Evaluation of the usefulness of a sensitive immunoradiometric assay for thyroid stimulating hormone as a first-line thyroid function test in an unselected patient population

1987 ◽  
Vol 47 (3) ◽  
pp. 215-221 ◽  
Author(s):  
U. -B. Ericsson ◽  
P. Fernlund ◽  
J. I. Thorell
Keyword(s):  
Thyroid Function ◽  
Patient Population ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Immunoradiometric Assay ◽  
First Line ◽  
Unselected Patient ◽  
Function Test ◽  
Unselected Patient Population ◽  
Stimulating Hormone

Immunoradiometric assay of thyrotropin as a "first-line" thyroid-function test in the routine laboratory.

1986 ◽  
Vol 32 (4) ◽  
pp. 691-693 ◽  
Author(s):  
M R Hopton ◽  
J S Harrop
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Primary Hypothyroidism ◽  
Thyroid Function Tests ◽  
Immunoradiometric Assay ◽  
Routine Laboratory ◽  
First Line ◽  
Function Test ◽  
Antithyroid Treatment

Abstract We compared the utility of a sensitive immunoradiometric assay for serum thyrotropin as a "first-line" thyroid-function test with a strategy based on first measuring total thyroxin in serum. The immunoradiometric assay appears to distinguish primary hypothyroidism and hyperthyroidism from euthyroidism in "new" patients. The role of this test in monitoring antithyroid treatment or thyroxin-replacement therapy is not yet established, there being particular difficulty in interpreting low thyrotropin concentrations in such patients. Nevertheless, because a normal thyrotropin concentration in most, if not all, situations signifies the euthyroid state, thyrotropin determination by immunoradiometric assay merits consideration as an initial test by laboratories performing thyroid-function tests.

scholarly journals The Characteristics of Children with Abnormalities Detected in Thyroid Function Tests, and Distribution of Diagnoses

2020 ◽  
Author(s):  
Elif Çelik ◽  
Ayşe Anık
Keyword(s):  
Thyroid Function ◽  
Thyroid Disease ◽  
Correct Diagnosis ◽  
Thyroid Function Test ◽  
Hashimoto Thyroiditis ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Function Tests ◽  
Test Results ◽  
Function Tests ◽  
Function Test

INTRODUCTION: Thyroid function tests are among the most frequently implemented laboratory tests in primary, and secondary healthcare institutions. The aim of the present study was to investigate the demographic and clinical characteristics and final diagnosis of children referred by primary and secondary healthcare institutions with the suspicion of an abnormality in thyroid function test and/or with the initial diagnosis of specific thyroid disease. METHODS: A total of two hundred eighty-nine pediatric patients, aged between 4 and 18 years admitted to the outpatient clinics of Behçet Uz Children’s Health and Diseases Hospital between January 2018 and January 2020, were included in the study. The patient data were obtained retrospectively from the hospital records. RESULTS: A total of 66% of the patients who were included in the study were female with a median age of 12 years (8.7-14.4), while 64% of them were pubertal; and 78% of the cases were referred by secondary healthcare institutions. The most common reason for referral was isolated elevation of thyroid stimulating hormone (TSH). A total of 56% of the patients were asymptomatic at the time of admission, and thyroid function test results of 75% of them were within normal limits. When evaluated according to their final diagnoses, the children were normal/healthy (64%), diagnosed with Hashimoto thyroiditis (30%), nodular thyroid disease (3%), Graves disease (2%) and isolated increase of TSH was related to obesity in 5 patients (1%). DISCUSSION AND CONCLUSION: It is essential to evaluate children with abnormal thyroid function test results with detailed history and physical examination. Besides, the thyroid function tests should be performed with reliable and sensitive methods in standardized laboratories to reach the correct diagnosis in these children.

Pitfalls in the use of thyrotropin concentration as a first-line thyroid-function test

The Lancet ◽  
2001 ◽  
Vol 357 (9261) ◽  
pp. 1013-1014 ◽  
Author(s):  
Catherine A Wardle ◽  
William D Fraser ◽  
Christine R Squire
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
First Line ◽  
Function Test

Establishment of trimester-specific reference intervals for thyroid stimulating hormone and free thyroxine during pregnancy in southwest China by indirect method

2021 ◽  
pp. 000456322110631
Author(s):  
Ying Guo ◽  
Bin Wei ◽  
Wei Dai ◽  
Hongjian Xie
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Indirect Method ◽  
Southwest China ◽  
Thyroid Function Test ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Test Results ◽  
Function Test

Objective A series of physiological changes in thyroid function occur during pregnancy and differ from those non-pregnant women. This study aimed to establish the pregnancy-specific reference intervals of TSH and FT4 using an indirect method based on the healthy pregnant women from southwest China population. Methods Thyroid function test results which available on the Laboratory Information System (LIS) were collected from the pregnancies who visited the Obstetric Clinic or the Department of Gynecology between 1 January 2015, and 30 December 2020. We grouped the data by trimesters to establish the reference intervals (RIs) based on the clinical consensus of different levels of TSH and FT4 at different weeks of gestation. All arrangements were referenced to the document CLSI EP28-A3C. Results A total of 33,040 thyroid function test results of pregnant women, aged 31 (28,33) years were statistical analyzed. Estimated RIs for TSH and FT4 in the first, second and third trimesters corresponding to the 2.5th and 97.5th percentiles in TPOAb negative were 0.02–5.23, 0.03–5.24, 0.37–5.68 mIU/L, 11.66–20.69, 10.1–18.59, 9.85–16.86pmol/L, respectively. Conclusion This study provides trimester-specific RIs for TSH and FT4 among healthy pregnant women in southwest China which guides clinicians to diagnosis and screen for thyroid disorders in this region.

scholarly journals Serial Thyroid Function Test in Very Low Birth Weight Neonates

2021 ◽  
Vol 11 (01) ◽  
pp. e173-e177
Author(s):  
Birendra Pradhan ◽  
Santosh Kumar Panda ◽  
Deepti Damayanty Pradhan ◽  
Manas Kumar Nayak ◽  
Soumini Rath ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Thyroid Function ◽  
Very Low Birth Weight ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Low Birth Weight Infants ◽  
Vlbw Infants ◽  
Resource Limited ◽  
Function Test

AbstractThyroid dysfunction is more common in preterm and low birth weight infants, and may be missed if thyroid function test (TFT) is not repeated. Thus, we attempted to study the pattern of thyroid function among very low birth weight (VLBW) infants with birth weight less than 1,500 g by serial TFTs. Serum free thyroxine (FT4) and thyrotropin (thyroid-stimulating hormone [TSH]) levels of VLBW infants were tested on fifth to seventh days of life and repeated after 4 weeks of age. Based on serial FT4 and TSH results, abnormal TFT was classified into four groups—transient hypothyroxinemia of prematurity (THOP), transient hyperthyrotropinemia (THT), delayed TSH rise, and overt congenital hypothyroidism (CH). Stata 15.1 (Stata Corp, Texas, United States) was used for analysis. Ninety-six VLBW infants were enrolled with mean gestational age of 30.5 ± 2.7 weeks and median (interquartile range) birth weight of 1,200 (317) g. Out of 96 cases, 30 (31.2%) infants had abnormal TFT. Ten (10.4%) infants had THOP, 7 (7.3%) infants had THT, 11 (11.5%) infants had delayed TSH rise, and 2 (2.1%) infants had overt CH. There were no significant differences in demographic profile and clinical characteristics between neonates with normal and abnormal TFTs. Five infants required levothyroxine supplementation (two infants with overt CH and three infants with delayed TSH rise). VLBW neonates have higher incidence of CH and delayed rise of TSH in this study. In resource-limited settings, repeating TFTs at least once after 4 weeks of age may be suggested to identify delayed rise of TSH which may need intervention.

scholarly journals EVALUATION OF THYROID FUNCTION TEST IN OBESE PATIENTS

2016 ◽  
Vol 9 (9) ◽  
pp. 353 ◽  
Author(s):  
Faazila Fathima ◽  
Preetha P
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Obese Patients ◽  
Obese People ◽  
Hormone Synthesis ◽  
Significant Difference ◽  
Function Test ◽  
Tsh Levels ◽  
Paired T Test

ABSTRACTObjective: To evaluate thyroid function in 20-50 aged obese people. As obesity is a widespread problem today, knowledge about the factors affectingor influencing it is important. Little is known about the changes in thyroid function obese people. Influence on thyroid hormone synthesis has beenproposed.Methods: Thyroid function test was done for 30 obese and 30 nonobese people, and their thyroid-stimulating hormone (TSH) levels were compared.Results: Using paired t-test, we found that there is a statistically significant difference between TSH levels in obese and nonobese people at p<0.001.Keywords: Thyroid, Obese, Nonobese, Thyroid function test.

scholarly journals Thyroid Function Test as First-line Investigation of Hypernatremia: Is It Necessary?

2020 ◽  
Vol 4 (1) ◽  
pp. 12-18
Author(s):  
Nada Syazana ◽  
Huzairi Sani ◽  
Zahir Izuan Azhar
Keyword(s):  
Thyroid Function ◽  
Strong Association ◽  
Thyroid Function Test ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
Bivariate Analysis ◽  
Thyroid Function Tests ◽  
First Line ◽  
Cross Sectional

Non-severe hypothyroidism has no strong association with hyponatremia. However, thyroid function tests (TFT) continue to be ordered as a first-line investigation. The objective of this study was to establish the prevalence of inpatient hyponatremia and to reiterate the association between thyroid disorders and hyponatremia based on study findings and current literature. A cross-sectional study on 3,478 in-patients adults of both gender admitted to a Malaysian tertiary hospital was carried out.  Age, gender, sodium levels, thyroid stimulating hormone (TSH), free thyroxine (fT4) and clinical notes between 1/11/17-31/12/17 were extracted from the hospital’s information system. Bivariate analysis was performed using Mann-Whitney U, Chi-square and Spearman correlation tests. 21.9% of inpatients had hyponatremia of which 52% were mild. 359 (69%) of hyponatremic patients had a TFT sent where 71.9% were euthyroid. Sodium level is significantly correlated with age (R=-0.257, P<0.001). No correlations were found between sodium and TSH and fT4. Sodium was significantly lower in the non-thyroidal illness (NTI) group compared to the hypothyroid group. No significant differences in sodium were found between the hypothyroid group and other thyroid states. Hence it was conclude that in hyponatremia, TFT is indicated when there is clinical evidence of severe hypothyroidism, suspicion of hypothalamus-pituitary-axis disorder or when no cause of SIADH is apparent. Otherwise, TFT is unnecessary and costly as a first-line investigation.   Keywords: hyponatremia, hypothyroidism, hypothyroid, non-thyroidal illness, sodium

scholarly journals Premature ovarian failure could be an alarming sign of polyglandular autoimmune dysfunction

2017 ◽  
Vol 51 (2) ◽  
pp. 114-116 ◽  
Author(s):  
Aasem Saif ◽  
M. Assem
Keyword(s):  
Blood Pressure ◽  
Thyroid Function ◽  
General Condition ◽  
Premature Ovarian Failure ◽  
Skin Infection ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Ovarian Failure ◽  
Function Test ◽  
Very High

Abstract A 31-year-old lady, diagnosed to have premature ovarian failure in the gynecology clinic, was referred for endocrine assessment because of an abnormal thyroid function test. Clinical examination revealed hypotension, and fungal skin infection under her atrophic breasts. Thyroid stimulating hormone (TSH) level was very high. Assessment of the suprarenal function revealed evidence of Addison’s disease. Polyglandular autoimmune dysfunction was diagnosed. She was treated with prednisone, fludrocortisone, and levothyroxine with significant improvement of her general condition and blood pressure.

scholarly journals A study on thyroid dysfunction in acne vulgaris

2019 ◽  
Vol 5 (4) ◽  
pp. 736
Author(s):  
Shreya Srinivasan ◽  
Jayakar Thomas
Keyword(s):  
Thyroid Function ◽  
Acne Vulgaris ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Antibodies ◽  
Male Population ◽  
Free T4 ◽  
Free T3 ◽  
Function Test

<p class="abstract"><strong>Background:</strong> This study was done to evaluate the role of thyroid function i.e., free T3, free T4 and thyroid stimulating hormone (TSH) in relation to the occurrence of acne vulgaris.</p><p class="abstract"><strong>Methods:</strong> A total of 50 patients clinically diagnosed with acne vulgaris were subjected to a thyroid function test and results were evaluated.<strong></strong></p><p class="abstract"><strong>Results:</strong> While all the 50 patients had normal free T3 and free T4 levels, 9 (18%) of the 50 patients displayed an elevated TSH level. Gender distribution among the patients with elevated TSH learned more towards the male population with 6 patients while there were only 3 female patients with elevated TSH.</p><p><strong>Conclusions:</strong> There have been few studies regarding the role of thyroid function in acne vulgaris in relation to free T3, free T4 and TSH, though the presence of thyroid antibodies have been highlighted in quite a few studies. This study has shown the insignificance of thyroid function in acne vulgaris thus accentuating the negative.</p>

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