scholarly journals Angioleiomyoma of the Tongue- A Rare Peculiar Entity

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Garima Rawat
Keyword(s):  
Oral Cavity ◽  
Who Classification ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Histopathological Analysis ◽  
Mesenchymal Tumors ◽  
Lateral Border ◽  
Immunohistochemical Studies ◽  
Slow Growing ◽  
Who Classification 2016

Angioleiomyomas (ALs) are benign mesenchymal tumors which were considered to be of smooth muscle origin, until the latest WHO classification (2016) of soft tissue tumors, in which it was reclassified as a tumor of perivascular origin. The majority of ALs occurs in the uterus, gastrointestinal tract and skin; AL of the oral cavity is infrequent, and AL of the tongue is particularly rare. These usually appear as solitary, slow-growing masses and are seldom observed in oral cavity. Here, we present a case of a fifty four year old male with a lesion on the left lateral border of the tongue, clinically mimicking a neurofibroma/ schwannoma. In this article we highlight the importance of scrupulous and detailed histopathological analysis and differential immunohistochemical studies which are essential for the diagnosis of AL from other spindle cell lesions.

scholarly journals Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ammar Almaghrabi ◽  
Nizar Almaghrabi ◽  
Haneen Al-Maghrabi
Keyword(s):  
Glomus Tumor ◽  
Histopathological Analysis ◽  
Kidney Tumors ◽  
Mesenchymal Tumors ◽  
Unique Case ◽  
Glomus Tumors ◽  
Extensive Search ◽  
One Year ◽  
Immunohistochemical Studies ◽  
Histopathology Examination

Background. Glomus tumors are rare mesenchymal tumors originating from glomus bodies in the skin. Glomus tumors of the kidney are rare tumors and only a few cases have been reported in the medical literature. An extensive search revealed a very limited number of primary renal glomus tumors. Although most of these cases were benign in nature, including a case with uncertain diagnosis of malignant potential, two were malignant. Case Report. We present a unique case of a 57-year-old male patient with an incidentally discovered 2 cm left renal mass. Histopathology examination and immunohistochemical studies confirm the diagnosis of glomangioma (a form of glomus tumor). The patient was followed for one year after partial nephrectomy and showed a benign course without any evidence of local recurrence or metastasis. Conclusion. To the best of our knowledge, this is the 16th case of primary benign renal glomus tumors. Primary renal glomus tumors are rare and may mimic other mesenchymal renal neoplasms radiologically. Proper investigation (including histopathological analysis and immunohistochemical staining) of kidney tumors is essential to make the diagnosis of glomus tumors, which usually show a benign clinical course following resection.

scholarly journals Anterior Midline Glossotomy Approach for Large Schwannoma of the Tongue: Case Report

2018 ◽  
Vol 11 ◽  
pp. 117955061878693
Author(s):  
Johanna Diplan ◽  
Paola Cavallo ◽  
Seyla de los Santos
Keyword(s):  
Oral Cavity ◽  
Oral Language ◽  
Primary Closure ◽  
Complete Removal ◽  
Soft Tissue Tumors ◽  
Anterior Midline ◽  
Benign Soft Tissue Tumors ◽  
Progressive Growth ◽  
Slow Growing ◽  
Peripheral Nerve Neoplasms

Schwannoma corresponds to a benign neurogenic tumor, derived from neural crest cells. It accounts for approximately 5% of all benign soft tissue tumors. These are the most common cause of peripheral nerve neoplasms of the oral cavity and oropharynx representing 1%. Isolated or solitary neurofibromas of the oral cavity usually involve the tongue or the labial mucosa. They appear as soft, painless, slow-growing masses that are tender to depression or palpation. The case of a 40-year-old woman is studied because of the presence of painless swelling, slow, and progressive growth of the oral language. Complete removal of the lesion was performed and primary closure was performed. It had a satisfactory evolution, maintaining adequate sensory and sensory mobility and innervation.

scholarly journals The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 430
Author(s):  
Sasha Libbrecht ◽  
Jo Van Dorpe ◽  
David Creytens
Keyword(s):  
Soft Tissue ◽  
Spindle Cell ◽  
Adult Population ◽  
Suppressor Gene ◽  
Soft Tissue Tumors ◽  
Mesenchymal Tumors ◽  
Pleomorphic Liposarcoma ◽  
Molecular Features ◽  
Pleomorphic Lipoma ◽  
Older Adult Population

The classification of soft tissue tumors has evolved considerably in the last decade, largely due to advances in understanding the pathogenetic basis of many of these, sometimes rare, tumors. Deletion of Retinoblastoma 1 (RB1), a well-known tumor suppressor gene, has been implicated in the tumorigenesis of a particular group of soft tissue neoplasms. This group of so-called ”RB1-deleted soft tissue tumors” has been rapidly expanding in recent years, currently consisting of spindle cell/pleomorphic lipoma, atypical spindle cell/pleomorphic lipomatous tumor, pleomorphic liposarcoma, myofibroblastoma, cellular angiofibroma, and acral fibromyxoma. Most of these neoplasms, except pleomorphic liposarcoma, are considered benign entities and are mainly described in the older adult population. This article will review the currently known morphological, immunohistochemical, and molecular features of this heterogeneous group of mesenchymal tumors with an emphasis on differential diagnosis.

scholarly journals Primary Leiomyosarcoma of the Mandibular Alveolar Mucosa of a 12-Year-Old Child from Ethiopia: A Case Report

2017 ◽  
Vol 10 (1) ◽  
pp. 56-59 ◽  
Author(s):  
TewodrosTefera Kenea ◽  
BetelAbebe Kebede ◽  
FekaduMesele Gozjuze ◽  
Hagos Kiros ◽  
Frank Wilde
Keyword(s):  
Tumor Cells ◽  
Spindle Cell ◽  
Radical Resection ◽  
Immunohistochemical Examination ◽  
Mesenchymal Tumors ◽  
Radiographic Findings ◽  
Safety Margins ◽  
Neoplastic Lesions ◽  
Immunohistochemical Studies

Leiomyosarcomas (LMSs) are rare malignant mesenchymal tumors which show smooth-muscle differentiation. Most LMSs involving the oral tissues primarily affect the maxillary sinus, the maxillary or mandibular bone. We present a case of LMS of the mandibular alveolar mucosa, arising in a 12-year-old male child from Ethiopia. A malignant spindle cell-like neoplasm was diagnosed on clinical and radiographic findings as well as on incisional biopsy. The tumor was resected with wide margins. The following histopathologic examination with additional immunohistochemical studies secured the diagnosis LMS. Microscopically, the spindle-shaped tumor cells were arranged in an interlacing fascicular pattern and contained oval to elongated, blunt-ended (cigar-shaped) nuclei. The immunohistochemical examination showed immunoreactive tumor cells for vimentin, actin, desmin, and H-caldesmon, which is pathognomonic for LMS. Immunohistochemical studies are mandatory to differentiate the LMS from other similar spindle cell neoplastic lesions. Radical resection with safety margins and a lifelong periodic follow-up has to be recommended.

scholarly journals The lipomatosis of the parapharyngeal and retropharyngeal space: A case report

2015 ◽  
Vol 143 (7-8) ◽  
pp. 455-457 ◽  
Author(s):  
Klaudiusz Luczak ◽  
Karolina Dorobisz ◽  
Tomasz Krecicki ◽  
Dariusz Janczak ◽  
Mariusz Chabowski ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Sleep Apnea ◽  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Retropharyngeal Space ◽  
Respiratory Obstruction ◽  
Mesenchymal Tumors ◽  
Slow Growing ◽  
Progressive Dysphagia

Introduction. Lipomas are the most common benign mesenchymal tumors, which account for almost 50% of all soft-tissue tumors. Case Outline. The case of a 75-year-old patient with a slow growing lesion of para- and retropharyngeal space was reported. The patient was suffering from progressive dysphagia, respiratory obstruction and sleep apnea. Conclusion. An external surgical approach is the treatment of choice. Etiology, differential diagnosis and therapy of head and neck lipomas has been discussed.

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

scholarly journals FOXO1 gene involvement in a non-rhabdomyosarcomatous neoplasm

2021 ◽  
Author(s):  
Simon Haefliger ◽  
Muriel Genevay ◽  
Michel Bihl ◽  
Romina Marone ◽  
Daniel Baumhoer ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Soft Tissue ◽  
Genetic Heterogeneity ◽  
Gene Fusion ◽  
Fusion Gene ◽  
Soft Tissue Tumors ◽  
Gene Fusions ◽  
Mesenchymal Tumors ◽  
Myoepithelial Differentiation ◽  
Foxo1 Gene

AbstractMyoepithelial neoplasms of soft tissue are rare tumors with clinical, morphological, immunohistochemical, and genetic heterogeneity. The morphological spectrum of these tumors is broad, and the diagnosis often requires immunostaining to confirm myoepithelial differentiation. Rarely, tumors show a morphology that is typical for myoepithelial neoplasms, while the immunophenotype fails to confirm myoepithelial differentiation. For such lesions, the term “myoepithelioma-like” tumor was introduced. Recently, two cases of myoepithelioma-like tumors of the hands and one case of the foot were described with previously never reported OGT-FOXO gene fusions. Here, we report a 50-year-old woman, with a myoepithelial-like tumor localized in the soft tissue of the forearm and carrying a OGT-FOXO1 fusion gene. Our findings extend the spectrum of mesenchymal tumors involving members of the FOXO family of transcription factors and point to the existence of a family of soft tissue tumors that carry the gene fusion of the OGT-FOXO family.

scholarly journals Gastric Schwannoma: A Rare but Important Differential Diagnosis of a Gastric Submucosal Mass

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
William Yoon ◽  
Kari Paulson ◽  
Paul Mazzara ◽  
Sweety Nagori ◽  
Mohammed Barawi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Surgical Resection ◽  
Treatment Options ◽  
Partial Gastrectomy ◽  
Preoperative Imaging ◽  
Mesenchymal Tumors ◽  
Gastric Schwannoma ◽  
Gastric Mass ◽  
Submucosal Mass ◽  
Slow Growing

Schwannomas are generally slow growing asymptomatic neoplasms that rarely occur in the GI tract. However, if found, the most common site is the stomach. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and 60–70% of them occur in the stomach. Owing to their typical presentation as submucosal neoplasms, gastric schwannomas and GISTs appear grossly similar. Accordingly, the differential diagnosis for a gastric submucosal mass should include gastric schwannomas. Furthermore, GI schwannomas are benign neoplasms with excellent prognosis after surgical resection, whereas 10–30% of GISTs have malignant behavior. Hence, it is important to distinguish gastric schwannomas from GISTs to make an accurate diagnosis to optimally guide treatment options. Nevertheless, owing to the paucity of gastric schwannomas, the index of suspicion for this diagnosis is low. We report a rare case of gastric schwannoma in 53-year-old woman who underwent laparoscopic partial gastrectomy under the suspicion of a GIST preoperatively but confirmed to have a gastric schwannoma postoperatively. This case underscores the importance of including gastric schwannomas in the differential diagnosis when preoperative imaging studies reveal a submucosal, exophytic gastric mass. For a gastric schwannoma, complete margin negative surgical resection is the curative treatment of choice.

scholarly journals Rare extracranial localizations of the head and neck schwannomas

2010 ◽  
Vol 67 (7) ◽  
pp. 596-599
Author(s):  
Milan Jovanovic ◽  
Ljiljana Cvorovic ◽  
Rastislav Poljovka ◽  
Aleksandar Oroz ◽  
Ljubomir Pavicevic
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Soft Tissue Tumors ◽  
Autonomic Nerves ◽  
Head And Neck Region ◽  
Delay In Diagnosis ◽  
Benign Soft Tissue Tumors ◽  
Indispensable Tool ◽  
Slow Growing ◽  
Nerve Of Origin

Introduction. Schwannomas are tumors of neurogenic origin, that arise from Schwann cells which surround peripheral, cranial and autonomic nerves. Schwannomas account for only 5% of all benign soft tissue tumors, and 25-45% of extracranial schwannomas are present in the head and neck region. They are usually classified according to the nerve of origin and the site within the head and neck. Case report. We presented extremely rare extracranial localizations of schwannomas and discussed about diagnosis and management of these tumors. Conclusion. Schwannomas are slow-growing tumors and late symptoms appearance may cause a delay in diagnosis and treatment of patients with these tumors. An appropriate diagnostic protocol is indispensable tool in performing a differential diagnosis of malignant from benign lesions. Choice of surgical approach depends on schwannomas localization.

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