Identification of biological processes and signaling pathways for the knockout of C14orf159 in colorectal cancer cells

Functional mitochondria are crucial to the development and metastasis of cancer cells. C14orf159 is an important mitochondrial protein and is associated with the proliferation of cancer cells. In our study, we aim to identify essential signaling pathways and biological processes in the knockout of C14orf159 in colorectal cancer cells. The GSE167947 dataset was produced by using the Illumina HiSeq 2500 (Homo sapiens). The KEGG and GO analyses showed that biological processes “Staphylococcus aureus infection” and “Systemic lupus erythematosus” are the most important processes in the loss of C14orf159. Moreover, we identified a variety of genes by constructing the PPI network, which includes Albumin, Brain derived neurotrophic factor, and Matrix metallopeptidase 9. Therefore, our study provides insights into the treatment of colorectal cancer by targeting mitochondria.