scholarly journals Early Trauma Is Associated with Poor Pharmacological Treatment Response in Patients with Panic Disorder

Author(s):  
Hyun-Ju Kim ◽  
Ji Eun Kim ◽  
Sang-Hyuk Lee
1997 ◽  
Vol 42 (1) ◽  
pp. 29S-30S
Author(s):  
C. Toni ◽  
S. Ramacciotti ◽  
B. Simonetti ◽  
E. De Soricellis ◽  
T. Xuereb ◽  
...  

Author(s):  
Borwin Bandelow ◽  
David S. Baldwin ◽  
Peter Zwanzger

2011 ◽  
Vol 26 (S2) ◽  
pp. 157-157
Author(s):  
E. Heldt ◽  
C. Blaya ◽  
L. Kipper ◽  
G. Salum Junior ◽  
V.N. Hirakata ◽  
...  

BackgroundThere is a limitation of data about factors associated with treatment response in panic disorder (PD) patients at long-term follow-up period. The aim of this study was to evaluate the long-term treatment response of pharmacotherapy-resistant patients with PD after 5 years of cognitive-behavior group therapy (CBGT) and to identify factors that predict this outcome.MethodSixty-four patients who completed 12 sessions of CBGT were followed for 5-year. Outcome measures were evaluated by the Clinical Global Impression (CGI) and quality of life (QoL) using WHOQOL-bref. Demographic and clinical features, stressful life events were the variables investigated as predictors of CBGT response across follow-up period.ResultsTreatment was associated with significant reduction in symptoms severity (agoraphobia, anticipatory anxiety and panic attacks) with maintenance of gains at 5-year of follow-up (p < 0.05). Twenty-four (40%) of the sample remained in remission after 5 years, 12 (20%) relapsed during the follow-up period and 24 (40%) were non-responder to CBGT. The poor CBGT response had an important negative impact in QoL. Regression analyzes showed that comorbidity with dysthymia (p = 0.017) and stressful life events (p = 0.012) as the most important predictors to worse response.ConclusionsThe improvement in all evaluations suggested that brief CBGT for pharmacotherapy-resistant patients could be an alternative as next-step strategy for residual symptoms with maintenance of the gains after 5 years as assessed across follow-up period. New strategies should be tried for resistant patients, such as those with dysthymia comorbidity, and some specific tool in order to cope with adverse events.


2008 ◽  
Vol 25 (8) ◽  
pp. E18-E26 ◽  
Author(s):  
E.H. Uhlenhuth ◽  
Vladan Starcevic ◽  
Clifford Qualls ◽  
Edward J. Antal ◽  
William Matuzas ◽  
...  

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