scholarly journals Clinical and epidemiological differences in the course of psoriasis in children depending on Vitamin D levels and genotypes of the TaqI polymorphic variant of the VDR gene

2021 ◽  
Vol 5 (1) ◽  
pp. 006-012
Author(s):  
Elvina Murzina
Keyword(s):  
Vitamin D ◽  
Clinical Presentation ◽  
Disease Onset ◽  
Serum Levels ◽  
Polymorphic Variant ◽  
Vdr Gene ◽  
Epidemiological Features ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
History Of

When grouping children with psoriasis depending on TaqI (T/C) genotypes of the VDR gene, the youngest age of disease onset and the longest duration of dermatitis (5.60 ± 0.77 years and 4.90 ± 0.68 years, respectively) showed up in case of the CC genotype. In case of the TT genotype, disease onset coincided with an older age, and the history of present illness was the shortest (10.26 ± 0.64 years and 2.59 ± 0.58 years, respectively). PASI (20.32 ± 3.43) and BSA (40.00 ± 6.11) severity indices were the highest and of statistically significant difference to those in other groups in the presence of the CC genotype. In case of the TC genotype, the index PGA (2.80 ± 0.15) was the lowest and made a statistically significant difference to the values of other groups. A negative correlation between vitamin D levels and the PASI, PGA, BSA was identified in children holding CC and TC genotypes. Conclusion: The clinical presentation of dermatitis and its epidemiological features in children with psoriasis, namely the age of disease onset, duration of exacerbation, body surface area and the intensity of psoriasis symptoms depend on vitamin D serum levels and genotypes of the TaqI polymorphic variant of the VDR gene.

scholarly journals Comparative Study of Salivary and Serum Levels of Vitamin D in Patients with a History of High Blood Pressure and Healthy People

2018 ◽  
Vol 8 (1) ◽  
pp. 101 ◽  
Author(s):  
Hamidreza Abdolsamadi ◽  
Mohammad vahedi ◽  
Farnaz Fariba ◽  
Alireza Soltanian ◽  
Meghdad Zakavati Avval ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Serum Level ◽  
High Blood Pressure ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
History Of ◽  
The Mean

Introduction: Vitamin D deficiency is a major public health problem. Low vitamin D levels associated with adverse health consequences such as musculoskeletal health, cognitive decline and progression of cancer and death. The lack of vitamin D associated with major risk factors for cardiovascular disease (CVD) includes hypertension is considered. The ability to assess the general health, disease and treatment outcomes through saliva as a non-invasive, inexpensive and simple method of interest is located. The aim of this study was a comparative study of salivary and serum levels of vitamin D3 in patients with a history of developing high blood pressure and a healthy person.Methods: This study was a case - control survey, in which 40 patients with high blood pressure were examined. The control group including 40 healthy subjects. Both groups were matched in terms of age and gender. After collecting samples of serum and saliva, the amount of vitamin D level samples were measured using ELISA method by electrochemiluminescence (ELC), and then analyzed the results using software SPSS 16 and statistical test including Chi Square Test, Independent-Samples, linear regression model, the Mann-Whitney Test and Spearman correlation coefficient.Results: There was no significant difference in the mean serum levels of vitamin D among patients and healthy subjects (p= 0.588). In addition, there was no significant difference in the mean salivary levels of vitamin D between patients and healthy subjects (p= 0.833). There was no significant relationship between salivary and serum level of vitamin D in healthy individuals (p= 0.095). As well as there was no significant correlation between salivary and serum level of vitamin D in patients (p= 0.5).Conclusions: This study showed that vitamin D is a measurable marker in saliva, but its analysis in saliva, may not be a reliable tool for determining the vitamin D levels.

scholarly journals BsmI polymorphism in the vitamin D receptor gene is associated with 25-hydroxy vitamin D levels in individuals with cognitive decline

2018 ◽  
Vol 76 (11) ◽  
pp. 760-766 ◽  
Author(s):  
Ana Carolina R. de Oliveira ◽  
Carolina A. Magalhães ◽  
Cristina M. G. Loures ◽  
Vanessa G. Fraga ◽  
Leonardo C. de Souza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Decline ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Bsmi Polymorphism ◽  
Vitamin D Levels ◽  
Vdr Gene Polymorphisms ◽  
Significant Difference ◽  
25 Hydroxy Vitamin D

ABSTRACT Elderly people are at a high risk of developing vitamin D (VitD) deficiency due to both decreased intake and cutaneous synthesis. Most of the biological actions of VitD are mediated by the vitamin D receptor (VDR), which is present in neurons and glial cells of the hippocampus, and in the cortex and subcortical nuclei, essential areas for cognition. It is known that VDR gene polymorphisms may decrease the VDR affinity for VitD. Objective: The present study aimed to investigate the influence of VitD levels on cognitive decline in patients with dementia due to Alzheimer's disease (AD, n = 32) and mild cognitive impairment (MCI, n = 15) compared to cognitively healthy elderly (n = 24). We also evaluated the association of VDR gene polymorphisms with cognitive disturbance. Methods: Four polymorphisms on the VDR gene were studied, namely, BsmI, ApaI, FokI and TaqI, by polymerase chain reaction-restriction fragment length polymorphism. Serum levels of 25-hydroxy vitamin D (25(OH)D) were determined by high performance liquid chromatography. Results: No significant difference in 25(OH)D levels or genotypic/allelic frequencies was observed between the groups. Deficiency of 25(OH)D was more frequently observed in women. The AA/AG genotypes of the BsmI polymorphism was associated with sufficient 25(OH)D levels, while the GG genotype of this same polymorphism was associated to insufficient levels in the cognitively-impaired group (individuals with AD or MCI). Conclusions: The data obtained do not confirm the relationship between reductions of VitD levels, polymorphisms in the VDR gene, and altered cognitive function in this sample. However, the data indicate that BsmI polymorphism in the VDR gene is associated with the VitD levels in individuals with cognitive decline.

scholarly journals Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

2019 ◽  
Vol 41 (07) ◽  
pp. 425-431
Author(s):  
Thais Walverde Siqueira ◽  
Edward Araujo Júnior ◽  
Rosiane Mattar ◽  
Silvia Daher
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vdr Gene ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

scholarly journals Alert for bone alterations and low serum concentrations of vitamin D in patients with intestinal inflammatory disease

2017 ◽  
Vol 63 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Lorete Maria da Silva Kotze ◽  
◽  
Carolina Tabata Costa ◽  
Murilo Franco Cavassani ◽  
Renato Mitsunori Nisihara ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Bone Changes ◽  
Bowel Diseases ◽  
Intestinal Inflammatory Disease ◽  
Irritable Bowel

Summary Background: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation of the intestine that can reduce the absorption of nutrients such as vitamin D and calcium. Objective: To investigate bone alterations and serum levels of vitamin D in patients with IBD. Method: This was a cross-sectional study based on a review of medical records of patients from a private office in Curitiba, PR, Brazil. Serum levels of vitamin D and bone densitometry were measured at diagnosis of IBD. A total of 105 patients were included; 38 (58.4%) with CD; 27 (41.6%) with UC and 40 with irritable bowel syndrome (IBS) as comparison group. Results: When compared to patients with UC, CD patients showed a higher prevalence of bone alterations, being 15.8% with osteoporosis and 36.8% with osteopenia. In UC, bone alterations occurred in 29.6% of cases, 3.7% with osteoporosis and 25.9% with osteopenia. As for vitamin D levels, among CD patients, 10.5% had vitamin deficiency, 65.8% insufficiency and 23.7% were sufficient. In UC, 7.4% of cases had deficiency, 74.1% insufficiency and 18.5% had sufficient serum levels of vitamin D. In the group with IBS, deficiency was observed in 17.5% of cases, insufficiency in 55% and sufficiency in 27.5% of them. There was no significant difference between groups. Conclusion: IBD patients have a high prevalence of bone changes, especially those with CD. Serum levels of vitamin D are below the recommended in all the evaluated groups.

Investigating the Relationship the Severity of Coronary Artery Disease with Serum Levels of Vitamin D in Men after Eliminating the Effect of Diet

2020 ◽  
Vol 16 (4) ◽  
pp. 508-513
Author(s):  
Farshad K. Birgani ◽  
Majid M. Shahi ◽  
Bahman Cheraghian ◽  
Habib Haybar
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Artery Disease ◽  
The Relationship

Background: Coronary artery disease (CAD) is one of the most common cardiovascular diseases that can lead to mortality, inability, and lower productivity levels. Objective: The aim of this study was to determine the relationship between serum vitamin D level and cardiovascular risk factors and the severity of CAD after determining and eliminating the confounding effects of dietary patterns in male patients undergoing angiography. Methods: This descriptive-analytic study was carried out on 132 men undergoing angiography during 2017 and 2018. To this end, food frequency questionnaire (FFQ) and physical activity questionnaire (PAQ) were completed for the patients. Fasting blood sugar (FBS), triglyceride, total cholesterol, HDL-C, LDL-C and vitamin D levels were also investigated. Results: Serum vitamin D levels significantly decreased with an increase in CAD severity (p=0.001). Also, low serum levels led to the highest severity of CAD (p=0.005). However, there was no significant difference between patients with vitamin D deficiency with different degrees of CAD (p=0.084). Also, the highest percentage of individuals with normal serum levels of vitamin D was observed in the group without any blocked blood arteries (normal) (p=0.023). Conclusion: This study shows an inverse relationship between serum 25(OH) D level and the severity of CAD. Our data show that vitamin D plays an important role in preventing CAD. These findings could help design prospective studies and clinical trials on a wider scale to investigate the effects of vitamin D interventions in preventing the development of CAD.

Interleukin 37 Levels in Relation to Serum Vitamin D Levels Among Ain Shams University Medical Students

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Randa Reda Mabrouk ◽  
Afaf Abdelalim Mostafa ◽  
Dina Aly Mohamed Aly Ragab ◽  
Fouad Mohamed Fouad zaki
Keyword(s):  
Vitamin D ◽  
Medical Students ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Group I ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Group Ii

Abstract Background The extraskeletal role of vitamin D is being increasingly recognized. This has important clinical implications, as vitamin D deficiency has reached epidemic proportions worldwide. Vitamin D has proposed anti-inflammatory properties as recent data suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. Interleukin-37(IL-37) is an IL1 family cytokine discovered in recent years and has 5 different isoforms. As an immunosuppressive factor, IL-37 can suppress excessive immune response .IL37 plays a role in protecting the body against endotoxin shock, ischemia reperfusion injury, autoimmune diseases, and cardiovascular diseases. In addition, IL-37 has a potential antitumor effect. IL-37 and its receptors may serve as novel targets for the study, diagnosis, and treatment of immune-related diseases and tumors. Aim of the Work The aim of this study is to determine the relation between the level of interleukin-37 and 25-hydroxy Vitamin D among Ain Shams University medical students. Subjects and Methods The study was conducted at Clinical Pathology Department, Ain Shams University Hospitals. Ninety individuals, from medical students of Ain Shams University who participated in the Nutritional Assessment of Ain Shams University Medical Students (NAMESASU) Project, were selected to be in the study. The study included 2 groups: Group I: included 45 subjects selected from the NAMES-ASU project with deficient vitamin D serum levels. Group II: included 45 subjects selected from the NAMES-ASU project with sufficient vitamin D serum levels. Results There was a highly significant difference between the two groups regarding vitamin D levels. Serum IL-37 levels were significantly higher in group I subjects compared to group II subjects. No significant difference was observed between group I and group II regarding BMI, BFM, PBF and hsCRP. No significant difference was observed between the two subgroups regarding IL-37 levels and hsCRP levels. A highly significant negative correlation was observed between vitamin D levels and IL-37. A significant negative correlation was observed between hsCRP and vitamin D levels. However, no correlation was observed between hsCRP and IL-37 levels. Conclusion Data from our study showed that present study denote that in case of vitamin D deficiency, irrespective of BMI, a subclinical state of inflammation may be present as reflected by the increased hsCRP levels and this state of inflammation might induce an increase in IL-37, an anti-inflammatory cytokine, in an attempt to reduce the inflammation.

Vitamin D levels in Children with Recurrent Wheezing: An Observational Study

2021 ◽  
Author(s):  
Shyamajit Samaddar ◽  
Manvi Singh ◽  
Joseph Mathew ◽  
Naresh Sachdeva ◽  
Meenu Singh
Keyword(s):  
Vitamin D ◽  
Observational Study ◽  
Vitamin D Deficiency ◽  
Pearson Correlation ◽  
Sun Exposure ◽  
Serum Levels ◽  
Predictive Index ◽  
Recurrent Wheezing ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Aim: To study the vitamin D levels in toddlers with recurrent wheezing.Methods: In this prospective observational study, 108 children aged 1-3 years with recurrent wheezing and 41 healthy age and sex matched controls were included. The clinical, demographic, socio-economic, food habits, and sun exposure of both the groups were assessed. The serum levels of vitamin D were measured and Asthma predictive index (API) of all the cases was calculated. Spearman or Pearson correlation coefficients were used to see relationship of different variables with Vitamin D.Results: Among 108 cases and 41 controls we enrolled, majority of them had vitamin D deficiency or insufficiency. The difference in vitamin D levels in the two groups was not statistically significant (p=0.0619). We found no significant difference in the vitamin D levels between, urban and rural population, vegetarians and non-vegetarians, adequately and inadequately sun light exposed children. There was also no correlation between the vitamin D levels and the number of wheezing episodes in the last 1 year. There was no significant correlation between the number of criteria of API positive and the vitamin D levels.Conclusion: Our study showed that the overall prevalence of vitamin D deficiency is very high among toddlers with recurrent wheezing. We conclude that vitamin D rich diet and sunlight exposure cannot prevent vitamin D deficiency in Indian toddlers. National programme for universal supplementation of vitamin D is required to control this epidemic of vitamin D deficiency.

scholarly journals Vitamin D and Vitamin D Receptor in Scleroderma Subtypes

2020 ◽  
pp. 19-24
Author(s):  
Kocak Ayse
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Mrna Levels ◽  
Diffuse Type ◽  
Gene Expressions ◽  
Vdr Gene ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Tgf Β1

Vitamin D Receptor (VDR) is a member of the nuclear hormone receptor family. 1,25(OH)2D, a form of metabolically active vitamin D3 form, is the ligand of VDR. When VDR and 1,25(OH)2D are connected, many genes start to molecular interaction reactions that will modulate the transcription. VDR has been shown to be a negative regulator of the transforming growth factor beta-1 / Smad (TGF-β1 / Smad) signalling pathway. TGF-β1 / Smad signalling is important in the pathogenesis of scleroderma (SSc). Vitamin D has pleiotropic effects including immunomodulatory and antifibrotic properties in scleroderma pathogenesis. The aim of this study was to investigate the expression of VDR and the levels of vitamin D in scleroderma subtypes and study the possible correlation between the two parameters. 28 SSc patients and 30 healthy controls were included in the study and they were classified according to the 2013 ACR / EULAR criteria and Rodnan Scores were calculated. 14 were of the limited type and 14 were of the diffuse type of scleroderma. Vitamin D levels were determined in serum. Vitamin D level was measured by chemiluminescence immunometric assay. VDR gene expression was determined by quantitative PCR in isolated RNAs from the blood. Changes in mRNA levels were analysed and beta-actin was used as the housekeeping gene. Also, TGF-β1 gene expressions were determined. VDR gene expressions in diffuse type scleroderma patients were significantly decreased compared to the control. TGF-β1 gene expressions were increased in diffuse type scleroderma. It was found that VDR gene expression in limited type scleroderma patients did not show any significant difference when compared to control. Vitamin D levels and VDR gene expressions showed no correlation in scleroderma subtypes. VDR gene expression decreased in patients with diffuse type scleroderma and showed negative correlation with the Rodnan score and TGF-β1 gene expressions. There was no significant difference between vitamin D and VDR levels.

scholarly journals Association of vitamin D deficiency with clinical presentation of COVID-19

2021 ◽  
Vol 19 ◽  
pp. 205873922110383
Author(s):  
Mazen Almehmadi ◽  
Abdullah Turjoman ◽  
Ahmad El-Askary ◽  
Alaa Shafie ◽  
Fatimah Rebh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Inflammatory Markers ◽  
Clinical Presentation ◽  
Blood Levels ◽  
Positive Polymerase Chain Reaction ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
D Dimer

Background The coronavirus disease 2019 (COVID-19) is a respiratory virus, the spread of which has caused a global pandemic with catastrophic consequences. The current study aimed to investigate the association between vitamin D deficiency and the clinical presentation of COVID-19. Patients and methods The current study included 166 COVID-19 patients recruited from Prince Mohammad Bin Abdulaziz Hospital in Riyadh, Saudi Arabia. The study was conducted from October 2020 to January 2021. Patients were diagnosed by positive polymerase chain reaction (PCR) results. History and clinical data were collected for all subjects. In addition, laboratory analysis was done to estimate blood levels of 25 hydroxyvitamin D (25(OH)D), C-reactive protein (CRP), ferritin, parathyroid hormone (PTH), alanine aminotransferase (ALT), D-dimer, calcium, and relative lymphocytic count. COVID-19 patients were divided into three subgroups according to their vitamin D status. Patients were considered sufficient when their vitamin D level was above 30 ng/mL. Patients with vitamin D levels below 20 ng/mL were considered deficient. Patients with vitamin D levels ranging from 20 ng/mL to 30 ng/mL were considered insufficient. Results Our results showed that 81 patients (49%) were deficient in vitamin D, and 48 patients (29%) were insufficient in vitamin D. Only 37 patients (22%) had normal vitamin D levels. Moreover, a significant difference was found regarding the inflammatory markers of COVID-19 severity. Also, vitamin D levels were inversely correlated with the markers used for monitoring the condition of COVID-19 patients: ferritin, CRP, and D-dimer. Conclusion Our results showed that vitamin D deficiency was associated with increased levels of inflammatory markers of COVID-19 infection.

scholarly journals The association of the Fok1(rs2228570)vitamin D receptor (VDR) polymorphism with cardiovascular diseases predisposition in Sudanese patients.

2021 ◽  
pp. 33-39
Author(s):  
Manal A Fadl ◽  
Hadeel M.M. Hassan
Keyword(s):  
Vitamin D ◽  
Family History ◽  
Cardiovascular Diseases ◽  
Vitamin D Receptor ◽  
Mutant Allele ◽  
Heart Diseases ◽  
Vdr Gene ◽  
Vdr Polymorphism ◽  
Significant Difference ◽  
History Of

Cardiovascular diseases (CVDs) are public health concerns globally. The role of genetics in CVDs predisposition was evidenced in previous studies. The nuclear vitamin D receptor (VDR)regulates the transcription of a number of different genes implicated in a variety of diseases including CVDs.In this study we aimed to investigate “for the first time” the association of vitamin D receptor (VDR) FokI(rs2228570)gene polymorphismwith the risk of heart diseases (CVDs) in Sudanese patients. A cross sectional case-control study was conducted, including 60 of proven heart disease (CVD)patients and 77 controls. The demographic information was obtained using well designed questionnaire. The genotypes of the VDR FokIpolymorphism (rs2228570) were determined by polymerase chain reaction-restriction fragment length polymorphism method using Fok1 restriction enzyme.The results of this study showed that atherosclerosis represents 57.1% of the CVD cases. No gender difference was observed when compare cases to the controls (P= 0.13).Previous attack of CVDs was reported in16.7% of the CVD cases. 50% of the patients have family history of CVDs with high significant difference when compared to the controls (P=0.0001)52% and 48% of the CVD patients are hypertensive and diabetic respectively. The genotypes of the Fok1polymorphismof the VDR gene did not differ between CVD patients and control subjects (P=0.72).Thisindicates that this mutation is unlikely to play a major role in CVDs predisposition in our sample. However, the frequencies of the mutant CC and TC genotypes among CVD patients who encountered previous attack was 33.3% and 55.6% respectively.The frequency of the mutant allele among CVD cases and controls is71% and 74% respectively and among who patients have family history of CVD was 72%, indicating a potential presence of the mutant allele in the general population.Thisresult suggest that the Fok1 polymorphism of the VDR gene is unlikely to contribute to CVDs predisposition in this samples, however, a considerable frequency of the mutant allele among CVD cases and controls and among those who have family history of CVDs, indicating a latent presence of the mutant allele in the general population and mightpossibly contribute to disease susceptibility in Sudanese CVD patients.

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