scholarly journals Fetuin-A as a Marker of Insulin Resistance

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ganavi P Yamasandhi ◽  
Mala Dharmalingam
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Linear Regression Analysis ◽  
Predictive Biomarker ◽  
Multiple Linear Regression Analysis ◽  
P Value ◽  
Model Assessment ◽  
Fetuin A ◽  
Homeostatic Model Assessment ◽  
Relationship Of

Abstract Fetuin–A is a glycoprotein which helps in the regulation of metabolism. It is an early marker of insulin resistance (IR). The aim of this study was to evaluate the role of Fetuin–A as a predictive biomarker in cases of newly detected type 2 diabetes (NDD). The study involved 60 NDD and 60 Normal Healthy Controls (NHC). All the demographics and anthropological characteristics were noted. Fasting blood samples were drawn and various biochemical parameters were analyzed. The homeostatic model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) score was calculated. Chisquare, student T-test and Mann Whitney U tests were employed to associate and compare the mean and median between the NDD and NHC groups. Pearson's and Spearman’s correlation analysis were employed to examine the relationship of Fetuin–A levels with parametric and nonparametric variables. The independent predictors of Fetuin–A was determined by employing multiple forward linear regression. Fetuin–A was significantly high in NDD compared to NHC (1323 vs. 306.98 mcg/mL; p<0.001). Majority of NDD patients demonstrated IR based on the HOMA-IR (88.33% vs. 66.67%) and QUICKI score (96.67% vs. 85%). The multiple linear regression analysis showed that systolic blood pressure, age and QUICKI score were independently associated with Fetuin–A (p value <0.01). Fetuin–A may be used as a biomarker to detect NDD. Therefore, early detection of Fetuin–A levels in NDD gives an opportunity for suitable patient management.

scholarly journals Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Yong Chen ◽  
Haobin Huang ◽  
Xiaowei He ◽  
Weiwei Duan ◽  
Xuming Mo
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Linear Models ◽  
Fasting Glucose ◽  
Adult Population ◽  
Linear Regression Analysis ◽  
Cobalt Concentration ◽  
Model Assessment ◽  
Homeostatic Model Assessment ◽  
Cobalt Exposure

Abstract Background Little is known about the effects of environmental cobalt exposure on insulin resistance (IR) in the general adult population. We investigated the association between cobalt concentration and IR. Methods A total of 1281 subjects aged more than 20 years with complete blood cobalt data were identified from the National Health and Nutrition Examination Survey (NHANES) 2015–2016 cycle. Blood cobalt levels were analyzed for their association with IR among all populations and subgroups by sex. Regression coefficients and 95% confidence intervals (CIs) of blood cobalt concentrations in association with fasting glucose, insulin and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated using multivariate linear regression after adjusting for age, sex, ethnicity, alcohol consumption, body mass index, education level, and household income. A multivariate generalized linear regression analysis was further carried out to explore the association between cobalt exposure and IR. Results A negative association between blood cobalt concentration (coefficient = − 0.125, 95% CI − 0.234, − 0.015; P = 0.026) and HOMA-IR in female adults in the age- and sex-adjusted model was observed. However, no associations with HOMA-IR, fasting glucose, or insulin were found in the overall population. In the generalized linear models, participants with the lowest cobalt levels had a 2.74% (95% CI 0.04%, 5.50%) increase in HOMA-IR (P for trend = 0.031) compared with subjects with the highest cobalt levels. Restricted cubic spline regression suggested that a non-linear relationship may exist between blood cobalt and HOMA-IR. Conclusions These results provide epidemiological evidence that low levels of blood cobalt are negatively associated with HOMA-IR in female adults.

scholarly journals Association between the Time of Length since Smoking Cessation and Insulin Resistance in Asymptomatic Korean Male Ex-Smokers

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ko-Woon Kim ◽  
Sung-Goo Kang ◽  
Sang-Wook Song ◽  
Na-Rae Kim ◽  
Jun-Seung Rho ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Smoking Cessation ◽  
Regression Analysis ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Resistance Index ◽  
Significant Negative Correlation ◽  
Multiple Linear Regression Analysis ◽  
Model Assessment

Aim.Smoking is a major risk factor for diabetes mellitus, mainly due to decreased insulin secretion and increased insulin resistance. However, there has been little research on the effects of smoking cessation period on changes in insulin resistance. In this study, we investigated the relationships between the length of time since smoking cessation period and insulin resistance in asymptomatic Korean male ex-smokers.Methods.A total of 851 male adults were included in this study. We considered several factors that can affect insulin resistance, and through multiple linear regression analysis, we assessed the effect the length of time since smoking cessation on insulin resistance in ex-smokers. Insulin resistance was represented as the insulin resistance index estimated by homeostasis model assessment.Results. HOMA-IR values showed a statistically significant negative correlation with the length of time since smoking cessation (p=0.009) in ex-smokers. After performing multiple linear regression analysis using factors that could potentially influence insulin resistance, we found that waist circumference (p=0.026) and the length of time since smoking cessation (p=0.039) were independent predictors of HOMA-IR in asymptomatic male ex-smokers.Conclusion. The longer the smoking cessation period, the more the insulin resistance tended to decrease in asymptomatic Korean male ex-smokers.

scholarly journals PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jiayu Huang ◽  
Lin Liu ◽  
Chunyan Chen ◽  
Ying Gao
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary ◽  
Predictive Biomarker ◽  
Normal Weight ◽  
Inflammatory Factors ◽  
Low Grade ◽  
Model Assessment ◽  
Increased Risk ◽  
Homeostatic Model Assessment ◽  
Low Grade Inflammation

Abstract Background Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder, and its pathogenesis is still under debate. Trimethylamine-N-oxide (TMAO) is a small, organic compound generated by the gut microbiome with a hypothesized relation to insulin resistance (IR) and low-grade inflammation in PCOS. By comparing plasma TMAO levels in non-PCOS participants and PCOS patients without hyperandrogenism (HA), we aimed to determine whether plasma TMAO levels correlate with PCOS without HA and to analyze their relationship with low-grade inflammation and IR. Methods A total of 27 PCOS patients without HA and 23 non-PCOS participants were enrolled in this study and subdivided into “nonobese” and “obese” arms for each group. Levels of plasma TMAO were quantified, and basic clinical characteristics and plasma biomarkers of inflammation were assessed. Results First, plasma TMAO levels, insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) values were higher in PCOS patients without HA, especially in the obese subgroup. Second, the levels of the inflammatory factors interleukin (IL)-17A, IL-18 and interferon gamma (IFN-γ) were significantly increased in obese PCOS patients without HA. Third, plasma TMAO levels were associated with body mass index (BMI) in the normal-weight groups, and the obese groups had higher fasting plasma insulin (FINS) and HOMA-IR values. Finally, logistic regression showed that the plasma levels of TMAO and luteinizing hormone/follicle-stimulating hormone (LH/FSH) were independent predictors of PCOS and indicated an increased risk of PCOS. Conclusions Elevated plasma TMAO levels may be associated with the pathogenesis of PCOS without HA and correlated with increased systemic inflammation. Further studies are needed to determine the suitability of TMAO as a predictive biomarker and to identify possible therapies for PCOS.

Abstract 3595: Inverse Association of Adiponectin with Insulin Resistance is Attenuated with the Escalation of Insulin Resistance: a Possible Finding of Adiponectin Resistance

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Kunihiro Matsushita ◽  
Hiroshi Yatsuya ◽  
Koji Tamakoshi ◽  
Takashi Muramatsu ◽  
Hirotsugu Mitsuhashi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Linear Regression Analysis ◽  
Resistance Index ◽  
Multiple Linear Regression Analysis ◽  
Inverse Association ◽  
Insulin Resistant ◽  
Glucose And Lipid Metabolism ◽  
Adiponectin Resistance

Introduction: Adiponectin has been known to play an important role in the glucose and lipid metabolism, and thereby may be considered as a potential treatment target for diabetes mellitus or atherosclerotic diseases. Recently, some basic studies showed that adiponectin might not function in an insulin-resistant condition, a concept called “adiponectin resistance.” However, this concept has not been confirmed in human. Therefore, we assessed the hypothesis that the well-known inverse association between adiponectin and insulin resistance is weakened in the insulin-resistant state. Methods: We studied 2,316 middle-aged Japanese men without a medical history of cancer, cardiovascular disease, diabetes, hypertension, or dyslipidemia to determine whether or not the association between serum adiponectin levels and the insulin resistance index (HOMA-IR) differed according to insulin resistant states. Results: Mean age and body mass index of study subjects were 48±7 and 23±3, respectively. A multiple linear regression analysis revealed that log-adiponectin was inversely associated with log-HOMA-IR independently of covariates (β= − 0.235, P <0.001). Subsequently, we re-analyzed after dividing study subjects according to the tertile of HOMA-IR. As shown in the Table , the inverse association between adiponectin and HOMA-IR was considerably weakened with the escalation of insulin resistance. Specifically, adiponectin was almost positively associated with HOMA-IR in insulin-resistant subjects (β= 0.114, P =0.059). Interestingly, statistically significant associations of adiponectin with triglyceride and HDL-C were uniformly observed in all tertiles. Conclusion: The inverse association of adiponectin with insulin resistance weakened with the escalation of insulin resistance, suggesting the existence of “adiponectin resistance” in insulin-resistant individuals. This adiponectin resistance may be restricted in glucose metabolism. Table. Coefficients of adiponectin in multiple linear regression analyses with independent variables

scholarly journals PENGARUH LINGKUNGAN KERJA DAN KEPEMIMPINAN TERHADAP KEPUASAN KERJA KARYAWAN DI PT. LAHAN REZEKI KABUPATEN KUNINGAN

2021 ◽  
Vol 8 (2) ◽  
pp. 85
Author(s):  
Ariq Saeful Rochmaan Nurhidayat ◽  
Sandi Nasrudin Wibowo
Keyword(s):  
Job Satisfaction ◽  
Regression Analysis ◽  
Linear Regression ◽  
Work Environment ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Multiple Linear Regression Analysis ◽  
P Value ◽  
Employee Job Satisfaction ◽  
Saturated Sample

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh lingkungan kerja dan kepemimpinan terhadap kepuasan kerja karyawan di PT. Lahan Rezeki Kabupaten Kuningan. Populasi dalam penelitian ini adalah semua karyawan di PT. Lahan Rezeki. Teknik pengambilan sampel dalam penelitian ini menggunakan sampel jenuh. Sampel dalam penelitian ini sebanyak 55 orang responden. Metode dalam pengumpulan data ini menggunakan kuesioner, sedangkan metode dalam penelitian ini menggunakan analisis regresi linear berganda. Hasil penelitian ini menunjukan bahwa lingkungan kerja berpengaruh positif dan signifikan. Hal ini dibuktikan dengan nilai p-value (sig) < 0,05 yaitu 0,040 < 0,05 dan nilai thitung > ttabel yaitu 2,107 > 2,0057 sehingga dapat disimpulkan bahwa variabel berpengaruh positif dan signifikan terhadap kepuasan kerja karyawan. Kepemimpinan berpengaruh positif dan signifikan terhadap kepuasan kerja karyawan. Hal ini dibuktikan dengan nilai p-value (sig) < 0,05 yaitu 0,000 < 0,05 dan nilai thitung > ttabel yaitu 9,267 > 2,0057 sehingga dapat disimpulkan bahwa variabel berpengaruh positif dan signifikan terhadap kepuasan kerja karyawan. Lingkungan kerja dan kepemimpinan berprngaruh positif dan signifikan terhadap kepuasan kerja karyawan. Hal ini dibuktikan dengan nilai p-value (sig) < 0,05 yaitu 0,000 < 0,05 dan nilai fhitung > ftabel yaitu 44,565 > 3,28 sehingga dapat disimpulkan bahwa kedua variabel berpengaruh positif dan signifikan terhadap kepuasan kerja karyawan.. Kata-kata Kunci: lingkungan kerja; kepemimpinan; kepuasan kerja karyawan The Influence of Work Environment and Leadership on Employee Job Satisfaction at PT.Lahan Rezeki Kuningan Regency ABSTRACT This study aims to determine the effect of work environment and leadership on employee job satisfaction at PT.Lahan Rezeki Kuningan Regency. The population in this study were all employees at PT. Sustenance Land. The sampling technique in this study used a saturated sample. The sample in this study were 55 respondents. The method in collecting this data uses a questionnaire, while the method in this study uses multiple linear regression analysis. The results of this study indicate that the work environment has a positive and significant effect. This is evidenced by the value of p-value (sig) <0.05, namely 0.040 <0.05 and the value of tcount > ttable which is 2.107> 2.0057 so it can be concluded that the variable has a positive and significant effect on employee job satisfaction. Leadership has a positive and significant effect on employee job satisfaction. This is evidenced by the value of p-value (sig) <0.05, namely 0.000 <0.05 and the value of tcount > ttable which is 9.267> 2.0057 so it can be concluded that the variable has a positive and significant effect on employee job satisfaction. The work environment and leadership have a positive and significant impact on employee job satisfaction. This is evidenced by the value of p-value (sig) <0.05, namely 0.000 <0.05 and the value of fcount > ftable which is 44.565> 3.28, so it can be concluded that both variables have a positive and significant effect on employee job satisfaction.. Keywords: work environment ; leadership ; employee job satisfaction

scholarly journals Theory of Planned Behavior Application to ANC behavior for Early Detection of Pregnancy Risk in Public Health Center Saronggi, Sumenep Regency

2021 ◽  
Vol 5 (1) ◽  
pp. 195-202
Author(s):  
Siti Zainurrah ◽  
Katmini Katmini
Keyword(s):  
Linear Regression ◽  
Early Detection ◽  
Health Center ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Multiple Linear Regression Analysis ◽  
P Value ◽  
Pregnancy Risk ◽  
Cross Sectional

Antenatal care services are basic health services for pregnant women that must be carried out according to standards, namely at least 4 times during pregnancy. Each pregnancy can develop into problems or complications, so monitoring is necessary during pregnancy.The purpose of this study was to analyze the effect of attitudes and norms on ANC behavior for early detection of pregnancy risk at the Saronggi Health Center, Sumenep Regency. The design of this study is a quantitative observational study with a cross sectional approach with the focus of the research being directed at analyzing the influence of attitudes and norms on ANC behavior for early detection of pregnancy risk at the Saronggi Health Center, Sumenep Regency. The total population is 134 respondents and a sample of 100 respondents is taken using the Simple Random Sampling technique. Data analysis using Linear Regression test. The results showed thatalmost half of the respondents have attitudes in the moderate category, 46 respondents (46%). Most of the respondents have a norm in the sufficient category of 52 respondents (52%). Almost half of the respondents have behavior in the moderate category, as many as 48 respondents (48%).Based on the results of Multiple Linear Regression analysis shows that with a p-value of 0.000 <0.05 then H1 is accepted so it can be concluded that simultaneously there is the influence of attitudes and norms on ANC behavior for early detection of pregnancy risk at the Saronggi Health Center, Sumenep Regency with a magnitude of 86.9%. It is expected that respondents can carry out Integrated ANC regularly and follow all the treatment agendas that must be carried out during pregnancy in order to avoid the risk of pregnancy.

scholarly journals PENGARUH PERPUTARAN KAS DAN PEMBERIAN KREDIT PRODUKTIF TERHADAP PROFITABILITAS SERTA DAMPAKNYA TERHADAP NILAI PERUSAHAAN (STUDI KASUS PADA PT. BPR RAGA SURYA NUANSA PONOROGO)

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Dini Nurrahmawati ◽  
Titi Rapini ◽  
Edi Santoso
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Positive Impact ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Analysis Techniques ◽  
Cause And Effect ◽  
Company Value ◽  
Relationship Of ◽  
Positive Effect

The purpose of this study was to determine the effect of Cash Turnover and Earning Credit on Profitability and Impact on Company Value at PT. BPR RAGA SURYA NUANSA PONOROGO by using Multiple Linear Regression Analysis and Path Analysis techniques as a correlation of cause and effect relationships. Based on the results of the analysis and discussion described, it can be seen that 1). Cash velocity has a positive effect on the profitability of ROE and ROA. 2). Provision of Earning Loans has a positive effect on ROE and ROA profitability. 3). ROE and ROA profitability has a positive effect on Company Value. 4). Cash circulation and lending together have a positive effect on profitability. 5). The Cause and Effect Relationship of Cash Turnover and Earning Credit and Profitability to Company Value has a positive impact on the company.

scholarly journals Identification of neck circumference cut-off points for insulin resistance as a marker in adolescents

2021 ◽  
Vol 34 ◽  
Author(s):  
Ingrid Ribeiro da Cruz MELO ◽  
Márcia Ferreira Cândido de SOUZA ◽  
Íkaro Daniel de Carvalho BARRETO ◽  
Danielle Góes da SILVA ◽  
Ricardo Queiroz GURGEL
Keyword(s):  
Insulin Resistance ◽  
Linear Regression ◽  
Multiple Linear Regression ◽  
Characteristic Curve ◽  
Linear Regression Analysis ◽  
Neck Circumference ◽  
Model Assessment ◽  
Cardiovascular Risks ◽  
Homeostasis Model Assessment ◽  
Cross Sectional

ABSTRACT Objective To identify cut-off points of neck circumference measurement to predict insulin resistance in adolescents. Methods Cross-sectional analysis with data derived from the Study of Cardiovascular Risks in Adolescents, nationwide, multicenter, school-based survey. We evaluated 901 adolescents, aged 12 to 17, from public and private schools in two cities of Sergipe state in Brazil. We measured demographic, anthropometric, and biochemical data, and insulin resistance using Homeostasis Model Assessment-Insulin Resistance. We used multiple linear regression and logistic analysis to evaluate the association between dependent variables (biochemical) and independent variables (anthropometric) controlled by body mass index, age, gender, and Tanner’s stage. We used the Receiver operating characteristic curve to determine cut-off points of neck circumference that can identify insulin resistance. Results The multiple linear regression analysis showed a positive association between neck circumference measurement with fasting glycemia and glycated hemoglobin (p<0.001) and a negative association with insulin (p<0.024). Furthermore, in logistic regression, the measurement of neck circumference was the only anthropometric indicator positively correlated with homeostasis model assessment-insulin resistance. The cut-off points of neck circumference for predicting insulin resistance were: 30.55cm for female pubertal and 32.10cm for post-pubertal adolescents; 35.90cm for male pubertal adolescents and 36.65cm for post-pubertal adolescents. Conclusions The measurement of neck circumference is a simple, practical anthropometric indicator and can be used as a screening tool to identify insulin resistance in adolescents.

scholarly journals Plasma Periostin Levels Are Increased in Chinese Subjects with Obesity and Type 2 Diabetes and Are Positively Correlated with Glucose and Lipid Parameters

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yuanyuan Luo ◽  
Hua Qu ◽  
Hang Wang ◽  
Huili Wei ◽  
Jing Wu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Plasma Glucose ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Multiple Linear Regression Analysis ◽  
Chinese Patients ◽  
Model Assessment ◽  
Related Factors

The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). Plasma periostin levels in the T2DM group were significantly higher than the NGT group (P<0.01). Patients with both OB and T2DM had the highest periostin levels. Correlation analysis showed that plasma periostin levels were positively correlated with weight, waist circumference (WC), body mass index (BMI), waist-hip ratio (WHR), fasting plasma glucose (FPG), 2 h postchallenge plasma glucose (2 h PG), glycated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), TNF-α, and IL-6 (P<0.05or 0.001) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.001). Multiple linear regression analysis showed that TG, TNF-α, and HOMA-IR were independent related factors in influencing the levels of plasma periostin (P<0.001). These results suggested that Chinese patients with obesity and T2DM had significantly higher plasma periostin levels. Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.

scholarly journals Analysis of Patient Operation Interest in Sumber Glagah Hospital, Mojokerto Regency

2021 ◽  
Vol 5 (1) ◽  
pp. 85-95
Author(s):  
Mohamad Rofi'in ◽  
Sentot Imam Suprapto
Keyword(s):  
Linear Regression ◽  
Service Quality ◽  
Linear Regression Analysis ◽  
Sampling Technique ◽  
Multiple Linear Regression Analysis ◽  
Point Of View ◽  
P Value ◽  
Cross Sectional ◽  
Type Of Surgery

A person's interest in services is related to the ability of the service provider to provide services. The purpose of this research is to analyze the influence of perception, service quality, anxiety and type of surgery on patient interest in performing surgery at Sumber Glagah Hospital, Mojokerto Regency. The design of this study is a quantitative analytic study with a cross sectional approach with the focus of the research being aimed at analyzingthe influence of perception, service quality, anxiety and type of surgery on patient interest in performing surgery at Sumber Glagah Hospital, Mojokerto Regency with a population of a number 143 respondents and a sample of 105 respondents who were taken using purposive sampling technique. Data analysis using Linear Regression test.The findings found that Most of the respondents had the perception of a sufficient category as many as 65 respondents (61.9%). Most of the respondents had a sufficient service quality category as many as 66 respondents (62.9%). Most of the respondents had moderate anxiety as many as 61 respondents (58.1%). Most of the respondents had a selective category of operation as many as 92 respondents (87.6%).  Most of the respondents have a moderate interest category as many as 69 respondents (65.7%). Based on the results of the Multiple Linear Regression analysis, it shows that with a p-value of 0.000 <0.05, H1 is accepted so it can be concluded that simultaneously there isinfluence perception, quality of service, anxiety and type of surgery on patient interest in performing surgery at Sumber Glagah Hospital, Mojokerto Regency with a magnitude of influence 70.4%. Basically, a person's interest can be influenced by various factors ranging from the patient's point of view, the quality of existing services and even the patient's level of anxiety.

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