Specific cut-off for the 25-OH vitamin D levels to predict the highest Body Mass Index and fat mass: a sex-related analysis in obese patients

2020 ◽  
Vol 45 (3) ◽  
Author(s):  
Luigi Barrea ◽  
Annamaria Colao ◽  
Silvia Savastano ◽  
Giovanna Muscogiuri
2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Ghada Saad Abdelmotaleb ◽  
Ola Galal Behairy ◽  
Khalid Eid Abd El Azim ◽  
Dalia Mohamed Abd El-Hassib ◽  
Tasbeh Mohamed Hemeda

Abstract Background Beta-thalassemia major patients are at increased risk of complications including endocrinopathies and bone disease due to iron overload. So, this study aimed to assess the growth parameters, serum levels of 25-OH-vitamin D, calcium, and phosphorous in children with beta-thalassemia major. This was a case-control study that included 55 children with beta-thalassemia major compared with 30 sex- and age-matched healthy children that served as a control group. All enrolled children were subjected to full history taking, clinical examination including anthropometric measurements, and laboratory investigations including complete blood count, serum ferritin, levels of serum calcium, phosphorus, and 25-OH-vitamin D. Results Body mass index was statistically significantly lower in the thalassemic group (P < 0.001). It was observed that vitamin D levels were significantly lower in thalassemic patients than in controls (P value < .0001). The mean serum 25-OH-vitamin D levels were 19.84 ± 5.79 ng/ml and 44.98 ± 5.77 ng/ml, respectively; 22 cases (40%) had insufficient vitamin D, and 5 cases (9%) had deficient vitamin D. Regarding serum calcium and phosphorous, there was no significant difference between the thalassemic and control groups. Conclusion Children with beta-thalassemia major had low body mass index and metabolic abnormality in the form of lower serum levels of vitamin D that signify the importance of therapeutic interventions.


2011 ◽  
Vol 204 (1) ◽  
pp. S89
Author(s):  
Chloe Zera ◽  
Jennifer Stuart ◽  
Janet Rich-Edwards ◽  
Ellen Seely ◽  
Augusto Litonjua ◽  
...  

Author(s):  
Mahcube Çubukçu ◽  
Eda Türe ◽  
Bahadır Yazıcıoğlu ◽  
Erdinç Yavuz

Objective: In our study, we aimed to determine vitamin D levels among obese patients registered to Obesity Center and to investigate its relationship with body mass index (BMI). Methods: The study was conducted in the Obesity Center of Health Sciences University Samsun Training and Research Hospital. Records of 102 patients with BMI> 30 kg/m², 18 years of age and over, admitted to the obesity center between 01.12.2018 and 01.12.2019 were retrospectively analyzed. Serum 25-OH D level<20 ng/ml was accepted as severe insufficiency, 20-30 ng/ml insufficiency, >30 ng/ml proficiency. Mann-Whitney U, Pearson chi-squared and Spearman tests were used in the evaluation of the data. The data were evaluated by the SPSS 22.00 program. p<0.05 was considered significant. Results: A total of 102 patients participated. The mean age was 48.82±12.09 years. 62.75% of them were female. 24.51% of participants were class 1 obese, 32.35% of participants were class 2 obese, 43.14% of participants were class 3 obese. The prevalance of severe vitamin D insufficiency was 45.10% and insufficiency in 38.24% of the patients. The mean vitamin D levels of the patients registered to the Obesity Center was 13.26±7.74 ng/ml. The mean BMI was 35.26±4.28 kg/m². Serum 25-(OH)D levels were inversely related to BMI. There was a significant relationship between age and BMI (p=0.036). Conclusion: Vitamin D insufficiency is highly prevalent in obese patients registered to Obesity Center. Serum 25-(OH)D levels were inversely associated with BMI. Obese patients should be evaluated and followed for vitamin D insufficiency.


2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ana Paula dos Santos Rodrigues ◽  
Lorena Pereira Souza Rosa ◽  
Hugo Delleon da Silva ◽  
Elisângela de Paula Silveira-Lacerda ◽  
Erika Aparecida Silveira

Background. ThePPARG2Pro12Ala (rs1801282) andIL6-174G >C (rs1800795) have important function in body weight regulation and a potential role in obesity risk. We aimed to investigate the association betweenPPARG2Pro12Ala andIL6-174G >C variants and the genotypes interaction with body composition, metabolic markers, food consumption, and physical activity in severely obese patients.Methods. 150 severely obese patients (body mass index (BMI) ≥ 35 kg/m2) from Central Brazil were recruited. Body composition, metabolic parameters, physical activity, and dietary intake were measured. The genotype was determined by the qPCR TaqMan Assays System. Multiple linear regression and multiple logistic regression models were fitted adjusting for confounders.Results. Ala carriers of the Pro12Ala polymorphism had higher adiposity measures (BMI:p=0.031, and fat mass:p=0.049) and systolic blood pressure (p=0.026) compared to Pro homozygotes. We found no important associations between the -174G >C polymorphism and obesity phenotypes. When genotypes were combined, individuals with genotypes ProAla + AlaAla and GC + CC presented higher BMI (p=0.029) and higher polyunsaturated fatty acids (PUFAs) consumption (p=0.045) compared to the ones with genotypes ProPro and GG, and individuals carriers of thePPARG2Ala allele only (genotype ProAla + AlaAla and GG) had higher fat mass and systolic and diastolic blood pressure compared to the ones with genotypes ProPro and GG.Conclusions. Severely obese individuals carrying the Ala allele of thePPARG2Pro12Ala polymorphism had higher measures of adiposity and blood pressure, while no important associations were found for theIL6-174G >C polymorphism.


2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Maria Nikolova ◽  
Alexander Penkov

AbstractIntroduction:Obesity has been linked with vitamin D deficiency in a number of cross-sectional studies, reviews and meta-analyses. To assess the correlations of plasma 25(OH) vitamin D levels with indices of body composition examined by DXA with an emphasis on lean and bone mass as well as on indices such as android/gynoid fat, appendicular lean mass (ALM) and appendicular lean mass index (ALMI), fat-mass indexes (FMI), fat-free mass indexes (FFMI) and the ALM-to-BMI index.Materials and Methods:62 adult subjects consented to participate – 27 men (43.5 %) and 35 women (56.5 %). Their mean age was 45.3 ± 9.5 years. Fan-beam dual-energy X-ray (DXA) body composition analysis was performed on a Lunar Prodigy Pro bone densitometer with software version 12.30. Vitamin D was measured by electro-hemi-luminescent detection as 25(OH)D Total (ECLIA, Elecsys 2010 analyzer, Roche Diagnostics). Statistical analyses were done using the SPSS 23.0 statistical package.Results:The serum 25(OH)D level was correlated significantly only to the whole body bone mineral content, the appendicular lean mass index (ALMI) and the ALM-to-BMI index, underlining a predominant role for lean and fat-free mass. Vitamin D showed a very weak correlation to % Body Fat and the Fat Mass Index (FMI) in men only. Moreover, the multiple regression equation including the associated parameters could explain only 7 % of the variation in the serum 25(OH)D levels.Discussion:Our conclusion was, that there are differences in the associations of the vitamin D levels with the different body composition indices, but these associations are generally very weak and therefore – negligible.


2017 ◽  
Vol 140 (5) ◽  
pp. 1453-1456.e7 ◽  
Author(s):  
Hooman Mirzakhani ◽  
George O'Connor ◽  
Leonard B. Bacharier ◽  
Robert S. Zeiger ◽  
Michael X. Schatz ◽  
...  

Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. S2
Author(s):  
A.D. Polanco Jiménez ◽  
A. López Serrano ◽  
P. Latorre Año ◽  
A. Pascual Romero ◽  
M.J. Suárez Dávalos ◽  
...  

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