surface Area ◽

Body Surface Area ◽

Lean Body Mass ◽

Body Mass ◽

Body Surface ◽

Better Than

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Estimated Lean Body Mass Is More Appropriate than Body Surface Area for Scaling Glomerular Filtration Rate and Extracellular Fluid Volume

Nephron Clinical Practice ◽

10.1159/000314666 ◽

2010 ◽

Vol 116 (1) ◽

pp. c75-c80 ◽

Cited By ~ 17

Author(s):

A. Michael Peters ◽

Hayley L.R. Snelling ◽

Daphne M. Glass ◽

Shirley Love ◽

Nicholas J. Bird

Keyword(s):

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Surface Area ◽

Body Surface Area ◽

Lean Body Mass ◽

Body Mass ◽

Body Surface ◽

Filtration Rate ◽

Extracellular Fluid ◽

Extracellular Fluid Volume

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Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses

Frontiers in Neurology ◽

10.3389/fneur.2021.716548 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jose M. Serra López-Matencio ◽

Yaiza Pérez García ◽

Virginia Meca-Lallana ◽

Raquel Juárez-Sánchez ◽

Angeles Ursa ◽

...

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Plasma Concentration ◽

Surface Area ◽

Body Surface Area ◽

Body Mass ◽

Body Surface ◽

Treatment Duration ◽

Pharmacokinetics And Pharmacodynamics ◽

The Impact

Background: Plasma concentration of natalizumab falls above the therapeutic threshold in many patients who, therefore, receive more natalizumab than necessary and have higher risk of progressive multifocal leukoencephalopathy.Objective: To assess in a single study the individual and treatment characteristics that influence the pharmacokinetics and pharmacodynamics of natalizumab in multiple sclerosis (MS) patients in the real-world practice.Methods: Prospective observational study to analyse the impact of body weight, height, body surface area, body mass index, gender, age, treatment duration, and dosage scheme on natalizumab concentrations and the occupancy of α4-integrin receptor (RO) by natalizumab.Results: Natalizumab concentrations ranged from 0.72 to 67 μg/ml, and RO from 26 to 100%. Body mass index inversely associated with natalizumab concentration (beta = −1.78; p ≤ 0.001), as it did body weight (beta = −0.34; p = 0.001), but not height, body surface area, age or gender Extended vs. standard dose scheme, but not treatment duration, was inversely associated with natalizumab concentration (beta = −7.92; p = 0.016). Similar to natalizumab concentration, body mass index (beta = −1.39; p = 0.001) and weight (beta = −0.31; p = 0.001) inversely impacted RO. Finally, there was a strong direct linear correlation between serum concentrations and RO until 9 μg/ml (rho = 0.71; p = 0.003). Nevertheless, most patients had higher concentrations of natalizumab resulting in the saturation of the integrin.Conclusions: Body mass index and dosing interval are the main variables found to influence the pharmacology of natalizumab. Plasma concentration of natalizumab and/or RO are wide variable among patients and should be routinely measured to personalize treatment and, therefore, avoid either over and underdosing.

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Normalizing the thermal effects of radiofrequency radiation: Body mass versus total body surface area

Bioelectromagnetics ◽

10.1002/bem.2250080202 ◽

1987 ◽

Vol 8 (2) ◽

pp. 111-118 ◽

Cited By ~ 16

Author(s):

Christopher J. Gordon

Keyword(s):

Surface Area ◽

Body Surface Area ◽

Body Mass ◽

Body Surface ◽

Thermal Effects ◽

Total Body Surface Area ◽

Radiofrequency Radiation ◽

Total Body

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Derivation of new reference tables for human heart weights in light of increasing body mass index

Journal of Clinical Pathology ◽

10.1136/jcp.2010.084574 ◽

2010 ◽

Vol 64 (4) ◽

pp. 358-362 ◽

Cited By ~ 32

Author(s):

Kezia Gaitskell ◽

Rafael Perera ◽

Elizabeth J Soilleux

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Surface Area ◽

Body Surface Area ◽

Body Mass ◽

Body Surface ◽

Heart Weight ◽

Gender And Age ◽

Body Weights ◽

Effect Of Age

As body weights and body mass indices have increased over time, we questioned the validity of correlating heart weight with body weight and whether tables from previous decades remain relevant. We investigated this by collecting details of heart weight, body weight, height, gender and age from 384 autopsy cases with no obvious heart or lung disease. Heart weights, body weights and heights showed a normal distribution for both genders. Heart weight correlated slightly better with body surface area than body weight and we present new reference charts derived from these data. The correlation between heart weight and body weight has changed little, despite increases in body weight and body mass index. As life expectancy is increasing, we investigated the effect of age on heart weight and demonstrated a small increase in heart weight relative to body surface area for both genders, in contrast to a previous study.

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Is body surface area still the best way to determine pump flow rate during cardiopulmonary bypass?

Perfusion ◽

10.1191/0267659106pf865oa ◽

2006 ◽

Vol 21 (3) ◽

pp. 139-147 ◽

Cited By ~ 13

Author(s):

R Peter Alston ◽

Anna Anderson ◽

Keith Sanger

Keyword(s):

Body Mass Index ◽

Surface Area ◽

Body Surface Area ◽

Lean Body Mass ◽

Body Mass ◽

Flow Rate ◽

Body Surface ◽

Pump Flow ◽

Pump Flow Rate ◽

Mixed Venous

For over four decades, pump flow rate during cardio-pulmonary bypass (CPB) has been estimated using body surface area (BSA). As patients presenting for heart surgery are increasingly obese, this approach may no longer be appropriate and other estimates of systemic metabolism should be used, such as body mass index and lean body mass. Mixed venous oxygen saturation (SvO2) is a robust and independent estimate of the global efficacy of CPB. The aim of this study was to determine which factors, including body surface area, body mass index and lean body mass, best predict SvO2 during CPB. Forty-eight patients undergoing elective cardiac surgery requiring CPB were studied. Patients’ height, weight and skinfold thickness at four sites (biceps, triceps, subscapularis and suprailiac) were measured. Body surface area, lean body mass and body mass index were then calculated. Pump flow rate was maintained at 2.4 L/min/m2 during CPB as per standard unit protocol. Arterial and mixed venous blood samples were taken during the cooling, stable hypothermia and rewarming phases of CPB. Nasopharyngeal temperatures and flow rates were recorded contemporaneously. The blood samples were analysed for oxygen saturation, haemoglobin concentration and partial pressures of oxygen and carbon dioxide. The values of the three time points were meaned. All potential predictor variables were then univariately correlated with mixed venous oxygen saturation (SvO2). Those correlating significantly ( p < 0.1) were entered into a multivariate linear regression model. Nasopharyngeal temperature (β=0.615, p < 0.001) and lean body mass (β=0.256, p < 0.028) were the only significant predictors of SvO2 ( r2= 0.433, p < 0.001). Pump flow rates maintained at 2.4 L/min/m2 throughout CPB results in relative over-perfusion during hypothermia. Lean body mass may be a more sensitive estimate of systemic metabolism and, therefore, may provide a more accurate means of determining pump flow rate than body surface area in patients undergoing heart surgery.

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