scholarly journals ТOPOGRAPHIC AND ANOTOMICAL FEATURES OF THERAPEUTIC TACTICS WITH DIFFERENT FORMS OF ACUTE PERITONITIS DEPENDING ON GENETICALLY DETERMINED DISORDERS OF IMMUNOLOGIC REACTIVITY

2016 ◽  
Vol 15 (2) ◽  
pp. 36-38
Author(s):  
I. Yu. Polianskyi ◽  
P. V. Moroz
Keyword(s):  
Immunologic Reactivity ◽  
Acute Peritonitis ◽  
Genetically Determined

scholarly journals Personalized approach to acute peritonitis treatment based on genetic studies

2019 ◽  
Vol 41 part 2 (2) ◽  
pp. 24-28
Author(s):  
I. Yu. Polianskyi ◽  
V. I. Moskaliuk
Keyword(s):  
Personalized Medicine ◽  
Genetic Research ◽  
Individual Characteristics ◽  
Treatment Results ◽  
Genetic Studies ◽  
Inflammatory Reactions ◽  
Acute Peritonitis ◽  
Choice Of Treatment ◽  
Personalized Approach ◽  
Genetically Determined

The research presents treatment results of patients with peritonitis by using the personalized medicine principles, which are based on the choice of diagnostic, treatment and preventive measures taking in to account genetic, physiological, biochemical and other features of the patient. Purpose of the study. The treatment results improvement of patients with peritonitis, the reduction of the complications frequency. Materials and methods. 226 patients with signs of acute peritonitis had complex examination with serum cytokines and serotonin levels determination and analysis of the polymorphic sites alleles of IL1ß (-511C / T) and 5-HTTLPR genes by polymerase chain reaction evaluated the treatment outcomes using the developed algorithms. The treatment results with the use of developed algorithms were evaluated. Results. The processes of peroxide oxidation, antioxidant protection, proteolysis, fibrinolytic activity and their role in systemic disorders of homeostasis are shown. The connection between the nature of inflammatory reactions, its distribution in the peritoneal cavity and variants of the IL1ß gene (-511C/T) was proved. The relationship between the character of intestinal motility disorders in the postoperative period and variants of the 5-HTTLPR gene, which regulates the serotoninergic mechanisms of intestinal contractility, is shown. The algorithms for personalized approach to the peritonitis diagnostics, prognosis of and choice of treatment tactics were developed on the basis of the identified genetically determined individual characteristics of the inflammatory process. Advanced stages of surgical intervention were developed. Conclusion. Prediction of the course of peritonitis and the development of various complications based on genetic research allows developing algorithms of personalized therapeutic tactics, significantly improving the results of its treatment. Keywords: peritonitis, genetic studies, IL1β (-511C/T), 5-HTTLPR, diagnostics and treatment algorithms, personalized medicine.

Ultrastructural alterations in the fetal mouse myocardium in response to genetic and environmental factors

1987 ◽  
Vol 45 ◽  
pp. 724-725
Author(s):  
K.C. Feng-Chen ◽  
F.B. Essien ◽  
K.J. Prestwidge ◽  
J.T. Cheng ◽  
C.L. Shen
Keyword(s):  
Fetal Heart ◽  
Perinatal Period ◽  
Primary Energy ◽  
Cardiac Contraction ◽  
Ultrastructural Changes ◽  
Fetal Mouse ◽  
The Subject ◽  
Physiological Adjustments ◽  
Genetic And Environmental Factors ◽  
Genetically Determined

The physiology of the fetal heart differs significantly from that of the mature post-natal organ: e.g., the metabolic supply for adult cardiac contraction relies mainly on fatty acids; whereas, the fetal heart uses carbohydrates as its primary energy source. Limited morphological descriptions of the developing myocardium have appeared. However, additional studies are required to elucidate the ultrastructural changes occuring in the perinatal period when enormous physiological adjustments are made. Although adult animals are most often used in toxocological and pathological analyses, it is also important to investigate fetal cardiac responsiveness to various agents. The vulnerability of the ultrastructure of the fetal mouse myocardium to genetic and environmental assault is the subject of this report. The genetically determined effect on the heart was observed in mouse embryos homozygous for the cab (cardiac abnormality) mutation discovered by Essien.

Persistence of the striatal hypertrophy at the symptomatic stage of genetically determined and idiopathic parkinsonism

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
K. Lasek ◽  
C. Klein ◽  
C. Gaser ◽  
J. Hagenah ◽  
C. Büchel ◽  
...  
Keyword(s):  
Idiopathic Parkinsonism ◽  
Genetically Determined

CLINICAL AND ENDOCRINOLOGICAL EVALUATION OF GENETICALLY DETERMINED DWARFISM

1973 ◽  
Vol 71 (4_Suppl) ◽  
pp. S100 ◽  
Author(s):  
D. Schönberg ◽  
J. R. Bierich
Keyword(s):  
Genetically Determined

A Case Of Prader-Willi Syndrome With Behavioural Disturbances: A Successful Multidisciplinary Management Approach

2020 ◽  
Vol 5 (1) ◽  
pp. 83
Author(s):  
Nor Jannah Nasution Raduan ◽  
Mohd Razali Salleh ◽  
Norharlina Bahar ◽  
Mohd Faiz Md Tahir ◽  
Najwa Hanim Md Rosli
Keyword(s):  
Neurodevelopmental Disorder ◽  
Pressure Control ◽  
Family Therapist ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Management Approach ◽  
Adolescent Psychiatrist ◽  
Prader Willi Syndrome ◽  
Obstructive Sleep ◽  
Genetically Determined

Prader-Willi Syndrome (PWS) is a genetically determined neurodevelopmental disorder occurring in 1 in 15,000 births. PWS is a rare case in Malaysia and a successful approach to its management has not been well reported here. We present a case of a 13-year-old boy with Prader-Willi Syndrome with prominent behavioural disturbances characterised by temper tantrums, compulsive food intake, stubbornness, stealing and impulsivity further complicated by underlying morbid obesity, poorly controlled type 2 diabetes mellitus, hypertension, dyslipidaemia, obstructive sleep apnoea syndrome and intellectual disability. Multidisciplinary approach involving child and adolescent psychiatrist, occupational therapist, counsellor, family therapist, endocrinologist and dietician has shown to improve the patient’s weight, glucose and blood pressure control and most importantly the behavioural disturbances.

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