Non-invasive evaluation of the fibrosis stage in chronic hepatitis C: A comparative analysis of nine scoring methods

2009 ◽  
Vol 45 (1) ◽  
pp. 51-59 ◽  
Author(s):  
José M. Ladero ◽  
Jaime Delkader ◽  
Luis Ortega ◽  
Cristina Fernández ◽  
María J. Devesa ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Comparative Analysis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Fibrosis Stage ◽  
Scoring Methods ◽  
Non Invasive ◽  
Invasive Evaluation

scholarly journals The importance of aminotransferases and platelets count in non-invasive evaluation stages of chronic hepatitis C

2005 ◽  
Vol 133 (5-6) ◽  
pp. 262-265 ◽  
Author(s):  
Sladjana Pavic ◽  
Neda Svirtlih ◽  
Jasmina Simonovic ◽  
Ivan Boricic
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Chronic Hepatitis C ◽  
Alanine Aminotransferase ◽  
Positive Correlation ◽  
Non Invasive ◽  
Two Parameters ◽  
Invasive Evaluation

143 patients with chronic hepatitis C were investigated. The following two parameters were determined: the asparate to alanine aminotransferase ratio and the asparate aminotransferase to platelets count index. A liver biopsy was performed for every patient and stages of liver fibrosis were evaluated. Both parameters confirmed a positive correlation with liver fibrosis, which can be useful in predicting the progression of chronic hepatitis C.

Large-scale multicentre comparison of three algorithms combining serum non-invasive markers for liver fibrosis in chronic hepatitis C

2008 ◽  
Vol 40 (10) ◽  
pp. A119-A120
Author(s):  
G. Sebastiani ◽  
P. Halfon ◽  
L. Castera ◽  
A. Mangia ◽  
V. Di Marco ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Large Scale ◽  
Non Invasive

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

2018 ◽  
Vol 67 (3) ◽  
pp. 681-685 ◽  
Author(s):  
Ali Sobhy ◽  
Mohammed Fakhry M. ◽  
Haitham A Azeem ◽  
Ahmed M Ashmawy ◽  
Hamed Omar Khalifa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
B Virus

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

Investigation of chronic hepatitis C infection in individuals with haemophilia: assessment of invasive and non‐invasive methods

1996 ◽  
Vol 94 (1) ◽  
pp. 159-165 ◽  
Author(s):  
John Hanley ◽  
Lisa Jarvis ◽  
Janet Andrews ◽  
Rosemary Dennis ◽  
Robert Lee ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatitis C Infection ◽  
Non Invasive

scholarly journals Comparison of three algorithms of non-invasive markers of fibrosis in chronic hepatitis C

2011 ◽  
Vol 35 (1) ◽  
pp. 92-104 ◽  
Author(s):  
G. Sebastiani ◽  
P. Halfon ◽  
L. Castera ◽  
A. Mangia ◽  
V. Di Marco ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Non Invasive

Novel scores combining AFP with non-invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

2018 ◽  
Vol 90 (6) ◽  
pp. 1080-1086 ◽  
Author(s):  
Mohamed Gamil ◽  
Mohamed Alboraie ◽  
Mohammad El-Sayed ◽  
Aisha Elsharkawy ◽  
Noha Asem ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Non Invasive ◽  
Chronic Hepatitis C Patients
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