Ameliorative Effects of Saccharum officinarum (Sugarcane) Peel Extract against Paracetamol-Induced Disorders in Hematological Indices and Splenic Changes in Adult Male Sprague Dawley Rats

Objective: This study aims to formulate and characterize a transfersome apple peel extract, formulate it into a gel, and compare it with a control gelmade without transfersome.Methods: Both gels were evaluated, stability tested, and penetration tested using Franz diffusion cells on the skin of female Sprague-Dawley rats. Thetransfersome preparations were formulated with different concentrations of the active substance, quercetin: 0.5% (F1); 0.7% (F2), and 1.0% (F3).Results: Based on the characterization results, F1 was selected as the optimum gel formulation because it had spherical morphology, a Dmean volume of106.44±2.70 nm, a polydispersity index of 0.078±0.01, a zeta potential of −49.96±2.05 mV, and a drug efficiency entrapment percentage of 78.78±0.46%.The cumulative amount of quercetin that was penetrated with the transfersome gel was 1514.41±26.31 μg/cm2, whereas the penetration with thecontrol gel extract was 1133.62±18.96 μg/cm2. The cumulative percentages of the penetrated gel transfersome and gel extract were 78.40±1.89%and 49.89±0.88%, respectively. The fluxes of transfersome gel and control gel extract were 52.33±0.11 μg/cm²/hrs and 40.89±0.68 μg/cm²/hrs,respectively.Conclusions: Based on these results, it can be concluded that the gel with transfersome exhibited better penetration than the gel extract alone.

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Histomorphology, Sperm Quality and Hormonal Profile in Adult Male Sprague-Dawley Rats following administration of aqueous crude Extract of Solanum nigrum by gastric gavage

JBRA Assisted Reproduction ◽

10.5935/1518-0557.20180051 ◽

2018 ◽

Cited By ~ 1

Author(s):

Sunday Aderemi Adelakun ◽

Babatunde Ogunlade ◽

Toluwase Solomon Olawuyi ◽

Julius Akomaye Aniah ◽

Olusegun Dare Omotoso

Keyword(s):

Adult Male ◽

Crude Extract ◽

Sperm Quality ◽

Solanum Nigrum ◽

Sprague Dawley ◽

Hormonal Profile ◽

Sprague Dawley Rats

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Effects of Aqueous Quassia amara L. (Korales) Leaf Extract on the Cardiovascular and Respiratory Functions of Male Sprague-Dawley Rats

Acta Medica Philippina ◽

10.47895/amp.v52i6.280 ◽

2018 ◽

Vol 52 (6) ◽

Author(s):

Maria Concepcion C. Sison ◽

Lynn Crisanta R. Panganiban ◽

Daisy Mae A. Bagaoisan ◽

Nelia P. Cortes-Maramba

Keyword(s):

Blood Pressure ◽

Adult Male ◽

Leaf Extract ◽

Sprague Dawley ◽

Treatment Groups ◽

Respiratory Flow ◽

Sprague Dawley Rats ◽

Parallel Group ◽

Aqueous Leaf Extract ◽

Quassia Amara

Objective. To To evaluate potential effects of the aqueous extract of Quassia amara L. leaves on the cardiovascular and respiratory systems of adult male Sprague- Dawley rats. Methods. The cardiovascular and respiratory effects of the Quassia amara L. leaf extract on adult male SpragueDawley rats were assessed using non-invasive blood pressure (NIBP) determination and head-out plethysmography, respectively, in a randomized, parallel group study. Mean observations of blood pressure and heart rate were recorded at different time periods after dosing. Respiratory flow and irritation effects were evaluated using mean observations of respiratory rate (RR), tidal volume (TV), mid-expiratory flow rate (EF50), time of inspiration (TI) and expiration (TE), and time of break (TB) and pause (TP). Results. There were no significant differences among the control and the treatment groups in SBP, DBP and HR parameters. The extract showed statistically significant effect on mean RR by time period (F=2.45, p=0.0234), trends over time of TV among the dose groups (F=2.00, p=0.0202), and EF50 among dose groups ((F=3.11, p=0.0422). However, these did not correlate with the changes in the time of break (TB) and time of pause (TP) which are more sensitive and specific tests for respiratory irritation. Conclusion. Aqueous leaf extract of Quassia appeared to have no significant effects on SBP, DPB, Pulse pressure, and HR. There are no conclusive dose-related respiratory flow or pulmonary irritation effects.

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