scholarly journals Hypertension and sex related differences in mortality of COVID-19 infection: A systematic review and Meta-analysis

2020 ◽  
Vol 4 (1) ◽  
pp. 037-043
Author(s):  
Ghosh Probir Kumar ◽  
Hossain Mollah Mohammad Manir ◽  
Alauddin Chowdhury ABM ◽  
Alam Nazmul ◽  
Harun Golam Dostogir
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
P Value ◽  
Mortality And Morbidity ◽  
Premature Deaths ◽  
Male Patients ◽  
The Many ◽  
Relationship Of ◽  
The Relationship

Background: Hypertension is the leading cause of cardiovascular diseases and premature deaths. Hypertension plays a striking role in mortality and morbidity in case of Coronavirus Disease 2019 (COVID-19) infection; however, numerous studies have reported contradictory findings. Objective: To assess the relationship of hypertensive disease and mortality of COVID-19 infection and to assess the sex and age differentials on the association. Methods: We have conducted a systematic review of published literatures that identified the relationship between hypertension and mortality of COVID-19 infections. Nineteen articles were selected following structured inclusion and exclusion criteria for systematic review and analyses. A total of 21,684 hospital admitted COVID-19 patients were included in this review and meta-analysis from 19 studies. The studies covered the six months of the pandemic from December 2019 to May 2020. Results: In the pooled analysis, the median age of patients was 58 years, and the proportion of male patients was 58.8%. In contrast, we estimated 33.26% of hypertensive and 19.16% of diabetes mellitus patients in the studies. Hypertension was found to be associated with COVID-19 mortality (“Risk ratio (RR) = 1.45, [95% confidence interval (CI): 1.35 - 1.55]; I2 = 77.1%, p - value < 0.001”). The association in the meta-regression was affected by sex (p - value = 0.050). The association was found to be stronger in the studies with males ≥ 55% and age ≥ 55 years (“RR = 1.65, [95% CI: 1.52 - 1.78]; I2 = 77.1%, p - value < 0.001”) compared to male < 55% or age < 55 years (“RR = 1.11, [95% CI: 0.94 - 1.28]; I2 = 72.2%, p - value < 0.001”). Conclusion: Hypertension was significantly strong associated with COVID-19 mortality which may account for the contradiction in the many studies. The association between hypertension and mortality was affected by sex and there were significantly higher fatalities among older male patients.

Insulin therapy and outcome from coronavirus disease 2019 (COVID-19): A Systematic Review, Meta-Analysis, and Meta-Regression

2021 ◽  
Vol 21 ◽  
Author(s):  
Timotius Ivan Hariyanto ◽  
Nata Pratama Hardjo Lugito ◽  
Theo Audi Yanto ◽  
Jeremia Immanuel Siregar ◽  
Andree Kurniawan
Keyword(s):  
Systematic Review ◽  
Insulin Therapy ◽  
Meta Analysis ◽  
Random Effect ◽  
Pooled Analysis ◽  
The Poor ◽  
Meta Regression ◽  
Insulin Use ◽  
The Relationship ◽  
Review Manager

Background: Currently, the relationship between insulin therapy and COVID-19 outcome is not yet established. Our study aims to evaluate the possible association between insulin and the poor composite development of COVID-19. Methods: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 12th, 2020. All articles published on COVID-19 and insulin were retrieved. Statistical analysis was done using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software. Results: Our pooled analysis showed that insulin use was associated with poor composite development of COVID-19 [OR 2.06 (95% CI 1.70 – 2.48), p < 0.00001, I2 = 83%, random-effect modelling], and its subgroup which comprised of risk of COVID-19 [OR 1.70 (95% CI 1.40 – 2.08), p < 0.00001, I2 = 34%, random-effect modelling], severe COVID-19 [OR 2.30 (95% CI 1.60 – 3.30), p < 0.00001, I2 = 88%, random-effect modelling], and mortality [OR 2.14 (95% CI 1.47 – 3.10), p < 0.0001, I2 = 85%, random-effect modelling]. Meta-regression showed that the association was influenced by age (p = 0.008), but not by diabetes (p = 0.423), and cardiovascular disease (p = 0.086). Conclusion: Physicians should be more aware and take extra precautions with diabetes patients who use insulin therapy.

scholarly journals The efficacy of transcranial magnetic stimulation (TMS) for negative symptoms in schizophrenia: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Rasmus Lorentzen ◽  
Tuan Dang Nguyen ◽  
Alexander McGirr ◽  
Fredrik Hieronymus ◽  
Soren Dinesen Ostergaard
Keyword(s):  
Systematic Review ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Negative Symptoms ◽  
Meta Analysis ◽  
Preliminary Evidence ◽  
Pooled Analysis ◽  
P Value ◽  
Number Needed To Treat ◽  
Double Blind

Several trials have shown preliminary evidence for efficacy using Transcranial Magnetic Stimulation (TMS) as a treatment for negative symptoms in schizophrenia. Here, we synthesize this literature using a systematic review and quantitative meta-analysis of double-blind randomized controlled trials of TMS in patients with schizophrenia. Specifically, MEDLINE, EMBASE, Web of Science, and PsycINFO were searched for sham-controlled, randomized trials of TMS among patients with schizophrenia. The standardized mean difference (SMD, Cohen's d) with 95% confidence intervals (CI) was calculated for each study (TMS vs. sham) and pooled across studies using an inverse variance random effects model. We identified 56 studies with a total of 2550 participants that were included in the meta-analysis. The pooled analysis showed statistically significant superiority of TMS (SMD=0.37, 95%CI: 0.23; 0.52, p-value <0.00001), corresponding to a number needed to treat of 4.85. Furthermore, stratified analyses suggested that TMS targeting the left dorsolateral prefrontal cortex, using a stimulation frequency >1 Hz, and a stimulation intensity at or above the motor threshold, was most efficacious. There was, however, substantial heterogeneity and high risk of bias among the included studies. In conclusion, TMS appears to be an efficacious treatment option for patients with schizophrenia suffering from negative symptoms, but the optimal TMS parameters have yet to be resolved.

scholarly journals Sitagliptin and Acute Pancreatitis: A Systematic Review and Meta-analysis

2021 ◽  
pp. 45-50
Author(s):  
Hyder Osman Mirghani ◽  
Salem Ahmed S. Shaman S. Shaman ◽  
Ibrahim Mahmoud Hussain Aljwah
Keyword(s):  
Systematic Review ◽  
Acute Pancreatitis ◽  
Meta Analysis ◽  
P Value ◽  
Significant Heterogeneity ◽  
Chi Square ◽  
Number Of Patients ◽  
The Usa ◽  
Peptidase Inhibitor ◽  
Relationship Of

Background and Objectives: Sitagliptin is a dipepidyl peptidase inhibitor (DPP-4i) with gentle antidiabetic effects with a lower risk of hypoglycemia. The association with acute pancreatitis is controversial. The current meta-analysis aimed to assess the relationship of sitagliptin and acute pancreatitis. Methods: The literature in PubMed and Google Scholar was searched for relevant articles published in the last ten years up to September 2021. The keywords sitagliptins, DPP-4i, acute pancreatitis were used with the protean AND or OR. Among the 204 articles retrieved, 24 full-texts were assessed for eligibility and only five studies (Three from the USA, one from Asia, and one from Canada) met the inclusion criteria for the systematic review. The author name, year of publication, country, type of study, number of patients, and the duration of the study were reported. Results: There were five studies. The total number of patients were 729808 with 6459 events. The studies showed no increased rate of acute pancreatitis following sitagliptin use, odd ratio, 0.79, 95% CI, 0.29-2.15, a significant heterogeneity was observer, I2 for heterogeneity=98%, P-value, <001, the P-value for overall effect was 0.65 and the chi-square, 160.15. Interpretation and Conclusion: Sitagliptin use is not associated with acute pancreatitis.

scholarly journals The Relationship of COVID-19 Severity with Cardiovascular Disease and Its Traditional Risk Factors: A Systematic Review and Meta-Analysis

Global Heart ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 64 ◽  
Author(s):  
Kunihiro Matsushita ◽  
Ning Ding ◽  
Minghao Kou ◽  
Xiao Hu ◽  
Mengkun Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Disease ◽  
Meta Analysis ◽  
Traditional Risk Factors ◽  
Relationship Of ◽  
The Relationship

scholarly journals Paradoks Konsumsi Kopi Terhadap Risiko Kejadian Stroke: Sebuah Kajian Sistematis

2021 ◽  
Vol 3 (1) ◽  
pp. 51-60
Author(s):  
Andi Muh. Aunul Khaliq Gunawan ◽  
Indah Nurul Khairunnisa ◽  
Muthia Kintan Fais
Keyword(s):  
Systematic Review ◽  
Cardiovascular Events ◽  
Stroke Risk ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Increased Risk ◽  
The World ◽  
Meta Analyses ◽  
Relationship Of ◽  
The Relationship

Background: Coffee is one of the drinks most often consumed throughout the world and is the second most popular beverage in the world after water. At present, the effect of coffee consumption on the human body is increasingly being studied, especially on the cardiovascular system. Many studies say that coffee consumption can prevent stroke, either directly or indirectly against stroke risk factors by a variety of mechanisms caused by the compounds contained in coffee. However, to date various prospective studies looking at the relationship between coffee consumption and stroke risk are still inconsistent. Objectives: To determine the relationship of coffee consumption with the risk of stroke. Methods: We searched on MEDLINE and PubMed, using the keywords “coffee” or “caffeine” and "stroke or cardiovascular events" which follows the flow and search rules of the Reporting Item Options for Systematic Review and Meta Analysis (PRISMA) to find studies with cohort design in the last 10 years starting in 2009-2019. Discussion: Among 226 citations identified in this systematic review, only 10 studies met the inclusion criteria. Four studies provided evidence that coffee consumption habits were not associated with an increased risk of stroke, while 6 other studies explaining that more coffee consumption has protective benefits against the risk of stroke. Conclusion: Coffee consumption shows a preventive effect on stroke risk. Keywords: caffeine, coffee, relative risk, stroke risk   Latar Belakang: Kopi merupakan salah satu minuman yang paling sering dikonsumsi di seluruh dunia dan menjadi minuman populer kedua di dunia setelah air. Saat ini, pengaruh konsumsi kopi untuk tubuh manusia semakin banyak diteliti, khususnya terhadap sistem kardiovaskular. Banyak penelitian mengatakan bahwa konsumsi kopi dapat mencegah timbulnya penyakit stroke, baik secara langsung atau tidak langsung terhadap faktor risiko stroke dengan beragam mekanisme yang ditimbulkan oleh senyawa yang terkandung dalam kopi. Namun, hingga saat ini beragam studi prospektif yang mengamati hubungan antara konsumsi kopi dan risiko stroke masih belum konsisten. Tujuan: Untuk mengetahui hubungan konsumsi kopi dengan risiko terjadinya stroke. Metode: Pencarian dilakukan pada MEDLINE dan PubMed dengan menggunakan kata kunci “coffee or caffeine” and “stroke or cardiovascular events”. yang mengikuti alur dan kaidah pencarian Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) untuk mencari studi dengan desain cohort dalam rentang waktu 10 tahun terakhir mulai tahun 2009-2019. Pembahasan: Dari 226 sitasi yang teridentifikasi pada systematic review, hanya 10 studi yang sesuai dengan kriteria inklusi. Empat penelitian memberikan bukti bahwa kebiasaan mengonsumsi kopi tidak dikaitkan dengan peningkatan risiko stroke, sedangkan 6 penelitian lainnya, menjelaskan bahwa konsumsi kopi yang lebih banyak memiliki manfaat perlindungan terhadap risiko kejadian stroke. Kesimpulan: Konsumsi kopi menunjukkan efek pencegahan terhadap risiko stroke. Kata Kunci: kafein, kopi, risiko relatif, risiko stroke

scholarly journals Low-Hemoglobin Levels During Pregnancy with Low-Birth Weight: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 7 (1) ◽  
pp. 55
Author(s):  
Lucyana Septia Pramita ◽  
Widati Fatmaningrum ◽  
Martono Tri Utomo ◽  
Muhammad Ilham Aldika Akbar
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Meta Analysis ◽  
Neonatal Morbidity ◽  
Developed Countries ◽  
P Value ◽  
Research Bias ◽  
Low Birth Weight Babies ◽  
Relationship Of

Introduction: Low birth weight (LBW)  is one of the main risk factors for neonatal morbidity and mortality. Anemia in developing countries is still quite high compared to developed countries. Low hemoglobin levels in pregnancy can affect the birth of low birth weight babies.Methods: This study used a systematic review method. Studies published between 2015 and 2019. Search for articles was reviewed systematically through Scopus, ScienceDirect, Cochrane, and PubMed databases. The final results obtained 10 articles following the inclusion and exclusion criteria. Calculation result using Meta-Analysis with help of Comprehensive Meta-Analysis (CMA) software.Results: Compare the odds ratio and confidence interval of hemoglobin levels compared to low birth weight events. The results obtained OR 1.449 (95% CI 0.964 – 2.177) and p-Value 0.074 so that there is no relationship of hemoglobin levels in pregnant women ≤ 11gr / dL with the incidence of low birth weight babies. In the heterogeneity test results, I-Squared results obtained by 79.191%, which indicates the value of I-squared heterogeneity> 50% so that the sample used is heterogeneous. Maternal age less than 20 years or more than 35 years, number of parity, pregnancy spacing, and number of problems in the assessment of pregnancy and previous labor.Conclusion: There is no correlation between low maternal hemoglobin levels with the incidence of low birth weight because there are other factors that can affect outcomes such as different respondent characteristics, number of samples, different research countries, different trimester of pregnancy and other factors that can cause research bias.

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