Possibilities of preimplantation genetic screening (PGS) in overcoming the impact of age on assisted reproductive technologies (ART) results

Assisted reproductive technologies (ART) are the treatment of choice for some infertile couples and even though these procedures are generally considered safe, children conceived by ART have shown higher reported risks of some perinatal and postnatal complications such as low birth weight, preterm birth, and childhood cancer. In addition, the frequency of some congenital imprinting disorders, like Beckwith–Wiedemann Syndrome and Silver–Russell Syndrome, is higher than expected in the general population after ART. Experimental evidence from animal studies suggests that ART can induce stress in the embryo and influence gene expression and DNA methylation. Human epigenome studies have generally revealed an enrichment of alterations in imprinted regions in children conceived by ART, but no global methylation alterations. ART procedures occur simultaneously with the establishment and maintenance of imprinting during embryonic development, so this may underlie the apparent sensitivity of imprinted regions to ART. The impact in adulthood of imprinting alterations that occurred during early embryonic development is still unclear, but some experimental evidence in mice showed higher risk to obesity and cardiovascular disease after the restriction of some imprinted genes in early embryonic development. This supports the hypothesis that imprinting alterations in early development might induce epigenetic programming of metabolism and affect long-term health. Given the growing use of ART, it is important to determine the impact of ART in genomic imprinting and long-term health.

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The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases

Birth Defects Research ◽

10.1002/bdr2.1220 ◽

2018 ◽

Vol 110 (8) ◽

pp. 644-647

Author(s):

Shelby A. Neal ◽

Marie D. Werner

Keyword(s):

Genetic Screening ◽

Genetic Diseases ◽

Preimplantation Genetic Screening ◽

The Impact ◽

Screening And Diagnosis

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Reproductive fluids, used for the in vitro production of pig embryos, result in healthy offspring and avoid aberrant placental expression of PEG3 and LUM.

10.21203/rs.3.rs-42227/v2 ◽

2020 ◽

Author(s):

Evelynne Paris-Oller ◽

Sergio Navarro-Serna ◽

Cristina Soriano-Úbeda ◽

Jordana Sena Lopes ◽

Carmen Matas ◽

...

Keyword(s):

Reproductive Performance ◽

Assisted Reproductive Technologies ◽

Culture Media ◽

Reproductive Technologies ◽

In Vitro Production ◽

Aberrant Expression ◽

Low Efficiency ◽

The Impact

Abstract Background: In vitro embryo production (IVP) and embryo transfer (ET) are two very common assisted reproductive technologies (ART) in human and cattle. However, in pig, the combination of either procedures, or even their use separately, is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing ET in the long and contorted uterus of the sow. In addition, the potential impact of these two ART on the health of the offspring is unknown. We investigated here if the use of a modified IVP system, with natural reproductive fluids (RF) as supplements to the culture media, combined with a minimally invasive surgery to perform ET, affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular traits.Results: The blastocyst rates obtained by both in vitro systems, conventional (C-IVP) and modified (RF-IVP), were similar. Pregnancy and farrowing rates were also similar. However, when compared to in vivo control (artificial insemination, AI), litter sizes of both IVP groups were lower, while placental efficiency was higher in AI than in RF-IVP. Gene expression studies revealed aberrant expression levels for PEG3 and LUM in placental tissue for C-IVP group when compared to AI, but not for RF-IVP group.Conclusions: The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring.

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The impact of endometriosis on IVF: an evaluation using the society of assisted reproductive technologies (SART) database

Fertility and Sterility ◽

10.1016/j.fertnstert.2014.07.170 ◽

2014 ◽

Vol 102 (3) ◽

pp. e48-e49 ◽

Cited By ~ 2

Author(s):

S. Senapati ◽

M.D. Sammel ◽

S. Boudhar ◽

C.B. Morse ◽

K.T. Barnhart

Keyword(s):

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

The Impact

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The Impact of the Assisted Reproductive Technologies on Surgery of the Fallopian Tube

Seminars in Reproductive Medicine ◽

10.1055/s-2007-1021453 ◽

1990 ◽

Vol 8 (04) ◽

pp. 304-312 ◽

Cited By ~ 1

Author(s):

Randall Loy ◽

Alan DeCherney

Keyword(s):

Fallopian Tube ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

The Impact

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Diagnostic genetic screening for assisted reproductive technologies patients with macrozoospermia

Andrology ◽

10.1111/andr.12311 ◽

2017 ◽

Vol 5 (2) ◽

pp. 370-380 ◽

Cited By ~ 7

Author(s):

V. Carmignac ◽

J.-M. Dupont ◽

R. C. Fierro ◽

J. Barberet ◽

C. Bruno ◽

...

Keyword(s):

Genetic Screening ◽

Assisted Reproductive Technologies ◽

Reproductive Technologies

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Assisted reproductive technologies: psychoneurological, moral-ethical, and socio-cultural aspects

Neurology neuropsychiatry Psychosomatics ◽

10.14412/2074-2711-2020-5-104-110 ◽

2020 ◽

Vol 12 (5) ◽

pp. 104-110

Author(s):

N. A. Tyuvina ◽

A. O. Nikolaevskaya

Keyword(s):

Assisted Reproductive Technologies ◽

Reproductive Technologies ◽

Surrogate Mother ◽

Reproductive Process ◽

Vitro Fertilization ◽

Cultural Traditions ◽

Cultural Aspects ◽

The One ◽

The Impact

The paper provides a definition of sexual and reproductive health and infertility and also reflects modern ideas about ways to overcome infertility using assisted reproductive technologies, such as in vitro fertilization (IVF) and surrogacy. It shows the specificity of the impact of an IVF procedure on the mental health of a potential mother. The features of the neonatal health status, as well as neuropsychiatric disorders in babies born using the IVF procedure are described. The authors present two types of surrogacy (traditional and gestational ones) and the features of their use in different countries according to governmental legislative regulation, socioeconomic and religious factors, and cultural traditions in society. They unveil the features of a psychological relationship between the mother (surrogate and presumed one) and the fetus. The consequences of surrogacy for a surrogate mother, genetic parents, and a child himself/herself are noted to be little studied. It is shown that the development of assisted reproductive technologies (IVF and surrogacy), on the one hand, helps fight infertility and, on the other hand, entails a number of problems (moral and ethical, legal, cultural and religious, socioeconomic, and neuropsychiatric ones) that need to be solved in order to prevent psychological, neurological, and mental abnormalities in all the participants (a surrogate mother, an unborn child, and potential parents) in the assisted reproductive process:

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The Intersection of Reproductive, Work-Life Balance and Early-Education and Care Policies: ‘Solo’ Mothers by Choice in the UK and Spain

Social Sciences ◽

10.3390/socsci10120458 ◽

2021 ◽

Vol 10 (12) ◽

pp. 458

Author(s):

Ana Bravo-Moreno

Keyword(s):

Assisted Reproductive Technologies ◽

Early Education ◽

Reproductive Technologies ◽

Work Life ◽

Work Life Balance ◽

Life Balance ◽

Childhood Care ◽

Education And Care ◽

The Uk ◽

The Impact

This article focuses on women who have opted to be mothers on their own by choice in the UK and Spain, and how their access to assisted reproductive technologies in the National Health Service was affected because they were 35 years old or older, forcing them to go to private clinics for their treatment. Having given birth to their children, the participants face a second obstacle: the lack of policies that support work-life balance. A third obstacle also arises, in the form of a lack of childcare and early-education provision, particularly in the UK. The last two obstacles affect the whole population, but they are intensified in the case of solo-mother-families where the mother is responsible for simultaneously being the caregiver and the sole economic provider. Solo motherhood by choice highlights the impact of the absence of these policies, and the inequalities that result from current contemporary conceptualizations of family, woman and early-childhood-care and education. This article draws on ethnographic research that took place in the UK and Spain where I conducted 60 in-depth interviews and participant observations. The aim is to provide an analysis capable of capturing and confronting how inequalities affect women-mothers-workers and their children.

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