scholarly journals Differential expression of lysyl oxidase in human epithelial ovarian cancer.

2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding lysyl oxidase, LOX, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. LOX expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. LOX expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of LOX is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. LOX may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.

2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding sarcospan, SSPN, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. SSPN expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. SSPN expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of SSPN is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. SSPN may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding phosphodiesterase 5A, PDE5A, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. PDE5A expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. PDE5A expression correlated with progression-free survival in patients with p53 mutant ovarian cancer. These data indicate that expression of PDE5A is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. PDE5A may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding trophinin associated protein, TROAP, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. TROAP expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. TROAP expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of TROAP is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. TROAP may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding cyclin B2, CCNB2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CCNB2 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. These data indicate that expression of CCNB2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CCNB2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding dystrophin, DMD, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. DMD expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. DMD expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of DMD is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. DMD may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding seizure-related 6 homolog-like 2, SEZ6L2, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. SEZ6L2 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. SEZ6L2 expression correlated with progression-free survival in patients with ovarian cancer. These data indicate that expression of SEZ6L2 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. SEZ6L2 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding tropomyosin 3, TPM3, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. TPM3 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. TPM3 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of TPM3 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. TPM3 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding GULP, engulfment adaptor PTB domain containing 1, GULP1, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. GULP1 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. GULP1 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of GULP1 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. GULP1 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding coronin 6, CORO6, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. CORO6 expression was significantly lower in high-grade serous ovarian tumors relative to normal fallopian tube. CORO6 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of CORO6 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. CORO6 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


2021 ◽  
Author(s):  
Shahan Mamoor

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of primary tumors from women diagnosed with epithelial ovarian cancer or HGSC. We identified the gene encoding matrix remodeling associated 5, MXRA5, as among the genes whose expression was most different in epithelial ovarian cancer as compared to the normal fallopian tube. MXRA5 expression was significantly higher in high-grade serous ovarian tumors relative to normal fallopian tube. MXRA5 expression correlated with overall survival in patients with ovarian cancer. These data indicate that expression of MXRA5 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. MXRA5 may be relevant to pathways underlying ovarian cancer initiation (transformation) or progression.


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