Alveolar soft part sarcoma from soft tissue and bone. A single reference hospital experience

2018 ◽  
Author(s):  
Ignacio Ruz-Caracuel ◽  
Itziar de La Peña Navarro
Keyword(s):  
Soft Tissue ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Hospital Experience ◽  
Reference Hospital

scholarly journals A case of multiple synchronously diagnosed brain metastases from alveolar soft part sarcoma without concurrent lung involvement

2021 ◽  
Vol 12 ◽  
pp. 111
Author(s):  
Mark A. Damante ◽  
Kristin M. Huntoon ◽  
Joshua D. Palmer ◽  
David A. Liebner ◽  
James Bradley Elder
Keyword(s):  
Soft Tissue ◽  
Brain Metastasis ◽  
Lung Metastasis ◽  
Soft Tissue Mass ◽  
Soft Part ◽  
Primary Lesion ◽  
Alveolar Soft Part Sarcoma ◽  
Lung Involvement ◽  
Tissue Mass ◽  
Intracranial Involvement

Background: Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a propensity for early hematogenous dissemination to the lungs and frequent brain metastasis. The development of lung metastasis almost invariably precedes intracranial involvement. There are no previously reported cases in which a patient was synchronously diagnosed with ASPS and multiple brain metastasis without lung involvement. Case Description: A 29-year-old gentleman was found to have three intracranial lesions following the onset of generalized seizures. Staging studies identified a soft-tissue mass in the left thigh and an adjacent femoral lesion. Biopsy of the soft-tissue mass was consistent with ASPS. The patient then underwent neoadjuvant stereotactic radiotherapy to all three brain lesions, followed by en bloc resection of the dominant lesion. The patient was then started on a programmed death-ligand 1 (PD-L1) inhibitor. Subsequent surgical resection of the primary lesion and femur metastasis demonstrates a histopathologic complete response of the bony metastasis and partial response of the primary lesion. At present, the patient has received 14 cycles of atezolizumab without recurrence of the primary or bony lesions and the irradiated intracranial disease has remained stable without recurrence of the resected dominant lesion. Conclusion: While intracranial involvement is relatively common in ASPS, a case with multiple, synchronously diagnosed brain metastasis without concurrent lung metastasis has not been described. The presented case discusses the safety and efficacy of aggressive management of intracranial disease in the setting of atezolizumab. Prospective evaluation of the efficacy of checkpoint inhibitors and the prognostic value of PD-L1 expression in ASPS with brain metastasis are necessary.

scholarly journals Alveolar Soft-Part Sarcoma in Olfactory Cleft: A Case Report and Clinicopathological Review

2020 ◽  
pp. 014556132095513
Author(s):  
Saud Alromaih ◽  
Saleh Alqaryan ◽  
Saleh Alabood ◽  
Somaya Alabaishi ◽  
Abdulrazag Ajlan ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Malignant Disease ◽  
Clinical Presentation ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma ◽  
Olfactory Cleft

Sinonasal alveolar soft-part sarcoma (ASPS) is a rare malignant disease that comprises 0.4% to 1.2% of all soft-tissue sarcomas. Alveolar soft-part sarcoma is usually difficult to diagnose because it has many clinical and pathological mimickers. In this case study, ASPS occurred in the olfactory cleft, representing the second case in this location in the literature. This article presents the clinical presentation, radiologic, and histopathological case, and reviews the literature regarding the differentials.

A phase II trial of axitinib plus pembrolizumab for patients with advanced alveolar soft part sarcoma (ASPS) and other soft tissue sarcomas (STS).

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 11547-11547 ◽  
Author(s):  
Breelyn A. Wilky ◽  
Matteo Maria Trucco ◽  
Despina Kolonias ◽  
Eric Wieder ◽  
Ty Subhawong ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Soft Part ◽  
Soft Tissue Sarcomas ◽  
Alveolar Soft Part Sarcoma

Alveolar soft-part sarcoma: can MRI help discriminating from other soft-tissue tumors? A study of the French sarcoma group

2018 ◽  
Vol 29 (6) ◽  
pp. 3170-3182 ◽  
Author(s):  
Amandine Crombé ◽  
Hervé J. Brisse ◽  
Pauline Ledoux ◽  
Leila Haddag-Miliani ◽  
Amine Bouhamama ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Part ◽  
Soft Tissue Tumors ◽  
Alveolar Soft Part Sarcoma

Alveolar soft-part sarcoma: a rare soft-tissue malignancy with distinctive clinical and radiological features

2001 ◽  
Vol 31 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Lai Man Pang ◽  
Derek J. Roebuck ◽  
James F. Griffith ◽  
Shekhar M. Kumta ◽  
Constantine Metreweli
Keyword(s):  
Soft Tissue ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Radiological Features

scholarly journals Lung Metastasis of Primary Alveolar Soft-Part Sarcoma Occurring 20 Years after Initial Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
R. F. Falkenstern-Ge ◽  
M. Kimmich ◽  
M. Wohlleber ◽  
A. Grabner ◽  
G. Friedel ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lung Metastasis ◽  
Lung Tumor ◽  
Lung Metastases ◽  
Soft Part ◽  
Lower Limbs ◽  
Alveolar Soft Part Sarcoma ◽  
Malignant Soft Tissue Tumor ◽  
Previously Treated ◽  
The Right

A 30-year old woman was referred to our center because of suspicion of a primary lung tumor of the right upper lobe. Histological examination of the lung lesion revealed lung metastasis of a previously treated alveolar soft part sarcoma of the musculus vastus medialis of the right femur, which was resected 20 years ago. Alveolar soft-part sarcoma is a rare malignant tumor that occurs most often in the soft tissue of lower limbs. It is a slow-growing malignant soft tissue tumor arising in muscle tissue, usually in young adults. Due to pleural and extensive mediastinal infiltration with bilateral lung metastases, a systemic treatment with chemotherapy doxorubicin and ifosfamide was initiated. Late metastases from previously treated alveolar part sarcoma should be considered in patients with suspicious lung lesions even if surgical treatment was performed a long time ago.

Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm

Cytopathology ◽  
2010 ◽  
Vol 22 (5) ◽  
pp. 318-322 ◽  
Author(s):  
S. Agarwal ◽  
R. Gupta ◽  
V. K. Iyer ◽  
S. R. Mathur ◽  
R. Ray
Keyword(s):  
Soft Tissue ◽  
Soft Part ◽  
Alveolar Soft Part Sarcoma ◽  
Soft Tissue Neoplasm
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