New Laryngeal Functional Preservation Therapy for Advanced Laryngeal Cancer and Hypopharyngeal Cancer Using Superselective Intra-arterial Chemoradiotherapy

2013 ◽  
Vol 64 (2) ◽  
pp. 167-167
Author(s):  
J. Yokoyama
Keyword(s):  
Laryngeal Cancer ◽  
Hypopharyngeal Cancer ◽  
Functional Preservation

scholarly journals Organ and Functional Preservation Therapy of Selective Radiotherapy and Concomitant Intra-arterial Cisplatin for Patients with Locally Advanced Laryngeal Cancer

2019 ◽  
Vol 31 (02) ◽  
pp. 69-74
Author(s):  
Takeharu Ono ◽  
Norimitsu Tanaka ◽  
Takeichiro Aso ◽  
Shun-ichi Chitose ◽  
Mioko Fukahori ◽  
...  
Keyword(s):  
Laryngeal Cancer ◽  
Locally Advanced ◽  
Functional Preservation

Severe late dysphagia after multimodal treatment of stage III/IV laryngeal and hypopharyngeal cancer

2019 ◽  
Vol 50 (2) ◽  
pp. 185-192 ◽  
Author(s):  
Gene Huh ◽  
Soon-Hyun Ahn ◽  
Jun-Girl Suk ◽  
Min-Hyung Lee ◽  
Won Shik Kim ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Laryngeal Cancer ◽  
Multimodal Treatment ◽  
Concurrent Chemoradiotherapy ◽  
Primary Treatment ◽  
Hypopharyngeal Cancer ◽  
Stage Iii ◽  
Laryngeal Function ◽  
Significant Difference

Abstract Background Long-term side effects after radiotherapy for organ preservation ‘could deteriorate’ the laryngeal function. This study intended to identify the incidence of severe late dysphagia following the multimodal treatment for stage III/IV laryngeal and hypopharyngeal cancer ‘to evaluate the function of larynx’. Methods The medical records of patients successfully treated for laryngeal and hypopharyngeal cancer with a multimodal approach, including radiotherapy, were retrospectively analyzed. ‘Functional larynx was defined as tolerable oral diet without severe late dysphagia or tracheostoma’. Results The study included 99 patients with a median follow-up period of 72 months. ‘Tracheostomy during the follow-up period was required in only one patient due to aspiration pneumonia, and dysphagia is the main determinant for functional larynx’. The probability of maintaining functional larynx was 63% for 10 years, when the treatment was started with radiotherapy or concurrent chemoradiotherapy. In upfront surgery (operation first and adjuvant radiotherapy/concurrent chemoradiotherapy) group, 37% of patients required total laryngectomy as primary treatment and 43% of patients could maintain laryngeal function for 10 years. And severe late dysphagia in the latter group developed mainly after laryngeal preservation surgery. The patients aged ≥65 years showed significantly higher incidence of dysphagia. Severe late dysphagia was very rare in laryngeal cancer successfully cured with radiotherapy/concurrent chemoradiotherapy (1/25, 4%); however, it gradually increased over time in hypopharyngeal cancer patients showing a statistically significant difference from laryngeal cancer patients (P = 0.040). Conclusion Severe late dysphagia occurred in 19.2% of patients treated for laryngeal and hypopharyngeal cancers, regardless of whether treatment started with radiotherapy/concurrent chemoradiotherapy or surgery.

Thyroid Cancer Incidentally Found in Radical Surgery for Laryngeal/Hypopharyngeal Cancer

2009 ◽  
Vol 141 (3) ◽  
pp. 343-346 ◽  
Author(s):  
Chien Shih ◽  
Cheng-Ping Wang ◽  
Pei-Jen Lou ◽  
Ya-Ling Hu ◽  
Tsung-Lin Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Laryngeal Cancer ◽  
Radical Surgery ◽  
Thyroid Tissue ◽  
Case Series ◽  
Distant Metastases ◽  
Hypopharyngeal Cancer ◽  
Conservative Approach ◽  
Retrospective Case ◽  
One Year

OBJECTIVES: To report on four patients with thyroid cancer found in their specimen of laryngectomy for laryngeal/hypopharyngeal cancer. STUDY DESIGN: Retrospective case series. SETTING: Patients with laryngeal cancer and hypopharyngeal cancers treated at our institution between 1991 and 2005 were enrolled. SUBJECTS AND METHODS: There were 463 patients with laryngeal cancer and 219 patients with hypopharyngeal cancers under retrospective review. RESULTS: There were 254 patients with laryngeal caner and 130 patients with hypopharyngeal cancer receiving surgery. Thyroid cancer was observed in the resected thyroid gland in two cases of laryngeal cancer and in two cases of hypopharyngeal cancer. They received treatment only for their laryngeal/hypopharyngeal cancers. Two patients died of distant metastases from larynx/hypopharynx cancer within one year. The other two patients are currently alive without disease from either of the two types of cancer. CONCLUSIONS: It is rare to discover an unexpected simultaneous thyroid cancer confirmed postoperatively from thyroid tissue partially removed in laryngectomy. A conservative approach is suggested for such patients.

THE VALUE OF NARROW BAND IMAGING ENDOSCOPY IN DIAGNOSIS OF HYPOPHARYNGEAL AND LARYNGEAL CANCER AND FOLLOWING - UP POST TREATMENT

2018 ◽  
Vol 8 (6) ◽  
pp. 114-122
Author(s):  
Thong Le Chi ◽  
Thanh Dang ◽  
Nam Tran Phuong
Keyword(s):  
Laryngeal Cancer ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Hypopharyngeal Cancer ◽  
Post Treatment ◽  
Predominant Type ◽  
Mucosal Edema ◽  
Contrast Medium Injection ◽  
The Mean ◽  
Type V

Background: To evaluate the value of narrow band imaging (NBI) endosocopy in diagnosis of hypopharyngeal and laryngeal cancer and following – up post treatment. Material and methods: A total of 75 patients included 36 patients with hypopharyngeal cancer and 39 patients with laryngeal cancer who had diagnosed at Department of Otoloryngology – Hue Central Hospital from 5/2017 to 5/2018. A prospective cohort study was conducted. Results: The age group 51 - 60 years occurred most often, 33.3%, the mean age was 62.1 ± 13.4. The UICC stage III was 65.3%. Tumor was in ulcerlarative and infiltrate form (89.4%), edema and inflammation of magrin tumor (41.3%), invasive (58.7%). Intrapapillary capillary loops – IPCL - type V was predominant, type V-n was 46.7%. The tumor with IPCL type V-n had strong enhancement (51.3%) and moderate enhancement (44.4%) after contrast medium injection on CT scan. One month after treatment, there were 33.3% of tumor – free, 53.7% of mucosal edema and 13% tumor size-decreasing on NBI image. Conclusion: NBI endoscopy is an useful tool for diagnosing of hypopharyngeal and laryngeal cancer and following – up post treatment. Key words: narrow band imaging endoscopy, hypopharyngeal cancer, laryngeal cancer

scholarly journals Consumption of Minimally Processed Foods as Protective Factors in the Genesis of Squamous Cell Carcinoma of the Head and Neck in Brazil (P05-032-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Olívia Galvão-Podestá ◽  
Maria Curado ◽  
Stela Peres ◽  
Luciane Salaroli ◽  
Monica Cattafesta ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Laryngeal Cancer ◽  
Hypopharyngeal Cancer ◽  
International Agency ◽  
Processed Foods ◽  
Citrus Fruits ◽  
Minimally Processed ◽  
Collard Greens ◽  
Risk Of Cancer

Abstract Objectives The objective of this study was to evaluate the habit of consuming minimally processed foods and the risk of cancer of the mouth, larynx, oropharynx and hypopharynx in three Brazilian states. Methods A multicenter case-control study integrating InterCHANGE, which patients with cancer of the mouth, larynx, oropharynx and hypopharynx in Vitória, São Paulo and Goiânia states of Brazil. Was analyzed the sociodemographic characteristics, lifestyle and consumption of minimally processed. Results We evaluated 2584 subjects (847 cases and 1737 controls). The higher the consumption of minimally processed foods, the lower the risk of cancer of the oral cavity. The consumption of apples and pears on every day decreased the chance by 66% (OR 0.34, CI95% 0.17–0.71). Likewise, individuals who consumed citrus fruits reduced the risk by up to 66%. Consumption of fresh tomatoes every day decreased the chance of oral cavity cancer by 72% (OR 0.28, CI95% 0.14–0.56). Consumption of bananas every day (OR 0.23, CI95% 0.09–0.55) decreased the odds of oropharyngeal cancer by 77% compared to those who never eat them. The higher the consumption of apples and pears, the lower the chance of laryngeal cancer, and consumption on most days and every day decreased the chance by 74% (OR 0.26, CI95%0.10–0.66). Consumption of broccoli, cabbage, or collard greens daily decreased the chance of laryngeal cancer by 80% (CI95% 0.06–0.66). Consumption of broccoli, cabbage, or collard greens 1 to 2 times/week decreased the chance of having hypopharyngeal cancer by 69% (OR 0.31, CI95% 0.11–0.87). Likewise, carrot consumption decreased the odds of this tumor by 86% (OR 0.14, CI95% 0.04–0.44). Conclusions Even after multiple analyses with highly recognized risk factors for head and neck cancer, the consumption of minimally processed foods decreased the risk of developing this type of tumor, especially the consumption of apples and pears, citrus fruits, fresh tomatoes, bananas, broccoli, cabbage, collard greens, carrots and fresh fruits. Public promotion is essential to facilitate access to minimally processed foods to strengthen the environments that promote healthy behavior. Funding Sources International Agency for Research on Cancer (IARC). Supporting Tables, Images and/or Graphs

scholarly journals Blocking long noncoding RNA MALAT1 restrained the development of laryngeal and hypopharyngeal carcinoma

2019 ◽  
Vol 277 (2) ◽  
pp. 611-621 ◽  
Author(s):  
Enhong Xu ◽  
Xiaoben Liang ◽  
Zhenhua Ji ◽  
Shuwei Zhao ◽  
Li Li ◽  
...  
Keyword(s):  
Cell Line ◽  
Laryngeal Cancer ◽  
Carcinoma Cell ◽  
Hypopharyngeal Cancer ◽  
Carcinoma Cell Line ◽  
Hypopharyngeal Carcinoma ◽  
Down Regulation ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Abstract Purpose The long non-coding RNA MALAT1 is a predictive marker in several solid tumors with highly conserved sequences. However, the role of non-coding RNA in development of laryngeal or hypopharyngeal cancer remains unclear. Methods Tumor tissues and adjacent non-cancer tissues of 24 patients were collected. We detected the expression of MALAT1 in laryngeal cancer tissues and hypopharyngeal cancer tissues. Moreover, we developed a MALAT1 silencing model in human laryngeal tumor cells by transfecting MALAT1 small interfering RNA into human laryngeal carcinoma cell line Hep-2 and pharyngeal carcinoma cell line FaDu with Lipofectamine 2000 system. Cell cycle analysis, Cell Counting Kit-8 assay, Transwell assay, quantitative reverse transcription PCR, and wound-healing assays were performed to evaluate the impact of MALAT1 depletion on laryngeal or hypopharyngeal cancer cell’s growth, proliferation, apoptosis, invasion and migration. Results MALAT1 was significantly up-regulated in laryngeal and hypopharyngeal carcinoma cells. MALAT1 down-regulation induced the increased apoptosis of both cell lines and suppressed cells’ proliferation. Cells were arrested in G1/G2 phase and cells of S phase were significantly decreased. Down-regulation of MALAT1 expression can also inhibit the migration and invasion of laryngeal squamous cell carcinoma cell (Hep-2) and hypopharyngeal cancer cell (FaDu). Conclusion In summary, our deactivation model of MALAT1 disentangled the active function of it as a regulator of gene expression governing the hallmarks of laryngeal and hypopharyngeal cancer. Blocking this long non-coding RNA may restrain the development of laryngeal cancer.

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