scholarly journals Content of Mineral Elements in Rat Liver Tissue with Acquired Insulin Resistance and Obesity in Combination with Iodine

2021 ◽  
Vol 6 (6) ◽  
pp. 239-244
Author(s):  
I. Z. Hlozhyk ◽  
Keyword(s):  
Insulin Resistance ◽  
Trace Element ◽  
Iodine Deficiency ◽  
Iron Content ◽  
Manganese Content ◽  
Liver Homogenate ◽  
Magnesium Content ◽  
Mineral Elements ◽  
Control Group ◽  
Experimental Group

The purpose of the study was to determine the content of mineral elements in the hepatocytes of rats with insulin resistance, obesity, iodine deficiency, insulin resistance in combination with iodine deficiency and obesity in combination with iodine deficiency. Materials and methods. The study was performed on 90 white nonlinear rats weighing 120-180 g, which were divided into five experimental groups: rats with insulin resistance (1st experimental group, n = 15), animals with iodine deficiency (2nd experimental group), animals with insulin resistance in combination with iodine deficiency (3rd experimental group, n = 15), obese animals (4th experimental group, n = 15), obese animals in combined with iodine deficiency (5th experimental group, n = 15). The control group consisted of 15 intact rats. The content of Fe, Ca, Cu, Mg, Zn, Mn, Cr in the liver homogenate was determined by atomic absorption spectrometry on a SPECORD M 40 spectrophotometer (Germany). Results and discussion. In animals with insulin resistance, there was a decrease in the content of copper in the liver by 26.9%, in animals with iodine deficiency the content of this trace element increased by 20.5%, and in the group of animals with insulin resistance in combination with iodine deficiency it increased by 10.1%. The iron content in the group of animals with insulin resistance is higher in relation to the control by 33.7%, in the group of animals with iodine deficiency – by 38.5%, in animals with insulin resistance in combination with iodine deficiency – by 40.8%. Regarding the content of Calcium, in the liver homogenate of animals with insulin resistance it is higher compared to the control by 24%, in animals of the second experimental group –by 26.4%, in animals of the 3rd experimental group – by 22%. The Magnesium content in animals with insulin resitance is lower compared to the control by 19%, in animals with iodine deficiency – by 25.5%, in animals with insulin resistance in combination with iodine deficiency – by 29%. As for Zinc, no significant fluctuations in the content of this trace element were detected. In animals of the 1st, 2nd and 3rd experimental groups it is lower compared to the control by 10%, 15% and 11.1%, respectively. The Manganese content in animals with insulin resistance is lower compared to the control by 13.6%, in animals with iodine deficiency – by 18.2%, in animals with insulin resistance in combination with iodine deficiency – by 14.8%. With regard to chromium, we found a probable decrease in the concentration of this trace element in animals of the group with insulin resistance by 48%, in animals of the 2nd experimental group – by 57.5%, in animals of the 3rd experimental group – by 58%. In the group of animals with obesity and obesity in combined with iodine deficiency we found an increase in copper content compared to the control by 27.4% and 36.2%, respectively. The iron content in animals with obesity exceeds the control by 34.8%, in the group of animals with obesity in combined with iodine deficiency – by 38.4%. Regarding the content of Calcium, in animals with obesity it is higher by 25.7%, and in animals with obesity in combined with iodine deficiency – by 28.4% compared to the control. Magnesium content in animals with obesity is lower by 27.3% compared to the control group, and in animals with obesity in combined with iodine deficiency – by 28.4%. Regarding Zinc, no significant fluctuations in the content of this trace element were detected. In animals of the 4th and 5th experimental groups it is lower compared to the control by 18.4% and 23.5%, respectively. The content of Manganese in the group of animals with obesity decreased by 14.8%, and in the group with obesity in combined with iodine deficiency the content of this trace element decreased by 16.2% compared to the control. With regard to chromium, we found a probable decrease in the concentration of this trace element in animals of the group with obesity by 58.1% and in the group of animals with obesity in combined with iodine deficiency by 56.2%. Conclusion. The obtained results demonstrate changes in the content of mineral elements in groups of animals with insulin resistance, iodine deficiency, insulin resistance in combination with iodine deficiency, obesity and obesity in combination with iodine deficiency

Effectiveness the use of additive MEGA-VIT in the ration of mares of Shetland pony breed

2020 ◽  
pp. 60-67
Author(s):  
G. Uskov ◽  
A. Tsopanova ◽  
T. Perezhogina
Keyword(s):  
Physiological State ◽  
Mineral Elements ◽  
Positive Influence ◽  
Control Group ◽  
Physiological Indicators ◽  
Mineral Additive ◽  
Nutritional Needs ◽  
Young Horses ◽  
The Cost ◽  
Experimental Group

Complete feeding of ponies is provided on the basis of data on their nutritional needs depending on age, sex, physiological state and level of productivity (the amount of milk produced and the intensity of growth of young animals). Ponies are sensitive to a lack of vitamins and mineral elements in the feed. When there is a sufficient amount of organic and mineral substances, but a lack or absence of vitamins, horses and ponies have impaired metabolism. The purpose of this work is to study the effectiveness of the use of vitamin and mineral additive MEGA-VIT in the rations of pregnant and lactating mares of Shetland pony breed. It has been found during of the researches that the vitamin and mineral additive MEGA-VIT had a positive influence on the productive and physiological indicators of animals. The cost of spent feed for the entire period of experiment in the control group was 50,6 thousand rubles, and in the experimental group it was 11,8 thousand rubles more or 23,5 %. Revenue from the sale of young horses of the control group amounted to 400 thousand rubles, and experimental group – 440 thousand rubles, this is by 40 thousand rubles more than in control group. This led to the increase in profit in the experimental group of mares by 28,1 thousand rubles and accordingly the level of profitability by 3,2 %. It has been recommended on the results have been obtained on the base of researches to include 30 g/head/day in the rations of mares of Shetland pony breed during pregnancy, and 50 g/head/day during lactation.

scholarly journals Effect of aquacitrate of micro elements on indices of nonspecific resistance and cellular immunity in chicken broilers

2018 ◽  
Vol 20 (84) ◽  
Author(s):  
S. M. Medvid
Keyword(s):  
Cellular Immunity ◽  
Broiler Chickens ◽  
Inorganic Compounds ◽  
Relative Number ◽  
Mineral Elements ◽  
Control Group ◽  
T Suppressors ◽  
Nonspecific Resistance ◽  
Micro Elements ◽  
Experimental Group

The article presents data on the influence of the complex of micro elements (Fe, Cu, Zn, Co, Mn) in the form of aquacitrate on the indices of non-specific and cellular immunity in chicken broilers. The poultry received a fodder, balanced by nutrients, according to its type, age and productivity. Control group of chickens were added standard mineral premix (SP) from inorganic compounds of bioelements. Broilers of experimental groups were given water with a complex mineral additive of aquacitrates. In particular, the chickens of the first experimental group – in the amount corresponding to their content in the standard premix (SP), and the 2nd, 3rd, 4th and 5th experimental groups – in the amount equal to 3/4, 1/2, 1/4 and 1/10 of the content of mineral elements in the standard premix. It was found that bactericidal and lysozyme activity of blood serum (BASB and LASB) were the highest in broiler chickens of the third and fourth experimental groups and exceeded the control values by 5.7 and 5.3%, respectively. In the bird of the second and fifth groups, the studied indicators were closer to the ones in control. However, in the chickens of the group D1, giving them the highest studied dose of aquacitrate of micor elements, the values of BASB and LASB tended to decrease. Concerning the level of CIC in serum, it was the highest in the chickens of the second, third and fourth groups, the lowest in the group D1. A similar pattern is also characteristic for phagocytic activity of pseudoiesinophils (PhA). The bite of half and even the quaternary amount of citrates of micro elements, compared with the amount of bioelements in inorganic form, provided an increase, compared to control, of PhA. At such a dose of micro elements in the nanoform in the blood of broilers, the number of T-total and T-active lymphocytes increased, including T-heeler cells and decreased the relative number of T-suppressors. The bird of the first experimental group was characterized by a decrease in the percentage of T-heeler against the background of a slight increase of T-suppressors. Thus, the results of studies of indices of nonspecific and cellular immunity suggest that micor elements in the nanodisperse form, due to better bioavailability and high bioactivity, have a positive effect on the formation and development of the immune system in broiler chickens at a dose corresponding to 25 and 50%, from recommended quantity of biometals in the standard premix.

scholarly journals Productivety of swine fed on poliacrylamide, mineral and vitamin additives

2019 ◽  
pp. 111-117
Author(s):  
P. Kuzmenko ◽  
V. Fesenko ◽  
V. Bilkevych ◽  
P. Karkach ◽  
Yu. Mashkin
Keyword(s):  
Live Weight ◽  
Mineral Elements ◽  
Iron Sulfate ◽  
Control Group ◽  
Blood Proteins ◽  
Standard Compound ◽  
Main Period ◽  
Feeding Effect ◽  
Feed Costs ◽  
Experimental Group

The feeding effect of polyacrylamide (PA), mineral and vitamin additives (MVA) on the reproductive and productive qualities of sows, as well as the development and viability of piglets gained from them has been studied. The polyacrylamide, mineral and vitamin additives have been added to the sow diet of the 2nd and 3rd experemental groups. It has been done according to the animal need in minerals and vitamins. In proportion of 0,5/1 kg of live weight, the mineral and vitamin aditives, polyacrylamide have been added to the ration of sows from the 2nd experimental group. The mineral and vitamin aditives have been added to the ration of the 3rd group in such proportion: iron sulfate – 200, copper carbonate – 15, zinc – 84, cobalt – 3, manganese chloride – 69, potassium iodide (stabilized) – 170 mcg, vitamins A – 2.8 th. IO, D – 736 IO, B1 – 1.4 mg; B2 – 8.4 micrograms per head per day. The mineral and vitamin additives, polyacrylamide have been added to the sow diet of the 4th experimental group in the same proportion as it has been already mentioned above. The sows fed on PA and MVA for 60 days. The feeding was stopped 10 days before farrowing. The experiment on piglets has been carried out in 2 stages. The equalization period was 25 days (the ration of piglets from the control and experimental group was the same). The main period was 150 days (the control group of animals fed on standard compound fodder). The experimental group fed on additional PA and MVA. It has been noticed when the additives are added to the sow diet the gained piglets have an increase of viability, immun response (due to gamma globulins increase in blood proteins) and the average live weight by 23.3% during the rising period. Key words: sows, piglets, polyacrylamide, mineral elements, vitamins, live weight, albumin, globulins, rearing, fattening, feed costs, slaughter yield.

scholarly journals PHYSIOLOGICAL STATUS AND PRODUCTIVITY OF TURKEY-BROILERS WHEN USE FEED SUPPLEMENTS IN THEIR RATIONS

2017 ◽  
pp. 5-9
Author(s):  
Айметов ◽  
Ruslan Aymetov
Keyword(s):  
Test Group ◽  
Mineral Elements ◽  
The Body ◽  
Control Group ◽  
Physiological Status ◽  
Maximum Output ◽  
Mineral Supplement ◽  
Basic Diet ◽  
The Republic ◽  
Experimental Group

The mineral elements interact not only among themselves, but also with the organic components during complex metabolism process. Identifying the features of the feed nutrient substances relationship allows you to direct the body’s metabolism in the direction of their effectiveness and to obtain the maximum output from the animals. The experimental part of the work was carried out on poultry complex “Agrofirma Zalesnyy” of the Republic of Tatarstan from January to May 2016. The objects of research were female turkey-broilers of “Hybrid Converter” cross, mineral supplement “Tseostimul”, probiotic “Provagen” and symbiotic preparation of a new generation. With this aim, four groups of turkey were formed of 40 heads. The first group was a control one and received a basic diet, adopted by the poultry farm. The second group received the basic diet, added with mineral supplements with a dosage of 30 gramm per 1 kilogramm of feed. Turkeys of III-experimental group was added to the diet of probiotic preparation “Provagen” at a dose of 3 gramm per 1 kilogramm of feed. The turkeys of IV-test group received in addition to the basic diet a symbiotic drug rate of 20 gramm per 1 kilogramm of feed. The main diet was consisted of complete feed. Duration of the experiment was 112 days. By the end of the experiment the body weight of experimental groups exceeded the similar index: in the control group to 1082 gramm (р ≥0,001), in the first test group to 781 gramm (р ≥0,001), in the second test group to 1339 gramm (р ≥0,001), in the third group with addition of symbiotic drugs or to 12.3%, 8.9% and 15.3% respectively. The numbers of leukocytes was decreased from 34.2 109/L to 33.3 109/L in I experimental group, to 33.2 109/L in II and to 34.4 109/L in IV experimental group. The mass of internal organs was significantly higher in females of experimental groups. Thus, the weight of the liver of experimental groups was greater to 12.3%, 8.9% and 15.3%, compared with the control group.

scholarly journals REASIL HUMICVET AND REASIL HUMIC HEALTH SUPPLEMENTS BASED ON HUMIC ACIDS IN THE DIETS OF DAIRY CALVES

2021 ◽  
Vol 6 (1) ◽  
pp. 64-70
Author(s):  
Andrei Frolkin ◽  
Haidar Valitov ◽  
Aleksandr Varakin ◽  
Valentina Kornilova
Keyword(s):  
Blood Serum ◽  
Live Weight ◽  
Mineral Elements ◽  
The Body ◽  
Control Group ◽  
Liquid Form ◽  
Daily Growth ◽  
Black And White ◽  
Significant Difference ◽  
Experimental Group

The purpose of the research is to increase the effectiveness of the supplement Reasil on the growth of milk-fed calves. For the scientific and economic experience, three groups of calves were formed (control, 1 and 2 experi-enced). Groups of animals of 10 heads were formed according to the principle of analogues. The indicators of live weight, growth and blood of calves were studied after Reasil use in a diet: Reasil HumicVet as a liquid form, and Reasil Humic Health – reduced to powder. In the experiment, animals of a black-and-white breed were used. The Reasil feeding in the diet contributed to an increase in the live weight of milk-fed calves in the 1-st and the 2-nd experimental groups at two months of age by 5.65 and 5.48 kg (or by 7.4 and 7.2%), respectively, compared to the indicator of the control group analogues. The average daily growth of calves of the experimental groups exceeded this indicator of control animals by 96 and 82 g, respectively. The blood of calves of the 1st and 2nd experimental groups, showed that hematoglobin was higher by 15.7 and 11.4%, red blood cells – by 16.5 and 15.1%, and the alkaline reserve – by 5.2%, compared with blood of calves from the control group, which indicates the activation of metabolic processes in the body. The total protein amount in the blood serum of animals from the experimental groups increased by 8.4 and 5.9% respectively, compared to the tests of calves from the control group. The albu-min content of animals of the 1st experimental group tested was higher by 5.3%; from the 2nd experimental group there was no significant difference compared to the control. The number of gamma-globulins in the blood of ani-mals of the experimental groups increased, which indicates an increase in defense reaction of animals. The con-tent of calcium in the blood serum of calves from the experimental groups was higher by 8.3 and 5.9%, phosphorus – by 4.8 and 2.4%, which indicates a more effective use of these mineral elements.

scholarly journals Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Shiqin Peng ◽  
Ping Wei ◽  
Qun Lu ◽  
Rui Liu ◽  
Yue Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Crude Extract ◽  
Liver Homogenate ◽  
Control Group ◽  
Diabetic Mice ◽  
Model Control

The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. Compared with the model control group, the 50% fraction-treated group showed significant decreases of malondialdehyde (MDA) and increases of superoxide dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factorα(TNF-α), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.

scholarly journals INDICATORS OF BLOOD OF GALDS OF KALMYK BREED ON FEEDING WHEN INCLUDED

2020 ◽  
Vol 55 (3) ◽  
pp. 80-84
Author(s):  
I.I. Sleptsov ◽  
◽  
A.A. Martynov ◽  
Ya.S. Vasiliev ◽  
◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Sharp Decrease ◽  
High Growth ◽  
Mineral Elements ◽  
Feed Additives ◽  
Control Group ◽  
Cattle Breeding ◽  
Hematological And Biochemical Parameters ◽  
Traditional Natural ◽  
Experimental Group

Obtaining high results in the production of highquality beef in beef cattle breeding is impossible without well-organized fattening of gobies. In the conditions of Yakutia, fattening of gobies from 15 months of age can be carried out in autumn, after the summer grazing feeding. Under economic conditions of feeding, high growth rates of fattening young animals cannot be obtained. Therefore, intensive fattening with the use of mineral feeding of cattle is used. The paper presents research materials on the morphological and biochemical composition of blood and its serum in calves of the Kalmyk breed, which are on scientific and industrial fattening. In the experimental group of animals, local natural feed additives – zeolite and salt – were added to the diet, which served as adaptogens and sources of mineral elements. During the feeding period before the slaughter, the morphological composition of blood in terms of indicators has insignificant decreases, but within the physiological norm. We see these changes in the gobies of the experimental control group and associate them with a sharp decrease in atmospheric air temperature to –15 °C in the first ten days of November 2019 and a constant transition to roughage. It is also possible that the use of natural feed additives in the form of feeding zeolite and salt increases metabolic processes in the animal's body. A comparative analysis of biochemical parameters in the blood serum of gobies of the experimental group confirmed significant differences in hepatic enzymes (ALT and AST) in animals. The use of non-traditional natural feed additives with the inclusion in the diet of fattening gobies affects the hematological and biochemical parameters of blood and its serum, and, accordingly, meat quality.

scholarly journals Peculiarities of nutrient digestibility of rations of pregnant ewes with the additional introduction of cobalt

2018 ◽  
pp. 24-31
Author(s):  
V. Mykytyuk ◽  
T. Vasilenko ◽  
O. Orischuk ◽  
S. Tsap ◽  
I. Porotikova
Keyword(s):  
Cobalt Chloride ◽  
Mineral Elements ◽  
Nutrient Digestibility ◽  
The Body ◽  
Control Group ◽  
Fourth Group ◽  
The Third ◽  
Experimental Group

The results of studies on the effect of various doses of cobalt with an optimized level of sulfur in rations of Askanian meat-and-wool ewes on digestibility of nutrients of consumed feed and digestibility of the studied mineral elements are presented. It was established that the level of nutrient digestibility of rations was higher in ewes of the experimental groups, which, to the generally accepted norm, were additionally injected with cobalt chloride in the amount of 10 %, which was equal 0.825 mg, 20 % – 0.900 mg, and 30 % – 0.975 mg per head per day . As a result of the conducted research, it was found that the ewes of the second experimental group differed in the highest indices of digestibility of nutrients of the ration, which increased the rate of cobalt by 10 %. The additional introduction of 20 % and 30 % cobalt to the basic ration did not contribute to a further increase in the digestibility factors of nutrients in the body of ewes of the experimental groups. The research has shown that the uptake of cobalt by experimental ewes increased as this element increased in the rations. Thus, 0.31 mg of cobalt was assimilated by the ewes of the second experimental group, which is 0.06 mg or 20.0 % higher compared to the control group; to the third-group of ewes by 0.07 mg or 28.0 % and to the fourth-group ewes by 0,08 mg or 32.0 % compared with analogues of the control group. However, when calculating these indicators in relative terms, it was established that the highest percentage of cobalt absorbed from that received was in the ewes of the second experimental group. Their advantage relative to the control group was 4.60 % (P <0.01), and III and IV experimental groups – 2.11 and 0.19 absolute percent.

scholarly journals Effects of Shade Net Colors on Mineral Elements and Postharvest Shelf Life and Quality of Fresh Fig (Ficus carica L.) under Rain-Fed Condition

Horticulturae ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. 93
Author(s):  
Ali Jokar ◽  
Hamid Zare ◽  
Abdolrasool Zakerin ◽  
Abdolhossein Aboutalebi Jahromi
Keyword(s):  
Shelf Life ◽  
Block Design ◽  
Magnesium Content ◽  
Mineral Elements ◽  
Mineral Nutrients ◽  
Fruit Weight ◽  
Postharvest Quality ◽  
Control Group ◽  
Fig Trees

Photoselective netting is well known for filtering the intercepted solar radiation, thus affecting light quality. While its effects on leaf mineral elements have been well investigated, how color netting affects fruit mineral nutrients remains elusive. This study was conducted to evaluate the effects of shade provided by blue and yellow nets on mineral nutrients of fig trees under rain-fed conditions. The experiment was arranged as a split-plot treatment in a randomized complete block design with three replications. Cultivars “Sabz” and “Siah” were covered with color nets or left uncovered (as the control group). The highest nitrogen content (8710 ppm) was recorded for cultivar “Sabz” covered with blue net. Color nets enhanced calcium concentration in cultivar “Siah”. Covering fig trees with yellow net increased magnesium content in cultivar “Siah” and phosphorus content in cultivar “Sabz”. Our observation showed the significant positive effect of photo selective nets on postharvest quality, by decreasing fig fruit weight loss and extending shelf life of fruits. In general, color nets as a new agro-technological approach can maintain fruit nutrition under rain-fed conditions and increase postharvest shelf life and quality of fresh fig.

scholarly journals STUDY OF THE SPECIFIC ACTIVITY OF THE PHYTOCOMPOSITION ON THE DEXAMETHASONE-INDUCED INSULIN RESISTANCE

2021 ◽  
pp. 5-14
Author(s):  
A. I. Dub ◽  
I. M. Klishch ◽  
L. V. Vronska ◽  
I. P. Stechyshyn
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance Test ◽  
Specific Activity ◽  
Tolerance Test ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Experimental Group

Introduction. Type 2 diabetes mellitus (DM2) has recently become an epidemic in the population. There are approximately 463 million patients in the world, and according to experts from the International Diabetes Federation, it is expected to increase to 700 million people by 2045, of which more than 90 % will fall on DM2. Despite the significant progress made in studying the pathogenesis of DM, the presence of a wide range of antidiabetic drugs, diabetes remains an acute medical and social problem. The aim of the study – to investigate the specific activity of the phytocomposition, which contains dry extracts of white mulberry leaves (Morus alba L.), common beans shells (Phaseolus vulgaris L.), bilberry sprouts (Vaccinium myrtillus L.) in the experimental model of insulin resistance caused by dexamethasone injections. Research Methods. The experiments were performed on male rats aged three months and weight (200±20) g. Experimental animals were divided into the following groups: negative and positive control, two reference groups, which received Arfazetin and metformin respectively, and experimental group, which received phytocomposition. Insulin resistance was modeled by intramuscular administration of glucocorticosteroid dexamethasone (0.125 mg/kg daily for 13 days in the morning). The state of glucose homeostasis was assessed by changes in basal glycemia and under oral glucose tolerance test, short insulin and adrenalin test. Functional glycemic coefficients were also calculated. Statistical processing was performed using computer programs IBM SPSS Statistics v.10.1 and MS Excel 2010. Results and Discussion. Basal glycemia after modeling insulin resistance in the experimental group, which received the phytocomposition, was significantly lower by 19.0 % from the positive control group and did not differ from the activity of metformin. During the oral glucose tolerance test, the phytocomposition significantly inhibited the growth of glycemia in all studied periods relative to the indicators of the positive control group. Functional glycemic coefficients, which were obtained based on test data, did not exceed the norm. Insulin sensitivity under the influence of phytomedicine increased by 16.2 % above the positive control group, indicating inhibition of insulin resistance development under its influence. The studied phytocomposition inhibited the development of adrenaline glycemia by 42.9, 70.2 % after 30 and 90 min, respectively, relative to the positive control group, which corresponds to the indicators of the negative control group and reference group, which received Arfazetin, but this decrease is not enough to exceed the effect of metformin. Conclusions. The obtained results indicate that the studied phytocomposition inhibits the development of insulin resistance and carbohydrate tolerance in the conditions of insulin resistance caused by the introduction of dexamethasone.

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