scholarly journals Correlation between interleukin 4 (IL-4) expression and allergen sensitization in allergic rhinitis patients

2021 ◽  
Vol 68 (2) ◽  
pp. 88-93
Author(s):  
Asti Widuri
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
Venous Blood ◽  
Clinical Manifestations ◽  
Egg Yolk ◽  
Interleukin 4 ◽  
Cross Sectional ◽  
Allergen Sensitization ◽  
Chicken Egg ◽  
Spearman Test

Objective: The objective of this research was to measure the correlation of the expression of IL-4 with allergen sensitization in patients with allergic rhinitis. Methods: Descriptive analytics was used as a method in this research, with a cross-sectional approach. The subjects were 37 persons with allergic rhinitis who met the inclusion and exclusion criteria. This research was conducted in patients with clinical manifestations of symptoms of allergic rhinitis, and skin prick tests were carried out with ten types of allergens, which are: house dust, cotton, chicken feathers, shrimp, tuna, chicken egg-yolk, chicken egg-white, peanuts, tea, and chocolate. Venous blood sampling was performed for the Interleukin-4 (IL-4) test by using an ELISA device. Results: The respondents were 37 patients with allergic rhinitis, of which 26 (70.3 %) were women and 11 (29.7 %) were men. The highest sensitivity to inhaled allergens in patients with rhinitis was to house dust in 31 samples (83.8 %). The correlation of the expression of IL-4 with sensitization to allergens in patients with allergic rhinitis based on the Spearman test resulted in p > 0.05, not significant with some allergens in a negative correlation. Conclusion: There was no significant correlation between the expression of IL-4 and the sensitization to allergens in patients with allergic rhinitis.

scholarly journals Clinical and Paraclinical Screening for Celiac Disease in Children with Intractable Epilepsy

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Golnaz Ghazizadeh Esslami ◽  
Bahar Allahverdi ◽  
Reza Shervin Badv ◽  
Morteza Heidari ◽  
Nahid Khosroshahi ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Serological Test ◽  
Venous Blood ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Intractable Epilepsy ◽  
Underlying Disease ◽  
Growth Disorders ◽  
Serological Tests ◽  
Cross Sectional

Background. Celiac disease is the inflammatory entropy caused by hypersensitivity to gluten, which occurs in susceptible individuals. Some studies have suggested a link between celiac disease and epilepsy in children. Our aim was to screen for clinical and paraclinical features of celiac disease in children with intractable epilepsy. Methods. This was a cross-sectional study. Children aged 2 to 18 years with refractory epilepsy that referred to the pediatric neurology clinic within one year (2018–2019) were enrolled. Demographic and clinical characteristics of patients, especially clinical manifestations of celiac disease, were recorded in a questionnaire. A venous blood sample was sent to determine the total IgA, anti-tTG (IgA), and anti-endomysial antibody (IgA). Endoscopy was performed in cases where the celiac serological test was positive. Results. Seventy children with idiopathic drug-resistant epilepsy (44 boys) were evaluated. The height-for-age index was 49.2% and the weight-for-age index was 38.2% less than normal. Constipation (48.6%), anorexia (25.7%), and abdominal pain (21.4%) were the most common gastrointestinal symptoms. Celiac serological tests were negative in all children. Therefore, endoscopy and bowel biopsy were not performed in any case. Conclusion. Celiac disease was not found in any patient with intractable epilepsy. Gastrointestinal symptoms and growth disorders in this group may be related to the underlying disease or medications and not to celiac disease.

scholarly journals Issues and Challenges in the Application of the IEUBK Model in the Health Risk Assessment of Lead: A Case Study from Blantyre Malawi

2021 ◽  
Vol 18 (15) ◽  
pp. 8207
Author(s):  
Wells Utembe ◽  
Mary Gulumian
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Food Consumption ◽  
Health Risk Assessment ◽  
House Dust ◽  
Statistical Tests ◽  
Venous Blood ◽  
Cross Sectional ◽  
Consumption Data ◽  
Food Consumption Data

The risk assessment of lead (Pb) requires the use of biokinetic models to translate measured concentrations of Pb in food and environmental media into blood lead (BPb). The aim of this study was to assess the applicability of the Integrated Exposure Uptake Biokinetic (IEUBK) model in the health risk assessment of Pb among children in Blantyre. Children (152) aged 1–6 years were recruited into this cross-sectional study, and foods, house dust, playground soil, water, and venous blood (1 mL) were collected and analyzed for Pb. A seven-day food frequency questionnaire (FFQ) was used to collect food consumption data. The concentrations of Pb ranged from 0.01 to 3.3 mg/kg in food, 2.3 to 265 mg/kg and 1.5 to 482 mg/kg in house dust and playground soil, respectively, as well as 2.0 µg/dL to 50.4 µg/dL and 6.8 to 39.2 µg/dL for measured and predicted BPb, respectively. Various statistical tests indicated less than satisfactory agreement between measured and predicted BPb values. Despite the lack of reliable food consumption data and other limitations, both the predicted and measured BPb values indicate that children in Blantyre are exposed to high levels of Pb, largely through food and soil as a minor source.

scholarly journals Serum IL-6 levels of atopic patients with recurrent aphthous stomatitis (RAS)

2019 ◽  
Vol 31 (1) ◽  
pp. 20
Author(s):  
Nanan Nur'aeny ◽  
Irna Sufiawati ◽  
Oki Suwarsa ◽  
Dida Akhmad Gurnida
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Inflammatory Marker ◽  
Clinical Manifestations ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cross Sectional ◽  
Allergic Condition ◽  
Board Review

Introduction: Atopy is a genetic tendency of allergic condition with specific clinical manifestations such as atopic dermatitis (AD), allergic rhinitis (AR), and bronchial asthma (BA). Atopic individuals might experience other health problems that coincide with atopic manifestations, including the appearance of recurrent aphthous stomatitis (RAS) which is an oral mucosal disease that can also be influenced by allergies. This study was aimed to be the preliminary study regarding the level of IL-6 serum in atopic patients who were also having RAS. Methods: Thirty subjects were recruited and grouped into three groups with ten subjects each were group of atopic (dermatitis, allergic rhinitis, or bronchial asthma) with RAS, atopic without RAS, and control. Blood specimens were obtained with an approved institutional board review protocol. This research was cross-sectional research with consecutive sampling method conducted at Dr Hasan Sadikin Hospital Bandung. Results: There were significant differences in IL-6 log levels in all three groups (p < 0.001). The higher IL-6 levels in the group of atopic with RAS might be due to the influence of atopy because this condition can increase the acute inflammation of RAS. IL-6 is a pro-inflammatory marker found in the circulation of atopic and RAS patients. Conclusion: Serum IL-6 levels in the group of atopic patients with RAS is higher than in other groups. Keywords: Serum, IL-6, atopic, recurrent aphthous stomatitis

Laser Surgery of the Inferior Turbinate for Allergic Rhinitis with Seasonal Exacerbation: An Acoustic Rhinometry Study

2003 ◽  
Vol 112 (5) ◽  
pp. 455-460 ◽  
Author(s):  
Sachio Takeno ◽  
Takashi Ishino ◽  
Rika Osada ◽  
Koji Yajin
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
Laser Surgery ◽  
Airborne Pollen ◽  
Japanese Cedar ◽  
Acoustic Rhinometry ◽  
House Dust Mites ◽  
Dust Mites ◽  
Cross Sectional ◽  
Postoperative Changes

Laser surgery has been used to successfully treat patients with perennial allergic rhinitis. We examined whether the numbers and types of sensitized allergens influence the effects of surgery. Two different groups (those allergic to house dust mites only, and those allergic to house dust mites and Japanese cedar pollen) prospectively underwent the same course of laser turbinectomy during the pollen dispersion season. The symptom scores for nasal obstruction significantly decreased in both groups, but the improvement of sneezing and rhinorrhea was less pronounced in the pollen group. We used acoustic rhinometry to measure postoperative changes in the nasal dimensions. Four months after treatment, the minimum cross-sectional area and nasal cavity volume had increased, respectively, by 61.7% and 30.7% in the house dust group, and by 30.7% and 16.2% in the pollen group. We conclude that laser surgery can be successfully applied to patients whose allergies show seasonal exacerbation by airborne pollen.

scholarly journals HUBUNGAN TUNGAU DEBU RUMAH TERHADAP ANGKA KEJADIAN RINITIS ALERGI YANG BEROBAT DI POLI THT RSUD BANGLI TAHUN 2019

2020 ◽  
Vol 5 (2) ◽  
pp. 57
Author(s):  
Ardyatri Kairavini ◽  
Trisna Ariani ◽  
Sukdriani Utami ◽  
Nurman Hikmallah
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
Secondary Data ◽  
House Dust Mites ◽  
P Value ◽  
Type I ◽  
Dust Mites ◽  
Household Dust ◽  
Chi Square ◽  
Cross Sectional

Background: Rhinitis Allergic is an inflammatory process in the nasal mucosa caused by type I hypersensitivity reactions that are triggered by certain allergens. The prevalence of rhinitis allergic in Indonesia is estimated to range between 10- 20% and is constantly increasing. The average Onset age of Rhinitis Allergic is 8- 11 years old and 80% of rhinitis allergic develops at the age of 20 years old. Usually rhinitis allergic occurs at a young age. Rhinitis Allergic can be triggered by several types of aeroallergens, one of which is house dust mites. Lopo C research mentioned that most allergens cause allergic rhinitis are house dust mites that is equal to (75.6%). Objective: To determine the correlation of house dust mites to the incidence of rhinitis allergic being treated at the ENT Polyclinic in Bangli Regional Hospital in 2019. Method: This study was an observational study with a cross sectional design. Samples were taken based on primary and secondary data using non-probability sampling techniques by purposive sampling. The samples used in this study were 143 samples of rhinitis patients. Data  analysis using Chi Square. Results: The results obtained from the Chi Square test did not have a significant correlation of house dust mites and the number of incidence of allergic rhinitis is p-value 0.060 (p> 0.05). Conclusion: There is no significant correlation of household dust mites and the incidence of rhinitis allergic in the ent polyclinic of Bangli hospital in 2019.

scholarly journals Preliminary correlation between blood viscosity and pulsatility index in healthy population resident at high altitude (Cusco 3300 masl)

2021 ◽  
Author(s):  
Charles Huamani Saldaña ◽  
William Bayona Pancorbo ◽  
Víctor Oré Montalvo ◽  
Carlos Pérez Alviz ◽  
Juan Carlos Acuña Mamani ◽  
...  
Keyword(s):  
Blood Viscosity ◽  
Pulsatility Index ◽  
Venous Blood ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Healthy Population ◽  
Test Results ◽  
Mean Flow ◽  
Cross Sectional ◽  
Spearman Test

Background: Viscosity affects flows by increasing resistance to movement, therefore, blood viscosity (BV) could modify the pulsatility index (PI). Objectives: To determine the correlation between BV and PI. Design and setting: A cross-sectional study was conducted in clinically healthy young adults residing in Cusco (a city located at 3399 masl). Methods: A venous blood sample was taken to determine their BV levels, and a transcranial Doppler of right middle cerebral artery (R-MCA) was performed, with which the min, maximum and mean flow velocity (MFV), resistance and pulsatility indices (PI) were obtained. The BV levels were measured in centipoises (cP) using acone-plate viscometer at 40RPM. We present medians with interquartile ranges (IQR), the correlation was evaluated using the Spearman test. Results: 42 participants were included, 25 women (60%), the mean age was 26.2±5.5 years. The median of BV was 5.08cP [IQR: 4.55-5.77cP], the MFV was 56 m/s [IQR: 49- 61 m/s], and the PI was 0.94 [0.85-1.02]. BV was positively correlated with PI (r:0.38, p=0.045) and negatively with MFV (r: -0.37, p=0.011) Conclusions: The increase in blood viscosity has a small but significant impact on cerebral vascular resistance (PI) and its fluxes (MFV) in clinically healthy and young people. This could have a role in the pathogenesis of cerebral infarction in the elderly. The results presented here are preliminary and we intend to gather more data and increasing our number of participants.

Clinical Manifestations of Allergic Rhinitis by Age and Gender: A 12-Year Single-Center Study

2020 ◽  
Vol 129 (9) ◽  
pp. 910-917
Author(s):  
Seung-No Hong ◽  
Jun Yeon Won ◽  
Eui-Cheol Nam ◽  
Tae Su Kim ◽  
Yoon-Jong Ryu ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Skin Prick Test ◽  
Clinical Characteristics ◽  
Clinical Manifestations ◽  
Nasal Symptom ◽  
House Dust Mites ◽  
Allergen Sensitization ◽  
Prick Test ◽  
Sensitization Rate ◽  
Age And Sex

Objectives: Currently, epidemiological data on allergic rhinitis collected through the skin prick test are scarce. Moreover, the relationship of age and sex to allergic rhinitis is not comprehensively understood. This study aimed to characterize allergic rhinitis and the associated clinical manifestations by age and sex. Methods: We retrospectively investigated data from 2883 patients who visited a single university hospital for rhinitis symptoms between January 2003 and December 2014. Of these 2883 patients, 1964 who underwent a skin prick test with 11 standardized allergen extracts and completed a nasal symptom questionnaire were enrolled. The clinical characteristics of allergen sensitization and nasal symptoms were analyzed by sex and age distribution. Results: The prevalence of allergen sensitization progressively decreased with age after peaking at between 20 and 29 years. The sensitization rate was higher in males than in females ( P = .046). The sensitization rate to house dust mites decreased with age, while sensitization to mugwort and ragweed increased. Six allergens ( Dermatophagoides pteronyssinus, Dermatophagoides farinae, mugwort, trees, ragweed, and cats) were sufficient to identify >96% of patients with allergen sensitization. Nasal obstruction tended to decrease with age and was more prevalent in males ( P = .002) than in females, while rhinorrhea ( P = .007) and itching ( P = .013) were more prevalent in females. Total nasal symptom scores did not differ by sex. Conclusions: The clinical characteristics of allergic rhinitis, including allergen-sensitization patterns and related symptoms, varied by age and sex. Six common allergens could be sufficient to generate a cost-effective tool to identify allergic rhinitis.

PROTEIN 24 HIV DAN LIMFOSIT T-CD4+ DI INFEKSI HIV TAHAP I

2016 ◽  
Vol 21 (3) ◽  
pp. 273
Author(s):  
I Made Sila Darmana ◽  
Endang Retnowati ◽  
Erwin Astha Triyono
Keyword(s):  
T Lymphocytes ◽  
Hiv Infection ◽  
T Lymphocyte ◽  
Negative Correlation ◽  
Stage I ◽  
Cross Sectional ◽  
Protein Levels ◽  
P24 Protein ◽  
Persistent Generalized Lymphadenopathy ◽  
Spearman Test

Measuring HIV p24 protein is a test which is more practical than determination of CD4+ T-lymphocyte counts and viral load, as it does not require a very sophisticated instrument and requires a lower cost. Independent predictive value of p24 to the decline of CD4+ T-lymphocytes, clinical progression and survival in HIV-infected patients have been reported. In this study, HIV-infected patients were found to have HIV p24 protein levels inversely proportional to CD4+ T-lymphocyte counts by using Spearman test (R2=0.225; p=0.0331). Studies on the correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIV infection have not yet been reported. The aim of this study was to prove the correlation between HIV p24 protein levels and CD4+ T-lymphocytes in stage I HIV infection. Research issue was whether a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIVinfection existed ? The hypothesis was that a correlation between HIV p24 protein levels and CD4+ T-lymphocyte counts in stage I HIV infection existed. The study design was cross sectional observational. Subjects consisted of 30 stage I HIV-infected patients treated at the Infectious Disease Intermediate Care Unit, Dr. Soetomo Hospital and VCT Clinic of the Dr. Ramelan Naval Hospital, Surabaya from May to July 2014. Stage I HIV infection is an asymptomatic HIV infection or with persistent generalized lymphadenopathy and the patient is able to perform normal activities. Levels of p24 were measured by ELISA method and CD4+ T-lymphocyte counts using flowcytometry(BD FACSCaliburTM). The results were statistically analyzed using Pearson’s correlation test. HIV p24 protein levels in stage I of HIV infection ranged from 1.8 to 10.8 pg/mL, mean of 5.14 pg/mL and a standard deviation of 2.08 pg/mL. CD4+ T-lymphocyte counts decreased with a range of 49-559 cells /uL for absolute values and 4.42–26.02% for percentage values Correlations between blood p24 levels and CD4+ T-lymphocyte counts either absolute (r=–0.392, p=0.032) or percentage (r=–0.363, p=0.049) were found. In stage I HIV-infected patients, a negative correlation was found between p24 levels and CD4+ T-lymphocyte counts, in both CD4+T-lymphocyte counts as absolute and as well as percentage values. This negative correlation showed that the p24 HIV levels were inversely proportional to the CD4+ T-lymphocyte counts. HIV p24 protein levels have a possibility to be used predicting CD4+ T-lymphocyte counts

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