scholarly journals In vitro and in vivo biological performance of Mg-based bone implants

2020 ◽  
Vol 3 (1) ◽  
pp. 11-41
Author(s):  
Andreea Mariana Negrescu ◽  
◽  
Madalina-Georgiana Necula ◽  
Marieta Costache ◽  
Anisoara Cimpean ◽  
...  
Keyword(s):  
Bone Implants ◽  
Biological Performance

scholarly journals Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2081 ◽  
Author(s):  
Teddy Tite ◽  
Adrian-Claudiu Popa ◽  
Liliana Balescu ◽  
Iuliana Bogdan ◽  
Iuliana Pasuk ◽  
...  
Keyword(s):  
High Performance ◽  
Life Time ◽  
Crystalline Lattice ◽  
Current Status ◽  
Synthesis Methods ◽  
Biological Interactions ◽  
Application Range ◽  
Biological Performance

High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

In vitro and in vivo biological performance of collagen-chitosan/silicone membrane bilayer dermal equivalent

2007 ◽  
Vol 18 (11) ◽  
pp. 2185-2191 ◽  
Author(s):  
Lie Ma ◽  
Yanchao Shi ◽  
Yixin Chen ◽  
Haiguang Zhao ◽  
Changyou Gao ◽  
...  
Keyword(s):  
Silicone Membrane ◽  
Membrane Bilayer ◽  
Dermal Equivalent ◽  
Biological Performance

scholarly journals A Critical Review of the Design, Manufacture, and Evaluation of Bone Joint Replacements for Bone Repair

Materials ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 153
Author(s):  
Yi Huo ◽  
Yongtao Lyu ◽  
Sergei Bosiakov ◽  
Feng Han
Keyword(s):  
Additive Manufacturing ◽  
Joint Replacement ◽  
Bone Repair ◽  
Bone Diseases ◽  
Bone Implants ◽  
Design Algorithm ◽  
Joint Replacements ◽  
Manufacturing Technique

With the change of people’s living habits, bone trauma has become a common clinical disease. A large number of bone joint replacements is performed every year around the world. Bone joint replacement is a major approach for restoring the functionalities of human joints caused by bone traumas or some chronic bone diseases. However, the current bone joint replacement products still cannot meet the increasing demands and there is still room to increase the performance of the current products. The structural design of the implant is crucial because the performance of the implant relies heavily on its geometry and microarchitecture. Bionic design learning from the natural structure is widely used. With the progress of technology, machine learning can be used to optimize the structure of bone implants, which may become the focus of research in the future. In addition, the optimization of the microstructure of bone implants also has an important impact on its performance. The widely used design algorithm for the optimization of bone joint replacements is reviewed in the present study. Regarding the manufacturing of the implant, the emerging additive manufacturing technique provides more room for the design of complex microstructures. The additive manufacturing technique has enabled the production of bone joint replacements with more complex internal structures, which makes the design process more convenient. Numerical modeling plays an important role in the evaluation of the performance of an implant. For example, theoretical and numerical analysis can be carried out by establishing a musculoskeletal model to prepare for the practical use of bone implants. Besides, the in vitro and in vivo testing can provide mechanical properties of bone implants that are more in line with the implant recipient’s situation. In the present study, the progress of the design, manufacture, and evaluation of the orthopedic implant, especially the joint replacement, is critically reviewed.

Applications of ROS-Induced Zr-MOFs Platform in Multimodal Synergistic Therapy

2021 ◽  
Vol 21 ◽  
Author(s):  
Qiongjie Ding ◽  
Yiwei Liu ◽  
Chuncheng Shi ◽  
Jifei Xiao ◽  
Wei Dai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Antitumor Effects ◽  
Metal Organic ◽  
Low Toxicity ◽  
Therapeutic Mechanisms ◽  
Biological Performance

Background: Metal-organic frameworks (MOFs) exhibited the adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities that have used to be as drug delivery carries in cancer therapy. Until now, Zr-MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and are widely studied for its excellent biological performance. Introduction: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs) with focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy(SDT), radiotherapy, immunotherapy, gene therapy and related combined therapies, which all generate reactive oxygen species (ROS) to achieve the high efficiency of tumor therapy. Conclusion: We described and summarized these pertinent examples of the therapeutic mechanisms and highlight the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and analogous challenge of the Zr-MOFs materials are given.

Degradation and biological performance of porous osteomimetic biphasic calcium phosphate in vitro and in vivo

Rare Metals ◽  
2021 ◽  
Author(s):  
Chun-Sheng Shao ◽  
Liang-Jian Chen ◽  
Rui-Min Tang ◽  
Bo Zhang ◽  
Jiang-Jie Tang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Biological Performance

In vitro–in vivo characterization of gentamicin bone implants

2002 ◽  
Vol 83 (3) ◽  
pp. 353-364 ◽  
Author(s):  
M. Baro ◽  
E. Sánchez ◽  
A. Delgado ◽  
A. Perera ◽  
C. Évora
Keyword(s):  
Bone Implants ◽  
In Vivo Characterization

Adsorption of Alendronate onto Biomimetic Apatite Nanocrystals to Develop Drug Carrier Coating for Bone Implants

2012 ◽  
Vol 529-530 ◽  
pp. 475-479 ◽  
Author(s):  
Ruggero Bosco ◽  
Michele Iafisco ◽  
Jeroen van den Beucken ◽  
Sander C.G. Leeuwenburgh ◽  
John A. Jansen
Keyword(s):  
Drug Delivery ◽  
Surface Engineering ◽  
Drug Carrier ◽  
Local Treatment ◽  
Titanium Implants ◽  
Bone Implants ◽  
Bone Implant ◽  
Biomimetic Apatite

The possibility to develop a bone implant with bioactive aspects and in situ drug-delivery properties, in order to provide local treatment in vivo, is a big challenge. Where conventional surface modifications for bone implants focused on the deposition of ceramic (mostly calcium phosphate, CaP) coatings, current surface engineering approaches attempt to incorporate active features to render bone implant surfaces capable to direct biological performance. Biomimetic apatite nanocrystals (nAp) represent, among the CaPs, an elective material for bone applications and their surface functionalization with drugs allows them to act as a drug-delivery vehicle. Since load-bearing bone implants are increasingly used in patients with compromised health conditions, surface engineering is important to warrant the performance of these implants under such conditions. In view of this, bisphosphonates (BPs) represent a treatment modality for a variety of disorders of bone metabolism associated to bone loss, including Paget's bone disease, osteoporosis, fibrous dysplasia and bone metastases. In this work, we have synthesized and characterized bioinspired nAp and evaluated their functionalization with alendronate. In vitro tests will be used to evaluate the efficacy of the functionalized compound to impede the formation of osteoclasts and to show that alendronate-functionalized nAp can significantly reduce osteoclasteogenesis. Finally, alendronate-functionalized nAp (FnAp) has been deposited on titanium implants via the electrospray deposition technique in order to develop inorganic-organic coatings for bone implants with improved functionality.

Plasma Deposition of Biomolecules for Enhanced Biomedical Applications

2015 ◽  
Vol 1723 ◽  
Author(s):  
Liam O’Neill ◽  
Barry Twomey ◽  
Peter Dobbyn ◽  
John O’Donoghue
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Plasma Deposition ◽  
Preclinical Trial ◽  
Minimal Impact ◽  
Plasma Device ◽  
Biological Performance ◽  
The Impact

ABSTRACTBiomolecules have been traditionally immobilised onto surfaces using wet chemical techniques for various medical applications. Recent decades have seen plasma methods being used to prepare these surfaces through various forms of surface modification, but the direct exposure of biomolecules to plasma has been avoided due to fears that the molecules would be denatured by the energetic plasma species. Recent results are now demonstrating that direct plasma deposition of biomolecule coatings can be achieved. This creates the possibility to directly modify the surface of implants without any form of surface pre-treatment and this opens up the possibility to alter the healing processes. Materials such as collagen, chitosan, catalase and heparin can be effectively deposited onto surfaces with minimal impact on biological performance and without any chemical binders, linkers or impurities. The performance of these materials has been characterised using both in vitro and in vivo methodologies. In a further step, the results of a preclinical trial are presented which reveal that direct deposition of biomolecules onto open wounds can also be achieved and the impact of this on wound healing is measured in an immunocompromised animal model. A non-thermal plasma device was used to deliver collagen on to chronic wounds and the treatment was shown to promote wound closure in a rabbit wound healing model.

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