Relationship between cobalt transporter II gene rs9606756 site mutant and serum homocysteine level and recurrent cerebral infarction in young and middle-aged people

Relevance. The success of treatment of periodontal diseases directly depends on the patient’s response to the therapy, therefore, the characteristics of the person’s personal characteristics can affect both the effectiveness of treatment and the prevention of relapse of the disease.Purpose. To study the features of the internal picture of the disease in the process of complex treatment of adult patients suffering from chronic generalized periodontitis.Materials and methods. The generally accepted comprehensive treatment of chronic generalized periodontitis in 69 middle-aged and elderly men was carried out taking into account the personal response of patients Solovyov «Psychosensory-anatomical-functional maladaptation syndrome».Results. When patients were discharged from the hospital, there was a difference in the phenomena of maladaptation among the elderly and middle-aged: in middle-aged people, sufficient adaptation to the conditions of existence was determined; in elderly people, due to the existing comorbid pathology, a state of maladaptation was diagnosed, which was caused by the presence of complaints of defects in the dentition.Conclusion. In elderly people, as soon as possible after completion of treatment in a hospital, dental rehabilitation cannot be considered completed, which requires the adoption of organizational measures for their timely provision of dentures.

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Association of Serum Homocysteine Level and Interstitial Lung Disease in Systemic Sclerosis: A Case-control Study

Current Rheumatology Reviews ◽

10.2174/1573397114666180628162907 ◽

2018 ◽

Vol 15 (1) ◽

pp. 74-78

Author(s):

Mohammadali Nazarinia ◽

Asghar Zare ◽

Mohammad javad Fallahi ◽

Mesbah Shams

Keyword(s):

Systemic Sclerosis ◽

Healthy Subjects ◽

Case Control Study ◽

Homocysteine Level ◽

Case Control ◽

Control Group ◽

Lung Involvement ◽

Serum Homocysteine ◽

The Mean ◽

Control Study

Background:Systemic sclerosis is a disorder of connective tissue with unknown cause, affecting the skin and internal organs, characterized by fibrotic changes.Objective:To determine the correlation between serum homocysteine level and interstitial lung involvement in systemic sclerosis. Materials and Methods: In this case – control study, 59 patients who fulfilled the ACR/EULAR classification criteria for systemic sclerosis and were referred to Hafez Hospital of Shiraz, Iran, were included as the case group. Fifty nine healthy subjects were involved as the control group. Patients were divided into two groups based on interstitial lung involvement and two subtypes, diffuse and limited type. Serum homocysteine, vitamin B12, and folate levels compared between the controls, and cases groups.Results:Of 59 case and control group, 53 (%89.8) were female and the mean age did not differ in both groups (P=0.929). Thirty five (%59.3) patients had interstitial lung involvement and 38(%64.4) had diffuse cutaneous systemic sclerosis. The mean serum homocysteine level was 13.9±6.3 µmol/L in the case and 13.7±9.2 µmol/L in the control group (P=0.86). The mean serum homocysteine level did not differ between the patients with and without interstitial lung involvement (P=0.52). The patients with lung involvement was older than those without lung involvement (P=0.004). Lung disease was more common in diffuse type (P=0.014).Conclusion:In our study, serum homocysteine level did not differ between the patients and healthy subjects. Also, there was no correlation between serum homocysteine level and lung involvement, but lung involvement was more common in older patients and also diffuse subtype.

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Spatio-temporal evolution and influencing mechanism of the COVID-19 epidemic in Shandong province, China

Scientific Reports ◽

10.1038/s41598-021-86188-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jinlong Shi ◽

Xing Gao ◽

Shuyan Xue ◽

Fengqing Li ◽

Qifan Nie ◽

...

Keyword(s):

Prevention And Control ◽

Temporal Evolution ◽

Geographical Location ◽

Shandong Province ◽

Control Measures ◽

Middle Aged ◽

Health Crisis ◽

Aged People ◽

Spatio Temporal ◽

And Control

AbstractThe novel coronavirus pneumonia (COVID-19) outbreak that emerged in late 2019 has posed a severe threat to human health and social and economic development, and thus has become a major public health crisis affecting the world. The spread of COVID-19 in population and regions is a typical geographical process, which is worth discussing from the geographical perspective. This paper focuses on Shandong province, which has a high incidence, though the first Chinese confirmed case was reported from Hubei province. Based on the data of reported confirmed cases and the detailed information of cases collected manually, we used text analysis, mathematical statistics and spatial analysis to reveal the demographic characteristics of confirmed cases and the spatio-temporal evolution process of the epidemic, and to explore the comprehensive mechanism of epidemic evolution and prevention and control. The results show that: (1) the incidence rate of COVID-19 in Shandong is 0.76/100,000. The majority of confirmed cases are old and middle-aged people who are infected by the intra-province diffusion, followed by young and middle-aged people who are infected outside the province. (2) Up to February 5, the number of daily confirmed cases shows a trend of “rapid increase before slowing down”, among which, the changes of age and gender are closely related to population migration, epidemic characteristics and intervention measures. (3) Affected by the regional economy and population, the spatial distribution of the confirmed cases is obviously unbalanced, with the cluster pattern of “high–low” and “low–high”. (4) The evolution of the migration pattern, affected by the geographical location of Wuhan and Chinese traditional culture, is dominated by “cross-provincial” and “intra-provincial” direct flow, and generally shows the trend of “southwest → northeast”. Finally, combined with the targeted countermeasures of “source-flow-sink”, the comprehensive mechanism of COVID-19 epidemic evolution and prevention and control in Shandong is revealed. External and internal prevention and control measures are also figured out.

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Anticholinergic Burden and Dry Mouth in Middle-Aged People

JDR Clinical & Translational Research ◽

10.1177/2380084419844511 ◽

2019 ◽

Vol 5 (1) ◽

pp. 62-70

Author(s):

A. Tiisanoja ◽

A.-M.H. Syrjälä ◽

A. Kullaa ◽

P. Ylöstalo

Keyword(s):

Regression Models ◽

Antihypertensive Drugs ◽

Salivary Flow ◽

Dry Mouth ◽

Subjective Feeling ◽

Oral Diseases ◽

Middle Aged ◽

Aged People ◽

Prophylactic Measures ◽

Anticholinergic Burden

Introduction:Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.Objectives:The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people.Methods:The study population included 1,345 people aged 46 y from the Northern Finland Birth Cohort 1966 (NFBC1966) study, who took part in a clinical medical and dental examination during 2012–2013. Medication data comprised both self-reported drug use and information obtained from the national register. Anticholinergic burden was measured using 10 different anticholinergic scales. Dry mouth was defined on the basis of having either a subjective feeling of dry mouth (xerostomia) or objectively measured low unstimulated or stimulated whole salivary flow rates (hyposalivation). Poisson regression models with robust error variance were used to estimate relative risk (RR). Regression models were adjusted for sex, smoking, diabetes, rheumatoid diseases, depressive symptoms, anxiety, total number of drugs, and antihypertensive drugs.Results:Approximately 14% of the participants reported having xerostomia and about 2% had hyposalivation. The RRs of different anticholinergic scales for xerostomia varied from 1.05 to 1.68. The scales’ RRs were between 0.89 and 2.03 for low unstimulated whole salivary flow (<0.1 mL/min) and between 0.59 and 1.80 for low stimulated whole salivary flow (<0.7 mL/min). Seven of 10 studied anticholinergic scales associated statistically significantly with dry mouth, either with xerostomia or hyposalivation.Conclusion:Most of the anticholinergic scales were associated with dry mouth, either with xerostomia or hyposalivation. There was considerable variation in the strength of the associations between anticholinergic scales and dry mouth.Knowledge Transfer Statement:The findings of this study suggest that dentists should take notice of the use of drugs with anticholinergic properties and their harmful effects among middle-aged people. Dentists should provide these patients with necessary guidance on how to cope with dry mouth and give them prophylactic measures against oral diseases associated with dry mouth.

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Evaluation of serum homocysteine level and its relation with carotid intima-media thickness in patients of chronic kidney disease

Medical Studies ◽

10.5114/ms.2017.72476 ◽

2017 ◽

Vol 33 (4) ◽

pp. 247-253 ◽

Cited By ~ 1

Author(s):

Deepak Jain ◽

Hari Krishan Aggarwal ◽

Shivraj Goyal ◽

Jyotsana Sen ◽

Shashi Seth

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Homocysteine Level ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

Serum Homocysteine

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Synergistic Effect of Serum Homocysteine and Diabetes Mellitus on Brain Alterations

Journal of Alzheimer s Disease ◽

10.3233/jad-210036 ◽

2021 ◽

pp. 1-9

Author(s):

Gihwan Byeon ◽

Min Soo Byun ◽

Dahyun Yi ◽

Jun Ho Lee ◽

So Yeon Jeon ◽

...

Keyword(s):

Diabetes Mellitus ◽

Older Adults ◽

Cognitive Decline ◽

Brain Atrophy ◽

Homocysteine Level ◽

Cognitive Impairments ◽

Interactive Effect ◽

Brain Mri ◽

Amyloid Β ◽

Serum Homocysteine

Background: Both elevated blood homocysteine and diabetes mellitus (DM) are related to cognitive impairments or dementia. A previous study also demonstrated that the association between homocysteine and cognitive decline was much stronger in individuals with DM than in those without DM. Objective: This study aimed to examine the interactive effect of blood homocysteine and DM on brain pathological changes including brain atrophy, amyloid-β and tau deposition, and small vessel disease (SVD) related to cognitive impairments. Methods: A total of 430 non-demented older adults underwent comprehensive clinical assessment, measurement of serum homocysteine level, [11C] Pittsburgh Compound B (PiB) PET, [18F] AV-1451 PET, and brain MRI. Results: The interactive effect of homocysteine with the presence of DM on brain atrophy, especially in aging-related brain regions, was significant. Higher homocysteine concentration was associated with more prominent brain atrophy in individuals with DM, but not in those without DM. In contrast, interaction effect of homocysteine and DM was found neither on Alzheimer’s disease (AD) pathologies, including amyloid-β and tau deposition, nor white matter hyperintensity volume as a measure of SVD. Conclusion: The present findings suggest that high blood homocysteine level and DM synergistically aggravate brain damage independently of AD and cerebrovascular disease. With regard to preventing dementia or cognitive decline in older adults, these results support the importance of strictly controlling blood glucose in individuals with hyperhomocysteinemia and lowering blood homocysteine level in those with DM.

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Health-improving systems and structure of health-improving and rehabilitation classes with the aim of correcting the state of the musculoskeletal system in middle-aged people

10.54092/9781678026479_22 ◽

2021 ◽

Author(s):

Alina Vasilievna Petrova

Keyword(s):

Musculoskeletal System ◽

The State ◽

Middle Aged ◽

Aged People

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信仰與斷裂——山中村祭祀圈的變遷與村民的奉祀理解

新世紀宗教研究 ◽

10.53106/168437382021061901004 ◽

2021 ◽

Vol 19 (1) ◽

pp. 083-114

Author(s):

楊國柱楊國柱 ◽

吳金奇 Yang, Kuo-Chu

Keyword(s):

Local Community ◽

Health And Safety ◽

Belief System ◽

The Elderly ◽

Middle Aged ◽

Aged People ◽

Mountain Village ◽

Field Investigations ◽

Meaning Interpretation ◽

The Village

嘉義縣民雄鄉山中村1（舊稱牛斗山或牛稠山），因牛稠溪域流經村莊而得此名，早期是全鄉人口最大村。山中村宗教信仰普遍為民間信仰，村莊主廟為廣濟宮，以奉祀池府王爺、媽祖、鄭成功為主，但村莊發展及信仰主體係圍繞池府王爺。本文採用文獻分析、田野調查及立意取樣後進行深度訪談，以探討山中村祭祀圈之形成，以及村民如何理解不同神靈之內涵，進而有助於山中村之社區發展與文化資源保存。 藉由祭祀圈概念切入，以理解山中村社區各神靈祭祀圈的範圍與分布，進而探討地方社區信仰中心發展，與山中村民對不同神靈認知及意義之解讀。經研究發現：（一）隨著人口增加及集居地擴大，主廟的祭祀圈變大；由於廟務活動增加，牛斗山土地公廟的祭祀圈擴大；五營中的東、西兩營，未隨著社區的新增而往外遷移，因此祭祀圈無明顯變化。（二）山中村神靈祭祀圈的分布，「五營」與居民輪祀居住的地理範圍有關，原具有分群概念的輪祀傳統逐漸模糊：老者對此模糊；中年人認知些許；青年則不明白為何奉祀，宗教信仰傳承出現斷層的可能。（三）山中村民對不同祭祀圈神靈解讀有所異同，普遍難闡述神靈的由來及背景，較理解者屬老年人；其次為中年人；青年人則對神靈認知不清楚。（四）不同祭祀圈神靈意義與山中村民早期生活環境較有其關聯性，老年人多數提及身體健康及平安；中年人求財運、事業；青年人求課業順利。據此，就結論提出建議以供參考。  Shanzhong Village (formerly known as Niudou Mountain or Niuhou Mountain) in Minxiong Township, Chiayi County, got its name because the Niuhou Stream passed through the village. In the early days, it was the village with the largest population in the township. For the Guangji Palace, it is mainly dedicated to the worship of Lord Chifu, Mazu and Zheng Chenggong (Cheng Ch’eng-Kung), but the village development and belief system surrounds Lord Chifu. This paper uses literature analysis, field investigations, and intentional sampling to conduct in-depth interviews to discuss the formation of the mountain village sacrificial circle and how the villagers understand the connotation of different gods, which can help the community development and cultural resource preservation of the mountain village. Through research, the concept of the religious field was cut in to understand the scope and distribution of the religious fields of the various deities in the Shanzhong Village community, and to discuss the development of local community faith centers and the understanding and meaning interpretation of the different deities of the Shanzhong villagers. The research found: (1) The religious realms become bigger because the population of village was increased；on the other side, Shanshang Viallage’s religious realms become wilder due to the increase of temple actives. However, for the "five camps", the east and west side of the deities’s emissary did not extend so the Religious Realms can not protect the new village, (2) The distribution of the spiritual field in the Shanzhong village, the ""five camps"" are more closely related to the geographical scope of the residents’ rotation worship. The tradition of rotation worship with the concept of grouping is gradually blurring, and the old people are blurring; Understand why there is a possibility that there is a fault in the inheritance of religious beliefs; (3) Villagers in the mountains have different interpretations of deities in different religious fields, and it is generally difficult to understand the origin and background of deities, older than those who understand; older than middle-aged; more young Unrecognizable to the gods; (4) The significance of the gods in different religious fields is more related to the early life environment of the villagers in the mountains. The elderly have significant health and safety; the middle-aged people seek wealth and career; the young people seek smooth schooling .Then refer to the above research results to make research suggestions.

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