ROLE OF KYNURENINE PATHWAY METABOLITES IN DEPRESSION-A REVIEW

Author(s):  
Priyadarshini Soni ◽  
Lubhan Singh ◽  
Prabhat Singh ◽  
Sokindra Kumar

Today most common psychiatric problem across the world is depression and stress is main source of ailment. According to World health organization, it will be the main cause of morbidity by 2020 in the world. Depression can critically affects the quality of life  as it is characterized by many symptoms like unhappy feeling, lack of interest and pleasure, down energy, inadequacy, regret feeling, slow-down of thoughts or reduction in physical movement, speech can affects, altered appetite or sleep, sad,  and increase the risk of suicide. Human body is inadequate to produce tryptophan which is a crucial amino acid; therefore it must be required from diet. After absorption, L-tryptophan crosses the BBB (Blood brain barrier) by non-specific L-type amino acid transporter and act as precursor to various metabolic pathways in central nervous system (CNS). Kynurenine is an important pathway that is associated with tryptophan (TRP) metabolism, where it develops a lot of metabolites such as 3-hydroxykynurenine (3HK), anthranilic acid (AA), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA) and quinolinic acid (QUIN) known as kynurenines. It is already reported previously that disturbance in neuroprotective and neurotoxic metabolites leads to many psychiatric disorders. This review summarizes the role of kynurenine pathway metabolites in depression.   

This chapter includes a brief overview of musculoskeletal conditions which are described in health terms as non-communicable diseases. Health systems internationally share common goals of improving the health and well-being of their populations and the management of non-communicable diseases is key in every country. This chapter describes how across the world governments share significant challenges for the future, with the growing elderly and chronic disease populations and increasing healthcare costs. Agreed international goals have been set by the World Health Organization and some of the key targets are outlined. The consequences of either trauma or disease can result in a musculoskeletal condition that may impact the individual’s quality of life, health, and functional ability. The role of the nurse and how individual nurses in all care sectors should consider public health factors when caring for patients are discussed.


Author(s):  
Lara Bittmann

On December 31, 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on January 7, 2020 and was provisionally named "2019-nCoV". This new Coronavirus causes a clinical picture which has received now the name COVID-19. The virus has spread subsequently worldwide and was explained on the 11th of March, 2020 by the World Health Organization to the pandemic.


2021 ◽  
Vol 29 (Supplement_1) ◽  
pp. i45-i46
Author(s):  
A Peletidi ◽  
R Kayyali

Abstract Introduction Obesity is one of the main cardiovascular disease (CVD) risk factors.(1) In primary care, pharmacists are in a unique position to offer weight management (WM) interventions. Greece is the European country with the highest number of pharmacies (84.06 pharmacies per 100,000 citizens).(2) The UK was chosen as a reference country, because of the structured public health services offered, the local knowledge and because it was considered to be the closest country to Greece geographically, unlike Australia and Canada, where there is also evidence confirming the potential role of pharmacists in WM. Aim To design and evaluate a 10-week WM programme offered by trained pharmacists in Patras. Methods This WM programme was a step ahead of other interventions worldwide as apart from the usual measuring parameters (weight, body mass index, waist circumference, blood pressure (BP)) it also offered an AUDIT-C and Mediterranean diet score tests. Results In total,117 individuals participated. Of those, 97.4% (n=114), achieved the programme’s aim, losing at least 5% of their initial weight. The mean % of total weight loss (10th week) was 8.97% (SD2.65), and the t-test showed statistically significant results (P<0.001; 95% CI [8.48, 9.45]). The programme also helped participants to reduce their waist-to-height ratio, an early indicator of the CVD risk in both male (P=0.004) and female (P<0.001) participants. Additionally, it improved participants’ BP, AUDIT-C score and physical activity levels significantly (P<0.001). Conclusion The research is the first systematic effort in Greece to initiate and explore the potential role of pharmacists in public health. The successful results of this WM programme constitute a first step towards the structured incorporation of pharmacists in public’s health promotion. It proposed a model for effectively delivering public health services in Greece. This study adds to the evidence in relation to pharmacists’ CVD role in public health with outcomes that superseded other pharmacy-led WM programmes. It also provides the first evidence that Greek pharmacists have the potential to play an important role within primary healthcare and that after training they are able to provide public health services for both the public’s benefit and their clinical role enhancement. This primary evidence should support the Panhellenic Pharmaceutical Association, to “fight” for their rights for an active role in primary care. In terms of limitations, it must be noted that the participants’ collected data were recorded by pharmacists, and the analysis therefore depended on the accuracy of the recorded data, in particular on the measurements or calculations obtained. Although the sample size was achieved, it can be argued that it is small for the generalisation of findings across Greece. Therefore, the WM programme should be offered in other Greek cities to identify if similar results can be replicated, so as to consolidate the contribution of pharmacists in promoting public health. Additionally, the study was limited as it did not include a control group. Despite the limitations, our findings provide a model for a pharmacy-led public health programme revolving around WM that can be used as a model for services in the future. References 1. Mendis S, Puska P, Norrving B, World Health Organization., World Heart Federation., World Stroke Organization. Global atlas on cardiovascular disease prevention and control [Internet]. Geneva: World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization; 2011 [cited 2018 Jun 26]. 155 p. Available from: http://www.who.int/cardiovascular_diseases/publications/atlas_cvd/en/ 2. Pharmaceutical Group of the European Union. Pharmacy with you throughout life:PGEU Annual Report [Internet]. 2015. Available from: https://www.pgeu.eu/en/library/530:annual-report-2015.html


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi-chang Chen ◽  
Keh-chung Lin ◽  
Chen-Jung Chen ◽  
Shu-Hui Yeh ◽  
Ay-Woan Pan ◽  
...  

Abstract Background Joint contractures, which affect activity, participation, and quality of life, are common complications of neurological conditions among elderly residents in long-term care facilities. This study examined the reliability and validity of the Chinese version of the PaArticular Scales in a population with joint contractures. Methods A cross-sectional study design was used. The sample included elderly residents older than 64 years with joint contractures in an important joint who had lived at one of 12 long-term care facilities in Taiwan for more than 6 months (N = 243). The Chinese version of the PaArticular Scales for joint contractures was generated from the English version through five stages: translation, review, back-translation, review by a panel of specialists, and a pretest. Test-retest reliability, internal consistency reliability, construct validity, and criterion validity were evaluated, and the results were compared with those for the World Health Organization Quality of Life scale and the World Health Organization Disability Assessment Schedule. Results The Chinese version of the PaArticular Scales had excellent reliability, with a Cronbach α coefficient of 0.975 (mean score, 28.98; standard deviation, 17.34). An exploratory factor analysis showed three factors and one factor with an eigenvalue > 1 that explained 75.176 and 62.83 % of the total variance in the Activity subscale and Participation subscale, respectively. The subscale-to-total scale correlation analysis showed Pearson correlation coefficients of 0.881 for the Activity subscale and 0.843 for the Participation subscale. Pearson’s product-moment correlation revealed that the correlation coefficient (r) between the Chinese version of the PaArticular Scales and the World Health Organization Disability Assessment Schedule was 0.770, whereas that for the World Health Organization Quality of Life scale was − 0.553; these values were interpreted as large coefficients. Conclusions The underlying theoretical model of the Chinese version of the PaArticular Scales functions well in Taiwan and has acceptable levels of reliability and validity. However, the Chinese version must be further tested for applicability and generalizability in future studies, preferably with a larger sample and in different clinical domains.


2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Heba K. Nabih

Abstract Background The global coronavirus disease 2019 (COVID-19) was announced as pandemic by the World Health Organization (WHO). With the increased number of infected and dead victims daily all over the world, it becomes necessary to stop or overcome its rapid spread. Main body Although the production of vaccine or even specified effective anti-virus may take about six months to a year, intravenous immunoglobulin (IVIg) may be clinically used as a safe treatment to save and improve the quality of life of patients with a variety of immunodeficiency diseases such as lymphocytopenia, which is a common clinical feature in COVID-19. Conclusion Through the current review, it was concluded that this passive immunization may promote the immunity to better fight against the virus, so the survival of the patients could be kept longer. The efficacy of immunotherapy with IVIg would be greater if the immune IgG antibodies were collected from convalescent plasma therapy.


2020 ◽  
Vol 14 (4) ◽  
pp. 193-197
Author(s):  
Alan Glasper

In light of the emergence in China of COVID-19, the novel corona virus, emeritus professor Alan Glasper, from the University of Southampton discusses the role of the World Health Organization and other public health institutions in responding to potential new global pandemics and deliberates on the role of NHS staff in coping with infectious disease in clinical environments.


2018 ◽  
Vol 9 (2) ◽  
pp. 165-170
Author(s):  
Husni Husni

One of the effects is not maintaining hygiene during menstruation is able to hitkankes Rahim neck (cervical). Based on data from the World Health Organization (WHO),cervical cancer is the second most cancer in women aged 15-45 years after breast cancer. Noless than 500,000 new cases with 280,000 patient deaths occur each year worldwide.Indonesia was ranked first by the victims died at least 555 women per day and 200,000women annually. This study aims to determine the correlation between knowledge andattitude towards personal hygiene during menstruation action at SMAN 2 Bengkulu City. Thisresearch is descriptive analytic. The number of respondents 84 people with a samplingtechnique that stratified random sampling. Presentation of data is done by using a frequencydistribution table. The collection of data taken using a questionnaire. The data were analyzedusing univariate and bivariate analysis with Chi-Square.The results showed that therespondents are classified as good knowledge of (54.8%), attitude unfavorabel or does notsupport (53.6%), and the biggest acts (52.4%) is good. From the bivariate analysis were foundno correlation between knowledge against acts of personal hygiene during menstruation (p =0.794), and no relation attitude towards personal hygiene actions during menstruation (p =0.975).Required role of schools, educators, parents to be more proactive in enhancingknowledge and useful information about the process of menstruation and how to maintainhygiene during menstruation.


2018 ◽  
Vol 1 (3) ◽  
pp. 1-14
Author(s):  
Rasha Babiker Gurashi Abu Sabah ◽  
Abubaker Haroun Mohamed Adam ◽  
Dawoud Mohamed Ali

The objectives of this study were to quantify the fresh water quality of Blue Nile River before processing, identify the pollutants, and to determine the most polluted areas, and their impacts on living organisms as well as the surrounding environment. Thus, random water samples were collected and analyzed at the laboratory of the Ministry of Irrigation and Water Resources, Ground water and Wadis Directorates - Khartoum. The outcomes were compared with the World Health Organization standardization. The results revealed variations in the concentration of the studied elements taken from the different locations. But, the results indicated that the water quality is good, and it is within the permissible water use. However, further study is recommended to include seasonal variation as well as the biological analysis.


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