Failure of systemic N-acetyl cysteine to protect the rat lung against bleomycin toxicity

Pathology ◽  
1987 ◽  
Vol 19 (4) ◽  
pp. 358-360 ◽  
Author(s):  
Helen E. Ward ◽  
Anthony Nicholson ◽  
Norbert Berend
Keyword(s):  
Rat Lung ◽  
Acetyl Cysteine

Cysteine Esters Protect Cultured Rodent Lung Slices from Sulphur Mustard

1994 ◽  
Vol 13 (11) ◽  
pp. 743-748 ◽  
Author(s):  
Paul E. Wilde ◽  
David G. Upshall
Keyword(s):  
Structural Changes ◽  
Methyl Esters ◽  
Dimethyl Ester ◽  
Rat Lung ◽  
Sulphur Mustard ◽  
Lung Slice ◽  
Pretreatment Time ◽  
Acetyl Cysteine

1 In previous studies an in vitro rat lung slice system was used to investigate the metabolic and structural changes after exposure to known lung toxicants. 2 In this study, the same system was used to identify the ability of cysteine esters to protect against sulphur mustard toxicity. 3 The cyclopentyl (CCPE), cyclohexyl (CCHE), isopropyl (CIPE), methyl (CME) esters of cysteine, cystine dimethyl ester (CDME), cysteine (CySH) and N-acetyl cysteine (NAc) were all non-toxic to cultured rat lung slices at 5 mM (equivalent cysteine concentration) after a pretreatment time of 30 min. 4 Pretreatment with the isopropyl, cyclohexyl, cyclopentyl and methyl esters of cysteine at concentrations higher than 1 mM protected against an IC50 of sulphur mustard, however, neither cysteine nor N-acetylcysteine protected. 5 We propose that the extent of protection is directly related to increased levels of intracellular cysteine provided by the esters of cysteine.

Replication of Internal Biological Surfaces

1972 ◽  
Vol 30 ◽  
pp. 308-309
Author(s):  
J. A. Nowell ◽  
J. Pangborn ◽  
W. S. Tyler
Keyword(s):  
Da Vinci ◽  
Leonardo Da Vinci ◽  
Rat Lung ◽  
Tubular Structures ◽  
Cerebral Ventricles ◽  
Internal Surfaces ◽  
Biological Surfaces ◽  
Dog Kidney ◽  
Lung And Kidney ◽  
Scanning Electron

Leonardo da Vinci in the 16th century, used injection replica techniques to study internal surfaces of the cerebral ventricles. Developments in replicating media have made it possible for modern morphologists to examine injection replicas of lung and kidney with the scanning electron microscope (SEM). Deeply concave surfaces and interrelationships to tubular structures are difficult to examine with the SEM. Injection replicas convert concavities to convexities and tubes to rods, overcoming these difficulties.Batson's plastic was injected into the renal artery of a horse kidney. Latex was injected into the pulmonary artery and cementex in the trachea of a cat. Following polymerization the tissues were removed by digestion in concentrated HCl. Slices of dog kidney were aldehyde fixed by immersion. Rat lung was aldehyde fixed by perfusion via the trachea at 30 cm H2O. Pieces of tissue 10 x 10 x 2 mm were critical point dried using CO2. Selected areas of replicas and tissues were coated with silver and gold and examined with the SEM.

N-acetyl-cysteine and H. pylori urease activity

2001 ◽  
Vol 120 (5) ◽  
pp. A589-A589
Author(s):  
H HUYNH ◽  
R COUPER ◽  
C TRAN ◽  
A MUHAMED ◽  
R BUTLER
Keyword(s):  
Urease Activity ◽  
Acetyl Cysteine ◽  
H Pylori

Radiation pneumonitis in rat lung after treatment with rhenium-188-microspheres

2008 ◽  
Vol 180 (09) ◽  
Author(s):  
K Liepe ◽  
M Haase ◽  
D Faulhaber ◽  
G Wunderlich ◽  
M Andreeff ◽  
...  
Keyword(s):  
Radiation Pneumonitis ◽  
Rat Lung

Transdifferentiation of fibroblasts and myofibroblasts from rat lung

Pneumologie ◽  
2005 ◽  
Vol 59 (01) ◽  
Author(s):  
T Zimmer ◽  
KP Knoch ◽  
R Koslowski
Keyword(s):  
Rat Lung

Maturation of fetal rat lung in diabetic pregnancies of graduated severity

Diabetes ◽  
1985 ◽  
Vol 34 (8) ◽  
pp. 734-743 ◽  
Author(s):  
J. R. Bourbon ◽  
B. Pignol ◽  
L. Marin ◽  
M. Rieutort ◽  
C. Tordet
Keyword(s):  
Rat Lung ◽  
Fetal Rat ◽  
Fetal Rat Lung
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