Putative role of Lateral Habenula projections to Dorsal Raphe Nucleus in encoding for depression-like behaviour and abnormal circadian rhythms.

2018 ◽  
Author(s):  
Dipesh Chaudhury ◽  
He Liu
Keyword(s):  
Circadian Rhythms ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Lateral Habenula ◽  
Putative Role ◽  
Dorsal Raphé

Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats

2019 ◽  
Vol 365 ◽  
pp. 178-184 ◽  
Author(s):  
Daniel Pereira Cavalcante ◽  
Larissa Córdova Turones ◽  
Gabriel Camargo-Silva ◽  
Joice Simões Santana ◽  
Diego Basile Colugnati ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Inhibitory Avoidance ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Escape Behaviors ◽  
Dorsal Raphé

scholarly journals The role of the dorsal raphe nucleus in the development, expression, and treatment of L-dopa-induced dyskinesia in hemiparkinsonian rats

Synapse ◽  
2009 ◽  
Vol 63 (7) ◽  
pp. 610-620 ◽  
Author(s):  
Karen L. Eskow ◽  
Kristin B. Dupre ◽  
Christopher J. Barnum ◽  
Sando O. Dickinson ◽  
John Y. Park ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Dorsal Raphé

Ethanol withdrawal induces anxiety-like effects: Role of nitric oxide synthase in the dorsal raphe nucleus of rats

Alcohol ◽  
2016 ◽  
Vol 52 ◽  
pp. 1-8 ◽  
Author(s):  
Natália Almeida Gonzaga ◽  
Melissa Resende Batistela ◽  
Diego Padovan ◽  
Bruno Spinosa de Martinis ◽  
Carlos Renato Tirapelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Ethanol Withdrawal ◽  
Oxide Synthase ◽  
Dorsal Raphé

Using loss- and gain-of-function approaches to target amygdala-projecting serotonergic neurons in the dorsal raphe nucleus that enhance anxiety-related and conditioned fear behaviors

2020 ◽  
Vol 34 (4) ◽  
pp. 400-411
Author(s):  
Cristian S Bernabe ◽  
Izabela F Caliman ◽  
William A Truitt ◽  
Andrei I Molosh ◽  
Christopher A Lowry ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Conditioned Fear ◽  
Critical Role ◽  
Brain Regions ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Selective Lesion ◽  
Anxious Behavior ◽  
Dorsal Raphé

Background: The central serotonergic system originating from the dorsal raphe nucleus (DR) plays a critical role in anxiety and trauma-related disorders such as posttraumatic stress disorder. Although many studies have investigated the role of serotonin (5-HT) within pro-fear brain regions such as the amygdala, the majority of these studies have utilized non-selective pharmacological approaches or poorly understood lesioning techniques which limit their interpretation. Aim: Here we investigated the role of amygdala-projecting 5-HT neurons in the DR in innate anxiety and conditioned fear behaviors. Methods: To achieve this goal, we utilized (1) selective lesion of 5-HT neurons projecting to the amygdala with saporin toxin conjugated to anti-serotonin transporter (SERT) injected into the amygdala, and (2) optogenetic excitation of amygdala-projecting DR cell bodies with a combination of a retrogradely transported canine adenovirus-expressing Cre-recombinase injected into the amygdala and a Cre-dependent-channelrhodopsin injected into the DR. Results: While saporin treatment lesioned both local amygdalar 5-HT fibers and neurons in the DR as well as reduced conditioned fear behavior, optical activation of amygdala-projecting DR neurons enhanced anxious behavior and conditioned fear response. Conclusion: Collectively, these studies support the hypothesis that amygdala-projecting 5-HT neurons in the DR represent an anxiety and fear-on network.

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