Optimal design for population pk/pd models

Sergei Leonov; Alexander Aliev

doi:10.2478/v10127-012-0012-1

Optimal design for population pk/pd models

Tatra Mountains Mathematical Publications ◽

10.2478/v10127-012-0012-1 ◽

2012 ◽

Vol 51 (1) ◽

pp. 115-130

Author(s):

Sergei Leonov ◽

Alexander Aliev

Keyword(s):

Optimal Design ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Optimal Sampling ◽

Design Algorithm ◽

Sampling Schemes ◽

Population Pk ◽

Different Types

ABSTRACT We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

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Optimal design of experiments for optimization-based model calibration using Fisher information matrix

Reliability Engineering & System Safety ◽

10.1016/j.ress.2021.107968 ◽

2021 ◽

pp. 107968

Author(s):

Yongsu Jung ◽

Ikjin Lee

Keyword(s):

Optimal Design ◽

Design Of Experiments ◽

Fisher Information ◽

Model Calibration ◽

Fisher Information Matrix ◽

Information Matrix ◽

Optimal Design Of Experiments

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Population Fisher information matrix and optimal design of discrete data responses in population pharmacodynamic experiments

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-011-9203-7 ◽

2011 ◽

Vol 38 (4) ◽

pp. 449-469 ◽

Cited By ~ 10

Author(s):

Kayode Ogungbenro ◽

Leon Aarons

Keyword(s):

Optimal Design ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Discrete Data

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The effect of Fisher information matrix approximation methods in population optimal design calculations

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-016-9499-4 ◽

2016 ◽

Vol 43 (6) ◽

pp. 609-619 ◽

Cited By ~ 3

Author(s):

Eric A. Strömberg ◽

Joakim Nyberg ◽

Andrew C. Hooker

Keyword(s):

Optimal Design ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Approximation Methods ◽

Matrix Approximation ◽

Design Calculations ◽

Population Optimal Design

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Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics

Statistics in Medicine ◽

10.1002/sim.1041 ◽

2002 ◽

Vol 21 (18) ◽

pp. 2623-2639 ◽

Cited By ~ 57

Author(s):

Sylvie Retout ◽

France Mentré ◽

René Bruno

Keyword(s):

Optimal Design ◽

Population Pharmacokinetics ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Mixed Effects ◽

Mixed Effects Models ◽

Linear Mixed Effects Models ◽

Linear Mixed Effects ◽

Non Linear

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Sequential Model-Based A-Optimal Design of Experiments When the Fisher Information Matrix Is Noninvertible

Industrial & Engineering Chemistry Research ◽

10.1021/acs.iecr.8b03047 ◽

2018 ◽

Vol 58 (3) ◽

pp. 1244-1261 ◽

Cited By ~ 5

Author(s):

Ali Shahmohammadi ◽

Kimberley B. McAuley

Keyword(s):

Optimal Design ◽

Design Of Experiments ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Sequential Model ◽

Optimal Design Of Experiments ◽

Model Based

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Optimal Design of Moving Short Base-Lines Based on Fisher Information Matrix

2014 Fourth International Conference on Instrumentation and Measurement, Computer, Communication and Control ◽

10.1109/imccc.2014.12 ◽

2014 ◽

Cited By ~ 1

Author(s):

Zhigang Shang ◽

Xiaochuan Ma ◽

Tieli Li ◽

Jincheng Lin

Keyword(s):

Optimal Design ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix

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Approximation of the Fisher Information Matrix for Nonlinear Mixed Effects Models in Population PK/PD Studies

Contributions to Statistics - mODa 10 – Advances in Model-Oriented Design and Analysis ◽

10.1007/978-3-319-00218-7_17 ◽

2013 ◽

pp. 145-152

Author(s):

Sergei Leonov ◽

Alexander Aliev

Keyword(s):

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Mixed Effects ◽

Mixed Effects Models ◽

Nonlinear Mixed Effects ◽

Nonlinear Mixed Effects Models ◽

Population Pk

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Quantum Fisher Information Matrix in Critical System with Topological Characterization

International Journal of Theoretical Physics ◽

10.1007/s10773-021-04847-4 ◽

2021 ◽

Author(s):

M. Chen ◽

B. W. Wang ◽

W. W. Cheng

Keyword(s):

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Quantum Fisher Information ◽

Critical System ◽

Topological Characterization

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Improved Monte Carlo Estimation of the Fisher Information Matrix with Independent Perturbations

2021 55th Annual Conference on Information Sciences and Systems (CISS) ◽

10.1109/ciss50987.2021.9400305 ◽

2021 ◽

Author(s):

Xuan Wu ◽

James C. Spall

Keyword(s):

Monte Carlo ◽

Fisher Information ◽

Fisher Information Matrix ◽

Information Matrix ◽

Monte Carlo Estimation

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The Fisher Information Matrix for Log Linear Models Arguing Conditionally on Observed Explanatory Variables

Biometrika ◽

10.2307/2335606 ◽

1981 ◽

Vol 68 (2) ◽

pp. 563 ◽

Cited By ~ 1

Author(s):

Juni Palmgren

Keyword(s):

Fisher Information ◽

Fisher Information Matrix ◽

Linear Models ◽

Information Matrix ◽

Explanatory Variables ◽

Log Linear

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