scholarly journals Syphilitic pemphigus

2020 ◽  
Vol 4 (1) ◽  
pp. 003-003
Piñeres Elvis ◽  
Ospina Carlos

A 34-week premature newborn, child of a mother without prenatal controls, a marijuana user, with gestational syphilis with a positive rapid plasma reagin test (RPR) titer 1:16, did not receive treatment during pregnancy. The newborn presented congenital syphilis, RPR titer 1: 256 positive test.

2007 ◽  
Vol 24 (2) ◽  
pp. 333
In Ok Hwang ◽  
Eun Sil Lee

2021 ◽  
Vol 15 (1) ◽  
Nsofwa Sukwa ◽  
Michelo Simuyandi ◽  
Masuzyo Chirwa ◽  
Yvonne Mutombo Kumwimba ◽  
Obvious N. Chilyabanyama ◽  

Abstract Background Despite an otherwise robust national antenatal clinic program, maternal and congenital syphilis remains an important public health issue in Zambia. This case series reports the clinical presentation of seven infants diagnosed with congenital syphilis in Lusaka, Zambia. Case presentations The cases in this series were incidental findings from a cohort of infants enrolled in a rotavirus vaccine immunogenicity study recruiting infants at 6 weeks of age. As part of clinical care for enrolled participants, we screened mothers of children who presented with adverse events of (i) repeated upper respiratory tract infections/coryza, (ii) skin lesions, and (iii) poor weight gain, for syphilis using rapid plasma reagin test. From a cohort of 214 mother–infant pairs enrolled between September and December 2018, a total of 115 (44.4%) of the mothers reported to have not been screened during antenatal care. Of these, four (3.5%) reported to have tested positive; and only two received treatment. Seven out of 57 (26.6%) children meeting the screening criteria had a positive rapid plasma reagin test result. The mean age at diagnosis was 4.5 months (1.3 months standard deviation), and the common presenting features included coryza (6/7), skin lesions (4/7), conjunctivitis (3/7), pallor/anemia (5/7), wasting (2/7), and underweight (5/7). Three of the seven infants were exposed to human immunodeficiency virus. Following diagnosis, all seven cases received standard treatment according to national treatment guidelines. That is, 6/7 cases received inpatient care with benzylpenicillin for 10 days, while 1/7 was treated as an outpatient and received daily procaine penicillin for 10 days. Conclusion These findings suggest that, though screening for syphilis is part of the standard antenatal care in Zambia, it is not offered optimally. There is urgent need to address programmatic shortcomings in syphilis screening and treatment to avoid long-term sequelae. Additionally, clinicians need to raise their index of suspicion and rule out syphilis when confronted with these clinical symptoms, regardless of the mother’s human immunodeficiency virus status.

2011 ◽  
Vol 23 (Suppl 1) ◽  
pp. S127 ◽  
Jin Ki Kim ◽  
Se Rim Choi ◽  
Hee Jung Lee ◽  
Dong Hyun Kim ◽  
Moon Soo Yoon ◽  

1967 ◽  
Vol 40 (3) ◽  
pp. 440-443
John C. Herweg ◽  
F. Donald Hoffmann ◽  
Charles A. Reed

In the United States, in 1966, 370 infants under 1 year of age were reported as having congenital syphilis. This is a twofold increase since 1957. Despite this fact, routine serologic testing for syphilis is not done on most infants and children hospitalized in the United States. For use in those institutions where routine serologic testing for syphilis is felt to be desirable, the Rapid Plasma Reagin (Circle) Card Test has been found to be a simple, practical, and inexpensive screening method.

Sexual Health ◽  
2015 ◽  
Vol 12 (2) ◽  
pp. 174 ◽  
Xingdong Ye ◽  
Shao-Kai Tang ◽  
Xiangnong Dai ◽  
Wanping He ◽  
Huilan Zhu ◽  

The purpose of this study was to evaluate the rationality of congenital syphilis (CS) cases reported by physicians in hospitals of various levels in Guangzhou, China. The over-reporting rate was calculated. The results suggested that 49.1% (54 out of 110) of the CS cases reviewed were identified as cases that should be reported; 18 of the 54 CS case were confirmed CS cases and 50.9% (56 out of 110) were identified as over reported. Factors associated with CS case misclassification were analysed. To decrease the incidence of CS, antenatal care management and rapid plasma reagin titres should be provided and the follow up for children should be raised.

2017 ◽  
Vol 94 (8) ◽  
pp. 562-564 ◽  
Caiying Wang ◽  
Shuxin He ◽  
Hongling Yang ◽  
Yuhuan Liu ◽  
Yang Zhao ◽  

ObjectivesThe objective of this retrospective study was to summarise the clinical manifestations of, and to analyse the incidence and risk factors of, Jarisch–Herxheimer reaction (JHR) during the treatment of children with symptomatic congenital syphilis.MethodsClinical data of 60 children with clinically and laboratory diagnosed congenital syphilis, hospitalised in Beijing Ditan Hospital between January 2010 and November 2015, were collected and analysed.ResultsA total of 11 patients with congenital syphilis (11/60, 18.3%) developed JHR. JHR occurred in 1–6 hour after the first dose of penicillin. Common clinical manifestations included fever (11/11, 100%), irritability (11/11, 100%), rapid pulse and breathing (11/11, 100%), exacerbation of existing rash (5/11, 45.6%) and chills (3/11, 27.3%). Of the 11 patients who developed JHR, 9 patients (9/11, 81.8%) had bone syphilis, 10 (10/11, 90.9%) had more than three organs affected by syphilis and 10 (10/11, 90.9%) had a high plasma concentration of rapid plasma reagin (RPR) (≥1:256); these percentages were significantly higher than in patients who had not developed JHR (p<0.05), suggesting that the occurrence of JHR was related to bone syphilis, having more than three organs affected by syphilis and a high plasma concentration of RPR.ConclusionsClinicians should be familiar with the risk factors for this reaction and its common clinical manifestations.

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