scholarly journals Effectiveness Of Siddha Formulations In Treating Breast Cancer: An Evidence-Based Case Series

2021 ◽  
Vol 12 (2) ◽  
pp. 1546-1551
Author(s):  
Shanmugasundaram Gouthaman ◽  
Roshni Saravanan ◽  
Jayaprakash Narayanan ◽  
Arputha Selvi A
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Adverse Effects ◽  
Case Series ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Natural Treatment ◽  
Anti Cancer ◽  
The World ◽  
Oncological Results

Breast cancer is one of the top-ranked cancers affecting women in the world. Although there are approved standard regimens for treatment, due to toxicological side effects, there is a demand for novel anti-cancer drugs with minimal adverse effects leading to the emergence of Indian Systems of Medicine. Natural treatment modalities such as Siddha, Ayurveda and Unani are emerging and have been given gaining importance in recent times. They have been in vogue for centuries together and have shown better prognosis over a period of time with lesser toxicity and admiring oncological results. The presentation is an evidence-based report on the cure of breast cancer using Siddha chemotherapeutic formulations.

Evidence-based approaches for the management of side-effects of adjuvant endocrine therapy in patients with breast cancer

2021 ◽  
Author(s):  
Maria Alice Franzoi ◽  
Elisa Agostinetto ◽  
Marta Perachino ◽  
Lucia Del Mastro ◽  
Evandro de Azambuja ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Endocrine Therapy ◽  
Adjuvant Endocrine Therapy ◽  
Evidence Based

scholarly journals Management of eight labor and delivery patients dependent on buprenorphine (Subutex™): A retrospective chart review

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 7 ◽  
Author(s):  
Solina Tith ◽  
Garinder Bining ◽  
Laurent A. Bollag
Keyword(s):  
Chart Review ◽  
Case Series ◽  
Retrospective Chart Review ◽  
The United States ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Labor And Delivery ◽  
Opioid Agonists ◽  
Opioid Administration ◽  
Evidence Based Guidelines

Background: Opioid use during pregnancy is a growing concern in the United States. Buprenorphine has been recommended by “The American College of Obstetrics and Gynecology” as an alternative to methadone to decrease risks associated with the use of illicit opioids during pregnancy. The partial μ-opioid agonists’ unique pharmacology, including its long half time and high affinity to the μ-opioid receptor, complicates patient management in a highly kinetic, and often urgent field like obstetric anesthesia. We reviewed our management and outcomes in this medically complex population. Methods: An Institutional Review Board (IRB) approved retrospective chart review was conducted of women admitted to the University of Washington Medical Center Labor and Delivery unit from July 2012 to November 2013 using buprenorphine. All deliveries, including intrauterine fetal demise, were included. Results: Eight women were admitted during this period to our L&D floor on buprenorphine. All required peri-partum anesthetic management either for labor and/or cesarean delivery management. Analgesic management included dilaudid or fentanyl PCA and/or continued epidural infusion, and in one instance ketamine infusion, while the pre-admission buprenorphine regimen was continued. Five babies were viable, two women experienced intrauterine fetal death at 22 and 36 weeks gestational age (GSA), respectively, and one neonate died shortly after delivery due to a congenital diaphragmatic hernia. Conclusions: This case series illuminates the medical complexity of parturients using buprenorphine. Different treatment modalities in the absence of evidence-based guidelines included additional opioid administration and continued epidural analgesia. The management of post-cesarean pain in patients on partial μ-opioid agonists remains complex and variable, and evidence-based guidelines could be useful for clinicians to direct care.

scholarly journals The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer

2019 ◽  
Vol 21 (3) ◽  
pp. 336
Author(s):  
Iulian Goidescu ◽  
Georgiana Nemeti ◽  
Gabriela Caracostea ◽  
Dan Tudor Eniu ◽  
Angelica Chiorean ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Adverse Effects ◽  
Imaging Techniques ◽  
Diagnostic Techniques ◽  
Imaging Diagnosis ◽  
The Postponement ◽  
Therapeutic Possibilities ◽  
In Pregnancy

Breast cancer diagnosed during pregnancy is at increasing incidence due to the increased frequency of obesity, the postponement of the first pregnancy to later decades of life and the advances of diagnostic techniques. Clinical and imaging diagnosis is difficult during gestation due to adaptive changes of the maternal organism , the mammary glads in particular. Furthermore, the therapeutic approach is limited both by the possible side effects on the fetus and by the skepticism of the couple over these therapeutic regimens.The present paper aims to review the main diagnostic steps to confirm pregnancy associated breast cancer, as well as the therapeutic possibilities during this period, related to the potential adverse effects concerning pregnancy

scholarly journals COVID-19 Vaccines in Pakistan: Efficacy, Adverse Effects and Availability

2021 ◽  
Vol 10 (2) ◽  
pp. 125-130
Author(s):  
Soma Siddique ◽  
Shaheer Ahmed
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
Adverse Effects ◽  
Mode Of Action ◽  
Public Awareness ◽  
Grey Literature ◽  
Large Population ◽  
Review Article ◽  
Pain On Injection ◽  
The World

In this review article, we aim to document the efficacy, adverse effects, mode of action, required doses, and availability of the major vaccines available in Pakistan till 20 May 2021. We reviewed all available literature on COVID-19 vaccines in PubMed and Google scholar. We also reviewed articles from grey literature. Currently, Pfizer–BioNTech and Moderna, Sinopharm (China), Sputnik V (Russia), CoronaVac (popularly known as Sinovac) (China), Cansino, and Vaxzevria vaccines have been authorized for emergency use in several countries. Pakistan has sanctioned the use of all the aforementioned vaccines except Pfizer and Moderna. As per their efficacy, Pfizer and Moderna have been found most effective among all the vaccines with 95% effectiveness, while the Vaxzevria, Sputnik V, Sinopharm, and Cansino have shown 70%, 91.6%, 79.34%, and 90% effectiveness, respectively. All the vaccines have shown milder side effects like headache, fever, and pain on injection sites. To curb the pandemic, more clinical trials are being conducted throughout the world. Importantly public awareness is warranted to achieve the target of vaccinating a large population.

scholarly journals Review on Evidence Based Ayurvedic Treatment Practices for Psoriasis

2018 ◽  
Vol 9 (2) ◽  
pp. 39-41
Author(s):  
Venkateshwarlu B ◽  
Anumol K ◽  
Mithuna Mohan ◽  
Priyanka Bai ◽  
Murali Krishna C ◽  
...  
Keyword(s):  
Side Effects ◽  
Time Use ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Therapeutic Approaches ◽  
Treatment Practices ◽  
Therapeutic Regime ◽  
Modern System ◽  
Long Time ◽  
Ayurvedic Treatment

Psoriasis is characterized by sharply defined erythematous squamous lesions. It is one of the commonest chronic, non-infectuous papulo-squamous disorder of the skin. Several treatment modalities are in existence in modern system of medicine; however they have limitations due to their side effects due to long time use. Considering this, search for new safe therapeutic regime in psoriasis is going on. The present paper presents some of the promising evidence based Ayurvedic therapeutic approaches in the management of psoriasis.  

Chlorambucil-Chitosan Nano-conjugate: An efficient Agent against Breast Cancer Targeted Therapy

2020 ◽  
Vol 17 ◽  
Author(s):  
Azadeh Shayegh ◽  
Farinaz Khalatbari ◽  
Niloofar Zonoubi ◽  
Farjad Zarazvand ◽  
Fatemeh Monavvari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Biological Effects ◽  
Rt Pcr ◽  
Chemotherapy Drugs ◽  
Anti Cancer ◽  
Afm Analysis ◽  
Cancer Targeted Therapy ◽  
Mcf 7

Background: Discovering new chemotherapy drugs and techniques with the least side effects is one of the most important and challenging world issues in recent years. Chlorambucil is an anticancer drug that is still commonly used as a primary treatmentin at treatment of some cancers, but it can cause side effects. Objective: In this study, we decided to use chitosan as a carrier for enhance the uptake of chlorambucil and reduce the toxicity of this drug. Method: After producing this nanoconjugate compound and analysing its structure by FTIR, DLS and AFM analysis, we investigated the therapeutic and biological effects of this nanoconjugate compound on the MCF-7 cell line (breast cancer). Results: The results of the MTT assay showed that this nanoconjugate compound not only retained its anti-cancer effect against chlorambucil but also showed less abnormal toxicity. Also, In vitro cellular uptake by flow cytometry indicated the better uptake final product into the MCF-7 cells. The detection of apoptosis induced cell death was confirmed by RT-PCR. Conclusion: This study has created a prospective pathway for targeting cancer cells using chitosan.

Predictors of patient-reported toxicities from endocrine therapy: Importance of illness perceptions, treatment beliefs, and fear of recurrence.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 542-542
Author(s):  
Xinni Song ◽  
Susan Faye Dent ◽  
Shailendra Verma ◽  
Mark J. Clemons ◽  
Nadine A. Graham ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Adverse Effects ◽  
Endocrine Therapy ◽  
Symptom Management ◽  
Self Report ◽  
Fear Of Cancer Recurrence ◽  
Management Interventions ◽  
Patient Reported ◽  
The Impact

542 Background: Numerous studies have documented the toxicities of endocrine therapy (ET) for early breast cancer (EBC) and their deleterious impact on quality of life and adherence. However, little is known about the factors that underlie patient's susceptibility to report toxicities. The identification of risk factors for toxicities from ET is important as it would allow early targeting of symptom management interventions for women more vulnerable to adverse effects of ET. This prospective study aims to examine the impact of pre-treatment perceptions of EBC, ET beliefs and fear of breast cancer (BC) recurrence (FBCR) on toxicities reported after 6 months of ET. Methods: Women diagnosed with EBC completed a survey prior to initiating endocrine therapy, then at 3, 6 and 12 months. Standardized self-report instruments were used to assess EBC perceptions, ET beliefs, FBCR and toxicities. Clinical and treatment variables were also evaluated. Univariate analyses and mulitivariate regression were conducted to identify factors associated (p<0.1) with side effects at 6 months. Results: Since 9/2010, 173 patients have consented and 84 (mean age = 60 y) have completed the questionnaires at baseline and after 6 months of ET. Controlling for age, none of the clinical or treatment variables (stage of disease, type of surgery, receipt of chemotherapy and radiation therapy) were significant univariate predictors of toxicities. In multiple regression, stronger perceptions that BC has serious consequences on their lives (β=0.218, p<0.05), greater concerns about the adverse effects of ET (β=0.215, p<0.05) and higher levels of FBCR (β=0.316, p<0.01) at baseline were associated with higher levels of reported toxicities. Conclusions: Baseline psychological factors predicted level of patient-reported toxicities to a larger extent than clinical/treatment factors. How patients perceived their illness, their beliefs about ET side effects and their fear of cancer recurrence are strongly associated with side effects experienced after 6 months of ET. These results could facilitate the identification of a subgroup of patients for early interventions to improve symptom management.

Role of Nutraceuticals in Cancer

2019 ◽  
pp. 388-406
Author(s):  
Kiran Dahiya ◽  
Rakesh Dhankhar
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Mechanism Of Action ◽  
Healthcare Professionals ◽  
Standard Treatment ◽  
Treatment Modalities ◽  
Active Components ◽  
Prevention And Treatment ◽  
Prevention Of Cancer

Nutraceuticals are increasingly becoming popular for prevention and treatment of cancer. Association of adverse effects with standard treatment modalities of cancer has led to consideration of safer approaches. Nutraceuticals may help in prevention of cancer as well as in treatment and avoidance of side effects associated with chemo-radiation. The active components of nutraceuticals are known as phytochemicals. Many mechanisms have been put forward for the actions of these phytochemicals but an exact mechanism for a well defined role of a particular phytochemical in a specific type of cancer is yet to be elucidated. Thus, nutraceutical industry has emerged as a research oriented sector. It is important for the healthcare professionals to understand the categories, research developments, mechanism of action and areas of concern in the field of nutraceuticals.

Multi-ligand modified PC-PA/EGCG micelles effectively inhibit the growth of ER+, PR+ or HER2+ breast cancer

2021 ◽  
Author(s):  
Xiaozhen Wang ◽  
Jiecheng He ◽  
Siyuan Jiang ◽  
Yifei Gao ◽  
Lingkun Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Treatment ◽  
Tumor Heterogeneity ◽  
Her2 Breast Cancer ◽  
The World

Breast cancer is one of the most common cancers in the world with tumor heterogeneity. Currently, cancer treatment mainly relied on surgical, chemotherapy, and radiotherapy, which the side effects, drug...

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