Pengaruh Luka Iris Pada Tikus Dengan Paparan Hidrogen Peroxida 3% terhadap Epitelisasi dan Pembentukan Eksudat pada Permukaan Epitel Kulit.

2020 ◽  
Vol 17 (2) ◽  
pp. 172
Author(s):  
HARMAN AGUSAPUTRA ◽  
MARIA SUGENG ◽  
AYLY SOEKAMTO ◽  
ATIK WULANDARI
Keyword(s):  
Hydrogen Peroxide ◽  
Wound Healing ◽  
The Other ◽  
Delayed Wound Healing ◽  
Peroxide Group ◽  
Hemostatic Effect ◽  
Significant Difference ◽  
Negative Effect ◽  
Wound Healing Effect ◽  
Epithelial Growth

<p><strong>Abstract</strong></p><p><strong>Background:</strong> Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) as antiseptic has been used frequently to clean woundsin in hospitals and clinics. Hydrogen peroxide has the effectof strong oxidative that can kill pathogens. It can clean up debris and necrotic tissuesin wounds. Hydrogen peroxidealso has hemostatic effect that can help to stop bleeding. Besides antiseptic effects, hydrogen peroxide i s suspected of having negative effect in wound healing. Hydrogen peroxide presumably could cause delayed wound healing by exudate formation and delayed epithelial growth.</p><p><strong>Method</strong>: This study was conducted in the laboratory using 48 white mice that were divided into 2 groups. All the mice were purposely wounded. Afterwards in one group the wounds were clean up using hydrogen peroxide, while in the other group without hydrogen peroxide as control. The wounds of both groups were observed on day 1, day 3 and day 7. On day 1 and day 3, both groups did not show significant difference.</p><p><strong>R</strong><strong>esult</strong> : on day 7 showed that the wound healing in hydrogen peroxide group were delayed. Fifty percent of them had the formation of exudate and 62.5% of them showed delayed epithelial growth.</p><p><strong>Conclusion </strong>: This study could show hydrogen peroxide as wound antiseptic has delayed wound healing effect.</p><p><strong>Keyword</strong>: hydrogen peroxide, wound healing</p>

Wound healing after craniotomy: a randomized trial comparing scalp clips to artery forceps for scalp hemostasis

2009 ◽  
Vol 111 (6) ◽  
pp. 1175-1178 ◽  
Author(s):  
Peter Langford ◽  
Rory Wolfe ◽  
R. Andrew Danks
Keyword(s):  
Clinical Trial ◽  
Wound Healing ◽  
Randomized Trial ◽  
Tissue Damage ◽  
The Self ◽  
Delayed Wound Healing ◽  
Prospective Randomized Clinical Trial ◽  
Skin Edge ◽  
Significant Difference ◽  
Artery Forceps

Object In this prospective randomized clinical trial, investigators looked at wound healing after craniotomy. The hypothesis was that the self-closing plastic scalp clips used for hemostasis on the skin edge might lead to localized microscopic tissue damage and subsequent delayed wound healing. Methods The trial consisted of 2 arms in which different methods were used to secure scalp hemostasis: 1) the routinely used plastic clips (Scalpfix, Aesculap); and 2) the older method of artery forceps placed on the galea. Participants were restricted to those > 16 years of age undergoing craniotomies expected to last > 2 hours. Repeat operations were not included. One hundred fifty patients were enrolled. They were visited at 3 and 6 weeks postoperatively by an observer blinded to the method used, and the wounds were assessed for macroscopic epithelial closure, signs of infection, and hair regrowth by using a predefined assessment scale. Results The results showed no significant difference in wound healing between the 2 groups at either 3 weeks (OR 0.55, 95% CI 0.27–1.11; p = 0.09) or 6 weeks (OR 0.79, 95% CI 0.39–1.58; p = 0.50). The length of operation was found to be a significant factor affecting wound healing at 6 weeks (OR/hour 0.68, 95% CI 0.51–0.92; p = 0.01). Conclusions The use of Aesculap Scalpfix self-retaining plastic scalp clips on the skin edge during craniotomy surgery does not appear to affect wound healing significantly to the postoperative 6-week mark.

scholarly journals Physical activity of school children and their parents in Vojvodina

2005 ◽  
Vol 58 (1-2) ◽  
pp. 52-56 ◽  
Author(s):  
Olja Niciforovic-Surkovic ◽  
Erzebet Ac-Nikolic ◽  
Snezana Ukropina ◽  
Vesna Mijatovic-Jovanovic
Keyword(s):  
Physical Activity ◽  
Health Promotion ◽  
Elementary Schools ◽  
Growth And Development ◽  
The Other ◽  
Young Population ◽  
Education And Health ◽  
Significant Difference ◽  
Negative Effect ◽  
Made In

Introduction. Physical activity is very important for normal physical and psychic growth and development. Recent studies in developed and developing countries have shown that today's schoolchildren are spending more and more time in front of the TV and computer, and less and less are engaged in sports. Such lifestyle has a negative effect on health. That is why it is very important for children to develop active habits for life, in order to sustain and promote their health. Material and methods. The study included, a random sample of 210 children from 4 elementary schools and their parents in Vojvodina. Specially designed questionnaires were used. Results and Discussion. The obtained results showed that 75% of schoolchildren are engaged in physical activity, but only 56.5% play sports regularly (every day or 2-3 times a week). There is a significant difference between boys and girls: about 75% of boys and 35% of girls are engaged in physical activity regularly. Similar results have been obtained by other authors (O'Reilly and Shelley, Faucette, Heath etc). Common reasons for physical activity are health, fitness and fun. Pupil's attitude to sports significantly depends on their parent's opinion about physical activity and also on their attitude to recreation in their future life. Parents are not active as their children, only 40% of fathers and 30% of mothers are engaged in various activities regularly. Conclusion. This study showed that schoolchildren are engaged in physical activity, but not enough. On the other hand, their parents are very inactive, although they see the importance of it. Considering the fact that present recreational habits are correlated with the attitude to recreation in the future, an additional effort should be made in health education and health promotion in young population. .

scholarly journals The Effect of Different Bleaching Protocols, Used with and without Sodium Ascorbate, on Bond Strength between Composite and Enamel

Materials ◽  
2020 ◽  
Vol 13 (12) ◽  
pp. 2710 ◽  
Author(s):  
Maroun Ghaleb ◽  
Giovanna Orsini ◽  
Angelo Putignano ◽  
Sarah Dabbagh ◽  
Georges Haber ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Bond Strength ◽  
Resin Composite ◽  
Testing Machine ◽  
Sodium Ascorbate ◽  
Control Group ◽  
Carbamide Peroxide ◽  
Total N ◽  
Peroxide Group ◽  
Significant Difference

This in vitro study aims to evaluate whether a solution of 10% sodium ascorbate (SA) may exert a beneficial effect on the bonding of composite to enamel after using different bleaching agents and protocols. Microtensile bond strength (µTBS) was evaluated on 72 freshly extracted human central incisors, divided into eight experimental groups and one control group (total n = 9): Group 1 serves as control (nonbleached). Group 2 was bleached with 5% carbamide peroxide. Group 3 was bleached with 5% carbamide peroxide and then treated with 10% SA. Group 4 was bleached with 10% carbamide peroxide. Group 5 was bleached with 10% carbamide peroxide, then treated with 10% SA. Group 6 was bleached with 16% carbamide peroxide. Group 7 was bleached with 16% carbamide peroxide, then treated with 10% SA. Group 8 was bleached with 6% hydrogen peroxide. Group 9 was bleached with 6% hydrogen peroxide, then treated with 10% SA. All groups were restored immediately after the different treatments using a resin composite. The µTBS values were measured using a universal testing machine and statistical analysis was performed by means of normality and variance analyses, SIDAK test for univariate test and multiple comparisons, and Student test to compare µTBS values of each group with the control. The mean µTBS values in groups 2, 4, 6, 8 were significantly lower than controls. For groups 3, 5, 7, 9, subjected to antioxidant (10% SA) application, all µTBS values increased significantly. However, only for Groups 3 and 5 there was no significant difference with the control. Applying 10% SA for 10 min may improve the bond strength composite/bleached enamel just when whitening is performed with 5% and 10% carbamide peroxide.

scholarly journals Anterior Incision Offloading for Primary and Revision Total Ankle Replacement: A Comparative Analysis of Two Techniques

2017 ◽  
Vol 11 (1) ◽  
pp. 678-686 ◽  
Author(s):  
Andrew D. Elliott ◽  
Thomas S. Roukis
Keyword(s):  
Wound Healing ◽  
Total Ankle Replacement ◽  
Wound Complications ◽  
Comparison Study ◽  
Delayed Wound Healing ◽  
Replacement Surgery ◽  
Ankle Replacement ◽  
Significant Difference ◽  
Incision Wound ◽  
Anterior Incision

Background: There exists a high risk of post-operative complications with primary and revision total ankle replacement surgery. Delayed wound healing of the anterior incision is common. The reason for this is multi-factorial and, to date, most of the research has focused on predisposing factors involving the patients themselves. Only recently have researchers begun to look at the post-operative dressing as a possible consideration when trying to prevent incision wound healing complications. Currently, no standard post-operative dressing for primary or revision total ankle replacement exists. However, the principles of post-operative edema reduction to improve healing, as advocated by Sir Robert Jones and demonstrated in his compressive dressing, have been known for decades. We have been using a modified Sir Robert Jones compressive dressing for both primary and revision total ankle replacements. Recently, we have added an aperture pad made of cotton cast padding over the anterior incision in order to protect the area from pressure necrosis. Methods: This is a comparison study of the post-operative wound complications involving 35 patients that received the original dressing and 33 patients that received the addition of the aperture pad. Results: With no significant difference in the patient populations, the results demonstrate a 3-fold decrease in the number of anterior incision wound healing complications with the use of the aperture pad. Conclusion: This dressing represents a simple, reproducible, easy to apply and inexpensive way to prevent post-operative edema and anterior incision wound healing complications.

scholarly journals Use of a Negative-Pressure Wound Dressing to Prevent Surgical Site Complications after Revision Knee Arthroplasty—A Randomized Controlled Trial

2021 ◽  
Vol 11 (19) ◽  
pp. 9102
Author(s):  
Christoph Deborre ◽  
Afoma Ezissi ◽  
Max Jaenisch ◽  
Mona Khoury ◽  
Christof Burger ◽  
...  
Keyword(s):  
Wound Healing ◽  
Knee Arthroplasty ◽  
Negative Pressure ◽  
Wound Dressing ◽  
Controlled Trial ◽  
Test Group ◽  
Control Group ◽  
Duration Of Treatment ◽  
Delayed Wound Healing ◽  
Significant Difference

The aim of this study was to determine if a negative pressure wound therapy (NPWT) system can facilitate wound healing and withstand mechanical stress owing to the high range of motion of the knee joint in total knee arthroplasty. The benefits of NPWT include aiding wound granulation and a reduction in wound edema and secretion; our goal is to investigate its benefits in primary wound closure. Within an eight-day duration of treatment, we compared standard wound dressing (gauze and compression) with the disposable NPWT system (PICO)TM. A total of 79 patients were recruited in a controlled, randomized, prospective, single-institution clinical trial. A total of 40 patients were allocated to the study group and 39 to the control group. In terms of blood loss and infection parameters, there was no significant difference between both groups. In the NPWT group, we determined a significant reduction in wound edema but none in wound secretion. While the NPWT dressings survived the mechanical effects of movement during postoperative physiotherapy, conventional compressive dressings were often renewed. Even though the risk factors that could lead to delayed wound healing were reduced in the test group, we could not identify any significant difference pertaining to delayed wound healing that required surgical treatment.

Three-Month Evaluation of Vital Tooth Bleaching Using Light Units—A Randomized Clinical Study

2013 ◽  
Vol 38 (1) ◽  
pp. 21-32 ◽  
Author(s):  
O Polydorou ◽  
M Wirsching ◽  
M Wokewitz ◽  
P Hahn
Keyword(s):  
Hydrogen Peroxide ◽  
Clinical Study ◽  
Chemical Activation ◽  
Color Stability ◽  
The Other ◽  
Tooth Bleaching ◽  
Bleaching Process ◽  
Randomized Clinical Study ◽  
Significant Difference

SUMMARY The aim of this study was to evaluate the color stability of vital bleaching using a halogen unit, laser, or only chemical activation up to three months after treatment. A total of 60 patients were divided into three groups, and their teeth were bleached with 38% hydrogen peroxide using three methods: acceleration of the bleaching process with halogen (eight minutes), laser (30 seconds), or chemical activation only. All teeth were bleached a maximum of four times (4 × 15 minutes) until a change of six shade tabs took place. The color was evaluated both visually and with a spectrophotometer before bleaching, immediately after bleaching, and one and three months after bleaching. Directly after bleaching, the use of halogen showed better results than laser (p≤0.05). One and three months after bleaching, no significant difference was found between the tested methods relative to the shade change, independent of the method of shade evaluation (p&gt;0.05). As far as the color stability is concerned, bleaching with halogen resulted in stable color throughout the three months (p&gt;0.05), whereas the other two methods resulted in whiter teeth after one and three months compared with the color directly after bleaching (p≤0.05). Bleaching with laser needed more time than halogen for the desired shade change (p≤0.05). Although directly after treatment bleaching with halogen resulted in better results, one and three months after bleaching the kind of acceleration used in the bleaching process did not have any effect on the esthetic results.

scholarly journals Hubungan antara Menopouse dengan Proses Penyembuhan Luka Paska Pencabutan Gigi di Klinik Gigi Universitas Wijaya Kusuma Surabaya

2018 ◽  
Vol 5 (1) ◽  
pp. 49
Author(s):  
Wahyuni Dyah Parmasari ◽  
Theodora Theodora ◽  
Enny Willianti
Keyword(s):  
Wound Healing ◽  
Oral Health ◽  
Tooth Extraction ◽  
Healing Process ◽  
Wound Healing Process ◽  
Delayed Wound Healing ◽  
The Third ◽  
Significant Difference ◽  
Main Factors ◽  
Experimental Use

Backgrounds : In medicine faculty specially in oral health university of Wijaya Kusuma Surabaya, extracting is the most common cases in clinic. As we know geriatry patients needs this treats too. The newest reports explain that estrogenes affected production of collaagens. Collagens are needed for asselarate wound healing. Menopause process decrease production of estrogen, so it can be influance for collagens output product.Purpose : This experimental to discribe the connection between menopause with clinical wound  healing process after tooth extraction at the Poli Gigi Universitas Wijaya Kusuma Surabaya. Methodes : This experimental use wound healing scale use parameters Tumor (swelling), Rubor (hyperemia) and Dolor (pain) Results : In this study used 20 patients divided two groups, menopause and non menopause group. There was a significant difference between menopause group and non menopause group in the third day and the fifth day after tooth extracted. For geriatry patients need dental care, specially tooth extraction. The complication in this age is delayed wound healing. For woman cases has many degeneration problems, one of this is because oldery ages woman has fisiology prosess menopause periode. Menopause is a regeneration process makes ovarium stops producting ovum. It was effected for maturation ovum and distrubing production of collagens. Collagens have main factors for wound healing process. In this articles, writer tried to connected the relations delayed wound healing in woman that have been in menopause period in case extracted teeth. Conclusion : There is a significant different between wound healing menopause and non menopause. The menopause the process wound healing takes more longer than non menopause.

The influence of Dolichoderus thoracicus (Hymenoptera: Formicidae) on losses due to Helopeltis theivora (Heteroptera: Miridae), black pod disease, and mammalian pests in cocoa in Malaysia

1992 ◽  
Vol 82 (4) ◽  
pp. 485-491 ◽  
Author(s):  
K.C. Khoo ◽  
C.T. Ho
Keyword(s):  
The Other ◽  
Phytophthora Palmivora ◽  
Helopeltis Theivora ◽  
Significant Difference ◽  
Negative Effect ◽  
Black Pod ◽  
Black Pod Disease ◽  
Other Regarding

AbstractThe influence of the black cocoa ant Dolichoderus thoracicus (Smith) on losses due to the mirid Helopeltis theivora Waterhouse, black pod disease (caused by Phytophthora palmivora (Peronosporales)) and mammalian pests (rats, squirrels and civet cats) was studied over a two-year period in two separate fields of cocoa. Both fields initially had high D. thoracicus activity. In each field, ant-scarce plots were created by treating these plots with insecticides; ant-abundant plots existed where the plots were left untreated. An abundance of D. thoracicus clearly had a negative effect on numbers of mirids, with respectively 380 and 2222% more nymphs and adults being recorded in the ant-scarce than in the ant-abundant plots over the two-year period. An abundance of D. thoracicus did not increase black pod incidence: on the contrary it reduced incidence of the disease in both fields. The number of rat-damaged pods in ant-scarce plots was significantly higher than in ant-abundant plots in one of the fields but no significant difference was detected in the other. Regarding number of pods lost to squirrels and civet cats, no significant difference between ant-scarce and ant-abundant plots was obtained for both fields; the losses to either of these mammalian pests were extremely low. The number of healthy ripe pods in ant-abundant plots was 40.4 and 32.1% higher than in ant-scarce plots in the two fields, these increases being ascribed to protection from H. theivora damage by D. thoracicus.

scholarly journals Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Hani Sinno ◽  
Meenakshi Malhotra ◽  
Justyn Lutfy ◽  
Barbara Jardin ◽  
Sebastian Winocour ◽  
...  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Sham Group ◽  
Breaking Strength ◽  
The Other ◽  
Systemic Effects ◽  
Skin Wounds ◽  
Collagen Deposition ◽  
Hemostatic Effect ◽  
Early Wound

Background. Complements C3 and C5 have independently been shown to augment and increase wound healing and strength. Our goal was to investigate the combinatorial effect of complements C3 and C5 on wound healing. Methods. Each rat served as its own control where topical collagen was applied to one incision and 100 nM of C3 and C5 in collagen vehicle was applied to the other incision (n=6). To compare between systemic effects, a sham group of rats (n=6) was treated with collagen alone on one wound and saline on the other. At day 3, the tissue was examined for maximal breaking strength (MBS) and sectioned for histological examination. Results. There was a statistically significant 88% increase in MBS with the topical application of C3C5 when compared to sham wounds (n<0.05). This was correlated with increased fibroblast and collagen deposition in the treated wounds. Furthermore, there appeared to be an additive hemostatic effect with the C3C5 combination. Conclusions. The combination of complements C3 and C5 as a topical application drug to skin wounds significantly increased wound healing maximum breaking strength as early as 3 days.

scholarly journals Sitotoksisitas pemutih gigi berdasarkan konsentrasi bahan

2010 ◽  
Vol 9 (2) ◽  
pp. 116
Author(s):  
Mardiana A. Adam ◽  
Asti Meizarini
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Line ◽  
Mtt Assay ◽  
Living Cell ◽  
Test Solution ◽  
Carbamide Peroxide ◽  
Tooth Whitening ◽  
Peroxide Group ◽  
Significant Difference ◽  
And Control

The aim of this study was to evaluate the cytotoxicity of several tooth whitening material,carbamide peroxide 10%, 15%, 20% and hydrogen peroxide 38% toward BHK-21 cellusing MTT assay. Each well of microplates which used for the test were aliquotted BHK21cell suspension, after that the test solution were added to eight well each group,respectively. The result showed that percentages of the living cell at 10% carbamideperoxide group = 86,73%; 15% = 81,22%; 20% = 81,82%; 38% hidrogen peroksida =64,08%, respectively. Anova test and LSD showed no significant difference between 10%,15%, 20% groups, but there are significant toward 38% group and control. The 38%hydrogen peroxide group is expectable to be more cytotoxic than those containing 10%carbamide peroxide, which is equivalent to 3.6% hidrogen peroxide. Conclusion.The10%, 15%, 20 % carbamide peroxide and 38% hydrogen peroxide tooth whiteningagents were not cytotoxic toward BHK-21 cell line using MTT assay within CD

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