scholarly journals Photodynamic reparative skin regeneration using application of photosensitizer gel based on chlorin e6

2021 ◽  
Vol 10 (3) ◽  
pp. 4-11
Author(s):  
O. S. Panova ◽  
V. V. Dubensky ◽  
V. V. Dubensky ◽  
V. V. Petunina ◽  
M. A. Beimanova ◽  
...  
Keyword(s):  
Clinical Effect ◽  
Clinical Effectiveness ◽  
Chlorin E6 ◽  
Optimal Time ◽  
Entire Surface ◽  
The Face ◽  
Local Reactions ◽  
Skin Moisture ◽  
Skin Phototype ◽  
Laser Radiation Wavelength

The results of a study of the clinical effectiveness of the correction of involutional changes in the skin by the method of photodynamic therapy (PDT) with the use of a photosensitizer gel (PS), the active substance of which is the trismeglumine salt of chlorin e6, are presented. The data of fluorescence spectroscopy for monitoring the level of PS fluorescence in order to determine the optimal time of its exposure are demonstrated. The study of the optimal exposure time involved 80 patients with different skin phototypes. The study of the effectiveness of PDT involved 42 patients aged 44–68 years with signs of chrono- and photoaging. The PDT procedure was performed by irradiating the entire surface treated with the PS with a power density of 100 mW/cm2, a light dose of 120–140 J/cm2, a laser radiation wavelength of 660 nm, and a light beam area of 400–800 cm2. It was found that exposure to PS for 10–20 min gives the highest fluorescence and does not depend on the skin phototype. The clinical effect of PDT was achieved in 85.7% of patients; there were no negative subjective sensations. Moisture metrics increased on the skin of the face by 53%, reaching the control values in young healthy volunteers, on the skin of the hands - by 64%. Elastometry indicators on the skin of the face and hands increased by 19% and 16%, respectively. Thus, the PDT procedure with PS based on chlorin e6 is an effective method for correcting involutional changes in the skin, leads to a pronounced clinical effect, improves the parameters of skin moisture measurement and elastometry, and passes without undesirable local reactions. Optical coherence tomography showed an increase in collagen ordering.

Hydrolytic enzymes in therapy of gestosis

2021 ◽  
Vol 50 (2) ◽  
pp. 76-79
Author(s):  
K. A. Gabelova
Keyword(s):  
Blood Pressure ◽  
Immune Complexes ◽  
Clinical Effect ◽  
Hydrolytic Enzymes ◽  
Clinical Effectiveness ◽  
The State ◽  
Complex Treatment ◽  
Traditional Therapy ◽  
Positive Clinical Effect

The clinical effectiveness o f complex enzymotherapy with preparation Vobenzim in treatment o f gestosis was studied in comparison with traditional therapy. The author analyzes the course оf gestation and delivery, and the state оf neonates in women with nephropathy o f I degree, who got common treatment (28 patients) and complex treatment including Vobenzim (17patients). Positive clinical effect o f complex enzymotherapy in case o f nephropathy is displayed in decreasing of edematic syndrome, eliminating or decreasing o f proteinuria, lowering o f blood pressure and impairment o f fetalhypoxia in labors. It goes along with the reduction o f immune complexes fixed in placenta.

TREATMENT OF AMENORRHOEA WITH MENOPAUSAL URINARY GONADOTROPHIN EVALUATED BY THIN-LAYER CHROMATOGRAPHIC DETERMINATION OF PREGNANEDIOL IN THE URINE

1966 ◽  
Vol 53 (4) ◽  
pp. 681-686
Author(s):  
Helge G. Berthelsen ◽  
H. O. Bang
Keyword(s):  
Thin Layer ◽  
Clinical Effect ◽  
Chromatographic Determination ◽  
Temperature Curve ◽  
Chorionic Gonadotrophin ◽  
Vaginal Examination ◽  
Abnormal Increase ◽  
Vaginal Cytology ◽  
Local Reactions

ABSTRACT Three young amenorrhoeic hypogonadal women, aged 19-24 years, all nulliparous, with a monophasic basal-temperature curve for at least 2 months, a low hypotrophic vaginal cytology, and a constantly low pregnanediol excretion were treated with an intramuscular injection of human menopausal urinary gonadotrophin (HMG) for ten days, followed by daily injections of chorionic gonadotrophin for four days. All the patients had previously been treated unsuccessfully with chorionic gonadotrophin. The clinical effect was checked by daily thin-layer-chromatographic determination of the pregnanediol excretion in the morning urine, vaginal cytology, and daily recording of the basal temperature. Vaginal examination was done every day. One patient exhibited enlargement of the ovaries during the treatment, but apart from that there were no side effects, in particular no abnormal increase in basal temperature and no local reactions in the treated patients. All the patients developed vaginal bleeding following an increase of the pregnanediol excretion. One woman conceived.

scholarly journals Bacteriophage use in the focus of hospital-acquired shigellosis

2017 ◽  
Vol 98 (6) ◽  
pp. 917-921
Author(s):  
E S Kurakin
Keyword(s):  
Infection Prevention ◽  
Clinical Effect ◽  
Shigella Flexneri ◽  
Clinical Effectiveness ◽  
Antibacterial Treatment ◽  
Clinical Recovery ◽  
Study Evaluation ◽  
Group 2 ◽  
Hospital Acquired ◽  
Group 1

Aim. Evaluation of epidemiologic effectiveness of polyvalent dysentery bacteriophage use for management of infection outbreak caused by Shigella flexneri. Methods. Investigation was performed in Tula psychoneurological hospital where the persistent focus of shigellosis was formed by Sh. flexneri 2a. As part of the study, evaluation of efficacy of antibacterial treatment (ciprofloxacin 250 mg per day for 7 days - group 1) was performed by evaluating duration of bacterial excretion in 18 patients with mild, 21 with moderate and 2 with severe Shigella infection. At the same time efficacy of Shigella bacteriophage (group 2) was assessed during treatment of 19 patients with mild and 17 with moderate form of the infection. Prevention of hospital-acquired shigellosis was provided for all patients in the departments where the infection was diagnosed. In this case bacteriophage was administered as following: first 5 days - 2 pills of bacteriophage 4 times a day, then 2 pills once a day during the whole period of hospitalization. This scheme was administered also to all patients newly admitted to the involved departments from day 1 of hospital stay. Results. Treatment with antibiotics led to fast and full recovery not in all cases. Insufficient clinical effect (persistence of disease signs and bacterial excretion for more than 7 days) in the treatment of mild, moderate and severe forms of Shigella infection was 16.7, 61.9 and 50.0%, respectively. High clinical effectiveness was noted in the treatment of patients with the use of Shigella bacteriophage. Ratio of insufficient clinical recovery from mild and moderate forms of the disease was 5.3 and 17.6%, respectively. In the course of anti-epidemiological measures aimed at localization and elimination of the focus, about 1000 patients were exposed to mentioned regimen of prevention. No patients had manifested infection or bacterial excretion registered. Conclusion. The study confirmed clinical and epidemiological effectiveness of polyvalent dysentery bacteriophage use for management of outbreak caused by Sh. flexneri 2a.

scholarly journals Photodynamic therapy for correction of involutive facial skin changes

2021 ◽  
Vol 19 (3) ◽  
pp. 140-144
Author(s):  
S. I. Surkichin ◽  
N. V. Bochkova ◽  
L. S. Kholupova
Keyword(s):  
Photodynamic Therapy ◽  
Light Exposure ◽  
Transepidermal Water Loss ◽  
Coherent Radiation ◽  
Chlorin E6 ◽  
Skin Changes ◽  
Self Confidence ◽  
Photodamaged Skin ◽  
The Face ◽  
Group 2

Background.The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy. Objective:the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure. Methods.The study involved patients aged 4060 years with signs of involutive changes in the skin of the face. In group 1 (n=36), patients underwent therapy using only light coherent radiation. In group 2 (n=35), patients underwent PDT using light coherent radiation. Results.According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group2, more positive indicators were obtained than in group1. When assessing safety, the results in groups 1 and2 are comparable. Conclusions.The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.

scholarly journals THE EFFECT OF ENTEROSORPTION AND INTRATISSULAR ELECTROFORESIS OF ANTIBACTERIAL DRUGS ON PROGRESS OF BURN DISEASE

2021 ◽  
pp. 117-121
Author(s):  
B. V. Petryuk ◽  
T. A. Petryuk ◽  
L. P. Khomko ◽  
O. Yо. Khomko ◽  
I. E. Semenyuk
Keyword(s):  
Electrical Conductivity ◽  
Blood Test ◽  
Thermal Damage ◽  
Clinical Effect ◽  
Clinical Effectiveness ◽  
Reparative Regeneration ◽  
Complex Treatment ◽  
Antibacterial Drugs ◽  
Average Mass ◽  
Burn Disease

Summary. The purpose of the research was to explore the appropriateness of combined usage of enterosorption amplification and intratissular electrophoresis (ITE) of antibiotics in injured with the substantial thermal burns. Clinical effect of the enterosorbtion and ITE antibacterial drugs in burn disease cases was studied in 26 patients with superficial and deep dermal burns (IIb-III deg.) from 27 to 60 % of their body surface. Enterosgel was prescribed from 3rd day after injury for 15–20 g 3–4 times a day for 7–14 days. ITE of antibiotics conducted from the 3–4 day by the «Поток-1» device, applying the direct current with density 0,03-0,05 mAh/cm2 for 60 min. Materials and methods. The authors studied the leukocyte reaction by a general blood test. The degree of intoxication was determined by the level of molecules of average mass and blood plasma electrical conductivity. They evaluated the dynamics of the wound process, conducted bacteriological and cytological researches of the burn wounds in dynamics on 1–3, 6–7, 13–14, and 19-21 days after traumatization. Results and discussion. This treatment tactic allows to reduce the level of endogenous intoxication, to optimize the course of the wound process in the area of thermal damage, to intensify demarcation-cleansing processes and reparative regeneration, which increases the clinical effectiveness of treatment. Conclusions. As a result of the research, it was found that the combined usage of enterosorption detoxification by enterosgel and ITE of antibacterial drugs in the complex treatment of victims with widespread burns is appropriate and justified.

scholarly journals FORMULASI SEDIAAN MASKER WAJAH MENGGUNAKAN EKSTRAK ETANOL BUNGA KECOMBRANG (ETLINGERA ELATIOR) TERHADAP KELEMBABAN KULIT WAJAH

2020 ◽  
Vol 2 (2) ◽  
pp. 63-68
Author(s):  
Chandra Pranata ◽  
Novidawati Boru Situmorang ◽  
Romauli Anna Teresia Marbun
Keyword(s):  
Natural Antioxidants ◽  
Facial Skin ◽  
Ginger Extract ◽  
Face Surface ◽  
Facial Mask ◽  
Flower Extract ◽  
Extract Concentration ◽  
The Face ◽  
Skin Moisture ◽  
Etlingera Elatior

ABSTRACT     Skin is an essential and vital organ and a reflection of health. Natural antioxidants such as flavonoids, polyphenols and Sapponin are believed to increase moisture on the skin. This ability is the main reason for using Torch Ginger flower extract which is formulated into a form of facial mask in the form of clay facial mask. Objective: To formulate facial moisturizing mask preparations using the extract of Torch Ginger(Etlingera elatior). This study used the Torch Ginger Flower extract facial moisturizing mask formulation method with a concentration of 0 (Blank), 5% and 10%. Evaluation of mask preparations included homogeneity, stability of dosage at temperatures of 80C and 250C, Organoleptic test and pH of preparations. Measurements of skin moisture activity were measured using alar Skin Analyzer which was tested on the face surface 3cm wide. The results showed that the preparation was stable in terms of odor, color and was at a pH of 4.2-6.3 using observations of litmus discoloration. Effectiveness of facial skin moisture with 10% Torch Ginger extract concentration is more effective to produce results at a concentration of 5% and blank. Conclusion: Torch Ginger flower extract can be formulated into preparations of face masks with various concentrations and has the effect of moisturizing the skin and brightening the complexion. Keywords: Torch Ginger Flower Extract, Facial Mask, Clay Facial Mask, Facial Skin Moisture

scholarly journals Selecting the most effective DBS contact in essential tremor patients based on individual tractography

2020 ◽  
Author(s):  
Jan Niklas Petry-Schmelzer ◽  
Till A. Dembek ◽  
Julia K. Steffen ◽  
Hannah Jergas ◽  
Haidar S. Dafsari ◽  
...  
Keyword(s):  
Essential Tremor ◽  
Clinical Effect ◽  
Diffusion Tensor ◽  
Clinical Effectiveness ◽  
Clinical Testing ◽  
Group Level ◽  
Linear Mixed Effects ◽  
Test Stimulation ◽  
The Individual ◽  
Deep Brain

AbstractPostoperative choice of the most effective DBS contact in patients with essential tremor (ET) so far relies on lengthy clinical testing. It has been shown that the postoperative effectiveness of DBS contacts depends on the distance to the dentatorubrothalamic tract (DRTT). Here, we investigated whether the most effective DBS contact could be determined from the stimulation overlap with the individual DRTT. Seven ET patients with bilateral thalamic deep brain stimulation were included retrospectively. Tremor control was assessed contact-wise during test stimulation with 2mA. The individual DRTTs were identified from diffusion tensor imaging. Contacts were ranked by their overlap of the test stimulation with the respective DRTT in relation to their clinical effectiveness. A linear mixed-effects model was calculated to determine the influence of the DRTT-overlap on tremor control. In 92.9 % of the cases, the contact with the best clinical effect was the contact with the highest or second-highest DRTT-overlap. On the group level, the DRTT-overlap explained 26.7% of the variance of the clinical outcome (p<0.001). To conclude, data suggest that the overlap with the DRTT based on individual tractography may serve as a marker to determine the most effective DBS contact in ET patients and reduce burdensome clinical testing in the future.

scholarly journals Intelligent software system for optimizing adaptive control of business planning processes

2020 ◽  
Vol 15 (89) ◽  
pp. 9-28
Author(s):  
Andrey F. Shorikov ◽  
◽  
Elena V. Butsenko ◽  
Keyword(s):  
Mathematical Modeling ◽  
Decision Making ◽  
Adaptive Control ◽  
Business Plan ◽  
Optimal Time ◽  
Software System ◽  
Business Planning ◽  
Intelligent Software ◽  
The Face ◽  
Planning Processes

The article describes the functionality developed by the authors of an intelligent software system for optimizing adaptive control of business planning processes in the face of uncertainty. The results are based on a new method for optimizing adaptive project management using network economic and mathematical modeling. Based on this method, a methodology has been developed for solving the problem of optimizing adaptive control of business planning processes, which in the proposed intelligent software decision support system uses a block containing an adaptive control optimization model. As the objective function (evaluation functional) in the method used, the value of the length of the time period for the execution of the business plan, which needs to be minimized, is considered. The method used allows you to create a class of acceptable strategies for adaptive control of the implementation process for the business plan in question. Within the framework of this class of strategies, an optimal adaptive control strategy for the implementation of business planning processes is formed, the optimal time for its implementation and the optimal schedule for implementing the business plan as a whole, and the corresponding optimal adaptive control strategies are calculated. Application of the proposed new method in an intelligent software system allows for feedback and optimal time for the implementation of the business project as a whole. The developed intelligent system is designed to automate the modeling of business planning processes and optimize adaptive decision-making control during their implementation on the basis of network economic and mathematical modeling, as well as methods and tools for developing intelligent soft systems. The created system takes into account the existing specific technical and economic conditions and information support. The results obtained in this work can serve as the basis for creating intelligent instrumental systems for supporting managerial decision-making in the implementation of business planning processes in the face of information uncertainty and risks.

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